Full Text Journal Articles by
Author Rohit Jain

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Autoimmune heparin-induced thrombocytopenia: a rare manifestation of COVID-19.

Katherine Julian, Donald Bucher, Rohit Jain,

We describe the case of a 65-year-old male who presented to an outside hospital for shortness of breath, nausea and vomiting 8 days after testing positive for COVID-19. Initial workup revealed massive bilateral pulmonary emboli and thrombocytopenia. The patient was then admitted to our hospital, received an inferior vena cava ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(5):]

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Intramuscular ancient schwannoma of the axillary nerve.

Vishali Moond, Preeti Diwaker, Reshma Golamari, Rohit Jain,

We present the case of an adolescent with an intramuscular ancient schwannoma of the axillary nerve which, to the best of our knowledge, has not been reported before. Due to its deep location, intramuscular schwannoma has less clinical signs and hence, is difficult to diagnose. Ancient schwannoma, characterised by degeneration ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(5):]

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TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With Metastatic Urothelial Carcinoma Progressing After Platinum-Based Chemotherapy and Checkpoint Inhibitors.

Scott T Tagawa, Arjun V Balar, Daniel P Petrylak, Arash Rezazadeh Kalebasty, Yohann Loriot, Aude Fléchon, Rohit K Jain, Neeraj Agarwal, Manojkumar Bupathi, Philippe Barthelemy, Philippe Beuzeboc, Phillip Palmbos, Christos E Kyriakopoulos, Damien Pouessel, Cora N Sternberg, Quan Hong, Trishna Goswami, Loretta M Itri, Petros Grivas,

<h4>Purpose</h4>Patients with metastatic urothelial carcinoma (mUC) who progress on platinum-based combination chemotherapy (PLT) and checkpoint inhibitors (CPIs) have limited options that offer objective response rates (ORRs) of approximately 10% with a median overall survival (OS) of 7-8 months. Sacituzumab govitecan (SG) is a TROP-2-directed antibody-drug conjugate with an SN-38 payload ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, :JCO2003489]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J Manley, Roger Li, Wade Sexton, Scott M Gilbert,

<h4>Purpose</h4>Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or improved overall survival (OS) for patients with variant histology. Our objective was to assess for associations between receipt of neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001855]

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Optimal pathological response after neoadjuvant chemotherapy for muscle-invasive bladder cancer: results from a global, multicentre collaboration.

Praful Ravi, Gregory R Pond, Leonidas N Diamantopoulos, Christopher Su, Ajjai Alva, Rohit K Jain, William P Skelton, Sumati Gupta, Jonathan D Tward, Kathleen M Olson, Parminder Singh, Camilla M Grunewald, Guenter Niegisch, Jae-Lyun Lee, Andrea Gallina, Marco Bandini, Andrea Necchi, Matthew Mossanen, Bradley A McGregor, Catherine Curran, Petros Grivas, Guru P Sonpavde,

<h4>Objectives</h4>To evaluate outcomes of patients achieving a post-treatment pathological stage of <ypT2N0 at radical cystectomy (RC) following neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) to identify an optimal definition of pathological response.<h4>Patients and methods</h4>Patients from 10 international centres who underwent NAC for cT2-4aN0-1 MIBC and achieved <ypT2N0 disease at ... Read more >>

BJU Int (BJU international)
[2021, :]

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Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit K Jain, Jad Chahoud, Philippe E Spiess, Wade Sexton, Scott M Gilbert, Brandon J Manley,

<h4>Importance</h4>Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a real-world cohort outside of a clinical trial setting is ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2111329]

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Acknowledging the Blind Spot of Bitemporal Hemianopsia: Keeping a High Index of Suspicion for Pituitary Macroadenomas in Uncommon Presentations

Joseph Raco, Maria Macias, Rohit Jain,

Abstract Background: Hyperglycemia in patients with type 2 diabetes mellitus commonly manifests as symptoms of polyuria, polydipsia, fatigue, and weight loss as a result of insulin resistance. In cases of severe hyperglycemia, patients may also experience visual disturbances and dizziness as a result of swelling of the lens and dehydration ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A569-A569]

