Full Text Journal Articles by
Author Rosalia Viterbo

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Renal mass biopsy: A strategy to reduce associated costs and morbidity when managing localized renal masses.

Abhishek Srivastava, Robert N Uzzo, Jennifer Lee, Eric Cho, Alex Grieco, Selma Masic, Elizabeth Handorf, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Marc C Smaldone, Alexander Kutikov, Robert G Uzzo,

<h4>Introduction and objectives</h4>Renal mass biopsy (RMB) has not been widely adopted in evaluating small renal mass due to concerns for safety, efficacy, and its perceived lack of consequence on management decisions. We assess the potential cost savings and morbidity avoidance of routine RMB on cT1 renal masses undergoing robotic-assisted partial ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Identification of oncological characteristics associated with improved overall survival in patients with adrenocortical carcinoma treated with adjuvant radiation therapy: Insights from the National Cancer Database.

Kevin B Ginsburg, Akhil A Chandra, Jared P Schober, Elizabeth A Handorf, Robert G Uzzo, Richard E Greenberg, David Yt Chen, Rosalia Viterbo, Marc C Smaldone, Alexander Kutikov, Mark A Hallman, Andres F Correa,

<h4>Objectives</h4>To test for an association between oncological risk factors and overall survival in patients with non-metastatic adrenocortical carcinoma treated with adjuvant radiation therapy at high-risk for recurrence per NCCN guidelines.<h4>Materials and methods</h4>We analyzed data from patients undergoing surgical resection with or without aRT in the NCDB from 2004 to 2017. ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Safety of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer and malignant ureteric obstruction.

Marshall C Strother, Alexander Kutikov, Matthew Epstein, Emily Bochner, Mengying Deng, Elizabeth Handorf, Bianca Lewis, Pooja Ghatalia, Richard E Greenberg, David Chen, Rosalia Viterbo, Fern Anari, Marc C Smaldone, Matthew R Zibelman, Robert G Uzzo, Elizabeth R Plimack, Daniel M Geynisman,

<h4>Objectives</h4>To determine whether patients with carcinoma invading bladder muscle (MIBC) and ureteric obstruction can safely receive cisplatin-based neoadjuvant chemotherapy (C-NAC), and to determine whether such patients require relief of obstruction with a ureteric stent or percutaneous nephrostomy prior to beginning C-NAC.<h4>Patients and methods</h4>We performed a single-institution retrospective analysis of MIBC ... Read more >>

BJU Int (BJU international)
[2021, :]

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Cystoscopy and Systematic Bladder Tissue Sampling in Predicting pT0 Bladder Cancer: A Prospective Trial.

Matthew Zibelman, Aeen M Asghar, Daniel C Parker, John O'Neill, Shuanzeng Wei, Richard E Greenberg, Marc C Smaldone, David Y T Chen, Rosalia Viterbo, Robert G Uzzo, Evan Bloom, Rutika Kokate, Daniel M Geynisman, Pooja Ghatalia, Mengying Deng, Eric A Ross, Elizabeth Plimack, Philip H Abbosh, Alexander Kutikov,

<h4>Purpose</h4>Concern for discordance between clinical staging and final pathology drives current management of patients deemed appropriate candidates for radical cystectomy. Therefore, we set out to prospectively investigate reliability and shortcomings of cystoscopic evaluation in radical cystectomy candidates.<h4>Materials and methods</h4>Patients undergoing radical cystectomy for urothelial carcinoma were enrolled in a prospective ... Read more >>

J Urol (The Journal of urology)
[2021, 205(6):1605-1611]

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Reply by Authors.

Daniel M Geynisman, Brian T Kadow, Brian M Shuch, Stephen A Boorjian, Surena F Matin, Edward Rampersaud, Barton N Milestone, Elizabeth R Plimack, Matthew R Zibelman, Alexander Kutikov, Marc C Smaldone, David Yt Chen, Rosalia Viterbo, Shreyas Joshi, Richard E Greenberg, Lois Malizzia, Thomas McGowan, Eric A Ross, Robert G Uzzo,

J Urol (The Journal of urology)
[2020, 204(3):536-537]

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Defects in DNA Repair Genes Confer Improved Long-term Survival after Cisplatin-based Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer.

