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Author Robindra Basu Roy


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“You said the hospital can't be bombed”

Ana García-Mingo, Aula Abbara, Robindra Basu Roy,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):804-805]

Cited: 0 times

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Recent Developments in Tuberculous Meningitis Pathogenesis and Diagnostics

Fiona Cresswell, Angharad Davis, Kusum Sharma, Robindra Basu Roy, Ahmad Rizal Ganiem, Enock Kagimu, Regan Solomons, Robert Wilkinson, Nathan Bahr, Nguyen Thuy Thuong Thuong, ,

The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in our understanding of TBM. For instance, neutrophils appear to play a significant role in the immunopathogenesis of TBM, and either a paucity or an excess of inflammation can be detrimental ... Read more >>

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Protection against mycobacterial infection: A case-control study of mycobacterial immune responses in pairs of Gambian children with discordant infection status despite matched TB exposure.

Robindra Basu Roy, Basil Sambou, Muhamed Sissoko, Beth Holder, Marie P Gomez, Uzochukwu Egere, Abdou K Sillah, Artemis Koukounari, Beate Kampmann,

BACKGROUND:Children are particularly susceptible to tuberculosis. However, most children exposed to Mycobacterium tuberculosis are able to control the pathogen without evidence of infection. Correlates of human protective immunity against tuberculosis infection are lacking, and their identification would aid vaccine design. METHODS:We recruited pairs of asymptomatic children with discordant tuberculin skin ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 59:102891]

Cited: 1 time

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Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study.

Robindra Basu Roy, Stephanie Thee, Daniel Blázquez-Gamero, Lola Falcón-Neyra, Olaf Neth, Antoni Noguera-Julian, Cristina Lillo, Luisa Galli, Elisabetta Venturini, Danilo Buonsenso, Florian Götzinger, Nuria Martinez-Alier, Svetlana Velizarova, Folke Brinkmann, Steven B Welch, Maria Tsolia, Begoña Santiago-Garcia, Renate Krüger, Marc Tebruegge, ,

INTRODUCTION:Tuberculous meningitis (TBM) is often diagnostically challenging. Only limited data exist on the performance of interferon-γ release assays (IGRA) and molecular assays in children with TBM in routine clinical practice, particularly in the European setting. METHODS:Multicentre, retrospective study involving 27 healthcare institutions providing care for children with tuberculosis (TB) in ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(1):]

Cited: 1 time

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Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis.

Nicholas J Andreas, Robindra Basu Roy, Maria Gomez-Romero, Verena Horneffer-van der Sluis, Matthew R Lewis, Stephane S M Camuzeaux, Beatriz Jiménez, Joram M Posma, Leopold Tientcheu, Uzochukwu Egere, Abdou Sillah, Toyin Togun, Elaine Holmes, Beate Kampmann,

We applied a metabonomic strategy to identify host biomarkers in serum to diagnose paediatric tuberculosis (TB) disease. 112 symptomatic children with presumptive TB were recruited in The Gambia and classified as bacteriologically-confirmed TB, clinically diagnosed TB, or other diseases. Sera were analysed using 1H nuclear magnetic resonance (NMR) spectroscopy and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7302]

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Tuberculosis disease in children and adolescents on therapy with anti-tumor necrosis factor-alpha agents: a collaborative, multi-centre ptbnet study.

Antoni Noguera-Julian, Joan Calzada-HernÁndez, Folke Brinkmann, Robindra Basu Roy, Olga Bilogortseva, Michael Buettcher, Isabel Carvalho, Vira Chechenyeva, Lola Falcon, Florian Goetzinger, Carmelo Guerrero-Laleona, Peter Hoffmann, Marija Jelusic, Tim Niehues, Iveta Ozere, Fiona Shackley, Elena Suciliene, Steven B Welch, Elisabeth H SchÖLvinck, Nicole Ritz, Marc Tebruegge,

BACKGROUND:In adults, anti-tumor-necrosis-factor (TNF)-α therapy is associated with progression of latent tuberculosis infection (LTBI) to tuberculosis (TB) disease. The existing paediatric data are very limited. METHODS:Retrospective multi-centre study within the Paediatric Tuberculosis Network European Trials Group, capturing patients <18 years who developed TB disease during anti-TNF-α therapy. RESULTS:Sixty-six tertiary healthcare ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

Cited: 2 times

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An Auto-luminescent Fluorescent BCG Whole Blood Assay to Enable Evaluation of Paediatric Mycobacterial Responses Using Minimal Blood Volumes.

