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Author Rodrigo Cavallazzi

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The Burden of Community-Acquired Pneumonia Requiring Admission to an ICU in the United States.

Rodrigo Cavallazzi, Stephen Furmanek, Forest W Arnold, Leslie A Beavin, Richard G Wunderink, Michael S Niederman, Julio A Ramirez,

BACKGROUND:A paucity of studies have assessed the epidemiology of community-acquired pneumonia (CAP) that require ICU admission. We conducted a study on this group of patients with the primary objective of defining the incidence, epidemiology, and mortality rate of CAP in the ICUs in Louisville, KY. The secondary objective was to ... Read more >>

Chest (Chest)
[2020, :]

Cited: 0 times

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Community-acquired pneumonia in chronic obstructive pulmonary disease.

Rodrigo Cavallazzi, Julio Ramirez,

PURPOSE OF REVIEW:The aim of this study was to discuss the literature on community-acquired pneumonia (CAP) in patients with chronic obstructive pulmonary disease (COPD). RECENT FINDINGS:Well designed studies show that COPD is the strongest risk factor for development of CAP. Lung microbiome, abnormal lung immunity and pathogen virulence are important ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):173-181]

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Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.

Rodrigo S Cavallazzi, Barbara J Polivka, Bryan L Beatty, Demetra E Antimisiaris, Rangaraj K Gopalraj, Rachel A Vickers-Smith, Rodney J Folz,

BACKGROUND:Asthma is common in older adults and is confirmed by demonstration of variable expiratory air-flow limitations, typically evaluated by spirometric assessment of bronchodilator responsiveness. However, many patients with clinically suspected asthma and documented air-flow obstruction do not exhibit a post-bronchodilator response that meets or exceeds current established guidelines. We investigated ... Read more >>

Respir Care (Respiratory care)
[2020, :]

Cited: 0 times

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Incidence and Mortality of Adults Hospitalized With Community-Acquired Pneumonia According to Clinical Course.

Paula Peyrani, Forest W Arnold, Jose Bordon, Stephen Furmanek, Carlos M Luna, Rodrigo Cavallazzi, Julio Ramirez,

BACKGROUND:After hospitalization for community-acquired pneumonia (CAP), patients' clinical course may progress to clinical improvement, clinical failure, or nonresolving pneumonia. The epidemiology and outcomes of patients with CAP according to clinical course has not been well studied. The objective of this study was to characterize the incidence and outcomes for each ... Read more >>

Chest (Chest)
[2020, 157(1):34-41]

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A 77-Year-Old Man With Acute Blood Loss and No Apparent Hemorrhage.

Hassan Zeb, Bilal A Jalil, Rodrigo Cavallazzi,

Chest (Chest)
[2019, 156(3):e73-e76]

Cited: 0 times

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Predicting Outcomes in Sepsis.

John D Price, Rodrigo Cavallazzi,

Am. J. Med. Sci. (The American journal of the medical sciences)
[2019, 358(3):173-174]

Cited: 0 times

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Predicting the need for ICU admission in community-acquired pneumonia.

Alessandra Morello Gearhart, Stephen Furmanek, Connor English, Julio Ramirez, Rodrigo Cavallazzi,

BACKGROUND:Multiple criteria have been proposed to define community-acquired pneumonia (CAP) severity and predict ICU admission. Validity studies have found differing results. We tested four models to assess severe CAP built upon the criteria included in the 2007 IDSA/ATS guidelines, hypothesizing that a model providing different weights for each individual criterion ... Read more >>

Respir Med (Respiratory medicine)
[2019, 155:61-65]

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High versus low mean arterial pressures in hepatorenal syndrome: A randomized controlled pilot trial.

Benadin Varajic, Rodrigo Cavallazzi, Jason Mann, Stephen Furmanek, Juan Guardiola, Mohamed Saad,

There is controversy regarding the mean arterial pressure (MAP) goals that should be targeted in the treatment of hepatorenal syndrome (HRS.) We conducted a study to assess different MAP targets in HRS in the intensive care unit (ICU). MATERIALS AND METHODS:This is a prospective randomized controlled pilot trial. ICU patients ... Read more >>

J Crit Care (Journal of critical care)
[2019, 52:186-192]

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A 30-Year-Old Woman With Tricuspid Valvectomy Presents With Shock.

Nikhil Borkhetaria, Molly Howsare, Rodrigo Cavallazzi,

Chest (Chest)
[2019, 155(1):e5-e7]

Cited: 0 times

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Influenza and Viral Pneumonia.

