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Author Roger S McIntyre

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In Vivo Phenotyping, Mechanism-Informed Treatments, Domain-Based Psychopathology and Nomological Networks: A Strategy for Treatment Discovery and Development in Bipolar Depression.

Roger S McIntyre,

A concatenation of study findings published during the last decade have brought into cold clarity the predominance and debilitating nature of depressive symptoms in adults with bipolar disorders (BD). For example, results from longitudinal, naturalistic studies in BD have concluded that for the majority of affected individuals, depressive symptoms manifest ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

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A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities.

Fengyi Hao, Wilson Tam, Xiaoyu Hu, Wanqiu Tan, Li Jiang, Xiaojiang Jiang, Ling Zhang, Xinling Zhao, Yiran Zou, Yirong Hu, Xi Luo, Roger S McIntyre, Travis Quek, Bach Xuan Tran, Zhisong Zhang, Hai Quang Pham, Cyrus S H Ho, Roger C M Ho,

This study examined the neuropsychiatric sequelae of acutely ill patients with coronavirus disease 2019 (COVID-19) infection who received treatment in hospital isolation wards during the COVID-19 pandemic. Ten COVID-19 patients who received treatment in various hospitals in Chongqing, China; 10 age- and gender-matched psychiatric patients; and 10 healthy control participants ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):355]

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How to improve adherence to antidepressant treatments in patients with major depression: a psychoeducational consensus checklist.

Bernardo Dell'Osso, Umberto Albert, Giuseppe Carrà, Maurizio Pompili, Maria Giulia Nanni, Massimo Pasquini, Nicola Poloni, Andrea Raballo, Fabio Sambataro, Gianluca Serafini, Caterina Viganò, Koen Demyttenaere, Roger S McIntyre, Andrea Fiorillo,

Studies conducted in primary care as well as in psychiatric settings show that more than half of patients suffering from major depressive disorder (MDD) have poor adherence to antidepressants. Patients prematurely discontinue antidepressant therapy for various reasons, including patient-related (e.g., misperceptions about antidepressants, side-effects, and lack of tolerability), clinician-related (e.g., ... Read more >>

Ann Gen Psychiatry (Annals of general psychiatry)
[2020, 19:61]

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The effectiveness of intravenous ketamine in adults with treatment-resistant major depressive disorder and bipolar disorder presenting with prominent anxiety: Results from the Canadian Rapid Treatment Center of Excellence.

Roger S McIntyre, Nelson B Rodrigues, Orly Lipsitz, Flora Nasri, Hartej Gill, Leanna Mw Lui, Mehala Subramaniapillai, Kevin Kratiuk, Kayla Teopiz, Roger Ho, Yena Lee, Rodrigo B Mansur, Joshua D Rosenblat,

BACKGROUND:Individuals meeting criteria for treatment-resistant depression (TRD) are differentially affected by high levels of anxiety symptoms. AIMS:There is a need to identify the efficacy of novel rapid-onset treatments in adults with mood disorders and comorbid anxious-distress. METHODS:This study included patients with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) ... Read more >>

J Psychopharmacol (Journal of psychopharmacology (Oxford, England))
[2020, :269881120954048]

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Antidepressant Medications and Weight Change: A Narrative Review.

Hartej Gill, Barjot Gill, Sabine El-Halabi, David Chen-Li, Orly Lipsitz, Joshua Daniel Rosenblat, Tamsyn E Van Rheenen, Nelson B Rodrigues, Rodrigo B Mansur, Amna Majeed, Leanna M W Lui, Flora Nasri, Yena Lee, Roger S Mcintyre,

Antidepressant medications are the first-line treatment option for moderate to severe major depressive disorder. However, most antidepressants have numerous documented adverse events, including cardiometabolic effects and weight gain, which are major public health concerns. Antidepressant agents provide varying risk of associated weight gain, including significant within-class differences. Some agents, such ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2020, :]

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Early symptomatic improvements as a predictor of response to repeated-dose intravenous ketamine: Results from the Canadian Rapid Treatment Center of Excellence.

