Full Text Journal Articles by
Author Roopa Dalal

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Chronic Electrical Stimulation for Tear Secretion: Lacrimal vs. anterior ethmoid nerve.

Andrea L Kossler, Mark Brinton, Zara M Patel, Roopa Dalal, Christopher N Ta, Daniel Palanker,

PURPOSE:To evaluate and compare the effect of lacrimal nerve stimulation (LNS) and anterior ethmoid nerve stimulation (AENS) on aqueous tear secretion, and tissue condition following chronic implantation. METHODS:A neurostimulator was implanted in rabbits adjacent to the (1) lacrimal nerve, and (2) anterior ethmoid nerve. Tear volume was measured with Schirmer ... Read more >>

Ocul Surf (The ocular surface)
[2019, 17(4):822-827]

Cited: 0 times

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Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis.

Thomas Flores, Tiffany Huang, Mohajeet Bhuckory, Elton Ho, Zhijie Chen, Roopa Dalal, Ludwig Galambos, Theodore Kamins, Keith Mathieson, Daniel Palanker,

High-resolution visual prostheses require small, densely packed pixels, but limited penetration depth of the electric field formed by a planar electrode array constrains such miniaturization. We present a novel honeycomb configuration of an electrode array with vertically separated active and return electrodes designed to leverage migration of retinal cells into ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):10657]

Cited: 2 times

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Retinal Laser Therapy Preserves Photoreceptors in a Rodent Model of MERTK-Related Retinitis Pigmentosa.

Seungbum Kang, Henri Lorach, Mohajeet B Bhuckory, Yi Quan, Roopa Dalal, Daniel Palanker,

Purpose:We investigated the effects of various retinal laser therapies on preservation of the photoreceptors in an animal model of Mer tyrosine kinase receptor (MERTK)-related retinitis pigmentosa (RP). These modalities included photocoagulation with various pattern densities, selective RPE therapy (SRT), and nondamaging retinal therapy (NRT). Methods:Laser treatments were performed on right ... Read more >>

Transl Vis Sci Technol (Translational vision science & technology)
[2019, 8(4):19]

Cited: 0 times

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Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration.

Henri Lorach, Seungbum Kang, Mohajeet B Bhuckory, Alix Trouillet, Roopa Dalal, Michael Marmor, Daniel Palanker,

Purpose:To demonstrate survival and integration of mature photoreceptors transplanted with the retinal pigment epithelium (RPE). Methods:Full-thickness retina with attached RPE was harvested from healthy adult rats. Grafts were implanted into two rat models of retinal degeneration, Royal College of Surgeons (RCS) and S334ter-3. Survival of the host and transplanted retina ... Read more >>

(Translational vision science & technology)
[2019, 8(3):30]

Cited: 1 time

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Silicone Oil-Induced Ocular Hypertension in Mouse Models Glaucomatous Neurodegeneration and Neuroprotection

Jie Zhang, Liang Li, Haoliang Huang, Hannah Webber, Pei Zhuang, Liang Liu, Roopa Dalal, Peter Tang, Vinit Mahajan, Yang Sun, Shaohua Li, Mingchang Zhang, Jeffrey Louis Goldberg, Yang Hu,

Abstract Understanding the molecular mechanism of glaucoma and development of neuroprotectants are significantly hindered by the lack of a reliable animal model that accurately recapitulates human glaucoma. Here we sought to develop a mouse model for the secondary glaucoma that is often observed in humans after silicone oil (SO) blocks ... Read more >>

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Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons.

Thomas Flores, Xin Lei, Tiffany Huang, Henri Lorach, Roopa Dalal, Ludwig Galambos, Theodore Kamins, Keith Mathieson, Daniel Palanker,

OBJECTIVE:High-resolution prosthetic vision requires dense stimulating arrays with small electrodes. However, such miniaturization reduces electrode capacitance and penetration of electric field into tissue. We evaluate potential solutions to these problems with subretinal implants based on utilization of pillar electrodes. APPROACH:To study integration of three-dimensional (3D) implants with retinal tissue, we ... Read more >>

J Neural Eng (Journal of neural engineering)
[2018, 15(3):036011]

Cited: 10 times

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Comparison of Continuous-Wave and Micropulse Modulation in Retinal Laser Therapy.

