Full Text Journal Articles by
Author Romil Saxena

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Got nerve? Autonomic innervation of the human liver.

Romil Saxena,

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2020, :]

Cited: 0 times

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SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.

Xiaolin Zhong, Menghao Huang, Hyeong-Geug Kim, Yang Zhang, Kushan Chowdhury, Wenjie Cai, Romil Saxena, Robert F Schwabe, Suthat Liangpunsakul, X Charlie Dong,

BACKGROUND & AIMS:Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (Sirt6), a nicotinamide adenine dinucleotide-dependent deacetylase, has been implicated in fatty liver disease; however, the underlying molecular mechanisms ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2020, :]

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A Comparative Study of 22G versus 19G Needles for EUS-Guided Biopsies for Parenchymal Liver Disease: Are Thinner Needles Better?

Harsh K Patel, Romil Saxena, Natalia Rush, Suchi K Patel, Chandra S Dasari, Wadad Mneimneh, Ariel Quickery, Mahmoud A Rahal, Lindsey Temnykh, John DeWitt, Mohammad Al-Haddad,

BACKGROUND AND AIMS:Data on comparative efficacy of various available endoscopic ultrasound-guided liver biopsy (EUS-LB) needles are limited. We sought to compare the performance of a novel Franseen-tip 22G fine-needle biopsy (FNB) device to that of 19G needle platforms for liver parenchyma. METHODS:Consecutive patients referred for EUS and suspected to have ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2020, :]

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Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids.

Suneha Sundaram, Raj Vuppalanchi, Romil Saxena, Naga Chalasani,

Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite ... Read more >>

ACG Case Rep J (ACG case reports journal)
[2020, 7(2):e00319]

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Increased Mast Cell Counts and Degranulation in Microscopic Colitis.

Zhikai Chi, Jing Xu, Romil Saxena,

Objectives:Microscopic colitis (MC) is characterized by chronic diarrhea, normal colonoscopy findings, and mucosal inflammation in colonic biopsies and can be classified as collagenous colitis (CC) or lymphocytic colitis (LC). However, the pathogenesis of MC is largely unknown. In this study, we aimed to study mast cell counts and activation in ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:9089027]

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Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

Konstantina Kyritsi, Lixian Chen, April O'Brien, Heather Francis, Travis W Hein, Julie Venter, Nan Wu, Ludovica Ceci, Tianhao Zhou, David Zawieja, Anatoliy A Gashev, Fanyin Meng, Pietro Invernizzi, Luca Fabris, Chaodong Wu, Nicholas J Skill, Romil Saxena, Suthat Liangpunsakul, Gianfranco Alpini, Shannon S Glaser,

BACKGROUND AND AIMS:Serotonin (5HT) is a neuroendocrine hormone synthetized in the central nervous system (CNS) as well as enterochromaffin cells of the gastrointestinal tract. Tryptophan hydroxylase (TPH1) and monoamine oxidase (MAO-A) are the key enzymes for the synthesis and catabolism of 5HT, respectively. Previous studies demonstrated that 5-hydroxytryptamine receptor (5HTR)1A/1B ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, 71(3):990-1008]

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Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction.

Menghao Huang, Hyeong Geug Kim, Xiaolin Zhong, Chuanpeng Dong, Brian Zhang, Zhigang Fang, Yang Zhang, Xiaoyu Lu, Romil Saxena, Yunlong Liu, Chi Zhang, Suthat Liangpunsakul, X Charlie Dong,

Sestrin 3 (Sesn3) belongs to the three-member sestrin protein family. Sestrins have been implicated in antioxidative stress, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin signal transduction, and metabolic homeostasis. However, the role of Sesn3 in the development of nonalcoholic steatohepatitis (NASH) has not been previously studied. In this ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, 71(1):76-92]

Cited: 1 time

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Non-obese histologically confirmed NASH patients with abnormal liver biochemistry have more advanced fibrosis.

Qianyi Wang, Hong You, Xiaojuan Ou, Xinyan Zhao, Yameng Sun, Min Wang, Ping Wang, Yu Wang, Weijia Duan, Xiaoming Wang, Shanshan Wu, Yuanyuan Kong, Romil Saxena, Annette S H Gouw, Jidong Jia,

BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) commonly affects subjects with obesity, yet non-obese NAFLD is increasingly being recognized. We aimed to investigate the clinicopathological and genetic characteristics of non-obese NAFLD patients. METHODS:The clinical, histological and genetic data of 84 NAFLD patients with biopsy for abnormal liver function test were ... Read more >>

Hepatol Int (Hepatology international)
[2019, 13(6):766-776]

Cited: 1 time

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Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC).