Orly Lipsitz, Roger S McIntyre, Nelson B Rodrigues, Tyler S Kaster, Danielle S Cha, Elisa Brietzke, Hartej Gill, Flora Nasri, Kangguang Lin, Mehala Subramaniapillai, Kevin Kratiuk, Kayla Teopiz, Leanna M W Lui, Yena Lee, Roger Ho, Margarita Shekotikhina, Rodrigo B Mansur, Joshua D Rosenblat,

BACKGROUND:Early symptomatic improvement with monoamine-based antidepressants is predictive of treatment response. The objective of this study was to determine if early symptomatic improvements with intravenous (IV) ketamine predicted treatment response to an acute course of four infusions. METHOD:134 adults with treatment resistant depression (TRD) received four ketamine infusions over one ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2020, 105:110126]

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The emerging role of psilocybin and MDMA in the treatment of mental illness.

Hartej Gill, Barjot Gill, David Chen-Li, Sabine El-Halabi, Nelson B Rodrigues, Danielle S Cha, Orly Lipsitz, Yena Lee, Joshua Daniel Rosenblat, Amna Majeed, Rodrigo B Mansur, Flora Nasri, Roger Ho, Roger S McIntyre,

INTRODUCTION:Mental illness has a chronic course of illness with a number of clinical manifestations. Affected individuals experience significant functional, emotional, cognitive, and/or behavioral impairments. The growing prevalence of mental illness has been associated with significant social and economic costs. Indeed, the economic burden of mental illness is estimated to exceed ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, :1-11]

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Cumulative Cardiovascular Disease Risk and Triglycerides Differentially Relate to Subdomains of Executive Function in Bipolar Disorder; preliminary findings.

Tamsyn E Van Rheenen, Roger S McIntyre, Vicent Balanzá-Martínez, Michael Berk, Susan L Rossell,

OBJECTIVES:Cardiovascular disease is disproportionally prevalent in bipolar disorder (BD) and has been linked to cognition in preliminary studies. Herein we evaluate the association between known risk factors for cardiovascular disease and executive function in BD patients compared to healthy controls. METHODS:In a sample of n=57 individuals (n=23 BD, n=34 controls) ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 278:556-562]

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C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.

Nina Dalkner, Eva Reininghaus, Karin Schwalsberger, Alexandra Rieger, Carlo Hamm, René Pilz, Melanie Lenger, Robert Queissner, Valerie S Falzberger, Martina Platzer, Frederike T Fellendorf, Armin Birner, Susanne A Bengesser, Elisabeth M Weiss, Roger S McIntyre, Harald Mangge, Bernd Reininghaus,

Cognitive dysfunction is a prominent feature of psychiatric disorders. Studies have shown that systemic low-grade inflammation is crucial in the development of cognitive deficits across psychiatric disorders. The aim of this study was to further examine the role of inflammation and inflammatory mediators in cognitive function in psychiatric disorders. This ... Read more >>

Nutrients (Nutrients)
[2020, 12(10):]

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Acyl-Carnitine plasma levels and their association with metabolic syndrome in individuals with schizophrenia.

Bing Cao, Yan Chen, Roger S McIntyre, Lailai Yan,

The metabolic syndrome (MetS) affects individuals with schizophrenia at a higher rate when compared to individuals in the general population. Accumulating evidence indicated that subjects with MetS generally manifest elevated levels of acyl-carnitines, which are important carriers for transporting fatty acyl group. Abnormalities of acyl-carnitines in individuals with schizophrenia with ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 293:113458]

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Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications.

Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earley,

Introduction:Bipolar disorder is a complex mood disorder characterized by a chronic and subtle course of fluctuating manic/hypomanic and depressive symptoms. Cariprazine, a dopamine D₃-preferring D₃/D₂ receptor partial agonist with serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. ... Read more >>

Prim Care Companion CNS Disord (The primary care companion for CNS disorders)
[2020, 22(5):]

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The Association Between Physical and Mental Health and Face Mask Use During the COVID-19 Pandemic: A Comparison of Two Countries With Different Views and Practices.

Cuiyan Wang, Agata Chudzicka-Czupała, Damian Grabowski, Riyu Pan, Katarzyna Adamus, Xiaoyang Wan, Mateusz Hetnał, Yilin Tan, Agnieszka Olszewska-Guizzo, Linkang Xu, Roger S McIntyre, Jessica Quek, Roger Ho, Cyrus Ho,

Background:The physical and mental health of citizens living in a country that encouraged face masks (China) and discouraged face masks (Poland) during the initial stage of the COVID-19 pandemic remained unknown. We conducted a cross-country study to compare the psychological impact of the COVID-19 pandemic on Poles and Chinese. This study aimed ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:569981]

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The Prevalence of Suicidal Behaviour in Fibromyalgia Patients.

