Full Text Journal Articles by
Author Romil Saxena

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Modulation of the TPH1/MAO-A/5HT/5HTR2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

Konstantina Kyritsi, Lixian Chen, April O'Brien, Heather Francis, Travis W Hein, Julie Venter, Nan Wu, Ludovica Ceci, Tianhao Zhou, David Zawieja, Anatoliy A Gashev, Fanyin Meng, Pietro Invernizzi, Luca Fabris, Chaodong Wu, Nicholas J Skill, Romil Saxena, Suthat Liangpunsakul, Gianfranco Alpini, Shannon Glaser,

Serotonin (5HT) is a neuroendocrine hormone synthetized in the central nervous system (SNS) as well as enterochromaffin cells of the gastrointestinal tract. Tryptophan hydroxylase (TPH1) and monoamine-oxidase (MAO-A) are the key enzymes for the synthesis and catabolism of 5HT, respectively. Previous studies demonstrated that 5HTR1A/1B receptor agonists inhibit biliary hyperplasia ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, :]

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Sesn3 protects against diet-induced nonalcoholic steatohepatitis in mice via suppression of the TGFβ signal transduction.

Menghao Huang, Hyeong Geug Kim, Xiaolin Zhong, Chuanpeng Dong, Brian Zhang, Zhigang Fang, Yang Zhang, Xiaoyu Lu, Romil Saxena, Yunlong Liu, Chi Zhang, Suthat Liangpunsakul, X Charlie Dong,

Sesn3 belongs to the three-member sestrin protein family. Sestrins have been implicated in anti-oxidative stress, AMPK and mTOR signal transduction, and metabolic homeostasis. However, the role of Sesn3 in the development of nonalcoholic steatohepatitis (NASH) has not been previously studied. In this work, we generated Sesn3 whole-body knockout and liver-specific ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, :]

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Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS).

Nicholas J Skill, Campbell M Elliott, Brian Ceballos, Romil Saxena, Robert Pepin, Lisa Bettcher, Matthew Ellensberg, Daniel Raftery, Mary A Malucio, Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal,

BACKGROUND Acute liver rejection (ALR), a significant complication of liver transplantation, burdens patients, healthcare payers, and the healthcare providers due to an increase in morbidity, cost, and resources. Despite clinical resolution, ALR is associated with an increased risk of graft loss. A unique protocol of delayed immunosuppression used in our ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2019, 24:341-349]

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Long-term metformin use may improve clinical outcomes in diabetic patients with non-alcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis.

Eduardo Vilar-Gomez, Raj Vuppalanchi, Archita Desai, Samer Gawrieh, Marwan Ghabril, Romil Saxena, Oscar W Cummings, Naga Chalasani,

BACKGROUND:Metformin may protect against hepatocellular carcinoma and mortality among patients with type 2 diabetes. AIM:To investigate whether long-term use of metformin improves survival and reduces liver-related outcomes among patients with type 2 diabetes and non-alcoholic steatohepatitis. METHODS:A total of 191 diabetic patients with biopsy-proven non-alcoholic steatohepatitis and bridging fibrosis or ... Read more >>

Aliment. Pharmacol. Ther. (Alimentary pharmacology & therapeutics)
[2019, 50(3):317-328]

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Vitamin E Improves Transplant-Free Survival and Hepatic Decompensation Among Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis.

Eduardo Vilar-Gomez, Raj Vuppalanchi, Samer Gawrieh, Marwan Ghabril, Romil Saxena, Oscar W Cummings, Naga Chalasani,

Vitamin E improves liver histology in adults with nonalcoholic steatohepatitis (NASH) but not diabetes, but its impact on long-term patient outcomes is unknown. We evaluated whether vitamin E treatment improves clinical outcomes of NASH patients with bridging fibrosis or cirrhosis. Two hundred and thirty-six patients with biopsy-proven NASH and bridging ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2018, :]

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Clinicopathological features of He Shou Wu-induced liver injury: This ancient anti-aging therapy is not liver-friendly.

Yan Wang, Lan Wang, Romil Saxena, Aileen Wee, Ruiyuan Yang, Qiuju Tian, Jiping Zhang, Xinyan Zhao, Jidong Jia,

BACKGROUND & AIMS:Polygonum Multiflorum Thumb (PMT), an ancient anti-aging Chinese herb known traditionally as He Shou Wu, has side effects of liver toxicity. To determine the main clinical and pathological characteristics of liver toxicity induced by PMT and the clinical course after its cessation. METHODS:Data of patients, diagnosed as drug-induced ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2019, 39(2):389-400]

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Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.