Robindra Basu Roy, Basil Sambou, Iria Uhía, Sophie Roetynck, Brian D Robertson, Beate Kampmann,

Introduction: Understanding protective human immunity against mycobacteria is critical to developing and evaluating new vaccines against tuberculosis. Children are the most susceptible population to infection, disease, and death from tuberculosis, but also have the strongest evidence of BCG-inducible protection. Limited amounts of blood can be obtained for research purposes in ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:151]

Cited: 2 times

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Prevalence of Panton-Valentine Leukocidin (PVL) and Antimicrobial Resistance in Community-Acquired Clinical Staphylococcus aureus in an Urban Gambian Hospital: A 11-Year Period Retrospective Pilot Study.

Saffiatou Darboe, Sarah Dobreniecki, Sheikh Jarju, Mamadou Jallow, Nuredin Ibrahim Mohammed, Miriam Wathuo, Buntung Ceesay, Sam Tweed, Robindra Basu Roy, Uduak Okomo, Brenda Kwambana-Adams, Martin Antonio, Richard S Bradbury, Thushan I de Silva, Karen Forrest, Anna Roca, Bolarinde Joseph Lawal, Davis Nwakanma, Ousman Secka,

Background: Staphylococcus aureus is a major human pathogen. Panton-Valentine leukocidin (PVL) is a virulence factor produced by some strains that causes leukocyte lysis and tissue necrosis. PVL-associated S. aureus (PVL-SA) predominantly causes skin and soft-tissue infections (SSTIs) but can also cause invasive infections such as necrotizing pneumonia. It is carried ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2019, 9:170]

Cited: 5 times

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Tuberculosis susceptibility and protection in children.

Robindra Basu Roy, Elizabeth Whittaker, James A Seddon, Beate Kampmann,

Children represent both a clinically important population susceptible to tuberculosis and a key group in whom to study intrinsic and vaccine-induced mechanisms of protection. After exposure to Mycobacterium tuberculosis, children aged under 5 years are at high risk of progressing first to tuberculosis infection, then to tuberculosis disease and possibly ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(3):e96-e108]

Cited: 12 times

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Increased detection of human parechovirus infection in infants in England during 2016: epidemiology and clinical characteristics.

Laura Ferreras Antolín, Seilesh Kadambari, Serena Braccio, Julian Wei-Tze Tang, Jacqueline Xerry, David James Allen, Shamez N Ladhani, ,

BACKGROUND:Human parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received increasing reports of severe HPeV infections nationally. We, therefore, reviewed all infants with confirmed HPeV across ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2018, 103(11):1061-1066]

Cited: 4 times

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Evaluating UK National Guidance for Screening of Children for Tuberculosis. A Prospective Multicenter Study.

Beate Kampmann, James A Seddon, James Paton, Zohreh Nademi, Denis Keane, Bhanu Williams, Amanda Williams, Sue Liebeschutz, Anna Riddell, Jolanta Bernatoniene, Sanjay Patel, Nuria Martinez, Paddy McMaster, Robindra Basu-Roy, Steven B Welch,

RATIONALE:To identify infected contacts of tuberculosis (TB) cases, the UK National Institute for Health and Care Excellence (NICE) recommended the addition of IFN-γ release assays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children who screened TST-positive ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 197(8):1058-1064]

Cited: 3 times

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Diagnostic Performance of Tuberculosis-Specific IgG Antibody Profiles in Patients with Presumptive Tuberculosis from Two Continents.

