Full Text Journal Articles by
Author Ron A M Fouchier

Advertisement

Find full text journal articles






Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020.

Nicola S Lewis, Ashley C Banyard, Elliot Whittard, Talgat Karibayev, Thamer Al Kafagi, Ilya Chvala, Alex Byrne, Saduakassova Meruyert Akberovna, Jacqueline King, Timm Harder, Christian Grund, Steve Essen, Scott M Reid, Adam Brouwer, Nikolay G Zinyakov, Azimkhan Tegzhanov, Victor Irza, Anne Pohlmann, Martin Beer, Ron A M Fouchier, Sultanov Akhmetzhan Akievich, Ian H Brown,

Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed undetected maintenance of H5N8, likely in galliform poultry since 2017/18 and both H5N5 and H5N1. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):148-151]

Cited: 9 times

View full text PDF listing >>



Author Correction: The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.

Bas B Oude Munnink, Nathalie Worp, David F Nieuwenhuijse, Reina S Sikkema, Bart Haagmans, Ron A M Fouchier, Marion Koopmans,

Nat Med (Nature medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

ANTIBODIES AGAINST INFLUENZA VIRUS TYPES A AND B IN CANADIAN SEALS.

Lena N Measures, Ron A M Fouchier,

Influenza viruses have been reported from marine mammals worldwide, particularly in pinnipeds, and have caused mass mortalities of seals in North America and Europe. Because influenza viruses in marine mammals can be zoonotic, our objective was to examine Canadian phocids for exposure to influenza A and B viruses in order ... Read more >>

J Wildl Dis (Journal of wildlife diseases)
[2021, 57(4):808-819]

Cited: 0 times

View full text PDF listing >>



The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.

Bas B Oude Munnink, Nathalie Worp, David F Nieuwenhuijse, Reina S Sikkema, Bart Haagmans, Ron A M Fouchier, Marion Koopmans,

The current coronavirus disease 2019 (COVID-19) pandemic is the first to apply whole-genome sequencing near to real time, with over 2 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole-genome sequences generated and shared through the GISAID platform. This genomic resource informed public health decision-making throughout the pandemic; it also ... Read more >>

Nat Med (Nature medicine)
[2021, 27(9):1518-1524]

Cited: 0 times

View full text PDF listing >>



Whole genome sequencing of human metapneumoviruses from clinical specimens using MinION nanopore technology.

Kevin Groen, Stefan van Nieuwkoop, Theo M Bestebroer, Pieter L Fraaij, Ron A M Fouchier, Bernadette G van den Hoogen,

Human metapneumovirus (HMPV), a member of the Pneumoviridae family, is a causative agent of respiratory illness in young children, the elderly, and immunocompromised individuals. Globally, viruses belonging to two main genetic lineages circulate, A and B, which are further divided into four genetic sublineages (A1, A2, B1, B2). Classical genotyping ... Read more >>

Virus Res (Virus research)
[2021, 302:198490]

Cited: 0 times

View full text PDF listing >>



Secondary substitutions in the hemagglutinin and neuraminidase genes associated with neuraminidase inhibitor resistance are rare in the Influenza Resistance Information Study (IRIS).

Rueshandra Roosenhoff, Martin Schutten, Vaughan Reed, Barry Clinch, Anne van der Linden, Ron A M Fouchier, Pieter L A Fraaij,

Amino acid substitutions in influenza virus neuraminidase (NA) that cause resistance to neuraminidase inhibitors (NAI) generally result in virus attenuation. However, influenza viruses may acquire secondary substitutions in the NA and hemagglutinin (HA) proteins that can restore viral fitness. To assess to which extent this happens, the emergence of NAI ... Read more >>

Antiviral Res (Antiviral research)
[2021, 189:105060]

Cited: 0 times

View full text PDF listing >>



Very little influenza in the WHO European Region during the 2020/21 season, weeks 40 2020 to 8 2021.