Jenny Wang, Yi Quan, Roopa Dalal, Daniel Palanker,

Recent progress in retinal laser therapy has centered upon using thermal stress below damage threshold or selective destruction of targeted tissue layers as a stimulus for retinal repair. Temporal modulation, including micropulse, is thought to increase the selectivity of laser treatment, but has not been carefully analyzed. We measure and ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2017, 58(11):4722-4732]

Cited: 5 times

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Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula.

Daniel Lavinsky, Jenny Wang, Philip Huie, Roopa Dalal, Seung Jun Lee, Dae Yeong Lee, Daniel Palanker,

Retinal photocoagulation and nondamaging laser therapy are used for treatment of macular disorders, without understanding of the response mechanism and with no rationale for dosimetry. To establish a proper titration algorithm, we measured the range of tissue response and damage threshold. We then evaluated safety and efficacy of nondamaging retinal ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2016, 57(6):2488-2500]

Cited: 16 times

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Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration.

Henri Lorach, Xin Lei, Ludwig Galambos, Theodore Kamins, Keith Mathieson, Roopa Dalal, Philip Huie, James Harris, Daniel Palanker,

Prosthetic restoration of partial sensory loss leads to interactions between artificial and natural inputs. Ideally, the rehabilitation should allow perceptual fusion of the two modalities. Here we studied the interactions between normal and prosthetic vision in a rodent model of local retinal degeneration.Implantation of a photovoltaic array in the subretinal ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2015, 56(12):7444-7450]

Cited: 4 times

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High-resolution contrast-enhanced optical coherence tomography in mice retinae.

Debasish Sen, Elliott D SoRelle, Orly Liba, Roopa Dalal, Yannis M Paulus, Tae-Wan Kim, Darius M Moshfeghi, Adam de la Zerda,

Optical coherence tomography (OCT) is a noninvasive interferometric imaging modality providing anatomical information at depths of millimeters and a resolution of micrometers. Conventional OCT images limit our knowledge to anatomical structures alone, without any contrast enhancement. Therefore, here we have, for the first time, optimized an OCT-based contrast-enhanced imaging system ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2016, 21(6):66002]

Cited: 5 times

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Biocompatibility of poly(ethylene glycol) and poly(acrylic acid) interpenetrating network hydrogel by intrastromal implantation in rabbit cornea.

Luo Luo Zheng, Vijay Vanchinathan, Roopa Dalal, Jaan Noolandi, Dale J Waters, Laura Hartmann, Jennifer R Cochran, Curtis W Frank, Charles Q Yu, Christopher N Ta,

We evaluated the biocompatibility of a poly(ethylene glycol) and poly(acrylic acid) (PEG/PAA) interpenetrating network hydrogel designed for artificial cornea in a rabbit model. PEG/PAA hydrogel measuring 6 mm in diameter was implanted in the corneal stroma of twelve rabbits. Stromal flaps were created with a microkeratome. Randomly, six rabbits were ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2015, 103(10):3157-3165]

Cited: 8 times

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Safety of cornea and iris in ocular surgery with 355-nm lasers.

Jenny Wang, Jae Lim Chung, Georg Schuele, Alexander Vankov, Roopa Dalal, Michael Wiltberger, Daniel Palanker,

A recent study showed that 355-nm nanosecond lasers cut cornea with similar precision to infrared femtosecond lasers. However, use of ultraviolet wavelength requires precise assessment of ocular safety to determine the range of possible ophthalmic applications. In this study, the 355-nm nanosecond laser was evaluated for corneal and iris damage ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2015, 20(9):095005]

Cited: 1 time

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Miniature electrical stimulator for hemorrhage control.

Mark R Brinton, Yossi Mandel, Roopa Dalal, Daniel Palanker,

Noncompressible hemorrhage is currently the most common cause of preventable death in battlefield and in civilian trauma injuries. Tourniquets, specialized wound dressings, and hemorrhage-inhibiting biomaterials are not sufficiently effective in arrest of noncompressible hemorrhage and often cause collateral tissue damage. An effective, easy-to-use, portable device is needed to reduce blood ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2014, 61(6):1765-1771]

Cited: 4 times

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Performance of photovoltaic arrays in-vivo and characteristics of prosthetic vision in animals with retinal degeneration.

