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Author Roderick H W Simpson

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

Cited: 0 times

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Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.

Alena Skálová, Martina Banečkova, Lester D R Thompson, Nikola Ptáková, Todd M Stevens, Luka Brcic, Martin Hyrcza, Michael Michal, Roderick H W Simpson, Thalita Santana, Michal Michal, Tomas Vaněček, Ilmo Leivo,

<h4>Background</h4>Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by a recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET, ETV6-MAML3, and ETV6-MET fusions have been found in a subset of SCs lacking the classic ETV6-NTRK3 fusion transcript, but still ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1295-1307]

Cited: 2 times

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MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study.

John B McIntyre, Jenny J Ko, Jodi Siever, Angela M Y Chan, Roderick H W Simpson, Desiree Hao, Harold Y Lau,

<h4>Background</h4>Adenoid cystic carcinoma (ACC) is a slow growing salivary gland malignancy that is molecularly characterized by t(6:9)(q22-23;p23-24) translocations which predominantly result in MYB-NFIB gene fusions in nearly half of tumours. Detection of MYB-NFIB transcripts is typically performed with fresh ACC tissue using conventional RT-PCR fragment analysis or FISH techniques, which ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2019, 14(1):78]

Cited: 0 times

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The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.

Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito,

Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(2):e11-e27]

Cited: 20 times

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.

Alena Skalova, Tomas Vanecek, Petr Martinek, Ilan Weinreb, Todd M Stevens, Roderick H W Simpson, Martin Hyrcza, Niels J Rupp, Martina Baneckova, Michael Michal, David Slouka, Tomas Svoboda, Alena Metelkova, Arghavan Etebarian, Jaroslav Pavelka, Steven J Potts, Jason Christiansen, Petr Steiner, Michal Michal,

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(2):234-246]

Cited: 28 times

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SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.

Abbas Agaimy, Arndt Hartmann, Cristina R Antonescu, Simion I Chiosea, Samir K El-Mofty, Helene Geddert, Heinrich Iro, James S Lewis, Bruno Märkl, Stacey E Mills, Marc-Oliver Riener, Thomas Robertson, Ann Sandison, Sabine Semrau, Roderick H W Simpson, Edward Stelow, William H Westra, Justin A Bishop,

To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient sinonasal carcinomas collected from multiple medical centers. The tumors affected 23 males and 16 females with an age ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2017, 41(4):458-471]

Cited: 36 times

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Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.

Alena Skálová, Tomas Vanecek, Roderick H W Simpson, Jan Laco, Hanna Majewska, Martina Baneckova, Petr Steiner, Michal Michal,

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), and has not been documented in any other ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2016, 40(1):3-13]

Cited: 62 times

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Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.

Alena Skálová, Ilan Weinreb, Martin Hyrcza, Roderick H W Simpson, Jan Laco, Abbas Agaimy, Marina Vazmitel, Hanna Majewska, Tomas Vanecek, Peter Talarčik, Spomenka Manajlovic, Simona N Losito, Petr Šteiner, Adela Klimkova, Michal Michal,

This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clear cell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2015, 39(3):338-348]

Cited: 36 times

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Recent advances in the diagnostic pathology of salivary carcinomas.

Roderick H W Simpson, Alena Skálová, Silvana Di Palma, Ilmo Leivo,

This review concentrates on the most important developments since the WHO classification of 2005. In particular, the identification of specific translocations is revolutionising the way salivary tumours are considered and will have a major impact on future diagnostic practice. This is true so far in four malignancies: mammary analogue secretory, ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2014, 465(4):371-384]

Cited: 34 times

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CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.

Alena Skálová, Tomas Vanecek, Roderick H W Simpson, Marina A Vazmitsel, Hanna Majewska, Petr Mukensnabl, Lukas Hauer, Pavel Andrle, Lubor Hosticka, Petr Grossmann, Michal Michal,

The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified in a large proportion of mucoepidermoid carcinomas (MECs) of the salivary gland and have impact on prognosis. However, there are conflicting data on the specificity of this translocation, in particular, on its putative occurrence ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2013, 37(11):1743-1750]

Cited: 18 times

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Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes.

Alena Skálová, Tomas Vanecek, Hanna Majewska, Jan Laco, Petr Grossmann, Roderick H W Simpson, Lukas Hauer, Pavel Andrle, Lubor Hosticka, Jindrich Branžovský, Michal Michal,

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2014, 38(1):23-33]

Cited: 71 times

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Salivary duct carcinoma: new developments--morphological variants including pure in situ high grade lesions; proposed molecular classification.