Hartej Gill, Carlos D Perez, Barjot Gill, Sabine El-Halabi, Yena Lee, Orly Lipsitz, Caroline Park, Rodrigo B Mansur, Nelson B Rodrigues, Roger S McIntyre, Joshua D Rosenblat,

OBJECTIVE:Fibromyalgia (FM) is a condition associated with chronic pain in muscles and soft tissues. Extant literature has demonstrated an association between FM, mood symptoms and suicidal behaviour. This systematic review aims to synthesize available literature assessing the prevalence of suicidality in FM populations and qualitatively review the included articles. METHODS:PsycINFO, ... Read more >>

Prog. Neuropsychopharmacol. Biol. Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2020, :110078]

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Impact of COVID-19 pandemic on mental health in the general population: A systematic review.

Jiaqi Xiong, Orly Lipsitz, Flora Nasri, Leanna M W Lui, Hartej Gill, Lee Phan, David Chen-Li, Michelle Iacobucci, Roger Ho, Amna Majeed, Roger S McIntyre,

BACKGROUND:As a major virus outbreak in the 21st century, the Coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented hazards to mental health globally. While psychological support is being provided to patients and healthcare workers, the general public's mental health requires significant attention as well. This systematic review aims to ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 277:55-64]

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Effect of Vortioxetine in Subjects with Major Depressive and Alcohol Use Disorders: A Six-Months Retrospective Analysis.

Marco Di Nicola, Maria Pepe, Isabella Panaccione, Lorenzo Moccia, Luigi Dattoli, Marzia Molinaro, Gabriele Sani, Luigi Janiri, Roger S McIntyre,

CNS Spectr (CNS spectrums)
[2020, :1-32]

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Intravenous ketamine for postmenopausal women with treatment-resistant depression: Results from the Canadian Rapid Treatment Center of Excellence.

Orly Lipsitz, Roger S McIntyre, Nelson B Rodrigues, Yena Lee, Danielle S Cha, Hartej Gill, Mehala Subramaniapillai, Kevin Kratiuk, Kangguang Lin, Roger Ho, Rodrigo B Mansur, Joshua D Rosenblat,

Women are disproportionately represented amongst samples of adults with treatment-resistant depression (TRD). Ketamine has demonstrated rapid and robust efficacy in adults with TRD. Herein, we sought to determine whether the effectiveness of intravenous (IV) ketamine was influenced by menopausal status in women with TRD. We defined premenopausal women as those ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, :]

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NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder.

Karl K Johe, Gary Kay, Santosh Kumar, Katherine E Burdick, Roger S McIntyre, George I Papakostas, Maurizio Fava,

BACKGROUND:NSI-189 phosphate (NSI-189) is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent. NSI-189 was previously tested in patients with recurrent major depressive disorder in an inpatient setting. METHODS:This study involved 220 patients randomized to an ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(3):182-196]

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Burden of Treatment Resistant Depression (TRD) in patients with major depressive disorder in Ontario using Institute for Clinical Evaluative Sciences (ICES) databases: Economic burden and healthcare resource utilization.

Roger S McIntyre, Brad Millson, G Sarah Power,

INTRODUCTION:The burden of treatment-resistant depression (TRD) in Canada requires empirical characterization to better inform clinicians and policy decision-making in mental health. Towards this aim, this study utilized the Institute for Clinical Evaluative Sciences (ICES) databases to quantify the economic burden and resource utilization of Patients with TRD in Ontario. METHODS:TRD, ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 277:30-38]

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Changes in symptoms of anhedonia in adults with major depressive or bipolar disorder receiving IV ketamine: Results from the Canadian Rapid Treatment Center of Excellence.

Nelson B Rodrigues, Roger S McIntyre, Orly Lipsitz, Danielle S Cha, Yena Lee, Hartej Gill, Amna Majeed, Lee Phan, Flora Nasri, Roger Ho, Kangguang Lin, Mehala Subramaniapillai, Kevin Kratiuk, Rodrigo B Mansur, Joshua D Rosenblat,

BACKGROUND:Anhedonia is a trans-diagnostic, multidimensional phenotype that mediates patient outcomes and suicidality. Convergent evidence suggests that ketamine may be effective in targeting measures of anhedonia in adults with treatment resistant depression (TRD). METHODS:This retrospective, post-hoc analysis included 203 (x̄ = 45 ± 14.6 years of age) patients receiving four infusions of intravenous (IV) ketamine ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 276:570-575]

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The effect of intravenous, intranasal, and oral ketamine in mood disorders: A meta-analysis.

