Full Text Journal Articles by
Author Rogerio M Castilho

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Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study.

Vivian P Wagner, Tobias R Spuldaro, Felipe Nör, Eduardo J Gaio, Rogerio M Castilho, Vinicius C Carrard, Cassiano K Rösing,

The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer. We aimed to determine if low doses of propranolol can prevent the development of oral cancer using a tobacco-relevant and p53-associated animal model of cancer initiation. ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):315-321]

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Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma.

Kshitij Parag-Sharma, Jason Tasoulas, Adele M Musicant, Carlos H Viesi do Nascimento-Filho, Zhichuan Zhu, Chloe Twomey, Pengda Liu, Rogerio M Castilho, Antonio L Amelio,

<h4>Objectives</h4>Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to tumor recurrence/metastasis and abysmal ~35% 5-year survival. Causal links have been established between Epithelial Growth Factor Receptor (EGFR) activation and poor outcome. Herein we investigated the therapeutic efficacy ... Read more >>

Oral Oncol (Oral oncology)
[2021, 115:105166]

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Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing.

Manoela D Martins, Felipe Martins Silveira, Marco A T Martins, Luciana O Almeida, Vanderlei S Bagnato, Cristiane H Squarize, Rogerio M Castilho,

Emerging evidence indicates the clinical benefits of photobiomodulation therapy (PBMT) in the management of skin and mucosal wounds. Here, we decided to explore the effects of different regiments of PBMT on epithelial cells and stem cells, and the potential implications over the epigenetic circuitry during healing. Scratch-wound migration, immunofluorescence (anti-acetyl-Histone ... Read more >>

J Biophotonics (Journal of biophotonics)
[2021, 14(2):e202000274]

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Immunohistological composition of peri-implantitis affected tissue around ceramic implants-A pilot study.

Tobias Fretwurst, Janina Müller, Lena Larsson, Peter Bronsert, Derek Hazard, Rogerio M Castilho, Ralf Kohal, Katja Nelson, Gerhard Iglhaut,

<h4>Background</h4>Aim of the pilot study was the histologic classification of the inflamed peri-implant soft tissue around ceramic implants (CI) in comparison with titanium implants (TI).<h4>Methods</h4>Peri-implant tissue were retrieved from 15 patients (aged 34 to 88 years, seven males/eight females) with severe peri-implantitis (eight CI, seven TI). The peri-implant soft tissue ... Read more >>

J Periodontol (Journal of periodontology)
[2021, 92(4):571-579]

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Head and neck cancer patient-derived xenograft models - A systematic review.

Lauren F Schuch, Felipe M Silveira, Vivian P Wagner, Gabriell B Borgato, Guilherme Z Rocha, Rogerio M Castilho, Pablo A Vargas, Manoela D Martins,

<h4>Background</h4>Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.<h4>Methods</h4>An electronic search was undertaken in four databases, including publications having used HNC-PDX. ... Read more >>

Crit Rev Oncol Hematol (Critical reviews in oncology/hematology)
[2020, 155:103087]

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SCF/C-Kit Signaling Induces Self-Renewal of Dental Pulp Stem Cells.

Carolina Cucco, Zhaocheng Zhang, Tatiana M Botero, Daniel J Chiego, Rogerio M Castilho, Jacques E Nör,

<h4>Introduction</h4>The maintenance of a stem cell pool is imperative to enable healing processes in the dental pulp tissue throughout life. As such, knowing mechanisms underlying stem cell self-renewal is critical to understand pulp pathophysiology and pulp regeneration. The purpose of this study was to evaluate the impact of stem cell ... Read more >>

J Endod (Journal of endodontics)
[2020, 46(9S):S56-S62]

Cited: 1 time

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Entinostat is a novel therapeutic agent to treat oral squamous cell carcinoma.

Ana Elizia M Marques, Carlos Henrique V do Nascimento Filho, Thamara M Marinho Bezerra, Eliete N S Guerra, Rogerio M Castilho, Cristiane H Squarize,

<h4>Introduction</h4>Alterations of the epigenome may influence cancer initiation and progression. At the cellular level, histones are key regulators of chromatin accessibility and gene transcription; thus, the inhibition of histone deacetylase enzymes (HDACs) constitutes an attractive target for therapy. In this study, we investigated the effects of the HDAC inhibitor entinostat ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2020, 49(8):771-779]

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Skin wound healing triggers epigenetic modifications of histone H4.

Carlos H V Nascimento-Filho, Ericka J D Silveira, Eny M Goloni-Bertollo, Lelia Batista de Souza, Cristiane H Squarize, Rogerio M Castilho,

<h4>Background</h4>The skin is the largest organ of the human body. Upon injury, the skin triggers a sequence of signaling pathways that induce epithelial proliferation, migration, and ultimately, the re-establishment of the epithelial barrier. Our study explores the unknown epigenetic regulations of wound healing from a histone perspective. Posttranslational modifications of ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):138]

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BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism.

