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Prevalence, symptoms and risk factor profile of rumination syndrome and functional dyspepsia: a population-based study.

Mudar Zand Irani, Michael P Jones, Magnus Halland, Linda Herrick, Rok Seon Choung, Yuri A Saito Loftus, Marjorie M Walker, Joseph A Murray, Nicholas J Talley,

<h4>Background</h4>Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD).<h4>Aim</h4>To assess the clinical features of rumination syndrome and FD in a community-based study.<h4>Methods</h4>We mailed a survey assessing gastrointestinal ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Eosinophilic Gastroenteritis: Using Presenting Findings to Predict Disease Course.

Daniel Havlichek, Rok Seon Choung, Joseph A Murray,

<h4>Introduction</h4>Studies on eosinophilic gastroenteritis have identified broad spectrums of disease. We aimed to characterize subtypes of disease and ascertain outcomes of each group.<h4>Methods</h4>This is a retrospective cohort study from a large tertiary medical center including 35 patients diagnosed with eosinophilic gastroenteritis from 2007 to 2018. We defined 2 groups of ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2021, 12(10):e00394]

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Anti–GM-CSF autoantibodies promote a “pre-diseased” state in Crohn’s Disease

Arthur Mortha, Romain Remark, Diane Marie Del Valle, Ling-Shiang Chuang, Zhi Chai, Inês Alves, Catarina Azevedo, Joana Gaifem, Jerome Martin, Kevin Tuballes, Vanessa Barcessat, Siu Ling Tai, Hsin-Hui Huang, Ilaria Laface, Yeray Arteaga Jerez, Gilles Boschetti, Nicole Villaverde, Mona Wang, Ujunwa Korie, Joseph Murray, Rok-Seon Choung, Takahiro Sato, Renee Laird, Scot Plevy, Adeeb Rahman, Joana Torres, Chad Porter, Mark Riddle, Ephraim Kenigsberg, Salomé Pinho, Judy Cho, Miriam Merad, Jean-Frederic Colombel, Sacha Gnjatic,

<h4>Background & Aims</h4> Anti–GM-CSF autoantibodies (aGMAb) are detected in ileal Crohn’s Disease (CD) patients. Their induction and mode of action impacting homeostasis during, or prior to disease are not well understood. We aimed to investigate the underlying mechanisms leading to the induction of aGMAb, from functional orientation to recognized epitopes, ... Read more >>

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Fr230 EFFECT ON EARLY GROWTH OF OFFSPRING BY UNDIAGNOSED MATERNAL CELIAC DISEASE IN PREGNANCY

Rok Seon Choung, Stine D. Sander, Melis G. Celdir, Alexander Lee, Katherine S. King, Imad Absah, Steffen Husby, Joseph A. Murray,

Gastroenterology (Gastroenterology)
[2021, 160(6):S-268-S-269]

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Estimating the Impact of Verification Bias on Celiac Disease Testing.

Isabel A Hujoel, Claire L Jansson-Knodell, Philippe P Hujoel, Margaux L A Hujoel, Rok Seon Choung, Joseph A Murray, Alberto Rubio-Tapia,

<h4>Goal</h4>The goal of this study was to estimate the impact of verification bias on the diagnostic accuracy of immunoglobulin A tissue transglutaminase (IgA tTG) in detecting celiac disease as reported by an authoritative meta-analysis, the 2016 Comparative Effectiveness Review (CER).<h4>Background</h4>Verification bias is introduced to diagnostic accuracy studies when screening test ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, 55(4):327-334]

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The Natural History of Chronic Unexplained Gastrointestinal Disorders and Gastroesophageal Reflux During 20 Years: A US Population-Based Study.

Rok Seon Choung, Yuri A Saito, Cathy D Schleck, William S Harmsen, Alan R Zinsmeister, Joseph A Murray, Nicholas J Talley,

<h4>Objective</h4>To explore the natural history of chronic unexplained gastrointestinal (GI) symptoms and to determine the longitudinal trends of prevalence during a 20-year period in a single US community.<h4>Methods</h4>Between January 1, 1990, and December 31, 2009, valid self-report questionnaires of GI symptoms were mailed to randomly selected cohorts of a community. ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(3):563-576]

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Reproductive Characteristics and Pregnancy Outcomes in Hidden Celiac Disease Autoimmunity.

Melis G Celdir, Rok Seon Choung, Shahryar K Rostamkolaei, Claire L Jansson-Knodell, Katherine S King, Joseph J Larson, Imad Absah, Joseph A Murray,

<h4>Introduction</h4>Untreated symptomatic celiac disease (CD) adversely affects female reproduction; however, the effect of hidden CD autoimmunity is uncertain.<h4>Methods</h4>We identified women who were not previously diagnosed with CD and tested positive for tissue transglutaminase and endomysial antibodies between 2006 and 2011 in a community-based retrospective cohort study. We evaluated (i) the ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(3):593-599]

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Antibody profiling and prevalence in US patients during the SARS-CoV2 pandemic.

Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Karenah E Rajasekaran, Tianhao Wang, Kang Bei, John J Rajasekaran, Inna Yaskin, Alex J Rai, Rok Seon Choung, Joseph A Murray,

<h4>Background</h4>Antibody diagnostics play an important role in disease detection and can potentially aid in monitoring of the immune responses to see if an individual has developed immunity. Developing high throughput diagnostics which does not involve handling of infectious material becomes imperative in the case of pandemics such as the recent ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242655]

Cited: 7 times

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Effect of a Gluten-free Diet on Quality of Life in Patients With Nonclassical Versus Classical Presentations of Celiac Disease.

Rok Seon Choung, Abhinav Lamba, Eric V Marietta, Jacalyn A See, Joseph J Larson, Katherine S King, Carol T Van Dyke, Alberto Rubio-Tapia, Joseph A Murray,

<h4>Background</h4>Celiac disease (CD) often presents with symptoms of diarrhea and malabsorption, termed classical CD. However, it can also present as nonclassical CD, which is commonly associated with nongastrointestinal symptoms. Studies suggest that nonclassical CD tends to have less severe symptoms than classical CD, which may affect both adherence to a ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2020, 54(7):620-625]

Cited: 1 time

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Antibody Profiling and Prevalence in the US population during the SARS-CoV2 Pandemic

Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Karenah Rajasekaran, Tianhao Wang, Kang Bei, John Rajasekaran, Inna Yaskin, Alex Rai, Rok Seon Choung, Joseph Murray,

<h4>ABSTRACT</h4> <h4>Background</h4> Antibody diagnostics play an important role in disease detection and can potentially aid in monitoring of the immune responses to see if an individual has developed immunity. Developing high throughput diagnostics which does not involve handling of infectious material becomes imperative in the case of pandemics such as ... Read more >>

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Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis.

Joana Torres, Francesca Petralia, Takahiro Sato, Pei Wang, Shannon E Telesco, Rok Seon Choung, Richard Strauss, Xiao-Jun Li, Renee M Laird, Ramiro L Gutierrez, Chad K Porter, Scott Plevy, Fred Princen, Joseph A Murray, Mark S Riddle, Jean-Frederic Colombel,

<h4>Background & aims</h4>Biomarkers are needed to identify patients at risk for development of inflammatory bowel diseases. We aimed to identify serum biomarkers of Crohn's disease and ulcerative colitis that can be detected and quantified before diagnosis.<h4>Methods</h4>We obtained serum samples from patients archived before a diagnosis of Crohn's disease (n = 200) ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 159(1):96-104]

Cited: 11 times

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Celiac disease risk stratification based on HLA-DQ heterodimer (HLA-DQA1 ~ DQB1) typing in a large cohort of adults with suspected celiac disease.

Rok Seon Choung, John R Mills, Melissa R Snyder, Joseph A Murray, Manish J Gandhi,

<b>Backgrounds:</b>Patients with celiac disease (CeD) carry the major histocompatibility complex class II, HLA-DQ2 or DQ8 haplotype; the absence of these haplotypes excludes a diagnosis of CeD. While the most common and highest risk HLA haplotypes in CeD have been established, the risk profiles of the less common and equivocal HLA ... Read more >>

Hum Immunol (Human immunology)
[2020, 81(2-3):59-64]

Cited: 2 times

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Autoimmune and Allergic Disorders are More Common in People With Celiac Disease or on a Gluten-free Diet in the United States.

Hyun-Seok Kim, Aynur Unalp-Arida, Constance E Ruhl, Rok Seon Choung, Joseph A Murray,

<h4>Goals</h4>We analyzed demographics, lifestyle patterns, and clinical characteristics of people with celiac disease (CD) and people without CD avoiding gluten (PWAG) to better understand associations with medical conditions and consumer behavior.<h4>Background</h4>Clinical significance of CD and gluten avoidance in the general population is incompletely understood. Recently, a high incidence of CD ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2019, 53(10):e416-e423]

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Community-Based Study of Celiac Disease Autoimmunity Progression in Adults.

Rok Seon Choung, Shahryar Khaleghi, Amanda K Cartee, Eric V Marietta, Joseph J Larson, Katherine S King, Otto Savolainen, Alastair B Ross, S Vincent Rajkumar, Michael J Camilleri, Alberto Rubio-Tapia, Joseph A Murray,

<h4>Background & aims</h4>Celiac disease can develop at any age, but outcomes of adults with positive results from serologic tests for tissue transglutaminase antibodies (tTGA) without endoscopic determination of celiac disease (called celiac autoimmunity) have not been thoroughly evaluated. We investigated the proportion of adults with celiac autoimmunity at a community ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(1):151-159.e3]

Cited: 3 times

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The Role for Food Allergies in the Pathogenesis of Irritable Bowel Syndrome: Understanding Mechanisms of Intestinal Mucosal Responses Against Food Antigens.

Rok Seon Choung, Joseph A Murray,

Gastroenterology (Gastroenterology)
[2019, 157(1):15-17]

Cited: 4 times

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Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms.

