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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Prognostic Value and Therapeutic Implications of Pleural Carcinosis and Malignant Pleural Effusion in Advanced Epithelial Ovarian Cancer.

Sara Nasser, Christina Fotopoulou, Rolf Richter, Jana Kaulich, Elena Braicu, Carmen Beteta, Jessica Olschewski, Aygun Babayeva, Jalid Sehouli,

<h4>Aim</h4>To demonstrate the prognostic value of pleural carcinosis/effusion in a cohort of patients with advanced epithelial ovarian cancer (EOC) and the associated therapeutic implications.<h4>Patients and methods</h4>Overall, data for 388 patients with EOC with confirmed malignant pleural effusion (MPE) or pleural carcinosis were retrospectively analyzed. Exclusion criteria were non-epithelial ovarian malignancies ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(4):2033-2038]

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Frailty Index for prediction of surgical outcome in ovarian cancer: Results of a prospective study.

Melisa Guelhan Inci, Louise Anders, Hannah Woopen, Rolf Richter, Duygu Guzel, Robert Armbrust, Jalid Sehouli,

<h4>Background</h4>Complete macroscopic tumor resection is the strongest prognostic factor for patients with ovarian cancer, which requires complex surgery for achievement. Based on the mostly advanced tumor stage and high symptom burden many patients are classified as frail which may limit optimal surgical outcome. Aim of this study is to evaluate ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Evaluation of Biomarkers in Myoma Patients: A Prospective Study Investigating the Role of LDH, CA 125, and IGF-1 after Uterus-Preserving Surgical Therapy.

Michaela Jacob, Rolf Richter, Jalid Sehouli, Matthias David,

<h4>Objective</h4>Myomas are one of the most common tumors of the lower abdomen in women. At present, sonography and clinical examination are the prevalent diagnostic standards for these tumors, and no biomarkers have been established yet. The primary aim of this study was to determine if the surgical removal of myomas ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2021, :1-8]

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Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HR-QoL) in Patients with Ovarian Cancer: What Is Different Compared to Healthy Women?

Melisa Guelhan Inci, Rolf Richter, Kathrin Heise, Ricarda Dukatz, Hannah Woopen, Jalid Sehouli,

<h4>Introduction</h4>The aim of this analysis was to evaluate the health-related quality of life (HR-QoL) in patients with ovarian cancer using a patient-reported outcome (PRO) based questionnaire and to compare it to the healthy female population in Germany and to other ovarian cancer patients worldwide. Additionally, we looked for differences in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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[Use of emergency rooms by so-called multiple users: results of a prospective study with special consideration of the migration status].

Matthias David, Rolf Richter, Baharan Naghavi, Theda Borde, Oliver Razum, Rajan Somasundaram, Hendrike Stein, Jalid Sehouli,

<h4>Objectives</h4>Can we identify predictive factors for the group of so-called multiple users (MU; 4 and more uses of an emergency department [ED] in the past 12 months)? Are people with a migration background more likely to be classified in the MU group?<h4>Methodology</h4>Included were consecutive patients who visited three EDs in Berlin from ... Read more >>

Notf Rett Med (Notfall & rettungsmedizin)
[2021, :1-7]

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Effects of epigallocatechin gallate-enriched green tea extract capsules in uterine myomas: results of an observational study.

Rebekka Biro, Rolf Richter, Miriam Ortiz, Jalid Sehouli, Matthias David,

<h4>Purpose</h4>The daily ingestion of green tea extract (GTE) capsules in women with oligo- or asymptomatic uterine myomas was monitored over 6 months with regard to their quality of life, myoma-associated complaints and side effects.<h4>Methods</h4>The participants were interviewed and examined at the beginning of the study (T1) and then again after 6 months ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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Effects of sarcopenia and malnutrition on morbidity and mortality in gynecologic cancer surgery: results of a prospective study.