Benjamin Miron, Jean H Hoffman-Censits, Fern Anari, John O'Neill, Daniel M Geynisman, Matthew R Zibelman, Alexander Kutikov, Rosalia Viterbo, Richard E Greenberg, David Chen, Costas D Lallas, Edouard J Trabulsi, R Katherine Alpaugh, Essel Dulaimi, Erica A Golemis, Robert Uzzo, Eric A Ross, Elizabeth R Plimack,

Cisplatin-based neoadjuvant chemotherapy (NAC) has demonstrated an overall survival (OS) benefit in muscle-invasive bladder cancer (MIBC). However, only a subset of patients (25-50%) have a pathologic complete response at cystectomy. Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(4):544-547]

Cited: 5 times

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Sporadic Angiomyolipomas Growth Kinetics While on Everolimus: Results of a Phase II Trial.

Daniel M Geynisman, Brian T Kadow, Brian M Shuch, Stephen A Boorjian, Surena F Matin, Edward Rampersaud, Barton N Milestone, Elizabeth R Plimack, Matthew R Zibelman, Alexander Kutikov, Marc C Smaldone, David Yt Chen, Rosalia Viterbo, Shreyas Joshi, Richard E Greenberg, Lois Malizzia, Thomas McGowan, Eric A Ross, Robert G Uzzo,

PURPOSE:Everolimus decreases tumor volume of renal angiomyolipomas in patients with tuberous sclerosis. No prospective data are available regarding the effect of everolimus on the growth kinetics in patients with sporadic angiomyolipomas. We sought to determine the safety and efficacy of everolimus in the volumetric reduction of sporadic angiomyolipomas. MATERIALS AND ... Read more >>

J Urol (The Journal of urology)
[2020, 204(3):531-537]

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Non-contrast imaging characteristics of papillary renal cell carcinoma: implications for diagnosis and subtyping.

Anand V Badri, Nikhil Waingankar, Kristin Edwards, Alexander Kutikov, Rosaleen B Parsons, David Y Chen, Marc C Smaldone, Rosalia Viterbo, Richard E Greenberg, Robert G Uzzo,

INTRODUCTION:Current radiographic guidelines suggest unenhanced renal lesions < 20 Hounsfield Units (HU) are overwhelmingly benign, requiring no further evaluation. We evaluate our experience with papillary renal cell carcinoma (pRCC) presenting with low pre-contrast attenuation and the relationship of attenuation with histologic pRCC subtype. MATERIALS AND METHODS:We reviewed our institutional kidney ... Read more >>

Can J Urol (The Canadian journal of urology)
[2019, 26(5):9916-9921]

Cited: 1 time

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Prediction of significant estimated glomerular filtration rate decline after renal unit removal to aid in the clinical choice between radical and partial nephrectomy in patients with a renal mass and normal renal function.

Andrew G McIntosh, Daniel C Parker, Brian L Egleston, Robert G Uzzo, Mohammed Haseebuddin, Shreyas S Joshi, Rosalia Viterbo, Richard E Greenberg, David Y T Chen, Marc C Smaldone, Alexander Kutikov,

<h4>Objectives</h4>To develop a clinically applicable predictive model to quantitate the risk of estimated glomerular filtration rate (eGFR) decline to ≤45 mL/min/1.73 m<sup>2</sup> after radical nephrectomy (RN) to better inform decisions between RN and partial nephrectomy (PN).<h4>Patients and methods</h4>Our prospectively maintained kidney cancer registry was reviewed for patients with a preoperative eGFR >60 mL/min/1.73 m<sup>2</sup> ... Read more >>

BJU Int (BJU international)
[2019, 124(6):999-1005]

Cited: 4 times

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Incisional hernia after cystectomy: incidence, risk factors and anthropometric predisposition.

Daniel C Edwards, David B Cahn, Madhu Reddy, Dana Kivlin, Aseem Malhotra, Tianyu Li, David Y T Chen, Rosalia Viterbo, Robert G Uzzo, Richard E Greenberg, Marc C Smaldone, Paul Curcillo, Alexander Kutikov,

INTRODUCTION:Postoperative incisional hernias (PIH) are an established complication of abdominal surgery with rates after radical cystectomy (RC) poorly defined. The objective of this analysis is to compare rates and risk factors of PIH after open (ORC) and robotic-assisted (RARC) cystectomy at a tertiary-care referral center. MATERIALS AND METHODS:We performed a ... Read more >>

Can J Urol (The Canadian journal of urology)
[2018, 25(6):9573-9578]

Cited: 1 time

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Renal Hilar Lesions: Biological Implications for Complex Partial Nephrectomy.