Roderick H W Simpson,

Salivary duct carcinoma (SDC) is an aggressive primary salivary malignancy which microscopically resembles high-grade ductal carcinoma of the breast, with both in situ and invasive patterns. It is typically found in older men, most often in the parotid. It can arise de novo or as the malignant component of carcinoma ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2013, 7 Suppl 1:S48-58]

Cited: 38 times

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Pleomorphic adenoma of the salivary glands with intravascular tumor deposits: a diagnostic pitfall.

Alena Skalova, Albina Altemani, Silvana Di Palma, Roderick H W Simpson, Lubor Hosticka, Pavel Andrle, Jan Laco, Mary Toner, Marina A Vozmitsel, Susan Szakacs, Dmitry V Kazakov, Zdenek Kinkor, Michal Michal,

The diagnosis of pleomorphic adenoma (PA) of salivary glands is usually straightforward posing few diagnostic problems for the general surgical histopathologist. The purpose of our investigation was to present a series of 22 cases of PA of major salivary glands, each of which contained small foci of tumor within vascular ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2012, 36(11):1674-1682]

Cited: 12 times

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Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes.

Silvana Di Palma, Roderick H W Simpson, Caterina Marchiò, Alena Skálová, Marco Ungari, Ann Sandison, Stephen Whitaker, Suzanne Parry, Jorge S Reis-Filho,

<h4>Aims</h4>The aim of this study was to devise a molecular classification for salivary duct carcinomas (SDCs) based on the similarities between SDCs and breast carcinomas and on characteristics of the microarray-based gene expression profiling-defined molecular subtypes of breast cancer.<h4>Methods and results</h4>Forty-two pure salivary duct carcinomas, 35 of which contained an ... Read more >>

Histopathology (Histopathology)
[2012, 61(4):629-643]

Cited: 40 times

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Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors.

Raja R Seethala, Lester D R Thompson, Douglas R Gnepp, E Leon Barnes, Alena Skalova, Kathleen Montone, Shubhada Kane, James S Lewis, Lynn W Solomon, Roderick H W Simpson, Ashraf Khan, Manju L Prasad,

Lymphadenomas (LADs) are rare salivary gland tumors. Their clinicopathologic characteristics and etiopathogenesis are poorly understood. We examined 33 LADs in 31 patients (17 women and 14 men) aged 11-79 years (median 65 years). There were 22 sebaceous LADs in 21 patients (9 women and 12 men) and 11 non-sebaceous LADs ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2012, 25(1):26-35]

Cited: 25 times

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Signet ring cell tumor of the minor salivary gland exhibiting benign behavior.

Maria P Foschini, Chiara Baldovini, Maria G Pennesi, Roberto Cocchi, Roderick H W Simpson,

Signet ring cell (SRC) carcinomas are usually aggressive malignancies, arising most frequently in the stomach and gastrointestinal tract, but also, although less often, in other organs such as the breast, bladder, and lungs. They are particularly unusual in the salivary glands, and the aim of the present study is to ... Read more >>

Hum Pathol (Human pathology)
[2012, 43(2):303-306]

Cited: 7 times

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Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity.

Alena Skalova, Radek Sima, Jana Kaspirkova-Nemcova, Roderick H W Simpson, Goran Elmberger, Ilmo Leivo, Silvana Di Palma, Tomas Jirasek, Douglas R Gnepp, Ilan Weinreb, Bayardo Perez-Ordoñez, Petr Mukensnabl, Boris Rychly, Petr Hrabal, Michal Michal,

We present a series of 23 cases of a distinctive, hitherto poorly recognized low-grade adenocarcinoma, with several histologic features reminiscent of papillary carcinoma of the thyroid, and which mostly but not exclusively occurs in the tongue. All the tumors were unencapsulated and were divided into lobules that were composed mainly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2011, 35(8):1168-1176]

Cited: 36 times

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Relationship between endometriosis, endometrioid adenocarcinoma, gliomatosis peritonei, and carcinoid tumor in a patient with recurrent ovarian teratoma.