Jalid Sehouli, Kristina Mueller, Rolf Richter, Markus Anker, Hannah Woopen, Julia Rasch, Jacek P Grabowski, Eva Prinz-Theissing, Melisa Guelhan Inci,

<h4>Background</h4>Malnutrition and sarcopenia often occur simultaneously in cancer patients and are thought to have harmful effects on both surgical and oncological outcomes. Therefore, we want to evaluate the effects of sarcopenia and malnutrition on severe postoperative complications and overall survival in gynecologic cancer patients.<h4>Methods</h4>We assessed nutritional parameters and run a ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2021, :]

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Patients' subjective assessment as a decisive predictor of malignancy in pelvic masses: results of a multicentric, prospective pelvic mass study.

Elisa Koch, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Gerhard Nohe, Bodo Müller, Janine Boeneß-Zaloum, Kerstin Ames, Frank Chen, Carmen Beteta, Kati Hasenbein, Adak Pirmorady, Mathias Zimmermann, Desislava Dimitrova, Rudolf Tauber, Jalid Sehouli, Catherine Linn Knieper, Elena Ioana Braicu,

<h4>Objective</h4>The prognosis for ovarian cancer patients remains poor. A key to maximizing survival rates is early detection and treatment. This requires an accurate prediction of malignancy. Our study seeks to improve the accuracy of prediction by focusing on early subjective assessment of malignancy. We therefore investigated the assessment of patients ... Read more >>

J Psychosom Obstet Gynaecol (Journal of psychosomatic obstetrics and gynaecology)
[2020, :1-6]

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Preoperative quality of life as prediction for severe postoperative complications in gynecological cancer surgery: results of a prospective study.

Jalid Sehouli, Kathrin Heise, Rolf Richter, Hannah Woopen, Louise Anders, Melisa Guelhan Inci,

<h4>Purpose</h4>The aim of this study was to investigate preoperative quality of life (QoL) as a predictive tool for severe postoperative complications (POC) in gynecological cancer surgery.<h4>Methods</h4>This is a prospective study of patients undergoing gynecologic cancer surgery at an academic center in Germany. QoL was assessed by the EORTC Quality of ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 303(4):1057-1063]

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Role of predictive markers for severe postoperative complications in gynecological cancer surgery: a prospective study (RISC-Gyn Trial).

Melisa Guelhan Inci, Rolf Richter, Hannah Woopen, Julia Rasch, Kathrin Heise, Louise Anders, Kristina Mueller, Sara Nasser, Timo Siepmann, Jalid Sehouli,

<h4>Background</h4>Surgery for gynecological cancer involves highly invasive and complex procedures potentially associated with various complications, which can cause extended hospital stays and delay of subsequent therapy, with a detrimental effect on the prognosis. The aim of this study was to explore and define the predictors of severe postoperative complications in ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(12):1975-1982]

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Lymphovascular space invasion and Ki67 as predictors of lymph node metastasis in primary low grade serous ovarian cancer.

Jacek P Grabowski, Joanna Glajzer, Rolf Richter, Helmut Plett, Mustafa-Zelal Muallem, Elena Ioana Braicu, Eliane Taube, Jalid Sehouli,

<h4>Objective</h4>Low grade serous ovarian cancers characterize a unique clinical pattern and likely less frequent incidence of lymphatic metastasis. The expression level of Ki67 is associated with differences in prognosis and therapy outcome. However, its expression in combination with lymphovascular space invasion has not been evaluated in the prediction of lymphatic ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(1):98-103]

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Can Fried Frailty Score predict postoperative morbidity and mortality in gynecologic cancer surgery? Results of a prospective study.

Melisa Guelhan Inci, Louise Anders, Kathrin Heise, Rolf Richter, Hannah Woopen, Jalid Sehouli,

<h4>Background</h4>Aim of this study is to evaluate the predictive ability of Fried Frailty Score for surgical outcomes in patients undergoing gynecologic cancer surgery.<h4>Methods</h4>This is a prospective cohort study at an academic gynecological cancer center from Oct 2015 through Jan 2017. We applied systematically numerous screening tools, geriatric questionnaires and single ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2021, 12(3):428-433]

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Perioperative management of positioning in gynecological cancersurgery: a national NOGGO-AGO intergroup survey.