Andres F Correa, Hilary Yankey, Tianyu Li, Shreyas S Joshi, Alexander Kutikov, David Y Chen, Rosalia Viterbo, Richard E Greenberg, Marc C Smaldone, Robert G Uzzo,

<h4>Objective</h4>To perform a comprehensive histopathologic review of sporadic resected solitary cT1 renal masses comparing those with and without radiographic involvement of the hilum.<h4>Materials and methods</h4>A prospectively maintained database was queried for all cT1 renal masses undergoing resection classified per the R.E.N.A.L. nephrometry score. Hilar masses were defined as tumors that ... Read more >>

Urology (Urology)
[2019, 123:174-180]

Cited: 3 times

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Functional Parenchymal Volume-based Spectrum Score Is Able to Quantify Ischemic Injury After Partial Nephrectomy.

Ziho Lee, Robert Uzzo, Aeen Asghar, Phyllis Parkansky, Mahesh Botejue, Tianyu Li, Rosalia Viterbo, David Y T Chen, Marc Smaldone, Alexander Kutikov,

<h4>Objective</h4>To externally validate the Spectrum Score (SS) using a modified calculation based on functional parenchymal volumes (FPVs) instead of renal scans. The SS quantifies acute ischemic injury in the ipsilateral kidney after partial nephrectomy. However, this metric requires renal split function assessment via renal scans, which may be unavailable in ... Read more >>

Urology (Urology)
[2018, 120:150-155]

Cited: 0 times

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Perioperative Statin Use and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy.

Shreyas S Joshi, Karen Ruth, Marc C Smaldone, David Y T Chen, Richard E Greenberg, Rosalia Viterbo, Alexander Kutikov, Robert G Uzzo,

Background:Statin use is widespread among the general population. Data suggest a potentially beneficial effect of statin therapy on renal function following surgery. The impact of statins on post-partial nephrectomy (PN) renal function is unknown. We hypothesized that perioperative statin use may be associated with reduced rates of acute kidney injury ... Read more >>

Kidney Cancer (Kidney cancer (Clifton, Va.))
[2018, 2(1):47-55]

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Treatment Trends and Outcomes for Patients With Lymph Node-Positive Cancer of the Penis.

Shreyas S Joshi, Elizabeth Handorf, David Strauss, Andres F Correa, Alexander Kutikov, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Robert G Uzzo, Marc C Smaldone, Daniel M Geynisman,

Importance:Penile cancer is an uncommon disease with minimal level I evidence to guide therapy. The National Comprehensive Cancer Network (NCCN) guidelines advocate a lymph node dissection (LND) or radiotherapy with consideration of perioperative chemotherapy for all patients with lymph node-positive (LN+) penile cancer without metastasis. Objectives:To determine temporal trends in ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, 4(5):643-649]

Cited: 7 times

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Neoadjuvant Dose-dense Gemcitabine and Cisplatin in Muscle-invasive Bladder Cancer: Results of a Phase 2 Trial.

Fern Anari, John O'Neill, Woonyoung Choi, David Y T Chen, Mohammed Haseebuddin, Alexander Kutikov, Essel Dulaimi, R Katherine Alpaugh, Karthik Devarajan, Richard E Greenberg, Marijo Bilusic, Yu-Ning Wong, Rosalia Viterbo, Jean H Hoffman-Censits, Costas D Lallas, Edouard J Trabulsi, Marc Smaldone, Daniel M Geynisman, Matthew Zibelman, Jianqing Lin, W Kevin Kelly, Robert Uzzo, David McConkey, Elizabeth R Plimack,

<h4>Background</h4>Accelerated (also termed dose-dense, DD) chemotherapy regimens such as accelerated methotrexate, vinblastine, doxorubicin, and cisplatin have shown better efficacy and tolerability in the metastatic setting, and shortened the time to surgery in the neoadjuvant setting compared to standard-schedule regimens. We hypothesized that a DD schedule of gemcitabine and cisplatin (GC) ... Read more >>

Eur Urol Oncol (European urology oncology)
[2018, 1(1):54-60]

Cited: 5 times

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Active Surveillance for Localized Renal Masses: Tumor Growth, Delayed Intervention Rates, and >5-yr Clinical Outcomes.

