Full Text Journal Articles by
Author Roland Seiler

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Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma.

Tilman Todenhöfer, Ewan A Gibb, Roland Seiler, Alireza Kamyabi, Jörg Hennenlotter, Paul McDonald, Igor Moskalev, Craig Stewart, Jian Gao, Ladan Fazli, Shoukat Dedhar, Arnulf Stenzl, Htoo Zarni Oo, Peter C Black,

<h4>Objective</h4>Carbonic anhydrase IX (CA9) is important in the regulation of intra- and extracellular pH in solid tumors, contributing to cell growth and invasion. In urothelial carcinoma (UC), CA9 has been identified as a urinary marker for disease detection, but its biologic role is unknown. To date, differential gene expression patterns ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer.

Moritz Maas, Steffen Rausch, Teresa Guttenberg, Roland Seiler, Jörg Hennenlotter, Htoo Zarni Oo, Ladan Fazli, Ursula Kühs, Georgios Gakis, Arnulf Stenzl, Christian Schwentner, Peter C Black, Tilman Todenhöfer,

<h4>Background</h4>Receptor activator of NF kappa B (RANK) and its ligand have an essential role in T-cell regulation and the development of bone metastases. The role of RANK expression in muscle-invasive bladder cancer (MIBC) is unknown.<h4>Objective</h4>To assess the relevance of RANK expression in patients with MIBC.<h4>Design, setting, and participants</h4>Expression of RANK ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Molecular Characterization of Residual Bladder Cancer after Neoadjuvant Pembrolizumab.

Andrea Necchi, Joep J de Jong, Daniele Raggi, Alberto Briganti, Laura Marandino, Andrea Gallina, Marco Bandini, Bashar Dabbas, Elai Davicioni, Umberto Capitanio, Francesco Montorsi, Roland Seiler, Jonathan L Wright, Yair Lotan, Peter C Black, Ewan A Gibb,

<h4>Background</h4>In patients with muscle-invasive urothelial bladder cancer (MIBC), molecular alterations in immunotherapy-resistant tumors found at radical cystectomy (RC) remain largely unstudied.<h4>Objective</h4>To investigate the biology of pembrolizumab-resistant tumors in comparison to an RC cohort treated without any systemic therapy and a cohort of neoadjuvant chemotherapy (NAC)-treated tumors.<h4>Design, setting, and participants</h4>Transcriptome-wide expression ... Read more >>

Eur Urol (European urology)
[2021, 80(2):149-159]

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A showcase study on personalized in silico drug response prediction based on the genetic landscape of muscle invasive bladder cancer.

Friedemann Krentel, Franziska Singer, María Lourdes Rosano-Gonzalez, Ewan A Gibb, Yang Liu, Elai Davicioni, Nicola Keller, Daniel J Stekhoven, Marianna Kruithof-de Julio, Roland Seiler,

Improved and cheaper molecular diagnostics allow the shift from "one size fits all" therapies to personalised treatments targeting the individual tumor. However, the wealth of potential targets based on comprehensive sequencing remains a yet unsolved challenge that prevents its routine use in clinical practice. Thus, we designed a workflow that ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5849]

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Re: Intravesical Nadofaragene Firadenovec Gene Therapy for BCG-unresponsive Non-muscle-invasive Bladder Cancer: A Single-arm, Open-label, Repeat-dose Clinical Trial.

Markus Grabbert, Roland Seiler, Christian Gratzke,

Eur Urol (European urology)
[2021, 80(1):114]

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Seminal Vesical Sparing Cystectomy for Bladder Cancer is Feasible with Good Functional Results without Impairing Oncological Outcomes: A Longitudinal Long-Term Propensity-Matched Single Center Study.

Marc A Furrer, Bernhard Kiss, Urs E Studer, Patrick Y Wuethrich, Brigitta Gahl, Roland Seiler, Beat Roth, Piet Bosshard, Benjamin C Thomas, Fiona C Burkhard, Silvan Boxler, George N Thalmann,

<h4>Purpose</h4>Seminal vesicle-sparing radical cystectomy has been reported to improve short-term functional results without compromising oncological outcomes. However, there is still a lack of data on long-term outcomes after seminal vesicle-sparing radical cystectomy. The aim of this study was to compare oncological and functional outcomes in patients after seminal vesicle-sparing vs ... Read more >>

J Urol (The Journal of urology)
[2021, 205(6):1629-1640]

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Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer.