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Bypassing the Adrenals: A Rare Case of Adrenal Insufficiency Following Bariatric Surgery

Joseph Raco, Norhan Shamloul, Rohit Jain,

Abstract Background: Adrenal insufficiency (AI) is a life-threatening disorder that is generally caused by primary adrenal failure or by hypothalamic-pituitary impairment of the corticotropic axis. Patients often present with fatigue, hypotension, anorexia, and weight loss. There are few reported cases of AI following bariatric surgery; a type of procedure designed ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A121-A121]

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Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma.

Rohit K Jain, William Paul Skelton Iv, Gregory Russell Pond, Mahrukh Naqvi, Youngchul Kim, Catherine Curran, Dory Freeman, Pier Vitale Nuzzo, Sarah Abou Alaiwi, Amin H Nassar, Rakesh K Jain, Guru Sonpavde,

<h4>Background</h4>The renin-angiotensin system is involved in the regulation of angiogenesis and cell proliferation. Angiotensin inhibition may improve drug delivery by enhancing tumor perfusion partly by downregulating transforming growth factor (TGF)-β. Because TGF-β is associated with resistance in patients with metastatic urothelial carcinoma (mUC) receiving programmed cell death protein 1/programmed cell ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma.

Thomas E Hutson, M Dror Michaelson, Timothy M Kuzel, Neeraj Agarwal, Ana M Molina, James J Hsieh, Ulka N Vaishampayan, Ran Xie, Urmi Bapat, Weifei Ye, Rohit K Jain, Mayer N Fishman,

<h4>Background</h4>Non-clear cell renal cell carcinoma (nccRCC) accounts for ≤20% of RCC cases. Lenvatinib (a multitargeted tyrosine kinase inhibitor) in combination with everolimus (an mTOR inhibitor) is approved for the treatment of advanced RCC after one prior antiangiogenic therapy.<h4>Objective</h4>To determine the safety and efficacy of lenvatinib plus everolimus as a first-line ... Read more >>

Eur Urol (European urology)
[2021, :]

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A narrative review of chronic alcohol-induced atrial fibrillation.

Rea Mittal, Lilly Su, Devyani Ramgobin, Ashwani Garg, Rahul Jain, Rohit Jain,

Alcohol use disorder (AUD) is highly prevalent and can lead to many cardiovascular complications, including arrhythmias. Chronic alcohol use has a dose-dependent relationship with incidence of atrial fibrillation (AF), where higher alcohol intake (>3 drinks a day) is associated with higher risk of AF. Meanwhile, low levels of chronic alcohol ... Read more >>

Future Cardiol (Future cardiology)
[2021, :]

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Case Report: Immune Checkpoint Inhibitor-Induced Exuberant Tumor Inflammation With Accelerated Clinical Deterioration in Metastatic Renal Cell Carcinoma.

Dharmesh Gopalakrishnan, Rohit K Jain, Laurie Herbst, Marcus Sikorski, Silpa Mandava, Gissou Azabdaftari, Bo Xu, Charles LeVea, Kevin Robillard, Marc S Ernstoff, Saby George,

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. Nivolumab, an anti-PD-1 monoclonal antibody, markedly improved overall survival in advanced renal cell carcinoma (RCC). However, ICIs can rarely trigger massive inflammation, a phenomenon characterized by rapid acceleration in radiographic tumor growth, the mechanisms underlying which are largely unknown. We report three ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:679177]

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Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