Ericka J D Silveira, Carlos H V Nascimento Filho, Veronica Q Yujra, Liana P Webber, Rogerio M Castilho, Cristiane H Squarize,

The circadian rhythm regulates the physiology and behavior of living organisms in a time-dependent manner. Clock genes have distinct roles including the control over gene expression mediated by the transcriptional activators CLOCK and BMAL1, and the suppression of gene expression mediated by the transcriptional repressors PER1/2 and CRY1/2. The balance ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

Cited: 1 time

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Characterization of macrophages infiltrating peri-implantitis lesions.

Tobias Fretwurst, Carlos Garaicoa-Pazmino, Katja Nelson, William V Giannobile, Cristiane H Squarize, Lena Larsson, Rogerio M Castilho,

OBJECTIVES:The mechanisms involved in the initiation and progression of peri-implantitis lesions are poorly understood. It was the aim to determine the content and activation status of macrophages present in human peri-implantitis lesions and compare the current findings with the macrophage polarization associated with periodontitis lesions. MATERIAL AND METHODS:A total of ... Read more >>

Clin Oral Implants Res (Clinical oral implants research)
[2020, 31(3):274-281]

Cited: 4 times

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Pharmacological PTEN inhibition: potential clinical applications and effects in tissue regeneration.

Gabriel A Borges, Liana P Webber, Ana Elizia M Marques, Eliete Ns Guerra, Rogerio M Castilho, Cristiane H Squarize,

Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog ... Read more >>

Regen Med (Regenerative medicine)
[2020, 15(2):1329-1344]

Cited: 1 time

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Asparaginase induces selective dose- and time-dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells.

Gabriel Álvares Borges, Silvia Taveira Elias, Tassiana Souza De Araujo, Paula Monteiro Souza, Carlos Henrique Viesi Nascimento-Filho, Rogerio M Castilho, Cristiane H Squarize, Pérola de Oliveira Magalhães, Eliete Neves Silva Guerra,

Asparaginase is fundamental to the treatment of haematological malignancies. However, little has been studied on the effects that asparaginase could exert on solid tumours. Thus, this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The cytotoxicity of asparaginase in SCC-9 (tongue squamous cell carcinoma) ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(5):857-866]

Cited: 1 time

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Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN.

Carlos H V Nascimento-Filho, Liana P Webber, Gabriell B Borgato, Eny M Goloni-Bertollo, Cristiane H Squarize, Rogerio M Castilho,

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide and is characterized by a fast-paced growth. Like other solid tumors, the HNSCC growth rate results in the development of hypoxic regions identified by the expression of hypoxia-inducible factor 1α (HIF-1α). Interestingly, clinical data have shown ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(12):13435-13449]

Cited: 2 times

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Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics.

Rayana L Bighetti-Trevisan, Lucas O Sousa, Rogerio M Castilho, Luciana O Almeida,

A frequent observation in several malignancies is the development of resistance to therapy that results in frequent tumor relapse and metastasis. Much of the tumor resistance phenotype comes from its heterogeneity that halts the ability of therapeutic agents to eliminate all cancer cells effectively. Tumor heterogeneity is, in part, controlled ... Read more >>

Stem Cells Int (Stem cells international)
[2019, 2019:9618065]

Cited: 11 times

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Characterization of macrophage polarization in periodontal disease.

Carlos Garaicoa-Pazmino, Tobias Fretwurst, Cristiane H Squarize, Tord Berglundh, William V Giannobile, Lena Larsson, Rogerio M Castilho,

<h4>Aim</h4>To explore the M1/M2 status of macrophage polarization from healthy, gingivitis, and periodontitis patient samples.<h4>Materials and methods</h4>Gingival biopsies were collected from 42 individuals (14 gingivitis, 18 periodontitis, and 10 healthy samples) receiving periodontal therapy. Histomorphology analysis was performed with haematoxylin and eosin staining. Immunofluorescence was performed using a combination of ... Read more >>

J Clin Periodontol (Journal of clinical periodontology)
[2019, 46(8):830-839]

Cited: 6 times

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Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.

Liana P Webber, Veronica Q Yujra, Pablo A Vargas, Manoela D Martins, Cristiane H Squarize, Rogerio M Castilho,

Head and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the complications in managing and treating HNSCC advent from the complex genetic and epigenetic landscape of the disease. Emerging information has shown promising results ... Read more >>

Cancer Lett (Cancer letters)
[2019, 461:10-20]

Cited: 2 times

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Topical delivery of mTOR inhibitor halts scarring.