Tobias Broger, Robindra Basu Roy, Angela Filomena, Charles H Greef, Stefanie Rimmele, Joshua Havumaki, David Danks, Nicole Schneiderhan-Marra, Christen M Gray, Mahavir Singh, Ida Rosenkrands, Peter Andersen, Gregory M Husar, Thomas O Joos, Maria L Gennaro, Michael J Lochhead, Claudia M Denkinger, Mark D Perkins,

Development of rapid diagnostic tests for tuberculosis is a global priority. A whole proteome screen identified Mycobacterium tuberculosis antigens associated with serological responses in tuberculosis patients. We used World Health Organization (WHO) target product profile (TPP) criteria for a detection test and triage test to evaluate these antigens.Consecutive patients presenting ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 64(7):947-955]

Cited: 7 times

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Linezolid for Children With Tuberculous Meningitis: More Evidence Required.

Robindra Basu Roy, James A Seddon,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2017, 36(4):439]

Cited: 0 times

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Why the Convention on the Rights of the Child must become a guiding framework for the realization of the rights of children affected by tuberculosis.

Robindra Basu Roy, Nicola Brandt, Nicolette Moodie, Mitra Motlagh, Kumanan Rasanathan, James A Seddon, Anne K Detjen, Beate Kampmann,

Until recently, paediatric tuberculosis (TB) has been relatively neglected by the broader TB and the maternal and child health communities. Human rights-based approaches to children affected by TB could be powerful; however, awareness and application of such strategies is not widespread.We summarize the current challenges faced by children affected by ... Read more >>

BMC Int Health Hum Rights (BMC international health and human rights)
[2016, 16(1):32]

Cited: 2 times

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How to use: interferon γ release assays for tuberculosis.

Louisa Pollock, Robindra Basu Roy, Beate Kampmann,

Diagnosis and treatment of latent tuberculosis infection (LTBI) is important to reduce risk of progression to active tuberculosis (TB) disease. For the past century the tuberculin skin test (TST) has been used as a measure of exposure to Mycobacterium tuberculosis (MTB), but this test has limitations in test performance, sensitivity ... Read more >>

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2013, 98(3):99-105]

Cited: 14 times

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High fidelity and fun: but fallow ground for learning?

Robindra Basu Roy, Graham T McMahon,

Med Educ (Medical education)
[2012, 46(11):1022-1023]

Cited: 1 time

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Current understanding of the immune response to tuberculosis in children.

Robindra Basu Roy, Elizabeth Whittaker, Beate Kampmann,

PURPOSE OF REVIEW:Even in the era of promising molecular diagnostics for tuberculosis, understanding of the immune response remains urgent and fundamental to combating paediatric tuberculosis, given its paucibacillary nature. RECENT FINDINGS:Significant advances have been made in unravelling the contributions of previously underappreciated components of the immune response to Mycobacterium tuberculosis. ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2012, 25(3):250-257]

Cited: 21 times

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Identifying predictors of interferon-γ release assay results in pediatric latent tuberculosis: a protective role of bacillus Calmette-Guerin?: a pTB-NET collaborative study.

Robindra Basu Roy, Giovanni Sotgiu, Neus Altet-Gómez, Maria Tsolia, Ezia Ruga, Svetlana Velizarova, Beate Kampmann,

Interferon-γ (IFN-γ) release assays are widely used to diagnose latent infection with Mycobacterium tuberculosis in adults, but their performance in children remains incompletely evaluated to date.To investigate factors influencing results of IFN-γ release assays in children using a large European data set.The Pediatric Tuberculosis Network European Trials group pooled and ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2012, 186(4):378-384]

Cited: 49 times

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Video-based cases disrupt deep critical thinking in problem-based learning.

Robindra Basu Roy, Graham T McMahon,

CONTEXT:   Video is a popular tool in problem-based learning (PBL), although its production requires resources and time. Few studies have examined the impact of the use of video in PBL upon cognitive processes and critical thinking. Those that have done focused on cases involving physical signs, where video has ... Read more >>

Med Educ (Medical education)
[2012, 46(4):426-435]

Cited: 16 times

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