Tianhao Zhou, Konstantina Kyritsi, Nan Wu, Heather Francis, Zhihong Yang, Lixian Chen, April O'Brien, Lindsey Kennedy, Ludovica Ceci, Vik Meadows, Praveen Kusumanchi, Chaodong Wu, Leonardo Baiocchi, Nicholas J Skill, Romil Saxena, Amelia Sybenga, Linglin Xie, Suthat Liangpunsakul, Fanyin Meng, Gianfranco Alpini, Shannon Glaser,

BACKGROUND:Cholangiocytes are the target cells of cholangiopathies including primary sclerosing cholangitis (PSC). Vimentin is an intermediate filament protein that has been found in various types of mesenchymal cells. The aim of this study is to evaluate the role of vimentin in the progression of biliary damage/liver fibrosis and whether there ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 48:130-142]

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Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS).

Nicholas J Skill, Campbell M Elliott, Brian Ceballos, Romil Saxena, Robert Pepin, Lisa Bettcher, Matthew Ellensberg, Daniel Raftery, Mary A Malucio, Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal,

BACKGROUND Acute liver rejection (ALR), a significant complication of liver transplantation, burdens patients, healthcare payers, and the healthcare providers due to an increase in morbidity, cost, and resources. Despite clinical resolution, ALR is associated with an increased risk of graft loss. A unique protocol of delayed immunosuppression used in our ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2019, 24:341-349]

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Long-term metformin use may improve clinical outcomes in diabetic patients with non-alcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis.

Eduardo Vilar-Gomez, Raj Vuppalanchi, Archita P Desai, Samer Gawrieh, Marwan Ghabril, Romil Saxena, Oscar W Cummings, Naga Chalasani,

BACKGROUND:Metformin may protect against hepatocellular carcinoma and mortality among patients with type 2 diabetes. AIM:To investigate whether long-term use of metformin improves survival and reduces liver-related outcomes among patients with type 2 diabetes and non-alcoholic steatohepatitis. METHODS:A total of 191 diabetic patients with biopsy-proven non-alcoholic steatohepatitis and bridging fibrosis or ... Read more >>

Aliment. Pharmacol. Ther. (Alimentary pharmacology & therapeutics)
[2019, 50(3):317-328]

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Vitamin E Improves Transplant-Free Survival and Hepatic Decompensation Among Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis.

Eduardo Vilar-Gomez, Raj Vuppalanchi, Samer Gawrieh, Marwan Ghabril, Romil Saxena, Oscar W Cummings, Naga Chalasani,

Vitamin E improves liver histology in adults with nonalcoholic steatohepatitis (NASH) but not diabetes, but its impact on long-term patient outcomes is unknown. We evaluated whether vitamin E treatment improves clinical outcomes of NASH patients with bridging fibrosis or cirrhosis. Two hundred and thirty-six patients with biopsy-proven NASH and bridging ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, 71(2):495-509]

Cited: 3 times

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Clinicopathological features of He Shou Wu-induced liver injury: This ancient anti-aging therapy is not liver-friendly.

Yan Wang, Lan Wang, Romil Saxena, Aileen Wee, Ruiyuan Yang, Qiuju Tian, Jiping Zhang, Xinyan Zhao, Jidong Jia,

BACKGROUND & AIMS:Polygonum Multiflorum Thumb (PMT), an ancient anti-aging Chinese herb known traditionally as He Shou Wu, has side effects of liver toxicity. To determine the main clinical and pathological characteristics of liver toxicity induced by PMT and the clinical course after its cessation. METHODS:Data of patients, diagnosed as drug-induced ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2019, 39(2):389-400]

Cited: 1 time

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Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.

Sobha Puppala, Cun Li, Jeremy P Glenn, Romil Saxena, Samer Gawrieh, Amy Quinn, Jennifer Palarczyk, Edward J Dick, Peter W Nathanielsz, Laura A Cox,

KEY POINTS:Maternal obesity (MO) and exposure to a high-fat, high-simple-carbohydrate diet during pregnancy predisposes offspring to obesity, metabolic and cardiovascular disorders in later life. Underlying molecular pathways and potential epigenetic factors that are dysregulated in MO were identified using unbiased transcriptomic methods. There was increased lipid accumulation and severe steatosis ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2018, 596(23):5823-5837]

Cited: 6 times

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Variant differentiation patterns in primary liver carcinoma.