Michelle M McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao, Jad Zamerli, Peter Thatcher, Wunna Kyaw, Karrnan Pathmanandavel, Abigail K Grootveld, Imogen Moran, Danyal Butt, Akira Nguyen, Alexander Corr, Sean Warren, Maté Biro, Natalie C Butterfield, Siobhan E Guilfoyle, Davide Komla-Ebri, Michael R G Dack, Hannah F Dewhurst, John G Logan, Yongxiao Li, Sindhu T Mohanty, Niall Byrne, Rachael L Terry, Marija K Simic, Ryan Chai, Julian M W Quinn, Scott E Youlten, Jessica A Pettitt, David Abi-Hanna, Rohit Jain, Wolfgang Weninger, Mischa Lundberg, Shuting Sun, Frank H Ebetino, Paul Timpson, Woei Ming Lee, Paul A Baldock, Michael J Rogers, Robert Brink, Graham R Williams, J H Duncan Bassett, John P Kemp, Nathan J Pavlos, Peter I Croucher, Tri Giang Phan,

Cell (Cell)
[2021, 184(7):1940]

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Robotic radical nephroureterectomy in a patient with situs inversus totalis.

Jacob Britt, Rohit Jain, Roger Li,

Situs inversus totalis is a rare anatomical variant in which all major organs and blood vessels are mirrored from left to right. We present a case of upper tract urothelial carcinoma in a patient with situs inversus who underwent robotic-assisted laparoscopic nephroureterectomy. We utilized conventional surgical approaches and a successful ... Read more >>

Urol Case Rep (Urology case reports)
[2021, 37:101688]

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Amelanotic B16-F10 Melanoma Compatible with Advanced Three-Dimensional Imaging Modalities.

Shweta Tikoo, Rohit Jain, Florence Tomasetig, Kathy On, Brendon Martinez, Celine Heu, Daniel Stehle, Peyman Obeidy, Dajiang Guo, Jonathan N Vincent, Adam J L Cook, Ben Roediger, Robert Feil, Renee M Whan, Wolfgang Weninger,

J Invest Dermatol (The Journal of investigative dermatology)
[2021, :]

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Leaves and Roots of Micropropagated Plants Adopt Different Pathways for Withanolide Biosynthesis in Withania Coagulans: A Comparative Transcriptome Study

Swati Gupta, Manoj Kumar Bohra, Kalpna sharma, Sumita Kachhwaha, Shanker Lal Kothari, Rohit Jain,

Withania coagulans (Stocks) Dunal commonly known as paneerbandh due to its milk coagulating properties, is a widely used medicinal herb, and micropropagated plants of the plant to produce some novel withanolides. Trasncscriptome sequencing of leaves and roots of micropropagated plants of W. coagulans assembled total 8.08 and 6.35 GB of ... Read more >>

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Experimental therapies under investigation for COVID-19.

Reshma Golamari, Neeru Kapoor, Tanuja Devaraj, Nitasa Sahu, Courtney Kramer, Rohit Jain,

Coronavirus Disease 2019, caused by the virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a pandemic first discovered in Wuhan, China which has claimed over 1.7 million lives to date across the globe as of 24 December 2020. As the virus spreads across the world affecting millions of patients, there ... Read more >>

J Community Hosp Intern Med Perspect (Journal of community hospital internal medicine perspectives)
[2021, 11(2):187-193]

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Should Upper-tract Urothelial Carcinoma and Bladder Carcinoma Be Treated the Same or Different?

Rohit K Jain, Jeffery S Ross, Andrea Necchi, Philippe E Spiess,

Eur Urol Oncol (European urology oncology)
[2021, 4(2):180-181]

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Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

Michelle M McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao, Jad Zamerli, Peter Thatcher, Wunna Kyaw, Karrnan Pathmanandavel, Abigail K Grootveld, Imogen Moran, Danyal Butt, Akira Nguyen, Alexander Corr, Sean Warren, Maté Biro, Natalie C Butterfield, Siobhan E Guilfoyle, Davide Komla-Ebri, Michael R G Dack, Hannah F Dewhurst, John G Logan, Yongxiao Li, Sindhu T Mohanty, Niall Byrne, Rachael L Terry, Marija K Simic, Ryan Chai, Julian M W Quinn, Scott E Youlten, Jessica A Pettitt, David Abi-Hanna, Rohit Jain, Wolfgang Weninger, Mischa Lundberg, Shuting Sun, Frank H Ebetino, Paul Timpson, Woei Ming Lee, Paul A Baldock, Michael J Rogers, Robert Brink, Graham R Williams, J H Duncan Bassett, John P Kemp, Nathan J Pavlos, Peter I Croucher, Tri Giang Phan,

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into daughter cells called osteomorphs. Inhibiting RANKL blocked this ... Read more >>

Cell (Cell)
[2021, 184(5):1330-1347.e13]

Cited: 2 times

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A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family.

