Full Text Journal Articles by
Author Romain Parent

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Hepatic Stellate Cell Senescence in Liver Tumorigenesis.

Nadine Martin, Dorian V Ziegler, Romain Parent, David Bernard,

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the main causes of cancer-related deaths. HCC is mainly promoted by chronic viral hepatitis B and C, alcohol, non-alcoholic fatty liver disease (NAFLD) induced by obesity, as well as several genetic diseases of the liver. Due to ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

Cited: 0 times

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Effect of endothelial cell heterogeneity on nanoparticle uptake.

Aldy Aliyandi, Simon Satchell, Ronald E Unger, Birke Bartosch, Romain Parent, Inge S Zuhorn, Anna Salvati,

Endothelial cells exhibit distinct properties in morphology and functions in different organs that can be exploited for nanomedicine targeting. In this work, endothelial cells from different organs, i.e. brain, lung, liver, and kidney, were exposed to plain, carboxylated, and amino-modified silica. As expected, different protein coronas were formed on the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 587:119699]

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Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin.

Junzhi Ma, Janina Klemm, Monserrat Gerardo-Ramírez, Lucien Frappart, Darko Castven, Diana Becker, Ansgar Zoch, Romain Parent, Birke Bartosch, Kerstin Minnich, Marco Giovannini, Sven Danckwardt, Nils Hartmann, Helen Morrison, Peter Herrlich, Jens U Marquardt, Monika Hartmann,

Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. Several lines of evidence suggest that Merlin exerts its tumor suppressor activity, at least in part, by forming an inhibitory complex with cluster of differentiation 44 (CD44). Consistently, numerous NF2 mutations in cancer patients are predicted to perturb ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.

Konstantin Dirscherl, Martin Schläpfer, Birgit Roth Z'graggen, Roland H Wenger, Christa Booy, Renata Flury-Frei, Rita Fatzer, Costica Aloman, Birke Bartosch, Romain Parent, Vartan Kurtcuoglu, Diane de Zélicourt, Donat R Spahn, Beatrice Beck Schimmer, Erik Schadde,

Portal vein ligation (PVL) induces liver growth prior to resection. Associating liver partition and portal vein ligation (PVL plus transection=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PVL both accelerate growth via stabilization of HIF-α subunits. This study aims at clarifying the crosstalk of hepatocytes (HC), hepatic ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4392]

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Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.

Romain Barnault, Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Noémie Laverdure, Benjamin Ducarouge, Michel Rivoire, Patrick Mehlen, Fabien Zoulim, Romain Parent,

In the liver, HBV and HCV infections, exposure to toxics, genetic and metabolic disorders may induce endoplasmic reticulum (ER) stress and the unfolding protein response (UPR). The UPR allows cells to reach ER homeostasis after lumen overload, but also fosters survival of damaged cells and therefore HCC onset. Dependence receptors ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2018, 495(4):2425-2431]

Cited: 1 time

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Hepatitis C virus infection propagates through interactions between Syndecan-1 and CD81 and impacts the hepatocyte glycocalyx.

Boyan Grigorov, Emma Reungoat, Alice Gentil Dit Maurin, Mihayl Varbanov, Julie Blaising, Maud Michelet, Rachel Manuel, Romain Parent, Birke Bartosch, Fabien Zoulim, Florence Ruggiero, Eve-Isabelle Pécheur,

The hepatitis C virus (HCV) infects hepatocytes after binding to heparan sulfate proteoglycans, in particular Syndecan-1, followed by recognition of the tetraspanin CD81 and other receptors. Heparan sulfate proteoglycans are found in a specific microenvironment coating the hepatocyte surface called the glycocalyx and are receptors for extracellular matrix proteins, cytokines, ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2017, 19(5):]

Cited: 11 times

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[Hepatitis C, EGFR, cirrhosis and netrin-1: potential implications for HCC onset].

Marie-Laure Plissonnier, Thomas Lahlali, Patrick Mehlen, Romain Parent,

Med Sci (Paris) (Medecine sciences : M/S)
[2016, 32(6-7):566-568]

Cited: 0 times

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An immortalized human liver endothelial sinusoidal cell line for the study of the pathobiology of the liver endothelium.

Romain Parent, David Durantel, Thomas Lahlali, Aurélie Sallé, Marie-Laure Plissonnier, Daniel DaCosta, Gaëtan Lesca, Fabien Zoulim, Marie-Jeanne Marion, Birke Bartosch,

BACKGROUND: The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner organs. De novo infection of the liver parenchyma by ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 450(1):7-12]

Cited: 12 times

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Diversity of hepatocellular carcinoma clones bearing hematopoietic malignancies-related chromosomal translocation.