Rodrigo Cavallazzi, Julio A Ramirez,

Influenza and other respiratory viruses are commonly identified in patients with community-acquired pneumonia, hospital-acquired pneumonia, and in immunocompromised patients with pneumonia. Clinically, it is difficult to differentiate viral from bacterial pneumonia. Similarly, the radiological findings of viral infection are nonspecific. The advent of polymerase chain reaction testing has enormously facilitated ... Read more >>

Clin. Chest Med. (Clinics in chest medicine)
[2018, 39(4):703-721]

Cited: 1 time

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Predicting fluid responsiveness: A review of literature and a guide for the clinician.

Bilal A Jalil, Rodrigo Cavallazzi,

Volume resuscitation is of utmost importance in the treatment of shock. It is imperative that this resuscitation be guided using a reliable method of ascertaining volume status to avoid the ill-effects of hypovolemia while also avoiding those of over-resuscitation. There are numerous tools and methods available in this era to ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2018, 36(11):2093-2102]

Cited: 2 times

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Predicting asthma in older adults on the basis of clinical history.

Rodrigo Cavallazzi, Anna Jorayeva, Bryan L Beatty, Demetra Antimisiaris, Rangaraj Gopalraj, John Myers, Rodney J Folz, Barbara J Polivka,

BACKGROUND:The diagnosis of asthma is not always straightforward and can be even more challenging in older adults. Asthma is ideally confirmed by demonstration of variable expiratory airflow limitation. However, many patients with asthma do not demonstrate airflow obstruction nor show bronchodilator reversibility. We aimed to investigate predictors for a positive ... Read more >>

Respir Med (Respiratory medicine)
[2018, 142:36-40]

Cited: 1 time

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Impact of Quality Improvement on Care of Chronic Obstructive Pulmonary Disease Patients in an Internal Medicine Resident Clinic.

Robert M Burkes, Takudzwa Mkorombindo, Udit Chaddha, Alok Bhatt, Karim El-Kersh, Rodrigo Cavallazzi, Nancy Kubiak,

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality. Guideline-discordant care of COPD is not uncommon. Further, there is a push to incorporate quality improvement (QI) training into internal medicine (IM) residency curricula. This study compared quality of care of COPD patients in an IM residents' ... Read more >>

Healthcare (Basel) (Healthcare (Basel, Switzerland))
[2018, 6(3):]

Cited: 1 time

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Reply.

Karim El-Kersh, Rodrigo Cavallazzi, Stephen A McClave, Mohamed Saad,

J Crit Care (Journal of critical care)
[2018, 45:251-252]

Cited: 0 times

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Antibiotic Timing and Outcomes in Sepsis.

Richard Y Kim, Alex M Ng, Annuradha K Persaud, Stephen P Furmanek, Yash N Kothari, John D Price, Timothy L Wiemken, Mohamed A Saad, Juan J Guardiola, Rodrigo S Cavallazzi,

BACKGROUND:We evaluated the effect of time spent in the emergency department (ED) and process of care on mortality and length of hospital stay in patients with sepsis or septic shock. METHODS:An observational cohort study was conducted on 117 patients who came through the University of Louisville Hospital ED and subsequently ... Read more >>

Am. J. Med. Sci. (The American journal of the medical sciences)
[2018, 355(6):524-529]

Cited: 1 time

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Outcomes of adenotonsillectomy in severe pediatric obstructive sleep apnea.

Karim El-Kersh, Rodrigo Cavallazzi, Egambaram Senthilvel,

We conducted a retrospective chart review to examine the efficacy of adenotonsillectomy for the treatment of severe obstructive sleep apnea (OSA) in children. Our study population was made up of 85 patients-58 boys and 27 girls, aged 1 to 17 years (mean: 6.9 ± 4.4)-with severe OSA who had undergone ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2017, 96(12):E6-E9]

Cited: 1 time

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Sleep Disordered Breathing and Magnetic Resonance Imaging Findings in Children With Chiari Malformation Type I.

Karim El-Kersh, Rodrigo Cavallazzi, Alicia Fernandez, Karen Moeller, Egambaram Senthilvel,

Pediatr. Neurol. (Pediatric neurology)
[2017, 76:95-96]

Cited: 0 times

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Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality.

Julio A Ramirez, Timothy L Wiemken, Paula Peyrani, Forest W Arnold, Robert Kelley, William A Mattingly, Raul Nakamatsu, Senen Pena, Brian E Guinn, Stephen P Furmanek, Annuradha K Persaud, Anupama Raghuram, Francisco Fernandez, Leslie Beavin, Rahel Bosson, Rafael Fernandez-Botran, Rodrigo Cavallazzi, Jose Bordon, Claudia Valdivieso, Joann Schulte, Ruth M Carrico, ,

Understanding the burden of community-acquired pneumonia (CAP) is critical to allocate resources for prevention, management, and research. The objectives of this study were to define incidence, epidemiology, and mortality of adult patients hospitalized with CAP in the city of Louisville, and to estimate burden of CAP in the US adult ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(11):1806-1812]

Cited: 32 times

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Comparing Changes in Carotid Flow Time and Stroke Volume Induced by Passive Leg Raising.