Andrew G McIntosh, Benjamin T Ristau, Karen Ruth, Rachel Jennings, Eric Ross, Marc C Smaldone, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Alexander Kutikov, Robert G Uzzo,

BACKGROUND:Active surveillance (AS) has gained acceptance as a management strategy for localized renal masses. OBJECTIVE:To review our large single-center experience with AS. DESIGN, SETTING, AND PARTICIPANTS:From 2000 to 2016, we identified 457 patients with 544 lesions managed with AS from our prospectively maintained kidney cancer database. A subset analysis was ... Read more >>

Eur Urol (European urology)
[2018, 74(2):157-164]

Cited: 24 times

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Defining Novel and Practical Metrics to Assess the Deliverables of Multiparametric Magnetic Resonance Imaging/Ultrasound Fusion Prostate Biopsy.

Benjamin T Ristau, David Y T Chen, Jeffrey Ellis, Aseem Malhotra, Lyudmila DeMora, Rosaleen B Parsons, Barton Milestone, Marion Brody, Rosalia Viterbo, Richard Greenberg, Marc Smaldone, Robert Uzzo, Jordan Anaokar, Alexander Kutikov,

<h4>Purpose</h4>Multiparametric magnetic resonance/ultrasound targeted prostate biopsy is touted as a tool to improve prostate cancer care and yet its true clinical usefulness over transrectal ultrasound guided prostate biopsy has not been systematically analyzed. We introduce 2 metrics to better quantify and report the deliverables of targeted biopsy.<h4>Materials and methods</h4>We reviewed ... Read more >>

J Urol (The Journal of urology)
[2018, 199(4):969-975]

Cited: 0 times

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Contemporary practice patterns and survival outcomes for locally advanced urethral malignancies: A National Cancer Database Analysis.

David B Cahn, Elizabeth Handorf, Benjamin T Ristau, Daniel M Geynisman, Jay Simhan, Alexander Kutikov, Richard E Greenberg, Rosalia Viterbo, David Y T Chen, Robert G Uzzo, Marc C Smaldone,

<h4>Purpose</h4>Primary urethral carcinoma (PUC) has an aggressive natural history; however, controversy exists regarding the role of multimodal therapy for its treatment. Our objective was to examine practice patterns and survival outcomes for locally advanced urethral cancers.<h4>Methods</h4>The National Cancer Database was queried for patients with T2-4 or N1-2M0 PUC with urothelial, ... Read more >>

Urol Oncol (Urologic oncology)
[2017, 35(12):670.e15-670.e21]

Cited: 2 times

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Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder-preservation therapy for muscle-invasive bladder cancer.

David B Cahn, Elizabeth A Handorf, Eric M Ghiraldi, Benjamin T Ristau, Daniel M Geynisman, Thomas M Churilla, Eric M Horwitz, Mark L Sobczak, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone,

<h4>Background</h4>The current study was performed to examine temporal trends and compare overall survival (OS) in patients undergoing radical cystectomy (RC) or bladder-preservation therapy (BPT) for muscle-invasive urothelial carcinoma of the bladder.<h4>Methods</h4>The authors reviewed the National Cancer Data Base to identify patients with AJCC stage II to III urothelial carcinoma of ... Read more >>

Cancer (Cancer)
[2017, 123(22):4337-4345]

Cited: 24 times

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Differences in Survival Associated with Performance of Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database.

Andres F Correa, Elizabeth Handorf, Shreyas S Joshi, Daniel M Geynisman, Alexander Kutikov, David Y Chen, Robert G Uzzo, Rosalia Viterbo, Richard E Greenberg, Marc C Smaldone,

<h4>Purpose</h4>Inguinal lymphadenectomy remains under performed in patients with invasive penile cancer. Using a large national cancer registry we assessed temporal trends in inguinal lymphadenectomy performance and evaluated the impact of the procedure on survival in patients in whom inguinal lymphadenectomy was an absolute indication (T1b-4 N0/x-1) according to NCCN<sup>®</sup> (National ... Read more >>

J Urol (The Journal of urology)
[2018, 199(5):1238-1244]

Cited: 3 times

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Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer.

