Full Text Journal Articles by
Author Roshan Karki

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Anatomy and Pathology of the Cardiac Conduction System.

Roshan Karki, Anvi Raina, Fatima M Ezzeddine, Melanie C Bois, Samuel J Asirvatham,

The cardiac conduction system is formed of histologically and electrophysiologically distinct specialized tissues uniquely located in the human heart. Understanding the anatomy and pathology of the cardiac conduction system is imperative to an interventional electrophysiologist to perform safe ablation and device therapy for the management of cardiac arrhythmias and heart ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):569-584]

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Single-Dose Intraprocedural Steroid Administration Does Not Impact Early Atrial Fibrillation Recurrence.

Kolade M Agboola, Michael Dietrich, Roshan Karki, Fahad Lodhi, Trevon McGill, Samuel J Asirvatham, Abhishek J Deshmukh, Christopher V DeSimone,

<h4>Purpose</h4>To evaluate the effect of single-dose intravenous dexamethasone on atrial fibrillation (AF) recurrence following radiofrequency catheter ablation.<h4>Methods</h4>A cohort of 84 adult patients (> 18 years) underwent catheter ablation at Mayo Clinic Rochester from January to March 2019. Only first-time ablation patients were included, with all re-do ablations excluded to minimize heterogeneity. Administration ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Single-Dose Intraoperative Steroid Administration Does Not Impact Early Atrial Fibrillation Recurrence

Kolade Agboola, Michael Dietrich, Roshan Karki, Fahad Lodhi, Trevon McGill, Samuel Asirvatham, Abhishek Deshmukh, Christopher DeSimone,

<h4>Purpose: </h4> To evaluate the effect of single-dose intravenous dexamethasone on AF recurrence following radiofrequency catheter ablation. <h4>Methods: </h4>: A cohort of 94 adult patients (>18 years) underwent catheter ablation at Mayo Clinic Rochester from January to March 2019. Only first-time ablation patients were included, with all re-do ablations excluded ... Read more >>

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Sub-mitral valve aneurysm ventricular tachycardia masquerading as arrhythmogenic right ventricular cardiomyopathy.

Robert Ward, Roshan Karki, Samuel J Asirvatham, Abhishek J Deshmukh, Christopher V DeSimone,

HeartRhythm Case Rep (HeartRhythm case reports)
[2021, 7(9):588-592]

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Implantation of leadless pacemakers via inferior vena cava filters is feasible and safe: Insights from a multicenter experience.

Mahmoud Houmsse, Roshan Karki, James Gabriels, Michael Reinig, Dilesh Patel, Sarah K Hussain, Gaurang D Gandhi, Michael S Lloyd, Mina S Makary, Toshimasa Okabe, Kamala Tamirisa, Jacqueline Joza, Apoor Patel, Muhammad R Afzal, Laurence M Epstein, Yong-Mei Cha,

<h4>Background</h4>The leadless Micra transcatheter-pacing system (Micra-TPS) is implanted via a femoral approach using a 27-French introducer sheath. The Micra Transcutaneous Pacing Study excluded patients with inferior vena cava (IVC) filters.<h4>Objective</h4>To examine the feasibility and safety of Micra-TPS implantation through an IVC filter.<h4>Methods</h4>This multicenter retrospective study included patients with an IVC ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(12):3277-3285]

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Arrhythmias Associated with Inflammatory Cardiomyopathies.

Roshan Karki, Chaitra Janga, Abhishek J Deshmukh,

<h4>Purpose of review</h4>To provide an approach to the diagnosis and treatment of arrhythmias associated with inflammatory cardiomyopathies.<h4>Recent findings</h4>Inflammatory cardiomyopathies are increasingly recognized as the etiology of both ventricular and supraventricular arrhythmias. There have been recent studies providing novel insights into the pathogenesis of arrhythmias in inflammatory cardiomyopathies and exploring the ... Read more >>

Curr Treat Options Cardiovasc Med (Current treatment options in cardiovascular medicine)
[2020, 22(12):76]

Cited: 1 time

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The Future of Percutaneous Epicardial Interventions.

