Full Text Journal Articles by
Author Roberto Sansone


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Angioplasty of Flow-Limiting Stenosis Reduces Aortic and Brachial Blood Pressure in Patients With Peripheral Artery Disease.

Lucas Busch, Yvonne Heinen, Manuel Stern, Georg Wolff, Göksen Özaslan, Konstantina Tzetou, Roberto Sansone, Christian Heiss, Malte Kelm,

Background Arterial hypertension affects cardiovascular outcome in patients with peripheral artery disease (PAD). We hypothesized that angioplasty of peripheral arterial stenoses decreases aortic (aBP) and brachial blood pressure (bBP). Methods and Results In an index cohort (n=30), we simultaneously measured aBP, bBP, augmentation index (AIx), and aortic pulse wave velocity ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(14):e019724]

Cited: 0 times

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Improving the Assessment of Flow-Mediated Dilation Through Detection of Peak Time in Healthy Subjects and Subjects With Type 2 Diabetes.

Theresa Herbrand, Hans-Veit Coester, Roberto Sansone, Annelie Fischer, Christian Heiss, Tim Heise, Malte Kelm, J Hans DeVries,

The assessment of flow-mediated dilation (FMD) is widely used to quantify endothelial function. Historically, FMD was determined at 60 seconds post-cuff deflation. We investigated whether FMD would be more accurate if determined at maximum dilatory peak (MDP) than at 60 seconds in healthy subjects and subjects with type 2 diabetes ... Read more >>

Angiology (Angiology)
[2021, 72(5):434-441]

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Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial.

Luc Bergougnan, Grit Andersen, Leona Plum-Moerschel, Maria Francesca Evaristi, Bruno Poirier, Agnes Tardat, Marcel Ermer, Theresa Herbrand, Jorge Arrubla, Hans Veit Coester, Roberto Sansone, Christian Heiss, Olivier Vitse, Fabrice Hurbin, Rania Boiron, Xavier Benain, David Radzik, Philip Janiak, Anthony Muslin, Lionel Hovsepian, Stephane Kirkesseli, Paul Deutsch, Ashfaq Parkar,

SAR247799 is a G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial-protective properties, while limiting S1P1 desensitization and consequent lymphocyte-count reduction associated with higher doses. A dose-response study in diabetic rats with 5-week SAR247799 treatment demonstrated, at sub-lymphocyte-reducing doses, renal function and endothelial biomarker improvements ... Read more >>

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Impact of high on-treatment platelet reactivity after angioplasty in patients with peripheral arterial disease.

Lucas Busch, Manuel Stern, Lisa Dannenberg, Philipp Mourikis, Michael Gröne, Göksen Özaslan, Yvonne Heinen, Christian Heiss, Roberto Sansone, Amin Polzin, Malte Kelm,

<b>Objective</b>: High on-treatment platelet reactivity (HTPR) to dual antiplatelet therapy (DAPT) predicts adverse events in coronary artery disease patients. In peripheral artery disease (PAD) patients, data concerning the clinical impact of HTPR are limited. Therefore, we evaluated the incidence of (i) HTPR to DAPT and (ii) its impact on 6 months ... Read more >>

Platelets (Platelets)
[2021, 32(3):391-397]

Cited: 1 time

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Endovascular Occlusion of a Renal Arteriovenous Fistula with Renal Vein Aneurysm Formation for Rupture Prevention.

Yae Hyun Rhee, Lucas Busch, Roberto Sansone, Neslihan Ertas, Nikolaos Floros, Hubert Schelzig, Joscha Mulorz, Markus Udo Wagenhäuser,

Purpose:To report the effectiveness of left renal artery (LRA) occlusion using Amplatzer Vascular Plug (AVP) II as treatment for a high-flow renal arteriovenous fistula (RAVF) with multiple renal vein aneurysms (RVA) to prevent aneurysm rupture and cardiac decompensation. Case Report:A 59-year-old female suffering from a post-traumatic RAVF presented with tachycardia ... Read more >>

Case Rep Vasc Med (Case reports in vascular medicine)
[2019, 2019:8530641]

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Requirement of β1 integrin for endothelium-dependent vasodilation and collateral formation in hindlimb ischemia.