Mareike Bommert, Jenny Katharina Wagner, Jalid Sehouli, Alexander Burges, Barbara Schmalfeld, Hendrik Veldink, Irmela Schrettenbrunner, Markus Fleisch, Rolf Richter, Philipp Harter, Klaus Pietzner,

<h4>Introduction</h4>The daily clinical routine in the operating room includes patient positioning. The number of perioperative positioning-related complications is growing, along with the legal proceedings concerning this topic, and only a few guidelines exist to provide specific recommendations. The aim of this survey was to assess perioperative positioning and associated adverse ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(10):1589-1594]

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3D ultrasound as a surgical quality control of conization in patients with severe dysplasia: a prospective study.

Anna M Dückelmann, Julia Wordell, Rolf Richter, Jalid Sehouli,

<h4>Purpose</h4>To compare the techniques for cone measurement with ultrasound to determine the size of the resected tissue and to evaluate parameters which may be relevant for stratifying women at risk who need surveillance when pregnant.<h4>Methods</h4>The present study included women with a pathological cervical biopsy. Cervical length and volume were determined ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2020, 302(5):1189-1196]

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[Effects of hyperemesis gravidarum on the course of pregnancy and birth, with special attention to the risk factor of migration background].

Julia Stoba, Wolfgang Henrich, Rolf Richter, Jalid Sehouli, Matthias David,

<h4>Main questions</h4>In this investigation of hospitalized cases of HG and subsequent births, we examine differences between patients who have and who have not experienced migration as well as the effect of HG on perinatal outcome.<h4>Methods</h4>Retrospective quantitative data of hospitalized patients suffering from HG (1997-2015) was analyzed. Also analyzed was a ... Read more >>

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2021, 225(1):39-46]

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Total retroperitoneal en bloc resection of multivisceral-peritoneal packet (TROMP operation): a novel surgical technique for advanced ovarian cancer.

Mustafa Zelal Muallem, Jalid Sehouli, Andrea Miranda, Rolf Richter, Jumana Muallem,

<h4>Background</h4>A Total Retroperitoneal en bloc resection Of Multivisceral-Peritoneal packet (TROMP operation) is a no-touch isolation technique in a retroperitoneal space to resect the parietal peritoneum and the affected organs in advanced ovarian cancer. The study prescribed and analysed the results of this novel technique for primary cytoreductive surgery.<h4>Methods</h4>The study included ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(5):648-653]

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Ki67 expression as a predictor of chemotherapy outcome in low-grade serous ovarian cancer.

Jacek P Grabowski, Clara Martinez Vila, Rolf Richter, Eliane Taube, Helmut Plett, Elena Braicu, Jalid Sehouli,

<h4>Objective</h4>Low-grade serous ovarian cancers characterize a unique clinical pattern and lower chemotherapy responsiveness. The expression level of Ki67 is associated with differences in prognosis; however, this has not yet been evaluated in regard to predicting the outcome of therapy.<h4>Methods</h4>Patients with low-grade serous ovarian cancers were identified in an institutional database. ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(4):498-503]

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Expectations and preferences of patients with primary and relapsed ovarian cancer to maintenance therapy: A NOGGO/ENGOT-ov22 and GCIG survey (Expression IV).

Irena Rohr, Sara Alavi, Rolf Richter, Maren Keller, Radoslav Chekerov, Gülten Oskay-Özcelik, Michaela Heinrich, Cagatay Taskiran, Florence Joly, Regina Berger, Andreas du Bois, Andreja Gornjec, Ignace Vergote, Patriciu Achimas-Cadariu, Domenica Lorusso, Johanna Maenpaa, Jalid Sehouli,

<h4>Background</h4>Maintenance therapy induces remission and prolongs disease free interval in primary and recurrent ovarian disease. For the treatment decision making process, aspects of quality of life and patients' preferences are crucial, despite the fact that scientific data are lacking. Therefore, we conducted this European-wide study in patients with ovarian cancer.<h4>Methods</h4>A ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(4):509-514]

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Pre-operative serum CA125, peritoneal cancer index and intra-operative mapping score as predictors of surgical results in primary epithelial ovarian cancer.