Cornelia Adlhoch, Piers Mook, Favelle Lamb, Lisa Ferland, Angeliki Melidou, Andrew J Amato-Gauci, Richard Pebody, ,

Between weeks 40 2020 and 8 2021, the World Health Organization European Region experienced a 99.8% reduction in sentinel influenza virus positive detections (33/25,606 tested; 0.1%) relative to an average of 14,966/39,407 (38.0%; p < 0.001) over the same time in the previous six seasons. COVID-19 pandemic public health and physical distancing measures ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2021, 26(11):]

Cited: 4 times

View full text PDF listing >>



Highly Pathogenic Avian Influenza Viruses at the Wild-Domestic Bird Interface in Europe: Future Directions for Research and Surveillance.

Josanne H Verhagen, Ron A M Fouchier, Nicola Lewis,

Highly pathogenic avian influenza (HPAI) outbreaks in wild birds and poultry are no longer a rare phenomenon in Europe. In the past 15 years, HPAI outbreaks-in particular those caused by H5 viruses derived from the A/Goose/Guangdong/1/1996 lineage that emerged in southeast Asia in 1996-have been occuring with increasing frequency in ... Read more >>

Viruses (Viruses)
[2021, 13(2):]

Cited: 7 times

View full text PDF listing >>



Insertions of codons encoding basic amino acids in H7 hemagglutinins of influenza A viruses occur by recombination with RNA at hotspots near snoRNA binding sites.

Alexander P Gultyaev, Monique I Spronken, Mathis Funk, Ron A M Fouchier, Mathilde Richard,

The presence of multiple basic amino acids in the protease cleavage site of the hemagglutinin (HA) protein is the main molecular determinant of virulence of highly pathogenic avian influenza (HPAI) viruses. Recombination of HA RNA with other RNA molecules of host or virus origin is a dominant mechanism of multibasic ... Read more >>

RNA (RNA (New York, N.Y.))
[2021, 27(2):123-132]

Cited: 0 times

View full text PDF listing >>



Enterotropism of highly pathogenic avian influenza virus H5N8 from the 2016/2017 epidemic in some wild bird species.

Valentina Caliendo, Lonneke Leijten, Lineke Begeman, Marjolein J Poen, Ron A M Fouchier, Nancy Beerens, Thijs Kuiken,

In 2016/2017, H5N8 highly pathogenic avian influenza (HPAI) virus of the Goose/Guangdong lineage spread from Asia to Europe, causing the biggest and most widespread HPAI epidemic on record in wild and domestic birds in Europe. We hypothesized that the wide dissemination of the 2016 H5N8 virus resulted at least partly ... Read more >>

Vet Res (Veterinary research)
[2020, 51(1):117]