Yoshihisa Kawai, Kenjiro Imada, Shusuke Akamatsu, Fan Zhang, Roland Seiler, Tetsutaro Hayashi, Jeffrey Leong, Eliana Beraldi, Neetu Saxena, Alexander Kretschmer, Htoo Zarni Oo, Alberto Contreras-Sanz, Hideyasu Matsuyama, Dong Lin, Ladan Fazli, Colin C Collins, Alexander W Wyatt, Peter C Black, Martin E Gleave,

<i>Paternally expressed gene 10</i> (<i>PEG10</i>) has been associated with neuroendocrine muscle-invasive bladder cancer (MIBC), a subtype of the disease with the poorest survival. In this work, we further characterized the expression pattern of <i>PEG10</i> in The Cancer Genome Atlas database of 412 patients with MIBC, and found that, compared with ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2020, 19(10):2210-2220]

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Impact of tumor size on the oncological outcome of high-grade nonmuscle invasive bladder cancer - examining the utility of classifying Ta bladder cancer based on size.

Karl H Tully, Marco Moschini, Friedrich-Carl E von Rundstedt, Atiqullah Aziz, Luis A Kluth, Andrea Necchi, Michael Rink, Kees Hendricksen, Paul Sargos, Malte W Vetterlein, Roland Seiler, Cedric Poyet, Wojciech Krajewski, Harun Fajkovic, Shahrokh F Shariat, Evanguelos Xylinas, Florian Roghmann,

<h4>Purpose</h4>To examine survival rates and to calculate the risk of disease recurrence, progression, overall, and cancer-specific mortality in patients diagnosed with high-risk NMIBC using a multi-institutional dataset to evaluate differences between the guidelines of the European Association of Urology and the guidelines of the National Comprehensive Cancer Network (NCCN) with ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(11):851.e19-851.e25]

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Evolution of Urothelial Bladder Cancer in the Context of Molecular Classifications.

Martina Minoli, Mirjam Kiener, George N Thalmann, Marianna Kruithof-de Julio, Roland Seiler,

Bladder cancer is a heterogeneous disease that is not depicted by current classification systems. It was originally classified into non-muscle invasive and muscle invasive. However, clinically and genetically variable tumors are summarized within both classes. A definition of three groups may better account for the divergence in prognosis and probably ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(16):]

Cited: 2 times

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Re: A Clonal Expression Biomarker Associates with Lung Cancer Mortality.

Friedemann Krentel, Roland Seiler,

Eur Urol (European urology)
[2020, 78(6):925-926]

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The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group.

Philipp Gild, Malte W Vetterlein, Roland Seiler, Andrea Necchi, Kees Hendricksen, Laura S Mertens, Florian Roghmann, Nicolas V Landenberg, Paolo Gontero, Marcus Cumberbatch, Jakub Dobruch, Thomas Seisen, Pietro Grande, David D'Andrea, Julien Anract, Evi Comploj, Armin Pycha, Karim Saba, Cedric Poyet, Bas W van Rhijn, Aidan P Noon, Morgan Roupret, Shahrokh F Shariat, Margit Fisch, Evanguelos Xylinas, Michael Rink,

<h4>Objective</h4>To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials & methods</h4>We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 34:312-317]

Cited: 1 time

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Personalized in-silico drug response prediction based on the genetic landscape of muscle-invasive bladder cancer

Friedemann Krentel, Franziska Singer, María Lourdes Rosano-Gonzalez, Ewan Gibb, Yang Liu, Elai Davicioni, Nicola Keller, Daniel Stekhoven, Marianna Kruithof-de Julio, Roland Seiler,

In bladder cancer (BLCA) there are, to date, no reliable diagnostics available to predict the potential benefit of a therapeutic approach. The extraordinarily high molecular heterogeneity of BLCA might explain its wide range of therapy responses to empiric treatments. To better stratify patients for treatment response, we present a highly ... Read more >>

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Correction to: Genomic Subtyping in Bladder Cancer.

Tuomas Jalanko, Joep J de Jong, Ewan A Gibb, Roland Seiler, Peter C Black,

The original version of this article contained a mistake. The included Conflict of Interest statement was incorrect. ... Read more >>

Curr Urol Rep (Current urology reports)
[2020, 21(7):25]

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Distribution of Molecular Subtypes in Muscle-invasive Bladder Cancer Is Driven by Sex-specific Differences.