Roshan Karki, Paul A Friedman, Ammar M Killu,

The pericardial space provides a unique vantage point to access different cardiac structures for diagnosis and treatment of arrhythmias and other nonelectrophysiologic conditions, such as heart failure. There have been notable innovations to improve safety of percutaneous pericardial access and its use for various procedures. Percutaneous pericardial device therapies for ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2020, 12(3):419-430]

Cited: 0 times

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Catheter Ablation in Patients With Neuroendocrine (Carcinoid) Tumors and Carcinoid Heart Disease: Outcomes, Peri-Procedural Complications, and Management Strategies.

Samuel A Shabtaie, Sushil Allen Luis, Robert C Ward, Roshan Karki, Heidi M Connolly, Patricia A Pellikka, Suraj Kapa, Samuel J Asirvatham, Douglas L Packer, Christopher V DeSimone,

<h4>Objectives</h4>This report describes a series of patients with neuroendocrine tumors with or without carcinoid heart disease undergoing catheter ablation at the authors' institution.<h4>Background</h4>Neuroendocrine (carcinoid) tumors are a rare form of neoplasm with the potential for systemic vasoactive effects and cardiac valvular involvement. These tumors can create peri-operative management challenges for ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(2):151-160]

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Ventricular automaticity: A path to premature ventricular contraction ablation success.

Kolade M Agboola, Roshan Karki, Samuel J Asirvatham,

Indian Pacing Electrophysiol J (Indian pacing and electrophysiology journal)
[2020, 20(6):227-230]

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Ventricular asystole in the presence of a biventricular device.

Roshan Karki, James Lloyd, Siva K Mulpuru, Samuel J Asirvatham, Christopher V DeSimone,

In pacemaker-dependent patients with a newly implanted cardiac device, acute lead dislodgement constitutes one of the most common causes of loss of capture and ventricular asystole. In a biventricular system, it would be expected that such a potentially catastrophic event would be prevented with back-up right ventricular pacing unless both ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(11):3031-3035]

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The circuit for bundle-branch re-entrant tachycardia.

Roshan Karki, Samuel J Asirvatham,

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(4):972-974]

Cited: 0 times

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Elevated end-diastolic wall stress after acute myocardial infarction predicts adverse cardiovascular outcomes and longer hospital length of stay.

Wassim Mosleh, Kalaimani Elango, Tanvi Shah, Milind Chaudhari, Sumeet Gandhi, Sharma Kattel, Roshan Karki, Charl Khalil, Kevin Frodey, Suraj Dahal, Cale Okeeffe, Zaid Aljebaje, Makoto Nagahama, Natdanai Punnanithinont, Umesh C Sharma,

<h4>Background</h4>Acute myocardial infarction (MI) leads to ventricular remodeling in response to oxygen demand. Such changes include left ventricular (LV) dilatation and increased myocardial wall stress. Prior studies showed that wall stress is a vital parameter of cardiac remodeling. However, outcome data are lacking. We aim to investigate wall stress post-MI ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2018, 35(11):1721-1728]

Cited: 3 times

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Arrhythmias in Patients ≥80 Years of Age: Pathophysiology, Management, and Outcomes.

Anne B Curtis, Roshan Karki, Alexander Hattoum, Umesh C Sharma,

Advances in medical care have led to an increase in the number of octogenarians and even older patients, forming an important and unique patient subgroup. It is clear that advancing age is an independent risk factor for the development of most arrhythmias, causing substantial morbidity and mortality. Patients ≥80 years of ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2018, 71(18):2041-2057]

Cited: 14 times

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The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study.

Wassim Mosleh, Milind R Chaudhari, Swati Sonkawade, Supriya Mahajan, Charl Khalil, Kevin Frodey, Tanvi Shah, Suraj Dahal, Roshan Karki, Rujuta Katkar, W Matthijs Blankesteijn, Brian Page, Saraswati Pokharel, Minhyung Kim, Umesh C Sharma,

<h4>Introduction</h4>Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct ... Read more >>

Biomark Insights (Biomarker insights)
[2018, 13:1177271918771969]

Cited: 9 times

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High-risk carotid plaques identified by CT-angiogram can predict acute myocardial infarction.

