Full Text Journal Articles by
Author Robin B Gasser

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Lipid composition and abundance in the reproductive and alimentary tracts of female Haemonchus contortus.

Tao Wang, Guangxu Ma, Shuai Nie, Nicholas A Williamson, Gavin E Reid, Robin B Gasser,

BACKGROUND:Lipids play essential structural and functional roles in the biology of animals. Studying the composition and abundance of lipids in parasites should assist in gaining a better understanding of their molecular biology, biochemistry and host-parasite interactions. METHODS:Here, we used a combination of high-performance liquid chromatography and mass spectrometric analyses, combined ... Read more >>

Parasit Vectors (Parasites & vectors)
[2020, 13(1):338]

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Global Prevalence Estimates of Toxascaris leonina Infection in Dogs and Cats.

Ali Rostami, Seyed Mohammad Riahi, Vahid Fallah Omrani, Tao Wang, Andreas Hofmann, Aliyar Mirzapour, Masoud Foroutan, Yadolah Fakhri, Calum N L Macpherson, Robin B Gasser,

Toxascaris leonina is an ascaridoid nematode of dogs and cats; this parasite affects the health of these animals. This study estimated the global prevalence of Ta. leonina infection in dogs and cats using random effects meta-analysis as well as subgroup, meta-regression and heterogeneity analyses. The data were stratified according to ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(6):]

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Comatulins A-E, Taurine-Conjugated Anthraquinones from the Australian Crinoid Comatula rotalaria.

Kah Yean Lum, Aya C Taki, Robin B Gasser, Ian Tietjen, Merrick G Ekins, Jonathan M White, Russell S Addison, Sasha Hayes, James St John, Rohan A Davis,

Chemical investigations of two specimens of the Australian crinoid Comatula rotalaria afforded five new taurine-conjugated anthraquinones, comatulins A-E (1-5), together with 11 known marine natural products (6-16). The chemical structures of all the compounds were elucidated by detailed spectroscopic and spectrometric data analysis. The first X-ray crystal structure of a ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2020, 83(6):1971-1979]

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A Targeted "Next-Generation" Sequencing-Informatic Approach to Define Genetic Diversity in Theileria orientalis Populations within Individual Cattle: Proof-of-Principle.

Anson V Koehler, Abdul Jabbar, Ross S Hall, Robin B Gasser,

Oriental theileriosis is an economically important tickborne disease of bovines, caused by some members of the Theileria orientalis complex. Currently, 11 distinct operational taxonomic units (OTUs), or genotypes, are recognized based on their major piroplasm surface protein (MPSP) gene sequences. Two of these genotypes (i.e., chitose and ikeda) are recognized ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(6):]

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Predicting gene essentiality in Caenorhabditis elegans by feature engineering and machine-learning.

Tulio L Campos, Pasi K Korhonen, Paul W Sternberg, Robin B Gasser, Neil D Young,

Defining genes that are essential for life has major implications for understanding critical biological processes and mechanisms. Although essential genes have been identified and characterised experimentally using functional genomic tools, it is challenging to predict with confidence such genes from molecular and phenomic data sets using computational methods. Using extensive ... Read more >>

Comput Struct Biotechnol J (Computational and structural biotechnology journal)
[2020, 18:1093-1102]

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Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro.

H M P Dilrukshi Herath, Aya C Taki, Nghi Nguyen, José Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill C H Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser,

Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ceremonial beverage, and has been sold as an anxiolytic agent for some decades. Kavalactones are a major constituent of kava extract. In a previous investigation, we had identified three ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(8):]

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A Participatory Investigation of Bovine Health and Production Issues in Pakistan.

Abdul Ghafar, David McGill, Mark A Stevenson, Muhammad Badar, Aijaz Kumbher, Hassan M Warriach, Robin B Gasser, Abdul Jabbar,

Systems to record the frequency of animal health events in Pakistan are limited. A participatory approach was used to address gaps in farmers' knowledge and understanding of bovine health and production issues in five agroecological zones (AEZs) of Pakistan. Participatory tools, including simple ranking, pairwise ranking, constraint impact scoring, and ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2020, 7:248]

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Global and regional seroprevalence estimates for human toxocariasis: A call for action.