Joep J de Jong, Joost L Boormans, Bas W G van Rhijn, Roland Seiler, Stephen A Boorjian, Badrinath Konety, Trinity J Bivalacqua, Thomas Wheeler, Robert S Svatek, James Douglas, Jonathan Wright, Marc Dall'Era, Simon J Crabb, Jason A Efstathiou, Michiel S van der Heijden, Kent W Mouw, David T Miyamoto, Yair Lotan, Peter C Black, Ewan A Gibb, Sima P Porten,

Muscle-invasive bladder cancer (MIBC) is a sex-biased cancer with a higher incidence in men but worse outcomes in women. The root cause behind these observations remains unclear. To investigate whether sex-specific tumor biology could explain the differences in clinical behavior of MIBC, we analyzed the transcriptome profiles from transurethral resected ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(4):420-423]

Cited: 2 times

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Genomic Subtyping in Bladder Cancer.

Tuomas Jalanko, Joep J de Jong, Ewan A Gibb, Roland Seiler, Peter C Black,

PURPOSE OF REVIEW:Molecular characterization of cancer allows us to understand oncogenesis and clinical prognosis as well as facilitates development of biomarkers and treatment. Our aim was to review the current literature on genomic characterization of bladder cancer, and how far we are in implementing genomics into clinical practice. RECENT FINDINGS:Bladder cancers ... Read more >>

Curr Urol Rep (Current urology reports)
[2020, 21(2):9]

Cited: 3 times

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Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol 2020;77:434-5.

Aurélie Kamoun, Aurélien de Reyniès, Yves Allory, Gottfrid Sjödahl, A Gordon Robertson, Roland Seiler, Katherine A Hoadley, Clarice S Groeneveld, Hikmat Al-Ahmadie, Woonyoung Choi, Mauro A A Castro, Jacqueline Fontugne, Pontus Eriksson, Qianxing Mo, Jordan Kardos, Alexandre Zlotta, Arndt Hartmann, Colin P Dinney, Joaquim Bellmunt, Thomas Powles, Núria Malats, Keith S Chan, William Y Kim, David J McConkey, Peter C Black, Lars Dyrskjøt, Mattias Höglund, Seth P Lerner, Francisco X Real, François Radvanyi, Mattias Aine, Isabelle Bernard-Pierrot, Bogdan Czerniak, Ewan A Gibb, Jaegil Kim, David J Kwiatkowski, Thierry Lebret, Fredrik Liedberg, A Arlene Siefker-Radtke, Nanor Sirab, Ann Taber, John N Weinstein,

Eur Urol (European urology)
[2020, 77(4):436-438]

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A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.

Aurélie Kamoun, Aurélien de Reyniès, Yves Allory, Gottfrid Sjödahl, A Gordon Robertson, Roland Seiler, Katherine A Hoadley, Clarice S Groeneveld, Hikmat Al-Ahmadie, Woonyoung Choi, Mauro A A Castro, Jacqueline Fontugne, Pontus Eriksson, Qianxing Mo, Jordan Kardos, Alexandre Zlotta, Arndt Hartmann, Colin P Dinney, Joaquim Bellmunt, Thomas Powles, Núria Malats, Keith S Chan, William Y Kim, David J McConkey, Peter C Black, Lars Dyrskjøt, Mattias Höglund, Seth P Lerner, Francisco X Real, François Radvanyi, ,

<h4>Background</h4>Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application.<h4>Objective</h4>To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes.<h4>Design, setting, and participants</h4>We used 1750 MIBC ... Read more >>

Eur Urol (European urology)
[2020, 77(4):420-433]

Cited: 85 times

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Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-invasive Bladder Carcinoma.

Charlotte S Voskuilen, Htoo Zarni Oo, Vera Genitsch, Laura A Smit, Alvaro Vidal, Manuel Meneses, Andrea Necchi, Maurizio Colecchia, Evanguelos Xylinas, Jacqueline Fontugne, Mathilde Sibony, Morgan Rouprêt, Louis Lenfant, Jean-François Côté, Lorenz Buser, Karim Saba, Marc A Furrer, Michiel S van der Heijden, Mads Daugaard, Peter C Black, Bas W G van Rhijn, Kees Hendricksen, Cédric Poyet, Roland Seiler,

Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(12):1600-1610]

Cited: 2 times

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Validation of a neuroendocrine-like classifier confirms poor outcomes in patients with bladder cancer treated with cisplatin-based neoadjuvant chemotherapy.