Wassim Mosleh, Keenan Adib, Punnanithinont Natdanai, Andres Carmona-Rubio, Roshan Karki, Jacienta Paily, Mohamed Abdel-Aal Ahmed, Sujit Vakkalanka, Narasa Madam, Gregory D Gudleski, Charles Chung, Umesh C Sharma,

Prior studies identified the incremental value of non-invasive imaging by CT-angiogram (CTA) to detect high-risk coronary atherosclerotic plaques. Due to their superficial locations, larger calibers and motion-free imaging, the carotid arteries provide the best anatomic access for the non-invasive characterization of atherosclerotic plaques. We aim to assess the ability of ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2017, 33(4):561-568]

Cited: 4 times

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Defining "mutation" and "polymorphism" in the era of personal genomics.

Roshan Karki, Deep Pandya, Robert C Elston, Cristiano Ferlini,

<h4>Background</h4>The growing advances in DNA sequencing tools have made analyzing the human genome cheaper and faster. While such analyses are intended to identify complex variants, related to disease susceptibility and efficacy of drug responses, they have blurred the definitions of mutation and polymorphism.<h4>Discussion</h4>In the era of personal genomics, it is ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2015, 8:37]

Cited: 43 times

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Class III β-tubulin in normal and cancer tissues.

Marisa Mariani, Roshan Karki, Manuela Spennato, Deep Pandya, Shiquan He, Mirko Andreoli, Paul Fiedler, Cristiano Ferlini,

Microtubules are polymeric structures composed of tubulin subunits. Each subunit consists of a heterodimer of α- and β-tubulin. At least seven β-tubulin isotypes, or classes, have been identified in human cells, and constitutive isotype expression appears to be tissue specific. Class III β-tubulin (βIII-tubulin) expression is normally confined to testes ... Read more >>

Gene (Gene)
[2015, 563(2):109-114]

Cited: 26 times

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Taxanes in combination with biologic agents for ovarian and breast cancers.

Roshan Karki, Brandon-Luke L Seagle, Wilberto Nieves-Neira, Shohreh Shahabi,

Taxane-based cytotoxic therapy is commonly prescribed for breast and ovarian cancers. Although these cancers are often sensitive to such therapy, clinical benefit and overall survival are limited owing to the development of chemoresistance and recurrence. Biologic agents that specifically target proteins of growth factor signaling pathways, which are hyperactivated in ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2014, 25(5):536-554]

Cited: 1 time

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βIII-Tubulin: biomarker of taxane resistance or drug target?

Roshan Karki, Marisa Mariani, Mirko Andreoli, Shiquan He, Giovanni Scambia, Shohreh Shahabi, Cristiano Ferlini,

<h4>Introduction</h4>βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable. By contrast, this cytoskeletal protein is abundant in a wide range of tumors. βIII-Tubulin is linked to dynamic instability of microtubules (MTs), weakening the effects of agents ... Read more >>

Expert Opin Ther Targets (Expert opinion on therapeutic targets)
[2013, 17(4):461-472]

Cited: 34 times

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The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.

Roshan Karki, Sabine M Lang, Robert E Means,

Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In exploring the role of this viral protein in monocytes, we made the surprising ... Read more >>

PLoS Pathog (PLoS pathogens)
[2011, 7(4):e1001331]

Cited: 10 times

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The Kaposi’s sarcoma-associated herpesvirus E3 ubiquitin ligase K5 acts as a novel oncogene, altering cellular metabolism and signaling: implications for tumorigenesis

Roshan Karki, Sabine M Lang, Robert E Means,

Infect Agent Cancer (Infectious agents and cancer)
[2010, 5(Suppl 1):A79-A79]

Cited: 0 times

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