Cited: 4 times

View full text PDF listing >>



2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

Jens H Kuhn, Scott Adkins, Daniela Alioto, Sergey V Alkhovsky, Gaya K Amarasinghe, Simon J Anthony, Tatjana Avšič-Županc, María A Ayllón, Justin Bahl, Anne Balkema-Buschmann, Matthew J Ballinger, Tomáš Bartonička, Christopher Basler, Sina Bavari, Martin Beer, Dennis A Bente, Éric Bergeron, Brian H Bird, Carol Blair, Kim R Blasdell, Steven B Bradfute, Rachel Breyta, Thomas Briese, Paul A Brown, Ursula J Buchholz, Michael J Buchmeier, Alexander Bukreyev, Felicity Burt, Nihal Buzkan, Charles H Calisher, Mengji Cao, Inmaculada Casas, John Chamberlain, Kartik Chandran, Rémi N Charrel, Biao Chen, Michela Chiumenti, Il-Ryong Choi, J Christopher S Clegg, Ian Crozier, John V da Graça, Elena Dal Bó, Alberto M R Dávila, Juan Carlos de la Torre, Xavier de Lamballerie, Rik L de Swart, Patrick L Di Bello, Nicholas Di Paola, Francesco Di Serio, Ralf G Dietzgen, Michele Digiaro, Valerian V Dolja, Olga Dolnik, Michael A Drebot, Jan Felix Drexler, Ralf Dürrwald, Lucie Dufkova, William G Dundon, W Paul Duprex, John M Dye, Andrew J Easton, Hideki Ebihara, Toufic Elbeaino, Koray Ergünay, Jorlan Fernandes, Anthony R Fooks, Pierre B H Formenty, Leonie F Forth, Ron A M Fouchier, Juliana Freitas-Astúa, Selma Gago-Zachert, George Fú Gāo, María Laura García, Adolfo García-Sastre, Aura R Garrison, Aiah Gbakima, Tracey Goldstein, Jean-Paul J Gonzalez, Anthony Griffiths, Martin H Groschup, Stephan Günther, Alexandro Guterres, Roy A Hall, John Hammond, Mohamed Hassan, Jussi Hepojoki, Satu Hepojoki, Udo Hetzel, Roger Hewson, Bernd Hoffmann, Seiji Hongo, Dirk Höper, Masayuki Horie, Holly R Hughes, Timothy H Hyndman, Amara Jambai, Rodrigo Jardim, Dàohóng Jiāng, Qi Jin, Gilda B Jonson, Sandra Junglen, Serpil Karadağ, Karen E Keller, Boris Klempa, Jonas Klingström, Gary Kobinger, Hideki Kondō, Eugene V Koonin, Mart Krupovic, Gael Kurath, Ivan V Kuzmin, Lies Laenen, Robert A Lamb, Amy J Lambert, Stanley L Langevin, Benhur Lee, Elba R S Lemos, Eric M Leroy, Dexin Li, Jiànróng Lǐ, Mifang Liang, Wénwén Liú, Yàn Liú, Igor S Lukashevich, Piet Maes, William Marciel de Souza, Marco Marklewitz, Sergio H Marshall, Giovanni P Martelli, Robert R Martin, Shin-Yi L Marzano, Sébastien Massart, John W McCauley, Nicole Mielke-Ehret, Angelantonio Minafra, Maria Minutolo, Ali Mirazimi, Hans-Peter Mühlbach, Elke Mühlberger, Rayapati Naidu, Tomohide Natsuaki, Beatriz Navarro, José A Navarro, Sergey V Netesov, Gabriele Neumann, Norbert Nowotny, Márcio R T Nunes, Are Nylund, Arnfinn L Økland, Renata C Oliveira, Gustavo Palacios, Vicente Pallas, Bernadett Pályi, Anna Papa, Colin R Parrish, Alex Pauvolid-Corrêa, Janusz T Pawęska, Susan Payne, Daniel R Pérez, Florian Pfaff, Sheli R Radoshitzky, Aziz-Ul Rahman, Pedro L Ramos-González, Renato O Resende, Carina A Reyes, Bertus K Rima, Víctor Romanowski, Gabriel Robles Luna, Paul Rota, Dennis Rubbenstroth, Jonathan A Runstadler, Daniel Ruzek, Sead Sabanadzovic, Jiří Salát, Amadou Alpha Sall, Maria S Salvato, Kamil Sarpkaya, Takahide Sasaya, Martin Schwemmle, Muhammad Z Shabbir, Xiǎohóng Shí, Zhènglì Shí, Yukio Shirako, Peter Simmonds, Jana Širmarová, Manuela Sironi, Sophie Smither, Teemu Smura, Jin-Won Song, Kirsten M Spann, Jessica R Spengler, Mark D Stenglein, David M Stone, Petra Straková, Ayato Takada, Robert B Tesh, Natalie J Thornburg, Keizō Tomonaga, Noël Tordo, Jonathan S Towner, Massimo Turina, Ioannis Tzanetakis, Rainer G Ulrich, Anna Maria Vaira, Bernadette van den Hoogen, Arvind Varsani, Nikos Vasilakis, Martin Verbeek, Victoria Wahl, Peter J Walker, Hui Wang, Jianwei Wang, Xifeng Wang, Lin-Fa Wang, Tàiyún Wèi, Heather Wells, Anna E Whitfield, John V Williams, Yuri I Wolf, Zhìqiáng Wú, Xin Yang, Xīnglóu Yáng, Xuejie Yu, Natalya Yutin, F Murilo Zerbini, Tong Zhang, Yong-Zhen Zhang, Guohui Zhou, Xueping Zhou,

In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 ... Read more >>

Arch Virol (Archives of virology)
[2020, 165(12):3023-3072]

Cited: 32 times

View full text PDF listing >>



Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age.