Carina Henning, Anna Branopolski, Dominik Schuler, Dimitrios Dimitroulis, Patrik Huelsemann, Christopher Nicolaus, Roberto Sansone, Jelle Ludolf Postma, Daniel Eberhard, Ferdinand Le Noble, Malte Kelm, Eckhard Lammert, Christian Heiss,

An acute increase in blood flow triggers flow-mediated dilation (FMD), which is mainly mediated by endothelial nitric oxide synthase (eNOS). A long-term increase in blood flow chronically enlarges the arterial lumen, a process called arteriogenesis. In several common human diseases, these processes are disrupted for as yet unknown reasons. Here, ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):16931]

Cited: 3 times

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Cocoa Flavanols Improve Endothelial Functional Integrity in Healthy Young and Elderly Subjects.

Michael Gröne, Roberto Sansone, Philip Höffken, Patrick Horn, Ana Rodriguez-Mateos, Hagen Schroeter, Malte Kelm, Christian Heiss,

Cocoa flavanols (CFs) can improve flow-mediated dilation (FMD), blood pressure, and vascular stiffness in healthy subjects. Endothelial microparticles (EMPs) are markers of endothelial functional integrity, reflecting activation and injury. In plasma samples, we investigated whether age-dependent changes in circulating EMPs exist and whether CFs decrease EMPs in healthy humans. The ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2020, 68(7):1871-1876]

Cited: 1 time

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[Update ESC-Guideline 2017: Focus on PAD].

Roberto Sansone, Lucas Busch, Ralf Langhoff,

The updated ESC guidelines on PAD were developed, for the first time, as a collaboration between cardiologists and vascular surgeons and unveiled at the European Society of Cardiology (ESC) 2017 congress. Although awareness has improved, PAD is still associated with significant morbidity, mortality, and quality of life impairment. Primarily, the guidelines emphasize ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2018, 143(20):1455-1459]

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Stent fractures after common femoral artery bail-out stenting due to suture device failure in TAVR.

Verena Veulemans, Shazia Afzal, Paul Ledwig, Christian Heiss, Lucas Busch, Roberto Sansone, Dagmar B Soetemann, Oliver Maier, Laura Kleinebrecht, Malte Kelm, Tobias Zeus, Katharina Hellhammer,

<h4>Background</h4>Vascular access site-related complications are frequent in the context of transfemoral transcatheter aortic valve replacement (TAVR). The implantation of a covered stent graft is an effective treatment option for bleeding control. However, the external iliac and common femoral arteries are exposed to flexion of the hip joint. Therefore, stent compression ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2018, 47(5):393-401]

Cited: 0 times

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Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans.

Manuel Stern, Melanie Broja, Roberto Sansone, Michael Gröne, Simon S Skene, Joerg Liebmann, Christoph V Suschek, Matthias Born, Malte Kelm, Christian Heiss,

<h4>Aims</h4>Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(17):1875-1883]

Cited: 4 times

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Repetitive remote occlusion (RRO) stimulates eNOS-dependent blood flow and collateral expansion in hindlimb ischemia.

Dominik Schuler, Roberto Sansone, Christopher Nicolaus, Malte Kelm, Christian Heiss,

<h4>Objective</h4>Collateral expansion is an important compensatory mechanism to alleviate tissue ischemia after arterial occlusion. We investigated the efficacy and mechanisms of temporary remote hindlimb occlusion to stimulate contralateral blood flow and collateral expansion after hindlimb ischemia in mice and evaluated translation to peripheral artery disease in humans.<h4>Methods and results</h4>We induced ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2018, 129:520-531]

Cited: 0 times

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Release of endothelial microparticles in patients with arterial hypertension, hypertensive emergencies and catheter-related injury.

Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss,

BACKGROUND AND AIMS:Circulating endothelial microparticles (EMPs) are increased in arterial hypertension. The role of physicomechanical factors that may induce EMP release in vivo is still unknown. We studied the relationship of EMPs and physicomechanical factors in stable arterial hypertension and hypertensive emergencies, and investigated the pattern of EMP release after mechanical ... Read more >>

Atherosclerosis (Atherosclerosis)
[2018, 273:67-74]

Cited: 5 times

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On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability.

Lukas Diederich, Tatsiana Suvorava, Roberto Sansone, T C Stevenson Keller, Frederik Barbarino, Thomas R Sutton, Christian M Kramer, Wiebke Lückstädt, Brant E Isakson, Holger Gohlke, Martin Feelisch, Malte Kelm, Miriam M Cortese-Krott,

The main function of red blood cells (RBCs) is the transport of respiratory gases along the vascular tree. To fulfill their task, RBCs are able to elastically deform in response to mechanical forces and, pass through the narrow vessels of the microcirculation. Decreased RBC deformability was observed in pathological conditions ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:332]

Cited: 18 times

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Impact of Continuous Positive Airway Pressure on Left Ventricular Systolic Loading and Coronary Flow Reserve in Healthy Young Men.

