Full Text Journal Articles by
Author Ruben M Savizky

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Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

Joshua Mayourian, Ruben M Savizky, Eric A Sobie, Kevin D Costa,

Human mesenchymal stem cell (hMSC) delivery has demonstrated promise in preclinical and clinical trials for myocardial infarction therapy; however, broad acceptance is hindered by limited understanding of hMSC-human cardiomyocyte (hCM) interactions. To better understand the electrophysiological consequences of direct heterocellular connections between hMSCs and hCMs, three original mathematical models were ... Read more >>

PLoS Comput. Biol. (PLoS computational biology)
[2016, 12(7):e1005014]

Cited: 6 times

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Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.

Yashang Lee, Hosup Yeo, Shwu-Huey Liu, Zaoli Jiang, Ruben M Savizky, David J Austin, Yung-chi Cheng,

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2004, 47(22):5555-5566]

Cited: 17 times

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