Full Text Journal Articles by
Author Ronald W Wood

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Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging.

Molly Brady, Akib Rahman, Abigail Combs, Chethana Venkatraman, R Tristan Kasper, Conor McQuaid, Wing-Chi Edmund Kwok, Ronald W Wood, Rashid Deane,

BACKGROUND:Continuous circulation and drainage of cerebrospinal fluid (CSF) are essential for the elimination of CSF-borne metabolic products and neuronal function. While multiple CSF drainage pathways have been identified, the significance of each to normal drainage and whether there are differential changes at CSF outflow regions in the aging brain are ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):71]

Cited: 0 times

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Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in the Rheumatoid Hand with Active Arthritis.

Richard D Bell, Homaira Rahimi, H Mark Kenney, Alicia A Lieberman, Ronald W Wood, Edward M Schwarz, Christopher T Ritchlin,

OBJECTIVE:Assess differences in lymphatic function of RA hands with active synovitis versus healthy controls (Ctl) via near infrared-indocyanine green (NIR-ICG) imaging. METHODS:NIR imaging of 13 Ctl and 8 RA subjects with active disease was performed following web space injection of 0.1ml of 100μM ICG. Percent ICG retention from the web ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, :]

Cited: 0 times

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High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse.

Toy G Lee, Derrick Sanderson, Paula Doyle, Dongmei Li, Ronald W Wood,

Purpose:To examine associations if any between changes in voiding function, hematuria, and bladder ultrasonography metrics in murine cyclophosphamide-induced chemical cystitis. Materials and Methods:Cystitis was induced in 6 female mice by an intraperitoneal injection of cyclophosphamide (300 mg/kg). Voiding frequency, void volume, hematuria assessment, and ultrasonographic measurements of the bladder were ... Read more >>

Investig Clin Urol (Investigative and clinical urology)
[2020, 61(1):75-80]

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Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.

Richard D Bell, Emily K Wu, Christopher A Rudmann, Megan Forney, Claire R W Kaiser, Ronald W Wood, Joe V Chakkalakal, Nicole D Paris, Alanna Klose, Guang-Qian Xiao, Javier Rangel-Moreno, Maria L Garcia-Hernandez, Christopher T Ritchlin, Edward M Schwarz, Homaira Rahimi,

OBJECTIVE:To examine and quantify the sexual dimorphism in pathologic features manifested in the musculoskeletal and cardiopulmonary systems and incidence of mortality in the tumor necrosis factor-transgenic (TNF-Tg; Tg3647 strain) mouse model of inflammatory erosive arthritis. METHODS:Kaplan-Meier survival estimates were determined in male and female Tg3647 mice and sex-matched wild-type (WT) ... Read more >>

(Arthritis & rheumatology (Hoboken, N.J.))
[2019, 71(9):1512-1523]

Cited: 1 time

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Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

Qianqian Liang, Li Zhang, Ronald W Wood, Rui-Cheng Ji, Brendan F Boyce, Edward M Schwarz, Yongjun Wang, Lianping Xing,

NF-κB signals through canonical transcription factor p65 (RelA)/p50 and noncanonical avian reticuloendotheliosis viral oncogene related B (RelB)/p52 pathways. The RelA/p50 is involved in basal and inflammatory lymphangiogenesis. However, the role of RelB/p52 in lymphatic vessel biology is unknown. Herein, we investigated changes in lymphatic vessels (LVs) in mice deficient in ... Read more >>

Am J Pathol (The American journal of pathology)
[2019, 189(12):2516-2530]

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The 3D Spatial Autocorrelation of the Branching Fractal Vasculature.

Kevin J Parker, Jonathan J Carroll-Nellenback, Ronald W Wood,

The fractal branching vasculature within soft tissues and the mathematical properties of the branching system influence a wide range of important phenomena from blood velocity to ultrasound backscatter. Among the mathematical descriptors of branching networks, the spatial autocorrelation function plays an important role in statistical measures of the tissue and ... Read more >>

Acoustics (Basel) (Acoustics (Basel, Switzerland))
[2019, 1(2):369-382]

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Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.