Guangxu Ma, Ali Rostami, Tao Wang, Andreas Hofmann, Peter J Hotez, Robin B Gasser,

Human toxocariasis is a parasitic disease transmitted usually from dogs and/or cats that are infected with Toxocara species, and can be associated with a range of allergic, neurological and/or visual disorders. Recent epidemiological research has estimated that ~1.4 billion people worldwide, particularly in subtropical and tropical regions, are infected with, ... Read more >>

Adv. Parasitol. (Advances in parasitology)
[2020, 109:275-290]

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Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole.

Yan Lin, Yih Ching Ong, Sarah Keller, Johannes Karges, Rafika Bouchene, Eric Manoury, Olivier Blacque, Joachim Müller, Nicoleta Anghel, Andrew Hemphill, Cécile Häberli, Aya C Taki, Robin B Gasser, Kevin Cariou, Jennifer Keiser, Gilles Gasser,

Helminthiases, a group of neglected tropical diseases, affect more than one billion people mainly in tropical and subtropical regions. Moreover, major intestinal protozoa have a significant impact on global public health. Albendazole (ABZ) is a broad-spectrum anthelmintic recommended by the World Health Organisation (WHO). However, drug resistance is emerging due ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(20):6616-6626]

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Global prevalence of Toxocara infection in cats.

Ali Rostami, Mahdi Sepidarkish, Guangxu Ma, Tao Wang, Maryam Ebrahimi, Yadolah Fakhri, Hamed Mirjalali, Andreas Hofmann, Calum N L Macpherson, Peter J Hotez, Robin B Gasser,

Zoonotic parasites, including Toxocara species, of pet and stray cats are of public health importance. Justification for, and the design and implementation of prevention and control of human toxocariasis may benefit from an understanding of the zoonotic potential and prevalence of parasites in this definitive host species. This is the ... Read more >>

Adv. Parasitol. (Advances in parasitology)
[2020, 109:615-639]

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Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus.

Fang-Fang Li, Robin B Gasser, Feng Liu, Jia-Nan Shan, Wen-Da Di, Li He, Cai-Xian Zhou, Chun-Qun Wang, Rui Fang, Min Hu,

Smad proteins are essential cellular mediators within the transforming growth factor-β (TGF-β) superfamily. They directly transmit incoming signals from the cell surface receptors to the nucleus. In spite of their functional importance, almost nothing is known about Smad proteins in parasitic nematodes including Haemonchus contortus, an important blood-sucking nematode of ... Read more >>

Parasit Vectors (Parasites & vectors)
[2020, 13(1):164]

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Global prevalence of Toxocara infection in dogs.

Ali Rostami, Seyed Mohammad Riahi, Andreas Hofmann, Guangxu Ma, Tao Wang, Hamed Behniafar, Ali Taghipour, Yadolah Fakhri, Adel Spotin, Bill C H Chang, Calum N L Macpherson, Peter J Hotez, Robin B Gasser,

Dogs serve as the most important definitive hosts for Toxocara canis-a causative agent of human toxocariasis and one of the most widespread zoonotic helminth worldwide. The present study was undertaken to assess the global prevalence of T. canis infection in dogs. PubMed, Scopus, Web of Science, EMBASE and SciELO were ... Read more >>

Adv. Parasitol. (Advances in parasitology)
[2020, 109:561-583]

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Multiplex PCRs for the specific identification of marsupial and deer species from faecal samples as a basis for non-invasive epidemiological studies of parasites.

Anson V Koehler, Yan Zhang, Tao Wang, Shane R Haydon, Robin B Gasser,

BACKGROUND:The specific identification of animals through the analysis of faecal DNA is important in many areas of scientific endeavour, particularly in the field of parasitology. METHODS:Here, we designed and assessed two multiplex PCR assays using genetic markers in a mitochondrial cytochrome b (cytb) gene region for the unequivocal identification and ... Read more >>

Parasit Vectors (Parasites & vectors)
[2020, 13(1):144]

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A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here?

Yaqing Jiao, Sarah Preston, Andreas Hofmann, Aya Taki, Jonathan Baell, Bill C H Chang, Abdul Jabbar, Robin B Gasser,

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide. Anthelmintic treatment is central to controlling these worms, but widespread resistance to most of the commercially available anthelmintics for veterinary and agricultural use is compromising control, such that there is an urgency to discover new and effective drugs. The ... Read more >>

Adv. Parasitol. (Advances in parasitology)
[2020, 108:1-45]

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Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus.