Barbara Mühlemann, Lasse Vinner, Ashot Margaryan, Helene Wilhelmson, Constanza de la Fuente Castro, Morten E Allentoft, Peter de Barros Damgaard, Anders Johannes Hansen, Sofie Holtsmark Nielsen, Lisa Mariann Strand, Jan Bill, Alexandra Buzhilova, Tamara Pushkina, Ceri Falys, Valeri Khartanovich, Vyacheslav Moiseyev, Marie Louise Schjellerup Jørkov, Palle Østergaard Sørensen, Yvonne Magnusson, Ingrid Gustin, Hannes Schroeder, Gerd Sutter, Geoffrey L Smith, Christian Drosten, Ron A M Fouchier, Derek J Smith, Eske Willerslev, Terry C Jones, Martin Sikora,

Smallpox, one of the most devastating human diseases, killed between 300 million and 500 million people in the 20th century alone. We recovered viral sequences from 13 northern European individuals, including 11 dated to ~600-1050 CE, overlapping the Viking Age, and reconstructed near-complete variola virus genomes for four of them. ... Read more >>

Science (Science (New York, N.Y.))
[2020, 369(6502):]

Cited: 14 times

View full text PDF listing >>



Phylogeography and Antigenic Diversity of Low-Pathogenic Avian Influenza H13 and H16 Viruses.

Josanne H Verhagen, Marjolein Poen, David E Stallknecht, Stefan van der Vliet, Pascal Lexmond, Srinand Sreevatsan, Rebecca L Poulson, Ron A M Fouchier, Camille Lebarbenchon,

Low-pathogenic avian influenza viruses (LPAIVs) are genetically highly variable and have diversified into multiple evolutionary lineages that are primarily associated with wild-bird reservoirs. Antigenic variation has been described for mammalian influenza viruses and for highly pathogenic avian influenza viruses that circulate in poultry, but much less is known about antigenic ... Read more >>

J Virol (Journal of virology)
[2020, 94(13):]

Cited: 2 times

View full text PDF listing >>



Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008-2015.

Hana A Pawestri, Arie A Nugraha, Alvin X Han, Eka Pratiwi, Edyth Parker, Mathilde Richard, Stefan van der Vliet, Ron A M Fouchier, David H Muljono, Menno D de Jong, Vivi Setiawaty, Dirk Eggink,

Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared to other geographical regions affected by other genetic clades of the virus. However, there is limited information on the genetic ... Read more >>

Virus Genes (Virus genes)
[2020, 56(4):417-429]

Cited: 1 time

View full text PDF listing >>



Outbreak Severity of Highly Pathogenic Avian Influenza A(H5N8) Viruses Is Inversely Correlated to Polymerase Complex Activity and Interferon Induction.

René M Vigeveno, Marjolein J Poen, Edyth Parker, Melle Holwerda, Karen de Haan, Thijs van Montfort, Nicola S Lewis, Colin A Russell, Ron A M Fouchier, Menno D de Jong, Dirk Eggink,

Highly pathogenic avian influenza A(H5N8) viruses first emerged in China in 2010 and in 2014 spread throughout Asia and to Europe and the United States via migrating birds. Influenza A(H5N8) viruses were first detected in the Netherlands in 2014 and caused five outbreaks in poultry farms but were infrequently detected ... Read more >>

J Virol (Journal of virology)
[2020, 94(11):]

Cited: 2 times

View full text PDF listing >>



Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses.