Sri N Batchu, George J Dugbartey, Kristine M Wadosky, Deanne M Mickelsen, Kyung A Ko, Ronald W Wood, Yuqi Zhao, Xia Yang, Deborah J Fowell, Vyacheslav A Korshunov,

The balance between adaptive and innate immunity in kidney damage in salt-dependent hypertension is unclear. We investigated early renal dysfunction and the influence of Axl, a receptor tyrosine kinase, on innate immune response in hypertensive kidney in mice with lymphocyte deficiency (Rag1-/-). The data suggest that increased presence of CD11b+ ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2018, 188(8):1794-1806]

Cited: 1 time

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Adaptation of microscopy with ultraviolet surface excitation for enhancing STEM and undergraduate education.

Chi Z R Huang, Ronald W Wood, Stavros G Demos,

Microscopy with ultraviolet surface excitation (MUSE) is investigated as a means to enhance curricula and education in the life sciences based on simplicity of use, the incorporation of inexpensive hardware, and the simplest methods of tissue preparation. Ultraviolet excitation in effect replaces tissue sectioning because it penetrates only a few ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2018, 23(12):1-8]

Cited: 1 time

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Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice.

Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederick S Vom Saal, Ronald W Wood, William A Ricke,

Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the life span, but the urologic health risks in men are largely unknown. Bisphenol A (BPA) is an endocrine disruptor ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(5):F1208-F1216]

Cited: 4 times

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Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.

Echoe M Bouta, Richard D Bell, Homaira Rahimi, Lianping Xing, Ronald W Wood, Clifton O Bingham, Christopher T Ritchlin, Edward M Schwarz,

Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved with the use of biologic and conventional DMARDs, approximately 40% of patients do not achieve primary clinical outcomes in randomized trials, and only a small proportion achieve lasting remission. Over the past decade, studies in murine models point ... Read more >>

Nat Rev Rheumatol (Nature reviews. Rheumatology)
[2018, 14(2):94-106]

Cited: 14 times

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Longitudinal micro-CT as an outcome measure of interstitial lung disease in TNF-transgenic mice.

Richard D Bell, Christopher Rudmann, Ronald W Wood, Edward M Schwarz, Homaira Rahimi,

INTRODUCTION:Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a debilitating condition with poor survival prognosis. High resolution computed tomography (CT) is a common clinical tool to diagnose RA-ILD, and is increasingly being adopted in pre-clinical studies. However, murine models recapitulating RA-ILD are lacking, and CT outcomes for inflammatory lung disease ... Read more >>

PLoS One (PloS one)
[2018, 13(1):e0190678]

Cited: 9 times

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Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis.

Hao Xu, Echoe M Bouta, Ronald W Wood, Edward M Schwarz, Yongjun Wang, Lianping Xing,

To assess the utility of longitudinal ultrasound (US) to quantify volumetric changes in joint soft tissues during the progression of posttraumatic osteoarthritis (PTOA) in mice, and validate the US results with histological findings. A longitudinal cohort of 3-month-old wild-type C57BL/6 male mice received the Hulth-Telhag surgical procedure on right knee ... Read more >>

Bone Res (Bone research)
[2017, 5:17012]

Cited: 3 times

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Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress.

Echoe M Bouta, Igor Kuzin, Karen de Mesy Bentley, Ronald W Wood, Homaira Rahimi, Rui-Cheng Ji, Christopher T Ritchlin, Andrea Bottaro, Lianping Xing, Edward M Schwarz,

OBJECTIVE:Recent studies have demonstrated that there is an inverse relationship between lymphatic egress and inflammatory arthritis in affected joints. As a model, tumor necrosis factor (TNF)-transgenic mice develop advanced arthritis following draining lymph node (LN) collapse, and loss of lymphatic contractions downstream of inflamed joints. It is unknown if these ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2017, 69(6):1187-1193]

Cited: 10 times

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Relationship Between Lymph Node Volume and Pain Following Certolizumab Therapy for Rheumatoid Arthritis Flare: A Pilot Study.