Yanqun Dong, Nicholas G Zaorsky, Tianyu Li, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Yt Chen, Robert G Uzzo, Mark A Hallman, Eric M Horwitz,

INTRODUCTION:To evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer (PCa). METHODS:We included men with localized PCa treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) of escalated dose (≥74 Gy in 1.8 or 2 Gy fractions) between 1992 and 2013 at an ... Read more >>

J Med Imaging Radiat Oncol (Journal of medical imaging and radiation oncology)
[2018, 62(1):116-121]

Cited: 6 times

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WBC Associates with Readmission Following Cystectomy.

Andrew G McIntosh, Tianyu Li, Timothy Ito, Jason Mannion, Mark Dziemianowicz, Nikhil Waingankar, Mohammed Haseebuddin, David Y T Chen, Richard E Greenberg, Rosalia Viterbo, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone, Philip H Abbosh,

Background: Radical cystectomy is associated with perioperative complication rates exceeding 50% in some series. Readmission rates are increasingly used as a surgical quality metric. White blood cell count is a crude surrogate for physiologic processes which may reflect postoperative complications leading to readmission. Objective: We assessed the association between final ... Read more >>

Bladder Cancer (Bladder cancer (Amsterdam, Netherlands))
[2017, 3(2):95-103]

Cited: 2 times

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Robot-assisted Versus Open Radical Cystectomy in Patients Receiving Perioperative Chemotherapy for Muscle-invasive Bladder Cancer: The Oncologist's Perspective from a Multicentre Study.

Andrea Necchi, Gregory R Pond, Marc C Smaldone, Sumanta K Pal, Kevin Chan, Yu-Ning Wong, Rosalia Viterbo, Guru Sonpavde, Lauren C Harshman, Simon Crabb, Ajjai Alva, Simon Chowdhury, Ugo De Giorgi, Sandy Srinivas, Neeraj Agarwal, Aristotelis Bamias, Jack Baniel, Ali-Reza Golshayan, Sylvain Ladoire, Cora N Sternberg, Linda Cerbone, Evan Y Yu, Joaquim Bellmunt, Ulka Vaishampayan, Gunter Niegisch, Syed Hussain, Daniel W Bowles, Rafael Morales-Barrera, Matthew I Milowsky, Christine Theodore, Dominik R Berthold, Srikala S Sridhar, Thomas Powles, Jonathan E Rosenberg, Matthew D Galsky, ,

<h4>Background</h4>Little is known about the outcomes of robot-assisted radical cystectomy (RARC) compared to open radical cystectomy (ORC) combined with perioperative chemotherapy for muscle-invasive urothelial bladder cancer (UBC).<h4>Objective</h4>To evaluate surgical and oncological outcomes for RARC and ORC in multimodal treatment.<h4>Design, setting, and participants</h4>Data from 28 centres were collected for cystectomies performed ... Read more >>

Eur Urol Focus (European urology focus)
[2018, 4(6):937-945]

Cited: 3 times

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Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review.

Kyungsuk Jung, Pooja Ghatalia, Samuel Litwin, Eric M Horwitz, Robert G Uzzo, Richard E Greenberg, Rosalia Viterbo, Daniel M Geynisman, Alexander Kutikov, Elizabeth R Plimack, Marc C Smaldone, Yu-Ning Wong, Marijo Bilusic,

<h4>Introduction</h4>Small-cell carcinoma of the bladder is a poorly differentiated neoplasm with aggressive behavior. We analyzed clinical outcomes of patients who were treated at our institution to identify an optimal treatment strategy.<h4>Materials and methods</h4>Retrospective chart analysis was performed for patients who were treated for small-cell carcinoma of the bladder at Fox ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2017, 15(3):e337-e343]

Cited: 0 times

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The need for androgen deprivation therapy in patients with intermediate-risk prostate cancer treated with dose-escalated external beam radiation therapy.

Yanqun Dong, Karen J Ruth, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Y T Chen, Robert G Uzzo, Mark H Hallman, Eric M Horwitz,

<h4>Introduction</h4>To evaluate if androgen deprivation therapy (ADT) improves outcomes for patients with localized, intermediate-risk prostate cancer treated with definitive external beam radiation therapy (EBRT) in the dose-escalated era.<h4>Materials and methods</h4>This is a retrospective study using a single institutional database. We included patients with localized, intermediate-risk prostate cancer treated with dose-escalated ... Read more >>

Can J Urol (The Canadian journal of urology)
[2017, 24(1):8656-8662]

Cited: 4 times

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