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Author Robyn P M Saw

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Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy.

B Mark Smithers, Robyn P M Saw, David E Gyorki, Richard C W Martin, Victoria Atkinson, Andrew Haydon, Rachel Roberts-Thomson, John F Thompson,

Australia and New Zealand have the highest incidence and mortality rates for melanoma in the world. Local surgery is still the standard treatment of primary cutaneous melanoma, and it is therefore important that surgeons understand the optimal care pathways for patients with melanoma. Accurate staging is critical to ensure a ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91 Suppl 2:3-13]

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Histological regression in melanoma: impact on sentinel lymph node status and survival.

Karina Aivazian, Tasnia Ahmed, Mary-Ann El Sharouni, Jonathan R Stretch, Robyn P M Saw, Andrew J Spillane, Kerwin F Shannon, Sydney Ch'ng, Omgo E Nieweg, John F Thompson, Serigne N Lo, Richard A Scolyer,

Regression in melanoma is an immunological phenomenon that results in partial or complete replacement of the tumor with variably vascular fibrous tissue, often accompanied by pigment-laden macrophages and chronic inflammation. In some cases, tumor-infiltrating lymphocytes (TILs) may represent the earliest phase of this process. The prognostic significance of regression has ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Clinical and Molecular Heterogeneity in Patients with Innate Resistance to Anti-PD-1 +/- Anti-CTLA-4 Immunotherapy in Metastatic Melanoma Reveals Distinct Therapeutic Targets.

Tuba N Gide, Inês Pires da Silva, Camelia Quek, Peter M Ferguson, Marcel Batten, Ping Shang, Tasnia Ahmed, Alexander M Menzies, Matteo S Carlino, Robyn P M Saw, John F Thompson, Richard A Scolyer, Georgina V Long, James S Wilmott,

While immune checkpoint inhibitors targeting the CTLA-4 and PD-1 receptors have significantly improved outcomes of many patients with metastatic melanoma, there remains a group of patients who demonstrate no benefit. In this study, we sought to characterise patients who do not respond to anti-PD-1-based therapies based on their clinical, genetic ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies.

Sydney Ch'ng, Semra Uyulmaz, Matteo S Carlino, Thomas E Pennington, Kerwin F Shannon, Michael Rtshiladze, Jonathan R Stretch, Omgo E Nieweg, Alexander H R Varey, Edward Hsiao, Rony Kapoor, Ines Pires da Silva, Serigne N Lo, Andrew J Spillane, Richard A Scolyer, Georgina V Long, Angela M Hong, Robyn P M Saw, John F Thompson, Alexander M Menzies,

Although previously the mainstay of treatment, the role of surgery in the management of patients with oligometastatic stage IV melanoma has changed with the advent of effective systemic therapies (most notably immunotherapy). Contemporary treatment options for patients with asymptomatic solitary or oligo-metastases include upfront surgery followed by adjuvant immunotherapy or ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 153:8-15]

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Treatment of in-transit melanoma metastases using intralesional PV-10.

John F Thompson, Robyn P M Saw, Johanna M Dalton, Jonathan R Stretch, Andrew J Spillane, Natalie S Osborne, Gabrielle J Williams, Serigne N Lo,

Melanoma in-transit metastases (ITMs) can sometimes be difficult to manage by surgical excision due to their number, size or location. Treatment by intralesional injection of PV-10, a 10% solution of rose bengal, has been reported to be a simple, safe and effective alternative, but more outcome data are required to ... Read more >>

Melanoma Res (Melanoma research)
[2021, 31(3):232-241]

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Can patient-led surveillance detect subsequent new primary or recurrent melanomas and reduce the need for routinely scheduled follow-up? A protocol for the MEL-SELF randomised controlled trial.

Deonna M Ackermann, Amelia K Smit, Monika Janda, Cathelijne H van Kemenade, Mbathio Dieng, Rachael L Morton, Robin M Turner, Anne E Cust, Les Irwig, Jolyn K Hersch, Pascale Guitera, H Peter Soyer, Victoria Mar, Robyn P M Saw, Donald Low, Cynthia Low, Dorothy Drabarek, David Espinoza, Jon Emery, Peter Murchie, John F Thompson, Richard A Scolyer, Anthony Azzi, Alister Lilleyman, Katy J L Bell,

<h4>Background</h4>Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). Routinely scheduled clinic visits (clinician-led surveillance) is resource-intensive and has not been shown to improve health outcomes; fewer visits may be possible ... Read more >>

Trials (Trials)
[2021, 22(1):324]

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Reply to: CT and PET/CT Surveillance in Stage IIIA-D Melanoma Results in More False-Positive Than True-Positive Findings and Should Not be Routinely Recommended, by Nicholas Taylor et al.