Banfeng Ruan, Yuezhou Zhang, Solomon Tadesse, Sarah Preston, Aya C Taki, Abdul Jabbar, Andreas Hofmann, Yaqing Jiao, Jose Garcia-Bustos, Jitendra Harjani, Thuy Giang Le, Swapna Varghese, Silvia Teguh, Yiyue Xie, Jephthah Odiba, Min Hu, Robin B Gasser, Jonathan Baell,

Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to the diseases that they cause. The control of nematodes in livestock animals relies heavily on the use of anthelmintic drugs. However, their extensive use has led to a widespread problem of drug resistance ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 190:112100]

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High anti-Ascaris seroprevalence in fattening pigs in Sichuan, China, calls for improved management strategies.

Youle Zheng, Yue Xie, Peter Geldhof, Johnny Vlaminck, Guangxu Ma, Robin B Gasser, Tao Wang,

BACKGROUND:Ascariasis, caused by Ascaris suum, is an important soil-transmitted parasitic disease of pigs worldwide. It leads to significant economic losses in the pork industry, as a consequence of low feed conversion efficiency in pigs and liver condemnation at slaughter. Despite ascariasis still being widespread on pig farms in many developing ... Read more >>

Parasit Vectors (Parasites & vectors)
[2020, 13(1):60]

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Age of first infection across a range of parasite taxa in a wild mammalian population.

Leigh Combrink, Caroline K Glidden, Bree R Beechler, Bryan Charleston, Anson V Koehler, Danielle Sisson, Robin B Gasser, Abdul Jabbar, Anna E Jolles,

Newborn mammals have an immature immune system that cannot sufficiently protect them against infectious diseases. However, variation in the effectiveness of maternal immunity against different parasites may couple with temporal trends in parasite exposure to influence disparities in the timing of infection risk. Determining the relationship between age and infection ... Read more >>

Biol. Lett. (Biology letters)
[2020, 16(2):20190811]

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Elucidating the molecular and developmental biology of parasitic nematodes: Moving to a multiomics paradigm.

Guangxu Ma, Tao Wang, Pasi K Korhonen, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser,

In the past two decades, significant progress has been made in the sequencing, assembly, annotation and analyses of genomes and transcriptomes of parasitic worms of socioeconomic importance. This progress has somewhat improved our knowledge and understanding of these pathogens at the molecular level. However, compared with the free-living nematode Caenorhabditis ... Read more >>

Adv. Parasitol. (Advances in parasitology)
[2020, 108:175-229]

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Gene content evolution in the arthropods.

Gregg W C Thomas, Elias Dohmen, Daniel S T Hughes, Shwetha C Murali, Monica Poelchau, Karl Glastad, Clare A Anstead, Nadia A Ayoub, Phillip Batterham, Michelle Bellair, Greta J Binford, Hsu Chao, Yolanda H Chen, Christopher Childers, Huyen Dinh, Harsha Vardhan Doddapaneni, Jian J Duan, Shannon Dugan, Lauren A Esposito, Markus Friedrich, Jessica Garb, Robin B Gasser, Michael A D Goodisman, Dawn E Gundersen-Rindal, Yi Han, Alfred M Handler, Masatsugu Hatakeyama, Lars Hering, Wayne B Hunter, Panagiotis Ioannidis, Joy C Jayaseelan, Divya Kalra, Abderrahman Khila, Pasi K Korhonen, Carol Eunmi Lee, Sandra L Lee, Yiyuan Li, Amelia R I Lindsey, Georg Mayer, Alistair P McGregor, Duane D McKenna, Bernhard Misof, Mala Munidasa, Monica Munoz-Torres, Donna M Muzny, Oliver Niehuis, Nkechinyere Osuji-Lacy, Subba R Palli, Kristen A Panfilio, Matthias Pechmann, Trent Perry, Ralph S Peters, Helen C Poynton, Nikola-Michael Prpic, Jiaxin Qu, Dorith Rotenberg, Coby Schal, Sean D Schoville, Erin D Scully, Evette Skinner, Daniel B Sloan, Richard Stouthamer, Michael R Strand, Nikolaus U Szucsich, Asela Wijeratne, Neil D Young, Eduardo E Zattara, Joshua B Benoit, Evgeny M Zdobnov, Michael E Pfrender, Kevin J Hackett, John H Werren, Kim C Worley, Richard A Gibbs, Ariel D Chipman, Robert M Waterhouse, Erich Bornberg-Bauer, Matthew W Hahn, Stephen Richards,

BACKGROUND:Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad ... Read more >>

Genome Biol. (Genome biology)
[2020, 21(1):15]

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A serine/threonine-specific protein kinase of Haemonchus contortus with a role in the development.