Mary Alexander, Nichola Cope, John Renninson, Ann Hong, Roderick H W Simpson, Lynn Hirschowitz,

Gliomatosis peritonei (GP) describes the implantation of mature neuroglial tissue in the peritoneum and is usually associated with mature ovarian teratoma but is also found in cases of immature teratoma. We report the case of a patient with recurrent mature ovarian teratoma, GP, endometriosis (with malignant transformation), and carcinoid tumor, ... Read more >>

Int J Gynecol Pathol (International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists)
[2011, 30(2):151-157]

Cited: 2 times

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Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker.

Alena Skálová, Douglas R Gnepp, Roderick H W Simpson, Jean E Lewis, Dirk Janssen, Radek Sima, Tomas Vanecek, Silvana Di Palma, Michal Michal,

Sclerosing polycystic adenosis (SPA) is a recently described, rare lesion of the salivary glands that bears a resemblance to epithelial proliferative lesions of the breast. The true nature of the lesion is unknown, but up to now it has been generally believed to represent a pseudoneoplastic sclerosing and inflammatory process. ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2006, 30(8):939-944]

Cited: 28 times

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Mixed epithelial and stromal tumors of the kidney. A report of 22 cases.

Michal Michal, Ondrej Hes, Michele Bisceglia, Roderick H W Simpson, Dominic V Spagnolo, Alberto Parma, Ludmila Boudova, Milan Hora, Roman Zachoval, Saul Suster,

Mixed epithelial and stromal tumor of the kidney (MESTK) is a recently described subset of renal neoplasm that tends to occur in middle-aged and older women and is characterized by a distinctive histological appearance. To further characterize this lesion, we report the clinicopathological and immunohistochemical features of 22 additional cases ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2004, 445(4):359-367]

Cited: 67 times

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Mucinous carcinoma of the skin, primary, and secondary: a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast.

Dmitry V Kazakov, Saul Suster, Philip E LeBoit, Eduardo Calonje, Michele Bisceglia, Heinz Kutzner, Arno Rütten, Thomas Mentzel, Jörg Schaller, Bernhard Zelger, Mehmet Baltaci, Ilmo Leivo, Christian Rose, Masaharu Fukunaga, Roderick H W Simpson, Yu Yang, J Andrew Carlson, Alberto Cavazza, Ondrej Hes, Petr Mukensnabl, Tomas Vanecek, Ana Fidalgo, Karel Pizinger, Michal Michal,

We present the largest series of mucinous carcinoma involving the skin, describing the histopathologic, immunohistochemical, electron microscopic, and cytogenetic findings. Our aim was fully to characterize the clinicopathologic spectrum and compare it with that seen in the breast. In addition, we wished to reevaluate the differential diagnostic criteria for distinguishing ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2005, 29(6):764-782]

Cited: 65 times

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Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus.

Dmitry V Kazakov, Iva Mikyskova, Heinz Kutzner, Roderick H W Simpson, Ondrej Hes, Petr Mukensnabl, Jiri Bouda, Michal Zamecnik, Zdenek Kinkor, Michal Michal,

Reported here are 18 cases of hidradenoma papilliferum with oxyphilic metaplasia. All patients were women ranging in age from 29 to 74 years. Each presented clinically with a small, solitary tumor in the anogenital region. Microscopically, in addition to classic histopathological features, in every case there was oxyphilic metaplasia of ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2005, 27(2):102-110]

Cited: 24 times

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Low-grade salivary duct carcinoma: description of 16 cases.

Margaret Brandwein-Gensler, Jos Hille, Beverly Y Wang, Mark Urken, Ronald Gordon, Li Juan Wang, James R M Simpson, Roderick H W Simpson, Douglas R Gnepp,

Low-grade salivary duct carcinoma is a rare neoplasm. We report on 16 patients, with a median age of 64 years. All but one tumor arose from the parotid gland, including one tumor that arose in an intraparotid lymph node; one arose in the submandibular gland. Tumors consist of single to ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2004, 28(8):1040-1044]

Cited: 68 times

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Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases.

Roderick H W Simpson, Anil R Prasad, Jean E Lewis, Alena Skálová, Leonor David,

Salivary duct carcinoma is a relatively uncommon aggressive neoplasm, typically found in the parotid glands of older men. The histologic appearance is that of an in situ and invasive high-grade adenocarcinoma, and it closely resembles ductal carcinoma of the breast. Several variants of the latter are very well known, but ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2003, 27(8):1070-1079]

Cited: 47 times

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