Reina Yamaji, Magdi D Saad, Charles T Davis, David E Swayne, Dayan Wang, Frank Y K Wong, John W McCauley, J S Malik Peiris, Richard J Webby, Ron A M Fouchier, Yoshihiro Kawaoka, Wenqing Zhang,

The panzootic caused by A/goose/Guangdong/1/96-lineage highly pathogenic avian influenza (HPAI) A(H5) viruses has occurred in multiple waves since 1996. From 2013 onwards, clade 2.3.4.4 viruses of subtypes A(H5N2), A(H5N6), and A(H5N8) emerged to cause panzootic waves of unprecedented magnitude among avian species accompanied by severe losses to the poultry industry ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2020, 30(3):e2099]

Cited: 14 times

View full text PDF listing >>



Comparison of sequencing methods and data processing pipelines for whole genome sequencing and minority single nucleotide variant (mSNV) analysis during an influenza A/H5N8 outbreak.

Marjolein J Poen, Anne Pohlmann, Clara Amid, Theo M Bestebroer, Sharon M Brookes, Ian H Brown, Helen Everett, Claudia M E Schapendonk, Rachel D Scheuer, Saskia L Smits, Martin Beer, Ron A M Fouchier, Richard J Ellis,

As high-throughput sequencing technologies are becoming more widely adopted for analysing pathogens in disease outbreaks there needs to be assurance that the different sequencing technologies and approaches to data analysis will yield reliable and comparable results. Conversely, understanding where agreement cannot be achieved provides insight into the limitations of these ... Read more >>

PLoS One (PloS one)
[2020, 15(2):e0229326]

Cited: 1 time

View full text PDF listing >>



Susceptibility of Chickens to Low Pathogenic Avian Influenza (LPAI) Viruses of Wild Bird- and Poultry-Associated Subtypes.

Saskia A Bergervoet, Evelien A Germeraad, Marc Alders, Marit M Roose, Marc Y Engelsma, Rene Heutink, Ruth Bouwstra, Ron A M Fouchier, Nancy Beerens,

Analysis of low pathogenic avian influenza (LPAI) viruses circulating in the Netherlands in a previous study revealed associations of specific hemagglutinin (HA) and neuraminidase (NA) subtypes with wild bird or poultry hosts. In this study, we identified putative host associations in LPAI virus internal proteins. We show that LPAI viruses ... Read more >>

Viruses (Viruses)
[2019, 11(11):]

Cited: 5 times

View full text PDF listing >>



Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals.

Yukimasa Matsuzawa, Kiyoko Iwatsuki-Horimoto, Yoshinori Nishimoto, Yukiko Abe, Satoshi Fukuyama, Taiki Hamabata, Moe Okuda, Yui Go, Tokiko Watanabe, Masaki Imai, Yasumichi Arai, Ron A M Fouchier, Seiya Yamayoshi, Yoshihiro Kawaoka,

Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from ... Read more >>

Viruses (Viruses)
[2019, 11(11):]

Cited: 2 times

View full text PDF listing >>



Evidence of the Presence of Low Pathogenic Avian Influenza A Viruses in Wild Waterfowl in 2018 in South Africa.

Marjolein J Poen, Ron A M Fouchier, Richard J Webby, Robert G Webster, Mohamed E El Zowalaty,

Avian influenza viruses are pathogens of global concern to both animal and human health. Wild birds are the natural reservoir of avian influenza viruses and facilitate virus transport over large distances. Surprisingly, limited research has been performed to determine avian influenza host species and virus dynamics in wild birds on ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2019, 8(4):]

Cited: 3 times

View full text PDF listing >>



Circulation of low pathogenic avian influenza (LPAI) viruses in wild birds and poultry in the Netherlands, 2006-2016.

Saskia A Bergervoet, Sylvia B E Pritz-Verschuren, Jose L Gonzales, Alex Bossers, Marjolein J Poen, Jayeeta Dutta, Zenab Khan, Divya Kriti, Harm van Bakel, Ruth Bouwstra, Ron A M Fouchier, Nancy Beerens,

In this study, we explore the circulation of low pathogenic avian influenza (LPAI) viruses in wild birds and poultry in the Netherlands. Surveillance data collected between 2006 and 2016 was used to evaluate subtype diversity, spatiotemporal distribution and genetic relationships between wild bird and poultry viruses. We observed close species-dependent ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13681]

Cited: 5 times

View full text PDF listing >>



Taxonomy of the order Mononegavirales: update 2019.