Wenda Di, Robin B Gasser, Li He, Fangfang Li, Xiaofang Liu, Caixian Zhou, Yanqin Zhou, Rui Fang, Junlong Zhao, Min Hu,

In the free-living nematode Caenorhabditis elegans, the serine/threonine-specific protein kinase, AKT, is known to play a key role in dauer formation, life-span, and stress-resistance through the insulin-like signaling pathway. Although the structure and function of AKT-coding genes of C. elegans are understood, this is not the case for homologous genes ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(2):2075-2086]

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Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport.

Marziyeh Anari, Andreas J Stroehlein, Ross S Hall, Bill C H Chang, Robin B Gasser, Neil D Young,

BACKGROUND:The parasitic flatworm Clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. This parasite can survive and thrive in the bile duct, despite exposure to bile constituents and host immune attack. Although the precise biological mechanisms underlying this adaptation are unknown, previous work indicated that Niemann-pick type ... Read more >>

Parasit Vectors (Parasites & vectors)
[2020, 13(1):38]

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Bovine ticks harbour a diverse array of microorganisms in Pakistan.

Abdul Ghafar, Alejandro Cabezas-Cruz, Clemence Galon, Dasiel Obregon, Robin B Gasser, Sara Moutailler, Abdul Jabbar,

BACKGROUND:Ticks and tick-borne pathogens (TTBP) are a major constraint to livestock production in Pakistan; despite a high prevalence of TTBPs, knowledge on the capacity of Pakistani ticks to carry pathogens and endosymbionts is limited. Furthermore, mixed infections with multiple microorganisms further complicate and limit the detection potential of traditional diagnostic ... Read more >>

Parasit Vectors (Parasites & Vectors)
[2020, 13(1):1]

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Elucidating cryptic dynamics of Theileria communities in African buffalo using a high-throughput sequencing informatics approach.

Caroline K Glidden, Anson V Koehler, Ross S Hall, Muhammad A Saeed, Mauricio Coppo, Brianna R Beechler, Bryan Charleston, Robin B Gasser, Anna E Jolles, Abdul Jabbar,

Increasing access to next-generation sequencing (NGS) technologies is revolutionizing the life sciences. In disease ecology, NGS-based methods have the potential to provide higher-resolution data on communities of parasites found in individual hosts as well as host populations.Here, we demonstrate how a novel analytical method, utilizing high-throughput sequencing of PCR amplicons, ... Read more >>

Ecol Evol (Ecology and evolution)
[2020, 10(1):70-80]

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The developmental phosphoproteome of Haemonchus contortus.

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Andreas J Stroehlein, Neil D Young, Andreas Hofmann, Bill C H Chang, Nicholas A Williamson, Robin B Gasser,

Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics and proteomics of socioeconomically important parasitic nematodes, there is scant phosphoproteomic data to underpin molecular biological discovery. Here, using the phosphopeptide enrichment-based LC-MS/MS and data-independent acquisition (DIA) quantitation, we characterised the first developmental phosphoproteome ... Read more >>

J Proteomics (Journal of proteomics)
[2020, 213:103615]

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A TGF-β type II receptor that associates with developmental transition in Haemonchus contortus in vitro.

Li He, Robin B Gasser, Tingting Li, Wenda Di, Fangfang Li, Hongrun Zhang, Caixian Zhou, Rui Fang, Min Hu,

BACKGROUND:The TGF-β signalling pathway plays a key role in regulating dauer formation in the free-living nematode Caenorhabditis elegans, and previous work has shown that TGF-β receptors are involved in parasitic nematodes. Here, we explored the structure and function of a TGF-β type II receptor homologue in the TGF-β signalling pathway ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2019, 13(12):e0007913]

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