Sobha Puppala, Cun Li, Jeremy P Glenn, Romil Saxena, Samer Gawrieh, Amy Quinn, Jennifer Palarczyk, Edward J Dick, Peter W Nathanielsz, Laura A Cox,

KEY POINTS:Maternal obesity (MO) and exposure to a high-fat, high-simple-carbohydrate diet during pregnancy predisposes offspring to obesity, metabolic and cardiovascular disorders in later life. Underlying molecular pathways and potential epigenetic factors that are dysregulated in MO were identified using unbiased transcriptomic methods. There was increased lipid accumulation and severe steatosis ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2018, 596(23):5823-5837]

Cited: 3 times

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Variant differentiation patterns in primary liver carcinoma.

Christine Sempoux, Valérie Paradis, Romil Saxena,

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are two distinct forms of primary liver carcinoma recognizable at the microscope by their architectural and cytological characteristics, as well as specific immunohistochemical profiles. This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):176-182]

Cited: 1 time

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Introduction.

Romil Saxena,

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):111]

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Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes.

Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio,

To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT).The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 97(5):931-938]

Cited: 6 times

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Differential diagnosis of epithelioid and clear cell tumors in the liver.

Steven Alexander Mann, Romil Saxena,

A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):183-191]

Cited: 0 times

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Primary mesenchymal liver tumors of childhood.

Omer Saeed, Romil Saxena,

Primary mesenchymal tumors of the liver represent a significant proportion of liver tumors among neonates, infants and young children. They may be discovered incidentally or present with an alarmingly large, rapidly growing abdominal mass. One third of pediatric liver tumors are benign with hemangioma and mesenchymal hamartoma being the commonest ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):201-207]

Cited: 1 time

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Hepatoblastoma.

Divya Sharma, Girish Subbarao, Romil Saxena,

Hepatoblastoma is the most common primary malignant hepatic tumor of infancy and childhood, occurring predominantly in the first two years of life. The management of hepatoblastoma has changed markedly over the last 3 decades; neoadjuvant chemotherapy is now standard, particularly in unresectable tumors resulting in considerable preoperative tumor shrinkage and ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2017, 34(2):192-200]

Cited: 3 times

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Pseudocirrhosis and liver failure in patients with metastatic breast cancer after treatment with palbociclib.

Raj Vuppalanchi, Romil Saxena, Anna Maria V Storniolo, Naga Chalasani,

Hepatology (Hepatology (Baltimore, Md.))
[2017, 65(5):1762-1764]

Cited: 2 times

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Optimization of Perioperative Conditions to Prevent Ischemic Cholangiopathy in Donation After Circulatory Death Donor Liver Transplantation.

Chandrashekhar Kubal, Richard Mangus, Jonathan Fridell, Romil Saxena, Natalia Rush, Matthew Wingler, Burcin Ekser, Joseph Tector,

Donation after circulatory death (DCD) donor pool remains underutilized for liver transplantation (LT). We describe optimizing "modifiable risk factors," such as cold ischemia time (CIT) recipient warm ischemia time (WIT) and the use of thrombolytic flush at the time of procurement to minimize ischemic cholangiopathy (IC).From July 2011 (era II), ... Read more >>

Transplantation (Transplantation)
[2016, 100(8):1699-1704]

Cited: 12 times

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Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria.

Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal, Jonathan A Fridell, John A Powelson, Santosh Nagaraju, Plamen Mihaylov, Carrie L Phillips, Romil Saxena, William C Goggins,

Enteric hyperoxaluria (EH) occurs with a rate of 5-24% in patients with inflammatory bowel disease, ileal resection and modern bariatric surgery. The excessive absorption of calcium oxalate causes chronic kidney disease (CKD) in patients with EH. In the literature, a single experience was reported in combined intestine-kidney transplantation (CIKTx) in ... Read more >>

Am. J. Nephrol. (American journal of nephrology)
[2016, 44(2):85-91]

Cited: 0 times

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Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis.

Suthat Liangpunsakul, Puneet Puri, Vijay H Shah, Patrick Kamath, Arun Sanyal, Thomas Urban, Xiaowei Ren, Barry Katz, Svetlana Radaeva, Naga Chalasani, David W Crabb, ,

BACKGROUND & AIMS:Only a minority of heavy drinking individuals develop alcoholic hepatitis (AH), for unclear reasons. We analyzed data from the Translational Research and Evolving Alcoholic Hepatitis Treatment cohort, consisting of subjects who drink heavily with normal results from liver tests (controls) and patients with AH. We examined risk factors ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2016, 14(12):1831-1838.e3]

Cited: 13 times

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Hepatic arterial buffer response: pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis.