Henri Lorach, Georges Goetz, Yossi Mandel, Xin Lei, Ludwig Galambos, Theodore I Kamins, Keith Mathieson, Philip Huie, Roopa Dalal, James S Harris, Daniel Palanker,

Loss of photoreceptors during retinal degeneration leads to blindness, but information can be reintroduced into the visual system using electrical stimulation of the remaining retinal neurons. Subretinal photovoltaic arrays convert pulsed illumination into pulsed electric current to stimulate the inner retinal neurons. Since required irradiance exceeds the natural luminance levels, ... Read more >>

Vision Res (Vision research)
[2015, 111(Pt B):142-148]

Cited: 23 times

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Subvisible retinal laser therapy: titration algorithm and tissue response.

Daniel Lavinsky, Christopher Sramek, Jenny Wang, Philip Huie, Roopa Dalal, Yossi Mandel, Daniel Palanker,

PURPOSE: Laser therapy for diabetic macular edema and other retinal diseases has been used within a wide range of laser settings: from intense burns to nondamaging exposures. However, there has been no algorithm for laser dosimetry that could determine laser parameters yielding a predictable extent of tissue damage. This multimodal ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2014, 34(1):87-97]

Cited: 25 times

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Modulation of transgene expression in retinal gene therapy by selective laser treatment.

Daniel Lavinsky, Thomas W Chalberg, Yossi Mandel, Philip Huie, Roopa Dalal, Michael Marmor, Daniel Palanker,

PURPOSE: To develop a method for modulation of transgene expression in retinal pigment epithelium (RPE) using scanning laser that spares neurosensory retina. METHODS: Fifteen pigmented rabbits received subretinal injection of recombinant adeno-associated virus (rAAV-2) encoding green fluorescent protein (GFP). GFP expression was measured using confocal scanning laser ophthalmoscopy (cSLO) fluorescence ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2013, 54(3):1873-1880]

Cited: 7 times

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Vasoconstriction by electrical stimulation: new approach to control of non-compressible hemorrhage.

Yossi Mandel, Richard Manivanh, Roopa Dalal, Phil Huie, Jenny Wang, Mark Brinton, Daniel Palanker,

Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels ... Read more >>

Sci Rep (Scientific reports)
[2013, 3:2111]

Cited: 11 times

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Optical coherence tomography study of experimental anterior ischemic optic neuropathy and histologic confirmation.

Joyce K Ho, Madison P Stanford, Mohammad A Shariati, Roopa Dalal, Yaping Joyce Liao,

PURPOSE: The optic nerve is part of the central nervous system, and interruption of this pathway due to ischemia typically results in optic atrophy and loss of retinal ganglion cells. In this study, we assessed in vivo retinal changes following murine anterior ischemic optic neuropathy (AION) by using spectral-domain optical ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2013, 54(9):5981-5988]

Cited: 21 times

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Effect of intravitreal triamcinolone acetonide on healing of retinal photocoagulation lesions.

Hiroyuki Nomoto, Daniel Lavinsky, Yannis M Paulus, Loh-Shan Leung, Roopa Dalal, Mark S Blumenkranz, Daniel Palanker,

PURPOSE: To evaluate the effect of intravitreal triamcinolone acetonide (TA) on healing of retinal photocoagulation lesions using drug and laser dosing typically employed in clinical practice. METHODS: Laser burns with a 267-μm retinal beam size at 532-nm wavelength were applied to 40 eyes of Dutch belted rabbits. Barely visible to ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2013, 33(1):63-70]

Cited: 3 times

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Cellular composition of the ridge in retinopathy of prematurity.

Young Sun, Roopa Dalal, Ray F Gariano,

Arch Ophthalmol (Archives of ophthalmology (Chicago, Ill. : 1960))
[2010, 128(5):638-641]

Cited: 5 times

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