Mbathio Dieng, Sarah J Lord, Omgo E Nieweg, Robyn P M Saw, Andrew J Einstein, Amanda A G Nijhuis, Robin M Turner, John F Thompson, Rachael L Morton,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

Cited: 1 time

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Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).

Alexander M Menzies, Rodabe N Amaria, Elisa A Rozeman, Alexander C Huang, Michael T Tetzlaff, Bart A van de Wiel, Serigne Lo, Ahmad A Tarhini, Elizabeth M Burton, Thomas E Pennington, Robyn P M Saw, Xiaowei Xu, Giorgos C Karakousis, Paolo A Ascierto, Andrew J Spillane, Alexander C J van Akkooi, Michael A Davies, Tara C Mitchell, Hussein A Tawbi, Richard A Scolyer, Jennifer A Wargo, Christian U Blank, Georgina V Long,

The association among pathological response, recurrence-free survival (RFS) and overall survival (OS) with neoadjuvant therapy in melanoma remains unclear. In this study, we pooled data from six clinical trials of anti-PD-1-based immunotherapy or BRAF/MEK targeted therapy. In total, 192 patients were included; 141 received immunotherapy (104, combination of ipilimumab and ... Read more >>

Nat Med (Nature medicine)
[2021, 27(2):301-309]

Cited: 9 times

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Neoadjuvant ipilimumab plus nivolumab in synchronous clinical stage III melanoma.

Judith M Versluis, Irene L M Reijers, Elisa A Rozeman, Alexander M Menzies, Alexander C J van Akkooi, Michel W Wouters, Sydney Ch'ng, Robyn P M Saw, Richard A Scolyer, Bart A van de Wiel, Bastian Schilling, Georgina V Long, Christian U Blank,

<h4>Background</h4>Patients with synchronous clinical stage III melanoma can present with primary melanoma lesions, locally recurrent melanoma or in-transit metastases. Neoadjuvant ipilimumab plus nivolumab induces high pathologic response rates and an impressive relapse-free survival in patients with nodal macroscopic stage III melanoma. Whether primary site melanoma and in-transit metastases respond similarly ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 148:51-57]

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Performance of Long-Term CT and PET/CT Surveillance for Detection of Distant Recurrence in Patients with Resected Stage IIIA-D Melanoma.

Robin M Turner, Mbathio Dieng, Nikita Khanna, Mai Nguyen, Jiaxu Zeng, Amanda A G Nijhuis, Omgo E Nieweg, Andrew J Einstein, Louise Emmett, Sarah J Lord, Alexander M Menzies, John F Thompson, Robyn P M Saw, Rachael L Morton,

<h4>Background</h4>Follow-up for patients with resected stage IIIA-D melanoma may include computed tomography (CT) or positron emission tomography (PET)/CT imaging to identify distant metastases. The aim of this study was to evaluate the test performance over follow-up time, of structured 6- and 12-monthly follow-up imaging schedules in these patients.<h4>Methods</h4>We conducted a ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(8):4561-4569]

Cited: 2 times

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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Matthew H Bailey, William U Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, , , Gordon Saksena, Kyle Ellrott, Michael C Wendl, David A Wheeler, Gad Getz, Jared T Simpson, Mark B Gerstein, Li Ding, ,

Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20128-w. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):6232]

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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Matthew H Bailey, William U Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, , , Gordon Saksena, Kyle Ellrott, Michael C Wendl, David A Wheeler, Gad Getz, Jared T Simpson, Mark B Gerstein, Li Ding, ,

The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4748]

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Multiplex melanoma families are enriched for polygenic risk.

Matthew H Law, Lauren G Aoude, David L Duffy, Georgina V Long, Peter A Johansson, Antonia L Pritchard, Kiarash Khosrotehrani, Graham J Mann, Grant W Montgomery, Mark M Iles, Anne E Cust, Jane M Palmer, , Kerwin F Shannon, Andrew J Spillane, Jonathan R Stretch, John F Thompson, Robyn P M Saw, Richard A Scolyer, Nicholas G Martin, Nicholas K Hayward, Stuart MacGregor,

Cancers, including cutaneous melanoma, can cluster in families. In addition to environmental etiological factors such as ultraviolet radiation, cutaneous melanoma has a strong genetic component. Genetic risks for cutaneous melanoma range from rare, high-penetrance mutations to common, low-penetrance variants. Known high-penetrance mutations account for only about half of all densely ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, 29(17):2976-2985]

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Staging 18F-FDG PET/CT influences the treatment plan in melanoma patients with satellite or in-transit metastases.