Christine Sempoux, Valérie Paradis, Romil Saxena,

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are two distinct forms of primary liver carcinoma recognizable at the microscope by their architectural and cytological characteristics, as well as specific immunohistochemical profiles. This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):176-182]

Cited: 1 time

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Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes.

Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio,

To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT).The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 97(5):931-938]

Cited: 10 times

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Primary mesenchymal liver tumors of childhood.

Omer Saeed, Romil Saxena,

Primary mesenchymal tumors of the liver represent a significant proportion of liver tumors among neonates, infants and young children. They may be discovered incidentally or present with an alarmingly large, rapidly growing abdominal mass. One third of pediatric liver tumors are benign with hemangioma and mesenchymal hamartoma being the commonest ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):201-207]

Cited: 1 time

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Introduction.

Romil Saxena,

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):111]

Cited: 0 times

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Differential diagnosis of epithelioid and clear cell tumors in the liver.

Steven Alexander Mann, Romil Saxena,

A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):183-191]

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Hepatoblastoma.

Divya Sharma, Girish Subbarao, Romil Saxena,

Hepatoblastoma is the most common primary malignant hepatic tumor of infancy and childhood, occurring predominantly in the first two years of life. The management of hepatoblastoma has changed markedly over the last 3 decades; neoadjuvant chemotherapy is now standard, particularly in unresectable tumors resulting in considerable preoperative tumor shrinkage and ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):192-200]

Cited: 5 times

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Pseudocirrhosis and liver failure in patients with metastatic breast cancer after treatment with palbociclib.

Raj Vuppalanchi, Romil Saxena, Anna Maria V Storniolo, Naga Chalasani,

Hepatology (Hepatology (Baltimore, Md.))
[2017, 65(5):1762-1764]

Cited: 4 times

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Optimization of Perioperative Conditions to Prevent Ischemic Cholangiopathy in Donation After Circulatory Death Donor Liver Transplantation.

Chandrashekhar Kubal, Richard Mangus, Jonathan Fridell, Romil Saxena, Natalia Rush, Matthew Wingler, Burcin Ekser, Joseph Tector,

Donation after circulatory death (DCD) donor pool remains underutilized for liver transplantation (LT). We describe optimizing "modifiable risk factors," such as cold ischemia time (CIT) recipient warm ischemia time (WIT) and the use of thrombolytic flush at the time of procurement to minimize ischemic cholangiopathy (IC).From July 2011 (era II), ... Read more >>

Transplantation (Transplantation)
[2016, 100(8):1699-1704]

Cited: 12 times

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Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria.

Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal, Jonathan A Fridell, John A Powelson, Santosh Nagaraju, Plamen Mihaylov, Carrie L Phillips, Romil Saxena, William C Goggins,

Enteric hyperoxaluria (EH) occurs with a rate of 5-24% in patients with inflammatory bowel disease, ileal resection and modern bariatric surgery. The excessive absorption of calcium oxalate causes chronic kidney disease (CKD) in patients with EH. In the literature, a single experience was reported in combined intestine-kidney transplantation (CIKTx) in ... Read more >>

Am. J. Nephrol. (American journal of nephrology)
[2016, 44(2):85-91]

Cited: 0 times

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Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis.

Suthat Liangpunsakul, Puneet Puri, Vijay H Shah, Patrick Kamath, Arun Sanyal, Thomas Urban, Xiaowei Ren, Barry Katz, Svetlana Radaeva, Naga Chalasani, David W Crabb, ,

BACKGROUND & AIMS:Only a minority of heavy drinking individuals develop alcoholic hepatitis (AH), for unclear reasons. We analyzed data from the Translational Research and Evolving Alcoholic Hepatitis Treatment cohort, consisting of subjects who drink heavily with normal results from liver tests (controls) and patients with AH. We examined risk factors ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2016, 14(12):1831-1838.e3]

Cited: 15 times

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Hepatic arterial buffer response: pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis.

Natalia Rush, Hongliu Sun, Yukihiro Nakanishi, Wadad Mneimneh, Paul Y Kwo, Romil Saxena,

Increase in hepatic arterial flow in response to reduced portal flow (hepatic arterial buffer response) has been demonstrated experimentally and surgically. We provide pathologic evidence for hepatic arterial buffer response in non-cirrhotic patients with extrahepatic portal vein thrombosis and elucidate the histopathologic spectrum of non-cirrhotic portal vein thrombosis. Liver biopsies ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2016, 29(5):489-499]

Cited: 1 time

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