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Author Rolando Rolesi

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Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer.

Alberto Romano, Michele Antonio Capozza, Stefano Mastrangelo, Palma Maurizi, Silvia Triarico, Rolando Rolesi, Giorgio Attinà, Anna Rita Fetoni, Antonio Ruggiero,

Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric patients, but they also cause some toxic effects: ototoxicity, myelosuppression, nephrotoxicity, and ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

Cited: 0 times

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The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity.

Fabiola Paciello, Anna Rita Fetoni, Daniele Mezzogori, Rolando Rolesi, Antonella Di Pino, Gaetano Paludetti, Claudio Grassi, Diana Troiani,

Platinum-based agents, such as cisplatin, form the mainstay of currently used chemotherapeutic regimens for several malignancies; however, the main limitations are chemoresistance and ototoxic side effects. In this study we used two different polyphenols, curcumin and ferulic acid as adjuvant chemotherapeutics evaluating (1) in vivo their antioxidant effects in protecting ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1063]

Cited: 0 times

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Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling.

Anna Rita Fetoni, Fabiola Paciello, Rolando Rolesi, Gaetano Paludetti, Diana Troiani,

Hearing loss caused by exposure to recreational and occupational noise remains a worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of cochlear damage induced by noise exposure. In this review we discuss the dual function of ROS to both promote cell damage (oxidative stress) and cell adaptive ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2019, 135:46-59]

Cited: 1 time

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Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure.

Fabiola Paciello, Anna Rita Fetoni, Rolando Rolesi, Matthew B Wright, Claudio Grassi, Diana Troiani, Gaetano Paludetti,

Recent progress in hearing loss research has provided strong evidence for the imbalance of cellular redox status and inflammation as common predominant mechanisms of damage affecting the organ of Corti including noise induced hearing loss. The discovery of a protective molecule acting on both mechanisms is challenging. The thiazolidinediones, a ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1103]

Cited: 2 times

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Anodal transcranial direct current stimulation affects auditory cortex plasticity in normal-hearing and noise-exposed rats.

Fabiola Paciello, Maria Vittoria Podda, Rolando Rolesi, Sara Cocco, Laura Petrosini, Diana Troiani, Anna Rita Fetoni, Gaetano Paludetti, Claudio Grassi,

BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive tool capable to modulate cortical functions by affecting neuronal excitability and synaptic plasticity. OBJECTIVE:Here we investigated the effects of anodal tDCS on auditory cortex (ACx) in normal-hearing rats and following a paradigm of noise-induced hearing loss (NIHL), that causes morphological alterations in ... Read more >>

Brain Stimul (Brain stimulation)
[2018, 11(5):1008-1023]

Cited: 1 time

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The Antioxidant Effect of Rosmarinic Acid by Different Delivery Routes in the Animal Model of Noise-Induced Hearing Loss.

Anna R Fetoni, Sara Letizia Maria Eramo, Antonella Di Pino, Rolando Rolesi, Fabiola Paciello, Claudio Grassi, Diana Troiani, Gaetano Paludetti,

HYPOTHESIS:Trans-tympanic Rosmarinic Acid (RA), as compared with the systemic administration, protects against noise-induced auditory hair cell and hearing losses in rats in vivo. BACKGROUND:ROS production, lipoperoxidative damage, and an imbalance of antioxidant defences play a significant role in noise-induced hearing loss. Several molecules with antioxidant properties have been tested to ... Read more >>

Otol. Neurotol. (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2018, 39(3):378-386]

Cited: 1 time

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Ferulic Acid Regulates the Nrf2/Heme Oxygenase-1 System and Counteracts Trimethyltin-Induced Neuronal Damage in the Human Neuroblastoma Cell Line SH-SY5Y.

Stefania Catino, Fabiola Paciello, Fiorella Miceli, Rolando Rolesi, Diana Troiani, Vittorio Calabrese, Rosaria Santangelo, Cesare Mancuso,

Over the past years, several lines of evidence have pointed out the efficacy of ferulic acid (FA) in counteracting oxidative stress elicited by β-amyloid or free radical initiators, based on the ability of this natural antioxidant to up-regulate the heme oxygenase-1 (HO-1) and biliverdin reductase (BVR) system. However, scarce results ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2015, 6:305]

Cited: 18 times

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Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.

Anna R Fetoni, Sara L M Eramo, Fabiola Paciello, Rolando Rolesi, Maria Vittoria Podda, Diana Troiani, Gaetano Paludetti,

To investigate whether curcumin may have in vivo protective effects against cisplatin ototoxicity by its direct scavenger activity and/or by curcumin-mediated upregulation of HO-1.Cisplatin-induced ototoxicity is a major dose-limiting side effect in anticancer chemotherapy. A protective approach to decrease cisplatin ototoxicity without compromising its therapeutic efficacy remains a critical goal ... Read more >>

Otol. Neurotol. (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2014, 35(5):e169-77]

Cited: 19 times

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Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense.

Anna Rita Fetoni, Paola De Bartolo, Sara Letizia Maria Eramo, Rolando Rolesi, Fabiola Paciello, Christian Bergamini, Romana Fato, Gaetano Paludetti, Laura Petrosini, Diana Troiani,

This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q10 analog (Qter) was used. We analyzed auditory function, cochlear oxidative stress, morphological alterations in auditory cortices and ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(9):4011-4023]

Cited: 66 times

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Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: systemic versus transtympanic modality.

Anna Rita Fetoni, Diana Troiani, Sara L Eramo, Rolando Rolesi, Gaetano Paludetti Troiani,

CONCLUSION: The effectiveness of a coenzyme Q10 formulation, Q-ter, given via transtympanic injection is interesting for the future application of this minimally invasive procedure in the treatment of reactive oxygen species (ROS)-induced hearing loss. OBJECTIVE: We focused on antioxidant therapy in noise-induced hearing loss (NIHL). Our study was designed to ... Read more >>

Acta Otolaryngol. (Acta oto-laryngologica)
[2012, 132(4):391-399]

Cited: 12 times

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