Roger S McIntyre, Isabelle P Carvalho, Leanna M W Lui, Amna Majeed, Prakash S Masand, Hartej Gill, Nelson B Rodrigues, Orly Lipsitz, Alexandria C Coles, Yena Lee, Jocelyn K Tamura, Michelle Iacobucci, Lee Phan, Flora Nasri, Nikhita Singhal, Elizabeth R Wong, Mehala Subramaniapillai, Rodrigo Mansur, Roger Ho, Raymond W Lam, Joshua D Rosenblat,

BACKGROUND:Ketamine is established as a rapid and effective treatment in adults with treatment-resistant depression (TRD). The availability of different formulations and routes of delivery invites the need for evaluating relative effect sizes. METHODS:Effect size with respect to depression symptom reduction for each formulation and route of delivery was compared at ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 276:576-584]

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Synergistic effect of social media use and psychological distress on depression in China during the COVID-19 epidemic.

Yena Lee, Bing Xiang Yang, Qian Liu, Dan Luo, Lijun Kang, Fang Yang, Simeng Ma, Weicong Lu, David Chen-Li, Joshua D Rosenblat, Rodrigo B Mansur, Flora Nasri, Mehala Subramaniapillai, Zhongchun Liu, Roger S McIntyre, Kangguang Lin,

Psychiatry Clin. Neurosci. (Psychiatry and clinical neurosciences)
[2020, :]

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Novel therapeutic targets in mood disorders: Pentoxifylline (PTX) as a candidate treatment.

Ashley N Siegel, Nelson Rodrigues, Flora Nasri, Linas Wilkialis, Orly Lipsitz, Yena Lee, Hartej Gill, Mehala Subramaniapillai, Lee Phan, Amna Majeed, Leanna M W Lui, Houman Rashidian, Roger Ho, Simina Toma, Benjamin I Goldstein, Rodrigo B Mansur, Roger S McIntyre, Joshua D Rosenblat,

Numerous pharmacological treatments for mood disorders are currently available; however, rates of treatment resistance, relapse and recurrence remain high. Therefore, novel treatments acting outside of the conventionally targeted monoamine system are urgently needed to improve patient outcomes. Emerging and converging evidence suggests that immune dysfunction, oxidative stress, impaired cerebral blood ... Read more >>

Prog. Neuropsychopharmacol. Biol. Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2021, 104:110032]

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The Mental Health Effects of COVID-19 on Health Care Providers in China.

Kangguang Lin, Bing Xiang Yang, Dan Luo, Qian Liu, Simeng Ma, Run Huang, Weicong Lu, Amna Majeed, Yena Lee, Leanna M W Lui, Rodrigo B Mansur, Flora Nasri, Mehala Subramaniapillai, Joshua D Rosenblat, Zhongchun Liu, Roger S McIntyre,

Am J Psychiatry (The American journal of psychiatry)
[2020, 177(7):635-636]

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Economic and humanistic burden associated with noncommunicable diseases among adults with depression and anxiety in the United States.

Eric Armbrecht, Anuj Shah, Patricia Schepman, Ruchit Shah, Elizabeth Pappadopulos, Richard Chambers, Jennifer Stephens, Seema Haider, Roger S McIntyre,

Aims: This study estimated the economic and humanistic burden associated with chronic non-communicable diseases (NCCDs) among adults with comorbid major depressive and/or any anxiety disorders (MDD and/or AAD).Materials and methods: A retrospective analysis was conducted using the Medical Expenditure Panel Survey data (2010-2015). The analytic cohort included adults (≥18 years) with ... Read more >>

J Med Econ (Journal of medical economics)
[2020, 23(9):1032-1042]

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The THINC-it Tool for Cognitive Assessment and Measurement in Major Depressive Disorder: Sensitivity to Change.

Roger S McIntyre, Mehala Subramaniapillai, Caroline Park, Hannah Zuckerman, Bing Cao, Yena Lee, Michelle Iacobucci, Flora Nasri, Dominika Fus, Christopher R Bowie, Tanya Tran, Joshua D Rosenblat, Rodrigo B Mansur,

Background:Herein, we sought to determine the sensitivity to change in cognitive function, as measured by the THINC-it tool, in a sample of adults with major depressive disorder (MDD) receiving standardized antidepressant therapy. Methods:Adults meeting the DSM-5 criteria for MDD with at least moderate depressive symptom severity [i.e., Montgomery Åsberg Depression ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:546]

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