Gaya K Amarasinghe, María A Ayllón, Yīmíng Bào, Christopher F Basler, Sina Bavari, Kim R Blasdell, Thomas Briese, Paul A Brown, Alexander Bukreyev, Anne Balkema-Buschmann, Ursula J Buchholz, Camila Chabi-Jesus, Kartik Chandran, Chiara Chiapponi, Ian Crozier, Rik L de Swart, Ralf G Dietzgen, Olga Dolnik, Jan F Drexler, Ralf Dürrwald, William G Dundon, W Paul Duprex, John M Dye, Andrew J Easton, Anthony R Fooks, Pierre B H Formenty, Ron A M Fouchier, Juliana Freitas-Astúa, Anthony Griffiths, Roger Hewson, Masayuki Horie, Timothy H Hyndman, Dàohóng Jiāng, Elliott W Kitajima, Gary P Kobinger, Hideki Kondō, Gael Kurath, Ivan V Kuzmin, Robert A Lamb, Antonio Lavazza, Benhur Lee, Davide Lelli, Eric M Leroy, Jiànróng Lǐ, Piet Maes, Shin-Yi L Marzano, Ana Moreno, Elke Mühlberger, Sergey V Netesov, Norbert Nowotny, Are Nylund, Arnfinn L Økland, Gustavo Palacios, Bernadett Pályi, Janusz T Pawęska, Susan L Payne, Alice Prosperi, Pedro Luis Ramos-González, Bertus K Rima, Paul Rota, Dennis Rubbenstroth, Mǎng Shī, Peter Simmonds, Sophie J Smither, Enrica Sozzi, Kirsten Spann, Mark D Stenglein, David M Stone, Ayato Takada, Robert B Tesh, Keizō Tomonaga, Noël Tordo, Jonathan S Towner, Bernadette van den Hoogen, Nikos Vasilakis, Victoria Wahl, Peter J Walker, Lin-Fa Wang, Anna E Whitfield, John V Williams, F Murilo Zerbini, Tāo Zhāng, Yong-Zhen Zhang, Jens H Kuhn,

In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(7):1967-1980]

Cited: 69 times

View full text PDF listing >>



A30 Avian influenza viruses in wild birds: Virus evolution in a multi-host ecosystem

Divya Venkatesh, Marjolein J Poen, Theo M Bestebroer, Rachel D Scheuer, Oanh Vuong, Mzia Chkhaidze, Anna Machablishvili, Jimsher Mamuchadze, Levan Ninua, Nadia B Fedorova, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, David E Wentworth, Divya Kriti, Jayeeta Dutta, Harm van Bakel, Anita Puranik, Marek J Slomka, Steve Essen, Ian H Brown, Ron A M Fouchier, Nicola S Lewis,

Abstract Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways breed, winter, or stage. The Republic of Georgia is located at the intersection of three migratory ... Read more >>

Virus Evol (Virus evolution)
[2019, 5(Suppl 1):]

Cited: 0 times

View full text PDF listing >>



Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses.

Alexander P Gultyaev, Mathilde Richard, Monique I Spronken, René C L Olsthoorn, Ron A M Fouchier,

The acquisition of a multibasic cleavage site (MBCS) in the hemagglutinin (HA) glycoprotein is the main determinant of the conversion of low pathogenic avian influenza viruses into highly pathogenic strains, facilitating HA cleavage and virus replication in a broader range of host cells. In nature, substitutions or insertions in HA ... Read more >>

Virus Evol (Virus evolution)
[2019, 5(2):vez034]

Cited: 2 times

View full text PDF listing >>



Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.

Björn F Koel, David F Burke, Stefan van der Vliet, Theo M Bestebroer, Guus F Rimmelzwaan, Albert D M E Osterhaus, Derek J Smith, Ron A M Fouchier,

We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antigenic effect of substitutions introduced at haemagglutinin position 145 was ... Read more >>

J Gen Virol (The Journal of general virology)
[2019, 100(5):773-777]

Cited: 2 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1916 s