Lodewijka H J Holtkamp, Annette H Chakera, Sebastian Fung, Jonathan R Stretch, Robyn P M Saw, Kenneth Lee, Sydney Ch'ng, Maria Gonzalez, John F Thompson, Louise Emmett, Omgo E Nieweg,

Whole-body positron emission tomography/computed tomography (PET/CT) and brain magnetic resonance imaging (MRI) are commonly used to stage patients with palpable lymph node metastases from melanoma, but their role in patients with satellite and/or in-transit metastasis (S&ITM) is unclear. The aim of this study was to establish the diagnostic value of ... Read more >>

Melanoma Res (Melanoma research)
[2020, 30(4):358-363]

Cited: 1 time

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Sex differences in oncogenic mutational processes.

Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, , Paul C Boutros, ,

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4330]

Cited: 6 times

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Clinical outcomes following surgical treatment of lentigo maligna of the head and neck.

Gareth Crouch, Shiba Sinha, Serigne Lo, Robyn P M Saw, Kenneth K Lee, Jonathan Stretch, Kerwin Shannon, Pascale Guitera, Richard A Scolyer, John F Thompson, Sydney Ch'ng,

<h4>Introduction</h4>Lentigo maligna (LM), a subtype of melanoma in-situ commonly occurring in the head and neck region, often presents a treatment challenge due to anatomical constraints, particularly on the face of mostly elderly patients. This study sought to assess the clinical outcomes of wide local excision of head and neck LM, ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(5):1145-1151]

Cited: 1 time

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Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.

Felicity Newell, James S Wilmott, Peter A Johansson, Katia Nones, Venkateswar Addala, Pamela Mukhopadhyay, Natasa Broit, Carol M Amato, Robert Van Gulick, Stephen H Kazakoff, Ann-Marie Patch, Lambros T Koufariotis, Vanessa Lakis, Conrad Leonard, Scott Wood, Oliver Holmes, Qinying Xu, Karl Lewis, Theresa Medina, Rene Gonzalez, Robyn P M Saw, Andrew J Spillane, Jonathan R Stretch, Robert V Rawson, Peter M Ferguson, Tristan J Dodds, John F Thompson, Georgina V Long, Mitchell P Levesque, William A Robinson, John V Pearson, Graham J Mann, Richard A Scolyer, Nicola Waddell, Nicholas K Hayward,

To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching transcriptome sequencing for 63 tumors was performed. Here we report that mutational signature analysis reveals a subset of tumors, mostly ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5259]

Cited: 7 times

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Tumor Mutation Burden and Structural Chromosomal Aberrations Are Not Associated with T-cell Density or Patient Survival in Acral, Mucosal, and Cutaneous Melanomas.

Jarem Edwards, Peter M Ferguson, Serigne N Lo, Inês Pires da Silva, Andrew J Colebatch, Hansol Lee, Robyn P M Saw, John F Thompson, Alexander M Menzies, Georgina V Long, Felicity Newell, John V Pearson, Nicola Waddell, Nicholas K Hayward, Peter A Johansson, Graham J Mann, Richard A Scolyer, Umaimainthan Palendira, James S Wilmott,

Tumor mutation burden (TMB) has been proposed as a key determinant of immunogenicity in several cancers, including melanoma. The evidence presented thus far, however, is often contradictory and based mostly on RNA-sequencing data for the quantification of immune cell phenotypes. Few studies have investigated TMB across acral, mucosal, and cutaneous ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, 8(11):1346-1353]

Cited: 1 time

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Reappraisal of the prognostic significance of mitotic rate supports its reincorporation into the melanoma staging system.

Mohammed Kashani-Sabet, James R Miller, Serigne Lo, Mehdi Nosrati, Jonathan R Stretch, Kerwin F Shannon, Andrew J Spillane, Robyn P M Saw, James E Cleaver, Kevin B Kim, Stanley P Leong, John F Thompson, Richard A Scolyer,

<h4>Background</h4>Mitotic rate is a strong, independent prognostic factor in patients with melanoma. However, incorporating it into the melanoma staging system has proved challenging.<h4>Methods</h4>The prognostic impact of mitotic rate was assessed in a melanoma cohort comprising 5050 patients from 2 geographically distinct populations. Computer-generated cut points for mitotic rate were constructed ... Read more >>

Cancer (Cancer)
[2020, 126(21):4717-4725]

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Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.

