Full Text Journal Articles by
Author Rosario Scalia

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Targeting Mitochondrial Fission as a Potential Therapeutic for Abdominal Aortic Aneurysm.

Hannah A Cooper, Stephanie Cicalese, Kyle J Preston, Tatsuo Kawai, Keisuke Okuno, Eric T Choi, Shingo Kasahara, Haruhito A Uchida, Nozomu Otaka, Rosario Scalia, Victor Rizzo, Satoru Eguchi,

AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II-associated AAA remains unexplored. Here, we tested the hypothesis that ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2020, :]

Cited: 0 times

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Mitochondrial Fission Mediates Endothelial Inflammation.

Steven J Forrester, Kyle J Preston, Hannah A Cooper, Michael J Boyer, Kathleen M Escoto, Anthony J Poltronetti, Katherine J Elliott, Ryohei Kuroda, Masashi Miyao, Hiromi Sesaki, Tomoko Akiyama, Yayoi Kimura, Victor Rizzo, Rosario Scalia, Satoru Eguchi,

Endothelial inflammation and mitochondrial dysfunction have been implicated in cardiovascular diseases, yet, a unifying mechanism tying them together remains limited. Mitochondrial dysfunction is frequently associated with mitochondrial fission/fragmentation mediated by the GTPase Drp1 (dynamin-related protein 1). Nuclear factor (NF)-κB, a master regulator of inflammation, is implicated in endothelial dysfunction and ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(1):267-276]

Cited: 0 times

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Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.

Melissa Lieu, Christopher J Traynham, Claudio de Lucia, Jessica Pfleger, Michela Piedepalumbo, Rajika Roy, Jennifer Petovic, Gavin Landesberg, Steven J Forrester, Matthew Hoffman, Laurel A Grisanti, Ancai Yuan, Erhe Gao, Konstantinos Drosatos, Satoru Eguchi, Rosario Scalia, Douglas G Tilley, Walter J Koch,

Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of cardiac G protein-coupled receptor (GPCR) kinase 2 (GRK2) activity via S-nitrosylation of GRK2 at cysteine 340 (C340). This maintains GPCR ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2020, 318(5):H1162-H1175]

Cited: 0 times

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Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells.

Nikita Mokhashi, Robert Y Choi, Stephanie Cicalese, Kunie Eguchi, Michael J Boyer, Hannah A Cooper, Yayoi Kimura, Tomoko Akiyama, Rosario Scalia, Victor Rizzo, Satoru Eguchi,

Adenoviral vectors are useful tools in manipulating a gene of interest in vitro and in vivo, including in the vascular system. The transduction efficiencies of adenoviral vectors in vascular cells such as endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are known to be lower than those in epithelial ... Read more >>

J. Cardiovasc. Pharmacol. (Journal of cardiovascular pharmacology)
[2020, 75(6):603-607]

Cited: 0 times

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Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis.

Allison B Herman, Milessa Silva Afonso, Sheri E Kelemen, Mitali Ray, Christine N Vrakas, Amy C Burke, Rosario G Scalia, Kathryn Moore, Michael V Autieri,

OBJECTIVE:Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to cellular stress. SGs have been shown to contribute to the pathogenesis of several human diseases, but their role in vascular diseases is unknown. This study shows that SGs accumulate in vascular ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2019, 39(10):2014-2027]

Cited: 1 time

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Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation.

Kyle J Preston, Inna Rom, Christine Vrakas, Gavin Landesberg, Zienab Etwebi, Sanae Muraoka, Michael Autieri, Satoru Eguchi, Rosario Scalia,

High-fat diet (HFD)-induced obesity is associated with accumulation of inflammatory cells predominantly in visceral adipose depots [visceral adipose tissue (VAT)] rather than in subcutaneous ones [subcutaneous adipose tissue (SAT)]. The cellular and molecular mechanisms responsible for this phenotypic difference remain poorly understood. Controversy also exists on the overall impact that ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(11):11993-12007]

Cited: 0 times

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Xanthine Oxidase Inhibition as a Potential Treatment for Aortic Stiffness in Hypertension.

Stephanie Cicalese, Rosario Scalia, Satoru Eguchi,

Am. J. Hypertens. (American journal of hypertension)
[2019, 32(3):234-236]

Cited: 0 times

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Angiotensin II- and Alzheimer-Type Cardiovascular Aging.

Hannah A Cooper, Rosario Scalia, Victor Rizzo, Satoru Eguchi,

Circ. Res. (Circulation research)
[2018, 123(6):651-653]

Cited: 2 times

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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.