Homaira Rahimi, Gregory Dieudonne, Valeriy Kheyfits, Echoe M Bouta, Ronald W Wood, Rick Barrett, Sharon Moorehead, Edward M Schwarz, Christopher T Ritchlin,

OBJECTIVES:The mechanisms that trigger flare in rheumatoid arthritis (RA) are unknown. In murine arthritis models, dysfunctional lymph node (LN) drainage is associated with joint flare. To examine if LN alterations are associated with RA flare, we analyzed the change in LN volume via contrast-enhanced magnetic resonance imaging (CE-MRI) in patients ... Read more >>

Clin Med Insights Arthritis Musculoskelet Disord (Clinical medicine insights. Arthritis and musculoskeletal disorders)
[2016, 9:203-208]

Cited: 3 times

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Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.

Homaira Rahimi, Richard Bell, Echoe M Bouta, Ronald W Wood, Lianping Xing, Christopher T Ritchlin, Edward M Schwarz,

Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed synovium is associated with joint flare in murine models of inflammatory-erosive arthritis. Unfortunately, advances towards a greater understanding of lymphatic changes in ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2016, 18:194]

Cited: 10 times

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Shear Wave Elastography in the Living, Perfused, Post-Delivery Placenta.

Stephen A McAleavey, Kevin J Parker, Juvenal Ormachea, Ronald W Wood, Christopher J Stodgell, Philip J Katzman, Eva K Pressman, Richard K Miller,

The placenta is the critical interface between the mother and the developing fetus and is essential for survival and growth. Despite the widespread use of ultrasound imaging and Doppler in obstetrics and gynecology and the recent growth of elastographic technologies, little is known about the biomechanical (elastic shear wave) properties ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2016, 42(6):1282-1288]

Cited: 4 times

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Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Qianqian Liang, Yawen Ju, Yan Chen, Wensheng Wang, Jinlong Li, Li Zhang, Hao Xu, Ronald W Wood, Edward M Schwarz, Brendan F Boyce, Yongjun Wang, Lianping Xing,

In this study, we sought to determine the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell (LSMC) function and on the development of arthritis in TNF-transgenic (TNF-Tg) mice, ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2016, 18:62]

Cited: 17 times

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Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis.

Qian-Qian Liang, Qi Shi, Ronald W Wood, Lian-Ping Xing, Yong-Jun Wang,

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases, and they have characterization of synovial inflammation and cartilage destruction, associated with the accumulation of numerous catabolic mediators and inflammatory cells in the synovial space and surrounding soft tissues. How these factors are cleared and if the ... Read more >>

Chin J Integr Med (Chinese journal of integrative medicine)
[2015, 21(9):648-655]

Cited: 2 times

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Validation of power Doppler versus contrast-enhanced magnetic resonance imaging quantification of joint inflammation in murine inflammatory arthritis.

Echoe M Bouta, Peony D Banik, Ronald W Wood, Homaira Rahimi, Christopher T Ritchlin, Ralf G Thiele, Edward M Schwarz,

Contrast-enhancement magnetic resonance imaging (CE-MRI) of synovial volume is the radiographic gold standard to quantify joint inflammation; however, cost limits its use. Therefore, we examined if power Doppler-ultrasound (PD-US) outcomes of synovitis in tumor necrosis factor transgenic (TNF-Tg) mice correlate with CE-MRI. TNF-Tg mice underwent PD-US of their knees to ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2015, 30(4):690-694]

Cited: 6 times

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Sodium fluorescein use during intraoperative cystoscopy.