Rohit Jain, Khaja Muneeruddin, Jeremy Anderson, Michael J Harms, Scott A Shaffer, C Robert Matthews,

The amino acid sequences of proteins have evolved over billions of years, preserving their structures and functions while responding to evolutionary forces. Are there conserved sequence and structural elements that preserve the protein folding mechanisms? The functionally diverse and ancient (βα)<sub>1-8</sub> TIM barrel motif may answer this question. We mapped ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(17):]

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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio and Their Role as Predictors of Disease Severity of Coronavirus Disease 2019 (COVID-19).

Rohit Jain, Arun Gopal, Basant Kumar Pathak, Sourya Sourabh Mohakuda, Tvsvgk Tilak, Anchit Raj Singh,

<b>Context</b>  Due to the wide spectrum of clinical illness in coronavirus disease 2019 (COVID-19) patients, it is important to stratify patients into severe and nonsevere categories. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been evaluated rapidly by a few studies worldwide for its association with severe disease, but practically ... Read more >>

J Lab Physicians (Journal of laboratory physicians)
[2021, 13(1):58-63]

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Papering over the cracks: COVID-19's amplification of the failures of employer-based health insurance coverage.

Devyani Ramgobin, Brendan McClafferty, Courtney Kramer, Reshma Golamari, Brian McGillen, Rohit Jain,

<b>Background</b>: COVID-19 has altered numerous lives and accounted for significant mortality and morbidity throughout the world and, especially, the USA. During the pandemic, from mid-March to July 2020, around one-fourth of the US population filed for unemployment benefits. <b>Objective</b>: In this article, we discuss the economic ramifications exposed in the ... Read more >>

J Community Hosp Intern Med Perspect (Journal of community hospital internal medicine perspectives)
[2021, 11(1):107-110]

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Cardiac amyloidosis-A review of current literature for the practicing physician.

Samantha Ash, Eran Shorer, Devyani Ramgobin, Maique Vo, Jonathan Gibbons, Reshma Golamari, Rahul Jain, Rohit Jain,

The amyloidoses are a family of diseases in which misfolded precursor proteins aggregate to form amyloid and deposit in body tissues. A very serious yet underrecognized form of this disease is cardiac amyloidosis, in which amyloid deposits into the extracellular space of the myocardium, resulting in thickening and stiffening of ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(3):322-331]

Cited: 1 time

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Rare enough ? Cardiac Device-related pocket Infection due to Mycobacterium fortuitum.

Reshma Golamari, Nitasa Sahu, Rama Vunnam, Dhirisha Bhatt, Rameet Thapa, Ravi Patel, Rohit Jain,

Nontuberculous mycobacteria are rare causes of cardiac implantable electronic device (CIED)-related infections and may lead to device-related endocarditis, so preventing them is key. We present a case of CIED-related pocket infection due to Mycobacterium fortuitum which highlights the challenges in management of such infections. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(3):1566-1570]

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A Comprehensive Review of COVID-19 Associated Neurological Manifestations.

Chander Shekher Aggarwal, Sarah Walser, Abani Bhandari, Nikita Garg, Brendan McClafferty, Devyani Ramgobin, Reshma Golamari, Nitasa Sahu, Ashutosh Kumar, Rohit Jain,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 utilizes the angiotensin-converting enzyme 2 (ACE-2) receptor of cells in order to gain entry and continue infection. Recent literature has focused on acute respiratory distress syndrome (ARDS) and other associated pulmonary complications; however, only a scarce amount of literature exists on ... Read more >>

S D Med (South Dakota medicine : the journal of the South Dakota State Medical Association)
[2020, 73(12):569-571]

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