Romain Parent, Marie-Laure Plissonnier, Brigitte Bancel, Wan-Li Liao, Sylvie Rumin, Remal Asaad, Marianne Till, Damien Sanlaville, Fabien Zoulim, Christian Trépo, Marie-Jeanne Marion,

Interpatient heterogeneity of hepatocellular carcinoma has been in-depth addressed. Intrapatient heterogeneity is less known. Four clones were freshly isolated from an Edmondson grade I HCV-associated hepatocellular carcinoma. Biochemical approaches, functional assays and cytogenetics were used. Albumin inducibility was uncoupled from canonical cytokeratin profiles, suggesting pathological combinations of hepatospecific and biliary ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2014, 115(4):666-677]

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Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.

Romain Parent, Laura Beretta,

We investigated the molecular events associated with the differentiation of liver progenitor cells into functional and polarized hepatocytes, using human HepaRG cells that display potent hepatocytic differentiation-inducible properties and share some features with liver progenitor cells.Profiling of total and of polysome-bound transcripts isolated from HepaRG cells undergoing hepatocytic differentiation was ... Read more >>

Genome Biol. (Genome Biology)
[2008, 9(1):R19]

Cited: 22 times

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Characterization of the double-stranded RNA responses in human liver progenitor cells.

Magali Maire, Romain Parent, Anne-Laure Morand, Christine Alotte, Christian Trépo, David Durantel, Marie-Anne Petit,

Human HepaRG cells are liver progenitors which possess hepatocyte-like functionality. We investigated the effects of double-stranded (ds) RNA on interferon (IFN)-beta and chemokine (CK) expression in these cells. By microarray and ELISA, we showed strong induction of CXCL10 and interleulin (IL)-8 besides IFN-beta and other CK ligands. RNA interference directed ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2008, 368(3):556-562]

Cited: 12 times

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Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth.

Romain Parent, Deepak Kolippakkam, Garrett Booth, Laura Beretta,

The mammalian target of rapamycin (mTOR) pathway, a major regulator of translation, is frequently activated in hepatocellular carcinomas. We investigated the effects of mTOR activation in the human HepaRG cells, which possess potent hepatocytic differentiation capability. Differentiation of HepaRG cells into functional and polarized hepatocyte-like cells correlated with a decrease ... Read more >>

Cancer Res. (Cancer research)
[2007, 67(9):4337-4345]

Cited: 24 times

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Novel alpha interferon (IFN-alpha) variant with improved inhibitory activity against hepatitis C virus genotype 1 replication compared to IFN-alpha2b therapy in a subgenomic replicon system.

Vanessa Escuret, Amaury Martin, David Durantel, Romain Parent, Olivier Hantz, Christian Trépo, Thierry Menguy, Emmanuel Bottius, Jerome Dardy, Jean Maral, Jean Louis Escary, Fabien Zoulim,

Hepatitis C virus (HCV) treatment is based on the association of pegylated alpha interferon (IFN-alpha) and ribavirin. To improve the level of sustained virological response to treatment, especially in patients infected with HCV genotype 1, new IFNs with improved efficacy and toxicity profiles may be developed. In this report, we ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2006, 50(12):3984-3991]

Cited: 6 times

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Proteomics in the study of liver pathology.

Romain Parent, Laura Beretta,

J. Hepatol. (Journal of hepatology)
[2005, 43(1):177-183]

Cited: 20 times

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Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.

Soo-Jin Choi, Romain Parent, Carole Guillaume, Christiane Deregnaucourt, Christiane Delarbre, David M Ojcius, Jean-Jacques Montagne, Marie-Louise Célérier, Aude Phelipot, Mohamed Amiche, Jordi Molgo, Jean-Michel Camadro, Catherine Guette,

Two novel peptides that inhibit the intra-erythrocyte stage of Plasmodium falciparum in vitro were identified in the venom of the Trinidad chevron tarantula, Psalmopoeus cambridgei. Psalmopeotoxin I (PcFK1) is a 33-residue peptide and Psalmopeotoxin II (PcFK2) has 28-amino acid residues; both have three disulfide bridges and belong to the Inhibitor ... Read more >>

FEBS Lett. (FEBS letters)
[2004, 572(1-3):109-117]

Cited: 26 times

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Origin and characterization of a human bipotent liver progenitor cell line.

Romain Parent, Marie-Jeanne Marion, Laetitia Furio, Christian Trépo, Marie-Anne Petit,

BACKGROUND & AIMS:Liver progenitor cells may be important in carcinogenesis resulting from human chronic liver diseases. The HepaRG cell line has been established from a liver tumor associated with chronic hepatitis C. We observed that these cells showed an evident morphological heterogeneity, displaying both hepatocyte-like and biliary-like epithelial phenotypes. Our ... Read more >>

Gastroenterology (Gastroenterology)
[2004, 126(4):1147-1156]

Cited: 104 times

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