Petros Grivas, Tarek A Bismar, Aijai S Alva, Huei-Chung Huang, Yang Liu, Roland Seiler, Nimira Alimohamed, Liang Cheng, M Eric Hyndman, Bashar Dabbas, Peter C Black, Elai Davicioni, Jonathan L Wright, Moshe C Ornstein, Omar Y Mian, Hristos Z Kaimakliotis, Ewan A Gibb, Yair Lotan,

<h4>Purpose</h4>Neuroendocrine (NE)-like carcinoma is a newly recognized molecular subtype of conventional urothelial carcinoma of the bladder with transcriptomic profiles and clinical outcomes highly similar to histological NE carcinoma. The identification of NE-like tumors is challenging, as these tumors often appear histologically like urothelial carcinoma and can be missed by routine ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(4):262-268]

Cited: 2 times

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Re: Aurélie Kamoun, Aurélien de Reyniès, Yves Allory, et al. A Consensus Molecular Classification of Muscle-invasive Bladder Cancer. Eur Urol 2020;77:420-33: A Statement from the International Bladder Cancer Network.

Stephen B Williams, Peter C Black, Lars Dyrskjøt, Roland Seiler, Bernd Schmitz-Dräger, Roman Nawroth, Tilman Todenhöfer, Ashish M Kamat, Peter J Goebell,

Eur Urol (European urology)
[2020, 77(4):e105-e106]

Cited: 1 time

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Long non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis.

Joep J de Jong, Yang Liu, A Gordon Robertson, Roland Seiler, Clarice S Groeneveld, Michiel S van der Heijden, Jonathan L Wright, James Douglas, Marc Dall'Era, Simon J Crabb, Bas W G van Rhijn, Kim E M van Kessel, Elai Davicioni, Mauro A A Castro, Yair Lotan, Ellen C Zwarthoff, Peter C Black, Joost L Boormans, Ewan A Gibb,

BACKGROUND:Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease, and gene expression profiling has identified several molecular subtypes with distinct biological and clinicopathological characteristics. While MIBC subtyping has primarily been based on messenger RNA (mRNA), long non-coding RNAs (lncRNAs) may provide additional resolution. METHODS:LncRNA expression was quantified from microarray data of ... Read more >>

Genome Med (Genome medicine)
[2019, 11(1):60]

Cited: 6 times

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Editorial: Bladder cancer within the focus of basic and clinical research. Sixth IBCN Seminars Series.

Roland Seiler, Peter C Black, Stephen B Williams, Peter J Goebell, Ashish M Kamat, Roman Nawroth, Bernd J Schmitz-Dräger,

Urol Oncol (Urologic oncology)
[2019, 37(11):815-817]

Cited: 0 times

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Team Cognition in Sport: How Current Insights Into How Teamwork Is Achieved in Naturalistic Settings Can Lead to Simulation Studies.

Jérôme Bourbousson, Mathieu Feigean, Roland Seiler,

Front Psychol (Frontiers in psychology)
[2019, 10:2082]

Cited: 2 times

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Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Vera Genitsch, Attila Kollár, Gillian Vandekerkhove, Jennifer Blarer, Marc Furrer, Matti Annala, Cameron Herberts, Armin Pycha, Joep J de Jong, Yang Liu, Friedemann Krentel, Elai Davicioni, Ewan A Gibb, Marianna Kruithof-de Julio, Alexander W Wyatt, Roland Seiler,

INTRODUCTION:The sarcomatoid morphology of muscle-invasive bladder cancer (MIBC) is associated with unfavorable prognosis. However, the genomic, transcriptomic, and proteomic relationship between conventional urothelial and synchronous sarcomatoid morphology is poorly defined. METHODS:We compiled a cohort of 21 MIBC patients with components of conventional urothelial and adjacent sarcomatoid morphology within the same ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(11):826-836]

Cited: 2 times

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Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Vera Genitsch, Attila Kollár, Gillian Vandekerkhove, Jennifer Blarer, Marc Furrer, Matti Annala, Cameron Herberts, Armin Pycha, Joep J de Jong, Yang Liu, Friedemann Krentel, Elai Davicioni, Ewan A Gibb, Marianna Kruithof-de Julio, Alexander W Wyatt, Roland Seiler,

<h4>Introduction</h4>The sarcomatoid morphology of muscle-invasive bladder cancer (MIBC) is associated with unfavorable prognosis. However, the genomic, transcriptomic, and proteomic relationship between conventional urothelial and synchronous sarcomatoid morphology is poorly defined.<h4>Methods</h4>We compiled a cohort of 21 MIBC patients with components of conventional urothelial and adjacent sarcomatoid morphology within the same tumor ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(9):573.e19-573.e29]

Cited: 0 times

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