Liana P Webber, Brian Yip, Carlos H V do Nascimento Filho, Ha B Park, Rogerio M Castilho, Cristiane H Squarize,

J Dermatol Sci (Journal of dermatological science)
[2019, 95(2):76-79]

Cited: 2 times

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Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Renata L Markman, Liana P Webber, Carlos H V Nascimento Filho, Leonardo A Reis, Pablo A Vargas, Marcio A Lopes, Virgilio Zanella, Manoela D Martins, Cristiane H Squarize, Rogerio M Castilho,

<h4>Purpose</h4>Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be ... Read more >>

Cell Oncol (Dordr) (Cellular oncology (Dordrecht))
[2019, 42(2):143-155]

Cited: 1 time

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UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Kristy A Warner, Alexandra E Oklejas, Alexander T Pearson, Zhaocheng Zhang, Weishing Wu, Vasu Divi, Christie Rodriguez-Ramirez, Rogerio M Castilho, Peter J Polverini, Jacques E Nör,

<h4>Objectives</h4>Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line.<h4>Material and methods</h4>Immediately after surgery, a tumor fragment ... Read more >>

Oral Oncol (Oral oncology)
[2018, 87:21-28]

Cited: 2 times

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Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.

Vivian P Wagner, Manoela D Martins, Marco A T Martins, Luciana O Almeida, Kristy A Warner, Jacques E Nör, Cristiane H Squarize, Rogerio M Castilho,

Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the most common malignancy from the salivary glands. Low survival rates of high-grade Mucoepidermoid Carcinomas (MEC) are particularly associated with the presence of positive lymph nodes, extracapsular lymph ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):2065]

Cited: 5 times

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Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study.

Farah Asa'ad, Valentina Bollati, Giorgio Pagni, Rogerio M Castilho, Eleonora Rossi, Francesca Pomingi, Letizia Tarantini, Dario Consonni, William V Giannobile, Giulio Rasperini,

<h4>Objective</h4>To evaluate the influence of periodontal therapy on DNA methylation in patients with chronic periodontitis as compared to healthy individuals.<h4>Material and methods</h4>Twenty patients were enrolled into two groups: (i) 10 diagnosed as clinically healthy; and (ii) 10 diagnosed with chronic periodontitis. Clinical measures were recorded and gingival biopsies were harvested ... Read more >>

J Clin Periodontol (Journal of clinical periodontology)
[2017, 44(9):905-914]

Cited: 7 times

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DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma.

Maria G Varrica, Chiara Zagni, Placido G Mineo, Giuseppe Floresta, Giulia Monciino, Venerando Pistarà, Antonio Abbadessa, Angelo Nicosia, Rogerio M Castilho, Emanuele Amata, Antonio Rescifina,

((3RS,5SR)- and ((3RS,5RS)-2-(2-methoxybenzyl)-3-(1,10-phenanthrolin-2-yl)isoxazolidin-5-yl)methanol have been synthesized, according to 1,3-dipolar cycloaddition methodology, as DNA intercalating agents and evaluated for their anticancer activity against human cervical carcinoma HeLa and head and neck squamous cells carcinoma cell lines. The synthesized compounds exhibited good cytotoxic activity with IC50 better than cisplatin, used as the ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 143:583-590]

Cited: 0 times

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Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design.

Chiara Zagni, Venerando Pistarà, Luciana A Oliveira, Rogerio M Castilho, Giovanni Romeo, Ugo Chiacchio, Antonio Rescifina,

Histone deacetylase inhibitors (HDACis) play an important role as valuable drugs targeted to cancer therapy: several HDACis are currently being tested in clinical trials. Two new potential HDACis 1a and 1d, characterized by the presence of a biphenyl-4-sulfonamide group as a connection unit between the N-{4-[(E)-(2-formylhydrazinylidene)methyl]-3-hydroxyphenyl} and the 2-hydroxy-N-(trifluoroacetyl)benzamide moiety, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2017, 141:188-196]

Cited: 1 time

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PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Chiara Zagni, Luciana O Almeida, Tarek Balan, Marco T Martins, Luciana K Rosselli-Murai, Petros Papagerakis, Rogerio M Castilho, Cristiane H Squarize,

Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur with each new hair cycle or upon injury. We found that PTEN, a ... Read more >>

Stem Cell Reports (Stem cell reports)
[2017, 9(1):304-314]

Cited: 6 times

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Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Rogerio M Castilho, Cristiane H Squarize, Luciana O Almeida,

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one of the most aggressive malignancies worldwide. Despite continuous efforts to identify molecular markers for early detection, and to develop efficient treatments, the overall survival and prognosis of HNSCC patients remain poor. Accumulated scientific evidences suggest that ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(7):]

Cited: 31 times

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