Russell J Diefenbach, Jenny H Lee, Alexander M Menzies, Matteo S Carlino, Georgina V Long, Robyn P M Saw, Julie R Howle, Andrew J Spillane, Richard A Scolyer, Richard F Kefford, Helen Rizos,

Detection of melanoma-associated mutations using circulating tumor DNA (ctDNA) from plasma is a potential alternative to using genomic DNA from invasive tissue biopsies. In this study, we developed a custom melanoma next-generation sequencing (NGS) panel which includes 123 amplicons in 30 genes covering driver and targetable mutations and alterations associated ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(8):]

Cited: 4 times

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Improved Risk Prediction Calculator for Sentinel Node Positivity in Patients With Melanoma: The Melanoma Institute Australia Nomogram.

Serigne N Lo, Jiawen Ma, Richard A Scolyer, Lauren E Haydu, Jonathan R Stretch, Robyn P M Saw, Omgo E Nieweg, Kerwin F Shannon, Andrew J Spillane, Sydney Ch'ng, Graham J Mann, Jeffrey E Gershenwald, John F Thompson, Alexander H R Varey,

<h4>Purpose</h4>For patients with primary cutaneous melanoma, the risk of sentinel node (SN) metastasis varies according to several clinicopathologic parameters. Patient selection for SN biopsy can be assisted by National Comprehensive Cancer Network (NCCN) and ASCO/Society of Surgical Oncology (SSO) guidelines and the Memorial Sloan Kettering Cancer Center (MSKCC) online nomogram. ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(24):2719-2727]

Cited: 6 times

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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition.

Jenny H Lee, Elena Shklovskaya, Su Yin Lim, Matteo S Carlino, Alexander M Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y H Yang, Dario Strbenac, Robyn P M Saw, John F Thompson, James S Wilmott, Richard A Scolyer, Georgina V Long, Richard F Kefford, Helen Rizos,

Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that intra-patient heterogeneity of tumor responses to PD-1 inhibition limit the predictive performance of these signatures. We reasoned that resistance mechanisms will reflect the tumor microenvironment, and thus we examined ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1897]

Cited: 19 times

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Cumulative Incidence and Predictors of CNS Metastasis for Patients With American Joint Committee on Cancer 8th Edition Stage III Melanoma.

Lauren E Haydu, Serigne N Lo, Jennifer L McQuade, Rodabe N Amaria, Jennifer Wargo, Merrick I Ross, Janice N Cormier, Anthony Lucci, Jeffrey E Lee, Sherise D Ferguson, Robyn P M Saw, Andrew J Spillane, Kerwin F Shannon, Jonathan R Stretch, Patrick Hwu, Sapna P Patel, Adi Diab, Michael K K Wong, Isabella C Glitza Oliva, Hussein Tawbi, Matteo S Carlino, Alexander M Menzies, Georgina V Long, Alexander J Lazar, Michael T Tetzlaff, Richard A Scolyer, Jeffrey E Gershenwald, John F Thompson, Michael A Davies,

<h4>Purpose</h4>Improved understanding of the incidence, risk factors, and timing of CNS metastasis is needed to inform surveillance strategies for patients with melanoma.<h4>Patients and methods</h4>Clinical data were extracted from the databases of 2 major melanoma centers in the United States and Australia for 1,918 patients with American Joint Committee on Cancer ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(13):1429-1441]

Cited: 3 times

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Pan-cancer analysis of whole genomes.

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Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale<sup>1-3</sup>. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) ... Read more >>

Nature (Nature)
[2020, 578(7793):82-93]

Cited: 230 times

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Analysis of the Whole-Exome Sequencing of Tumor and Circulating Tumor DNA in Metastatic Melanoma.

Russell J Diefenbach, Jenny H Lee, Dario Strbenac, Jean Y H Yang, Alexander M Menzies, Matteo S Carlino, Georgina V Long, Andrew J Spillane, Jonathan R Stretch, Robyn P M Saw, John F Thompson, Sydney Ch'ng, Richard A Scolyer, Richard F Kefford, Helen Rizos,

The use of circulating tumor DNA (ctDNA) to monitor cancer progression and response to therapy has significant potential but there is only limited data on whether this technique can detect the presence of low frequency subclones that may ultimately confer therapy resistance. In this study, we sought to evaluate whether ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(12):]

Cited: 2 times

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