Mustafa Zelal Muallem, Jalid Sehouli, Rolf Richter, Aygun Babayeva, Khayal Gasimli, Asya Parashkevova,

<h4>Objective</h4>Prediction of post-operative residual disease after ovarian cancer cytoreductive surgery remains a topic of interest to gynecologic oncologists. The aim of this study was to explore the correlation between serum CA125, peritoneal cancer index, and intra-operative mapping of ovarian cancer and their predictive value for post-operative outcome.<h4>Methods</h4>A total of 70 ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(1):62-66]

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Incidence and Pattern of Spread of Lymph Node Metastasis in Patients With Low-grade Serous Ovarian Cancer.

Mohamed Wafa, Elena I Braicu, Mustafa Z Muallem, Rolf Richter, Eliane Taube, Jalid Sehouli, Jacek P Grabowski,

BACKGROUND/AIM:Involvement of lymph nodes (LNs) and their surgical resection in low-grade ovarian cancer remains a field of discussion. The aim of this study was to determine the incidence and pattern of distribution of lymph node metastases in patients with low-grade serous ovarian cancer. PATIENTS AND METHODS:A retrospective analysis was carried ... Read more >>

Anticancer Res (Anticancer research)
[2019, 39(10):5617-5621]

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Anxiety of myoma patients: results of standardized interviews with the State Trait Anxiety Inventory and the Kessler 10 questionnaire.

Nina Isabelle Knudsen, Rolf Richter, Heribert Kentenich, Jalid Sehouli, Matthias David,

<b>Introduction:</b> The aim of this study was to explore a possible relation between myoma-related anxieties and general state or trait anxiety or psychological distress, to get a better understanding of the impact of anxiety on the patients.<b>Methods:</b> This prospective study was conducted at the myoma clinic of a large university ... Read more >>

J Psychosom Obstet Gynaecol (Journal of psychosomatic obstetrics and gynaecology)
[2020, 41(2):122-130]

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Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium.

Jun Guan, Silvia Darb-Esfahani, Rolf Richter, Eliane T Taube, Ilary Ruscito, Sven Mahner, Linn Woelber, Katharina Prieske, Nicole Concin, Ignace Vergote, Els Van Nieuwenhuysen, Patriciu Achimas-Cadariu, Joanna Glajzer, Hannah Woopen, Mandy Stanske, Hagen Kulbe, Carsten Denkert, Jalid Sehouli, Elena Ioana Braicu,

OBJECTIVE:The impact of angiogenesis on long-term survival of high-grade serous ovarian cancer (HGSOC) patients remains unclear. This study investigated whether angiogenic markers correlated with 5-year progression-free survival (PFS) in a large cohort of matched advanced HGSOC tissue samples. METHODS:Tumor samples from 124 primary HGSOC patients were retrospectively collected within the ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2019, 145(4):1063-1073]

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Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network.

Jalid Sehouli, Elena Ioana Braicu, Rolf Richter, Carsten Denkert, Paul Jank, Philipp Sebastian Jurmeister, Catarina Alisa Kunze, Jan Budczies, Sylvia Darb-Esfahani, Wolfgang Daniel Schmitt, Alexander Traut, Jacek Grabowski, Eliane Tabea Taube, Helmut Plett,

Low-grade serous ovarian carcinoma (LGSOC) has recently come up as a distinct rare entity of epithelial ovarian cancer. Predictive and prognostic markers are not well studied yet. Because Ki-67 and hormone receptors (HR) have been established as relevant cancer biomarkers in several malignant tumors, we evaluated Ki-67 and HR expression ... Read more >>

Hum Pathol (Human pathology)
[2019, 85:299-308]

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Impact of Body Mass Index (BMI) on Chemotherapy-associated Toxicity in Ovarian Cancer Patients. A Pooled Analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO) Databank on 1,213 Patients.

Jacek Przemyslaw Grabowski, Rolf Richter, Hannah Rittmeister, Radoslav Chekerov, Hannah Woopen, Jalid Sehouli,

<h4>Background/aim</h4>Chemotherapy-associated toxicity is one of the limiting factors regarding treatment efficacy, patient outcome and quality of life in this collective. Underweight or obese patients represent a major group in which the therapy seems to be more challenging. The aim of this analysis was to evaluate the impact of BMI on ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(10):5853-5858]

Cited: 1 time

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