Adam C Bledsoe, Katherine S King, Joseph J Larson, Melissa Snyder, Imad Absah, Rok Seon Choung, Joseph A Murray,

OBJECTIVE:To evaluate micronutrient deficiencies in a contemporary cohort of adult patients with newly diagnosed celiac disease (CD). PATIENTS AND METHODS:This is a retrospective study of prospective adults newly diagnosed with CD from January 1, 2000, through October 31, 2014, at Mayo Clinic. Micronutrient data were collected for tissue transglutaminase IgA, ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2019, 94(7):1253-1260]

Cited: 3 times

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Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics.

Chad K Porter, Mark S Riddle, Ramiro L Gutierrez, Fred Princen, Rick Strauss, Shannon E Telesco, Joana Torres, Rok Seon Choung, Renee M Laird, Francisco Leon, Jean-Frédéric Colombel, Joseph A Murray, ,

<h4>Purpose</h4>The etiology of Inflammatory Bowel Disease (IBD) remains currently unknown but evidence would suggest that it results from a complex interplay between genetic susceptibility genes, the intestinal microbiome and the environment, resulting in an increased response towards microbial and self-antigens, followed by the development of pre-clinical intestinal inflammation as a ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2019, 14:100345]

Cited: 3 times

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Randomised clinical trial: pregabalin vs placebo for irritable bowel syndrome.

Yuri A Saito, Ann E Almazar, Katherine E Tilkes, Rok Seon Choung, Michael D Van Norstrand, Cathy D Schleck, Alan R Zinsmeister, Nicholas J Talley,

<h4>Background</h4>Pregabalin is a calcium channel α2δ ligand that modifies visceral hypersensitivity in IBS patients. Clinical data for pregabalin in IBS are lacking.<h4>Aim</h4>To test the efficacy of pregabalin on gastrointestinal symptoms in IBS patients.<h4>Methods</h4>A double-blind, placebo-controlled trial was performed. Adults meeting IBS Rome III criteria with ≥3 pain attacks per month ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 49(4):389-397]

Cited: 3 times

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Synthetic Neoepitopes of the Transglutaminase-Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease.

Rok Seon Choung, Shahryar Khaleghi Rostamkolaei, Josephine M Ju, Eric V Marietta, Carol T Van Dyke, J J Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Karenah E Rajasekaran, Karthik Krishna, Hari Krishnan Krishnamurthy, Joseph A Murray,

<h4>Background & aims</h4>Celiac disease (CeD) has characteristics of an autoimmune disease, such as increased antibody levels to tissue transglutaminase (tTG). However, assays to measure these biomarkers in blood samples do not identify patients with sufficient accuracy for diagnosis or monitoring of CeD. We aimed to discover biomarkers of CeD derived ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 156(3):582-591.e1]

Cited: 5 times

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Pediatric Celiac Disease: Increasing Incidence or Increased Awareness?

Imad Absah, Rok Seon Choung, Joseph A Murray,

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2018, 67(2):e42]

Cited: 0 times

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Self-reported Sleep Impairment in Functional Dyspepsia and Irritable Bowel Syndrome.

Seung Young Kim, Rok Seon Choung, Seung Ku Lee, Jung Wan Choe, Sung Woo Jung, Jong Jin Hyun, Ja Seol Koo, Sang Woo Lee, Chol Shin,

Background/Aims:Sleep impairment is a common complaint among patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). This study aimed to evaluate the prevalence of sleep impairment in FD or IBS patients, and to determine whether IBS-FD overlap induced more sleep disturbance than FD or IBS alone. Methods:A population-based cohort ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2018, 24(2):280-288]

Cited: 6 times

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Management of eosinophilic esophagitis and celiac disease.

Rok Seon Choung, Jeffrey A Alexander, David A Katzka, Joseph A Murray,

Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the ... Read more >>

Curr Opin Pharmacol (Current opinion in pharmacology)
[2017, 37:118-125]

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Reply.

Rok Seon Choung, Joseph A Murray,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(1):152-153]

Cited: 0 times

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Features of Adult Autoimmune Enteropathy Compared With Refractory Celiac Disease.

Ayush Sharma, Rok Seon Choung, Xiao Jing Wang, Pierre A Russo, Tsung-Teh Wu, Vandana Nehra, Joseph A Murray,

BACKGROUND & AIMS:Little is known about the features of immune-mediated non-celiac villous atrophies, such as autoimmune enteropathy (AIE). We investigated the demographic, clinical, and histologic features of adults with AIE compared to adults with refractory celiac disease type 1. We also report outcomes of treatment with open-label budesonide. METHODS:We performed ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(6):877-883.e1]

Cited: 5 times

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Machine Learning in Detection of Undiagnosed Celiac Disease.

Isabel A Hujoel, Dennis H Murphree, Carol T Van Dyke, Rok Seon Choung, Ayush Sharma, Joseph A Murray, Alberto Rubio-Tapia,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(8):1354-1355.e1]

Cited: 2 times

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