Full Text Journal Articles by
Author Roland Hartig

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A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.

Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni,

Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylating two important adaptor molecules, LAT and SLP76, which orchestrate the assembly of the signaling complex, leading to the activation ... Read more >>

Cells (Cells)
[2022, 11(17):2723]

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Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.

Matthias Kästle, Camilla Merten, Roland Hartig, Carlos Plaza-Sirvent, Ingo Schmitz, Ursula Bommhardt, Burkhart Schraven, Luca Simeoni,

Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we show that, in addition to its well-known function ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2022, 23(13):7271]

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