Paula Jaye Doyle, Lioudmilla Lipetskaia, Erin Duecy, Gunhilde Buchsbaum, Ronald W Wood,

BACKGROUND: Indigotindisulfonate sodium has been used during cystoscopy to identify the ureteral meatuses and to verify ureteral efflux during pelvic surgery. The U.S. Food and Drug Administration announced the shortage of indigotindisulfonate sodium in June 2014. Surgeons have since been searching for safe alternatives with comparable visualization and an economically ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2015, 125(3):548-550]

Cited: 20 times

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In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.

Echoe M Bouta, Ronald W Wood, Edward B Brown, Homaira Rahimi, Christopher T Ritchlin, Edward M Schwarz,

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with episodic flares. In TNF-Tg mice, a model of inflammatory-erosive arthritis, the popliteal lymph node (PLN) enlarges during the pre-arthritic 'expanding' phase, and then 'collapses' with adjacent knee flare associated with the loss of the intrinsic lymphatic pulse. As the mechanisms ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2014, 592(6):1213-1223]

Cited: 31 times

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Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

Jixiang Shi, Qianqian Liang, Michael Zuscik, Jie Shen, Di Chen, Hao Xu, Yong-Jun Wang, Yan Chen, Ronald W Wood, Jia Li, Brendan F Boyce, Lianping Xing,

OBJECTIVE:To investigate the distribution and alteration of lymphatic vessels and draining function in knee joints of normal and osteoarthritic mice. METHODS:For the mouse models of osteoarthritis (OA), we used mice with meniscal-ligamentous injury or mice with conditional knockout of the gene for cartilage transforming growth factor β (TGFβ) type II ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2014, 66(3):657-666]

Cited: 9 times

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Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis.

Echoe M Bouta, Yawen Ju, Homaira Rahimi, Karen L de Mesy-Bentley, Ronald W Wood, Lianping Xing, Edward M Schwarz,

Rheumatoid arthritis is a chronic inflammatory disease manifested by episodic flares in affected joints that are challenging to predict and treat. Longitudinal contrast enhanced-MRI (CE-MRI) of inflammatory arthritis in tumor necrosis factor-transgenic (TNF-Tg) mice has demonstrated that popliteal lymph nodes (PLN) increase in volume and contrast enhancement during the pre-arthritic ... Read more >>

PLoS One (PloS one)
[2013, 8(9):e73766]

Cited: 15 times

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Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow.

Jie Li, Yawen Ju, Echoe M Bouta, Lianping Xing, Ronald W Wood, Igor Kuzin, Andrea Bottaro, Christopher T Ritchlin, Edward M Schwarz,

OBJECTIVE:B cell depletion therapy ameliorates rheumatoid arthritis by mechanisms that are incompletely understood. Arthritis flare in tumor necrosis factor (TNF)-transgenic mice is associated with efferent lymph node (LN) "collapse," triggered by B cell translocation into lymphatic spaces and decreased lymphatic drainage. The aim of this study was to examine whether ... Read more >>

Arthritis Rheum. (Arthritis and rheumatism)
[2013, 65(1):130-138]

Cited: 27 times

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Polymorphism in the SCN9A voltage-gated sodium channel gene associated with interstitial cystitis/bladder pain syndrome.

Jay E Reeder, Timothy K Byler, David C Foster, Steve K Landas, Henry Okafor, Gillian Stearns, Ronald W Wood, Yachao Zhang, Robert D Mayer,

OBJECTIVE: To determine whether an association exists between interstitial cystitis/bladder pain syndrome (IC/BPS) and a nonsynonymous single nucleotide polymorphism in the SCN9A voltage-gated sodium channel gene previously associated with other chronic pain syndromes. MATERIALS AND METHODS: Germline deoxyribonucleic acid was sampled from archived bladder biopsy specimens from patients with a ... Read more >>

Urology (Urology)
[2013, 81(1):210.e1-4]

Cited: 10 times

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