Steven J Forrester, George W Booz, Curt D Sigmund, Thomas M Coffman, Tatsuo Kawai, Victor Rizzo, Rosario Scalia, Satoru Eguchi,

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (AT1R) is believed to mediate most functions of ANG II in the system. AT1R utilizes various signal transduction cascades causing hypertension, cardiovascular ... Read more >>

Physiol. Rev. (Physiological reviews)
[2018, 98(3):1627-1738]

Cited: 26 times

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Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology.

Satoru Eguchi, Tatsuo Kawai, Rosario Scalia, Victor Rizzo,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2018, 71(5):804-810]

Cited: 6 times

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Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase).

Zienab Etwebi, Gavin Landesberg, Kyle Preston, Satoru Eguchi, Rosario Scalia,

MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO remain though largely elusive. Calpain is a calcium-dependent protease expressed in the vascular wall. Activation of calpains ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2018, 71(4):761-770]

Cited: 1 time

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Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.

Tatsuo Kawai, Takehiko Takayanagi, Steven J Forrester, Kyle J Preston, Takashi Obama, Toshiyuki Tsuji, Tomonori Kobayashi, Michael J Boyer, Hannah A Cooper, Hang Fai Kwok, Tomoki Hashimoto, Rosario Scalia, Victor Rizzo, Satoru Eguchi,

Angiotensin II (AngII)-activated epidermal growth factor receptor has been implicated in abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMCs), AngII activates epidermal growth factor receptor via a metalloproteinase, ADAM17 (a disintegrin and metalloproteinase domain 17). We hypothesized that AngII-dependent AAA development would be prevented in mice lacking ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(5):959-963]

Cited: 5 times

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Disease drivers of aging.

Richard J Hodes, Felipe Sierra, Steven N Austad, Elissa Epel, Gretchen N Neigh, Kristine M Erlandson, Marissa J Schafer, Nathan K LeBrasseur, Christopher Wiley, Judith Campisi, Mary E Sehl, Rosario Scalia, Satoru Eguchi, Balakuntalam S Kasinath, Jeffrey B Halter, Harvey Jay Cohen, Wendy Demark-Wahnefried, Tim A Ahles, Nir Barzilai, Arti Hurria, Peter W Hunt,

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2016, 1386(1):45-68]

Cited: 19 times

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Targeting neutrophil: new approach against hypertensive cardiac remodeling?

Takashi Obama, Rosario Scalia, Satoru Eguchi,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2014, 63(6):1171-1172]

Cited: 0 times

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Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.

Takehiko Takayanagi, Steven J Forrester, Tatsuo Kawai, Takashi Obama, Toshiyuki Tsuji, Katherine J Elliott, Elisa Nuti, Armando Rossello, Hang Fai Kwok, Rosario Scalia, Victor Rizzo, Satoru Eguchi,

Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances cardiovascular remodeling and damage may be distinct. However, the signal transduction cascade by which AngII specifically initiates cardiovascular remodeling, such as hypertrophy and fibrosis, remains insufficiently ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2016, 68(4):949-955]

Cited: 15 times

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Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms.

Farah Kako, Khatuna Gabunia, Mitali Ray, Sheri E Kelemen, Ross N England, Bashar Kako, Rosario G Scalia, Michael V Autieri,

Neovascularization and inflammation are independent biological processes but are linked in response to injury. The role of inflammation-dampening cytokines in the regulation of angiogenesis remains to be clarified. The purpose of this work was to test the hypothesis that IL-19 can induce angiogenesis in the absence of tissue hypoxia and ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2016, 310(11):C931-41]

Cited: 7 times

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Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via μ-calpain activation.

Zhongjian Cheng, Xiaohua Jiang, Meghana Pansuria, Pu Fang, Jietang Mai, Karthik Mallilankaraman, Rajesh Kumar Gandhirajan, Satoru Eguchi, Rosario Scalia, Muniswamy Madesh, Xiaofeng Yang, Hong Wang,

Plasma homocysteine (Hcy) levels are positively correlated with cardiovascular mortality in diabetes. However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on endothelial dysfunction (ED) and the underlying mechanisms have not been studied. Mild (22 µmol/L) and moderate (88 µmol/L) HHcy were induced in cystathionine β-synthase wild-type (Cbs(+/+)) and ... Read more >>

Diabetes (Diabetes)
[2015, 64(3):947-959]

Cited: 27 times

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Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.

Yajing Wang, Xiaoliang Wang, Wayne Bond Lau, Yuexing Yuan, David Booth, Jing-Jing Li, Rosario Scalia, Kyle Preston, Erhe Gao, Walter Koch, Xin-Liang Ma,

RATIONALE:Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered. OBJECTIVE:The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ceramidase activation in adiponectin anti-inflammatory signaling. METHODS AND RESULTS:Adiponectin significantly reduced tumor necrosis ... Read more >>

Circ. Res. (Circulation research)
[2014, 114(5):792-805]

Cited: 27 times

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Three-dimensional reconstruction of neovasculature in solid tumors and basement membrane matrix using ex vivo X-ray microcomputed tomography.