Bilal Jalil, Patton Thompson, Rodrigo Cavallazzi, Paul Marik, Jason Mann, Karim El-Kersh, Juan Guardiola, Mohamed Saad,

Determining volume responsiveness in critically ill patients is challenging. We sought to determine if passive leg raise (PLR) induced changes in pulsed wave Doppler of the carotid artery flow time could predict fluid responsiveness in critically ill patients.Medical intensive care unit patients ≥18 years old with a radial arterial line ... Read more >>

Am. J. Med. Sci. (The American journal of the medical sciences)
[2018, 355(2):168-173]

Cited: 1 time

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Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study.

Karim El-Kersh, Bilal Jalil, Stephen A McClave, Rodrigo Cavallazzi, Juan Guardiola, Karen Guilkey, Annuradha K Persaud, Stephen P Furmanek, Brian E Guinn, Timothy L Wiemken, Bashar Chihada Alhariri, Scott P Kellie, Mohamed Saad,

PURPOSE:We investigated whether early enteral nutrition alone may be sufficient prophylaxis against stress-related gastrointestinal (GI) bleeding in mechanically ventilated patients. MATERIALS AND METHODS:Prospective, double blind, randomized, placebo-controlled, exploratory study that included mechanically ventilated patients in medical ICUs of two academic hospitals. Intravenous pantoprazole and early enteral nutrition were compared to ... Read more >>

J Crit Care (Journal of critical care)
[2018, 43:108-113]

Cited: 8 times

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The order of administration of macrolides and beta-lactams may impact the outcomes of hospitalized patients with community-acquired pneumonia: results from the community-acquired pneumonia organization.

Paula Peyrani, Timothy L Wiemken, Mark L Metersky, Forest W Arnold, William A Mattingly, Charles Feldman, Rodrigo Cavallazzi, Rafael Fernandez-Botran, Jose Bordon, Julio A Ramirez,

The beneficial effect of macrolides for the treatment of community-acquired pneumonia (CAP) in combination with beta-lactams may be due to their anti-inflammatory activity. In patients with pneumococcal meningitis, the use of steroids improves outcomes only if they are administered before beta-lactams. The objective of this study was to compare outcomes ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2018, 50(1):13-20]

Cited: 6 times

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Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study.

Timothy L Wiemken, Robert R Kelley, Rafael Fernandez-Botran, William A Mattingly, Forest W Arnold, Stephen P Furmanek, Marcos I Restrepo, James D Chalmers, Paula Peyrani, Rodrigo Cavallazzi, Jose Bordon, Stefano Aliberti, Julio A Ramirez,

Patients with severe community-acquired pneumonia (CAP) are believed to have an exaggerated inflammatory response to bacterial infection. Therapies aiming to modulate the inflammatory response have been largely unsuccessful, perhaps reflecting that CAP is a heterogeneous disorder that cannot be modulated by a single anti-inflammatory approach. We hypothesize that the host ... Read more >>

Univ Louisville J Respir Infect (The University of Louisville journal of respiratory infections)
[2017, 1(1):3-11]

Cited: 1 time

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Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis.

Delphine Weil, Eric Levesque, Marc McPhail, Rodrigo Cavallazzi, Eleni Theocharidou, Evangelos Cholongitas, Arnaud Galbois, Heng Chih Pan, Constantine J Karvellas, Bertrand Sauneuf, René Robert, Jérome Fichet, Gaël Piton, Thierry Thevenot, Gilles Capellier, Vincent Di Martino, ,

The best predictors of short- and medium-term mortality of cirrhotic patients receiving intensive care support are unknown.We conducted meta-analyses from 13 studies (2523 cirrhotics) after selection of original articles and response to a standardized questionnaire by the corresponding authors. End-points were in-ICU, in-hospital, and 6-month mortality in ICU survivors. A ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2017, 7(1):33]

Cited: 8 times

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Opioid overdose leading to intensive care unit admission: Epidemiology and outcomes.

Robert Burkes, Gregory Pfister, Brian Guinn, Rodrigo Cavallazzi,

J Crit Care (Journal of critical care)
[2017, 37:261]

Cited: 1 time

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Tuberculosis is always a possibility (even in the intensive care unit).

Rodrigo Cavallazzi, Rosemeri Maurici, Julio A Ramirez,

Rev Bras Ter Intensiva (Revista Brasileira de terapia intensiva)
[2016, 28(2):97-99]

Cited: 0 times

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