Natalia Rush, Hongliu Sun, Yukihiro Nakanishi, Wadad Mneimneh, Paul Y Kwo, Romil Saxena,

Increase in hepatic arterial flow in response to reduced portal flow (hepatic arterial buffer response) has been demonstrated experimentally and surgically. We provide pathologic evidence for hepatic arterial buffer response in non-cirrhotic patients with extrahepatic portal vein thrombosis and elucidate the histopathologic spectrum of non-cirrhotic portal vein thrombosis. Liver biopsies ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2016, 29(5):489-499]

Cited: 1 time

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Liver injury and fibrosis induced by dietary challenge in the Ossabaw miniature Swine.

Tiebing Liang, Mouhamad Alloosh, Lauren N Bell, Allison Fullenkamp, Romil Saxena, William Van Alstine, Phelan Bybee, Klára Werling, Michael Sturek, Naga Chalasani, Howard C Masuoka,

Ossabaw miniature swine when fed a diet high in fructose, saturated fat and cholesterol (NASH diet) develop metabolic syndrome and nonalcoholic steatohepatitis (NASH) characterized by liver injury and fibrosis. This study was conducted to further characterize the development of NASH in this large animal model.Ossabaw swine were fed standard chow ... Read more >>

PLoS ONE (PloS one)
[2015, 10(5):e0124173]

Cited: 7 times

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Prospective Monitoring of Donor-specific Anti-HLA Antibodies After Intestine/Multivisceral Transplantation: Significance of De Novo Antibodies.

Chandrashekhar Kubal, Richard Mangus, Romil Saxena, Andrew Lobashevsky, Nancy Higgins, Jonathan Fridell, A Joseph Tector,

Presence of circulating donor-specific antibodies (DSA) may be associated with worse clinical outcomes after intestine/multivisceral transplantation.In 79 intestine/multivisceral recipients, sera were prospectively screened for DSA by Luminex Single antigen test at 1, 3, 6, 9, 12, 18, 24, and 36 months after transplantation. Standard immunosuppression included thymoglobulin-rituximab induction and tacrolimus-prednisone ... Read more >>

Transplantation (Transplantation)
[2015, 99(8):e49-56]

Cited: 11 times

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Drug-Induced Liver Injury.

Kurt Fisher, Raj Vuppalanchi, Romil Saxena,

Drug-induced liver injury (DILI) represents a diverse set of responses following exposure to any manufactured or naturally occurring chemical compound. Drug-induced liver injury is of major concern owing to the ever increasing number of compounds introduced into the market for treatment of various diseases as well as the increasing popularity ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2015, 139(7):876-887]

Cited: 18 times

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Pathophysiology and Diseases of the Proximal Pathways of the Biliary System.

Yukihiro Nakanishi, Romil Saxena,

Diseases of the proximal pathways of the biliary system can be divided into those that affect the interlobular bile ducts and those that affect the bile canaliculi. The former include primary biliary cirrhosis, small-duct variant of primary sclerosing cholangitis, graft-versus-host disease, and drug-induced liver injury, whereas the latter include progressive ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2015, 139(7):858-866]

Cited: 7 times

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One hundred thirteen consecutive transgastric liver biopsies for hepatic parenchymal diseases: a single-institution study.

Yukihiro Nakanishi, Wadad S Mneimneh, Michael Sey, Mohammad Al-Haddad, John M DeWitt, Romil Saxena,

The transgastric approach is a novel method for obtaining liver biopsies in patients undergoing upper gastrointestinal endosonography. Avoidance of vascular puncture and ability to acquire tissue in patients with obesity or ascites offers a practice niche for this technique. Although several series have reported on specimen adequacy, biopsy core length, ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2015, 39(7):968-976]

Cited: 3 times

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Pathophysiological role of microRNA-29 in pancreatic cancer stroma.

Jason J Kwon, Sarah C Nabinger, Zachary Vega, Smiti Snigdha Sahu, Ravi K Alluri, Zahi Abdul-Sater, Zhangsheng Yu, Jesse Gore, Grzegorz Nalepa, Romil Saxena, Murray Korc, Janaiah Kota,

Dense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) is a major obstacle for drug delivery to the tumor bed and plays a crucial role in pancreatic cancer progression. Current, anti-stromal therapies have failed to improve tumor response to chemotherapy and patient survival. Furthermore, recent studies show that stroma impedes ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:11450]

Cited: 28 times

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Utility of pre-procurement bedside liver biopsy in the deceased extended-criteria liver donor.

Richard S Mangus, Tim C Borup, Sam Popa, Romil Saxena, Oscar Cummings, A Joseph Tector,

INTRODUCTION: The Indiana Organ Procurement Organization (IOPO) utilizes preoperative bedside liver biopsies in certain extended-criteria donors (ECDs), obtained by the on-site coordinator, to determine the utility of pursuing donation. This study reports the clinical and financial outcomes for this management strategy. METHODS: All bedside liver biopsies obtained in ECDs over ... Read more >>

Clin Transplant (Clinical transplantation)
[2014, 28(12):1358-1364]

Cited: 5 times

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