Seunghyung Lee, Mary F Barbe, Rosario Scalia, Lawrence E Goldfinger,

To create accurate, high-resolution 3D reconstructions of neovasculature structures in xenografted tumors and Matrigel plugs for quantitative analyses in angiogenesis studies in animal models.The competent neovasculature within xenografted solid tumors or Matrigel plugs in mice was perfused with Microfil, a radioopaque, hydrophilic polymerizing contrast agent, by systemic perfusion of the ... Read more >>

Microcirculation (Microcirculation (New York, N.Y. : 1994))
[2014, 21(2):159-170]

Cited: 6 times

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Pulmonary endothelial protein kinase C-delta (PKCδ) regulates neutrophil migration in acute lung inflammation.

Mark J Mondrinos, Ting Zhang, Shuang Sun, Paul A Kennedy, Devon J King, Marla R Wolfson, Linda C Knight, Rosario Scalia, Laurie E Kilpatrick,

Excessive neutrophil migration across the pulmonary endothelium into the lung and release of oxidants and proteases are key elements in pathogenesis of acute lung injury. Previously, we identified protein kinase C-delta (PKCδ) as an important regulator of proinflammatory signaling in human neutrophils and demonstrated that intratracheal instillation of a TAT-conjugated ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2014, 184(1):200-213]

Cited: 14 times

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Attenuation of experimental atherosclerosis by interleukin-19.

Stephen Ellison, Khatuna Gabunia, Sheri E Kelemen, Ross N England, Rosario Scalia, James M Richards, A Wayne Orr, James G Traylor, Thomas Rogers, William Cornwell, Lisa M Berglund, Isabel Goncalves, Maria F Gomez, Michael V Autieri,

Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2013, 33(10):2316-2324]

Cited: 24 times

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Ceacam1 deletion causes vascular alterations in large vessels.

Sonia M Najjar, Kelly J Ledford, Simon L Abdallah, Alexander Paus, Lucia Russo, Meenakshi K Kaw, Sadeesh K Ramakrishnan, Harrison T Muturi, Christian K Raphael, Sumona Ghosh Lester, Garrett Heinrich, Sandrine V Pierre, Ralf Benndorf, Veronika Kleff, Ayad A Jaffa, Emile Lévy, Guillermo Vazquez, Ira J Goldberg, Nicole Beauchemin, Rosario Scalia, Süleyman Ergün,

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1-/-) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association among hyperinsulinemia, fatty liver disease, and atherosclerosis, ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2013, 305(4):E519-29]

Cited: 12 times

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Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability.

Ross N England, Kyle J Preston, Rosario Scalia, Michael V Autieri,

Vascular endothelial cell (EC) inflammation is a key event in the pathogenesis of multiple vascular diseases. We tested the hypothesis that interleukin-19 (IL-19), an anti-inflammatory Th2 interleukin, could have a direct anti-inflammatory effect on ECs to decrease inflammation. IL-19 can significantly decrease tumor necrosis factor (TNF)-α-driven intracellular adhesion molecule (ICAM)-1 ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2013, 305(3):C255-65]

Cited: 14 times

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Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.

Salvatore Mancarella, Santhi Potireddy, Youjun Wang, Hui Gao, Rajesh Kumar Gandhirajan, Michael Autieri, Rosario Scalia, Zhongjian Cheng, Hong Wang, Muniswamy Madesh, Steven R Houser, Donald L Gill,

The Ca(2+)-sensing stromal interaction molecule (STIM) proteins are crucial Ca(2+) signal coordinators. Cre-lox technology was used to generate smooth muscle (sm)-targeted STIM1-, STIM2-, and double STIM1/STIM2-knockout (KO) mouse models, which reveal the essential role of STIM proteins in Ca(2+) homeostasis and their crucial role in controlling function, growth, and development ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2013, 27(3):893-906]

Cited: 32 times

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Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.

Qing Mei Wang, Timothy J Stalker, Yulan Gong, Yoshiyuki Rikitake, Rosario Scalia, James K Liao,

Resuscitation from hemorrhagic shock induces endothelial dysfunction and activates inflammatory cascades leading to organ damage. Following restoration of blood flow to ischemic vascular beds, leukocyte-endothelium interactions leading to leukocyte infiltration into the vascular wall occur very early due, in part, to the loss of endothelium-derived nitric oxide (NO). The mechanism ... Read more >>

Vasc Med (Vascular medicine (London, England))
[2012, 17(6):379-385]

Cited: 10 times

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