Volker Schulze, Christian Meyer, Christian Eickholt, Roberto Sansone, Stefanie Keymel, Christian Heiss, Tienush Rassaf, Malte Kelm, Stephan Steiner,

Increased augmentation index (AIx) is accompanied by an elevated cardiovascular risk. A reduction of AIx is known for long-term continuous positive airway pressure (CPAP) therapy. We hypothesised that acute preload and left ventricular workload effects AIx and subendocardial viability ratio (SEVR) as a marker of coronary flow reserve.Increased augmentation index ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2018, 27(3):344-349]

Cited: 0 times

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Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies.

Roberto Sansone, Javier I Ottaviani, Ana Rodriguez-Mateos, Yvonne Heinen, Dorina Noske, Jeremy P Spencer, Alan Crozier, Marc W Merx, Malte Kelm, Hagen Schroeter, Christian Heiss,

<h4>Background</h4>Cocoa flavanol intake, especially that of (-)-epicatechin, has been linked to beneficial effects on human cardiovascular function. However, cocoa also contains the methylxanthines theobromine and caffeine, which may also affect vascular function.<h4>Objective</h4>We sought to determine whether an interaction between cocoa flavanols and methylxanthines exists that influences cocoa flavanol-dependent vascular effects.<h4>Design</h4>Test ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2017, 105(2):352-360]

Cited: 19 times

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Carbon Dioxide Angiography Is a Standard Technique to Supplement Iodinated Contrast Angiography and Can Be a Feasible Alternative.

Emilia Stegemann, Roberto Sansone, Christian Heiss,

Angiology (Angiology)
[2016, 67(10):974]

Cited: 1 time

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SeQuent Please vs. Pantera Lux drug coated balloon angioplasty in real life: Results from the Düsseldorf DCB registry.

Athena Assadi-Schmidt, Annemarie Mohring, Eva Liebsch, Lisa Dannenberg, Alina Achilles, Martin Pöhl, Shazia Afzal, Verena Veulemans, Patrick Horn, Roberto Sansone, Florian Bönner, Bodo Levkau, Malte Kelm, Tobias Zeus, Amin Polzin,

<h4>Background</h4>In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in ... Read more >>

Int J Cardiol (International journal of cardiology)
[2017, 231:68-72]

Cited: 4 times

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Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease.

Stefanie Keymel, Benedikt Schueller, Roberto Sansone, Rabea Wagstaff, Stephan Steiner, Malte Kelm, Christian Heiss,

<h4>Introduction</h4>Epidemiological studies have shown increased morbidity and mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). We aimed to characterize the oxygen dependence of endothelial function in patients with CAD and coexisting COPD.<h4>Material and methods</h4>In CAD patients with and without COPD (<i>n</i> = 33), we ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2018, 14(2):297-306]

Cited: 2 times

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The aryl hydrocarbon receptor promotes aging phenotypes across species.

Anna Eckers, Sascha Jakob, Christian Heiss, Thomas Haarmann-Stemmann, Christine Goy, Vanessa Brinkmann, Miriam M Cortese-Krott, Roberto Sansone, Charlotte Esser, Niloofar Ale-Agha, Joachim Altschmied, Natascia Ventura, Judith Haendeler,

The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR ligands promote atherosclerosis, an age-associated vascular disease. Therefore, we investigated the role of AhR in vascular functionality and aging. We report a lower pulse wave velocity in ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:19618]

Cited: 25 times

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Carbondioxide-Aided Angiography Decreases Contrast Volume and Preserves Kidney Function in Peripheral Vascular Interventions.

Emilia Stegemann, Catharina Tegtmeier, Nana Yaw Bimpong-Buta, Roberto Sansone, Mark Uhlenbruch, Andreas Richter, Berthold Stegemann, Michael Roden, Ralf Westenfeld, Malte Kelm, Christian Heiss,

Chronic kidney disease is a common comorbidity in patients with peripheral artery disease. We investigated the safety and efficacy of carbon dioxide (CO2) as supplemental contrast agent to decrease contrast volume during fluoroscopy-guided peripheral vascular procedures in routine angiological practice. We analyzed 191 consecutive interventions of the lower extremity in ... Read more >>

Angiology (Angiology)
[2016, 67(9):875-881]

Cited: 10 times

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Local association between endothelial dysfunction and intimal hyperplasia: relevance in peripheral artery disease.

Yvonne Heinen, Emilia Stegemann, Roberto Sansone, Kolja Benedens, Rabea Wagstaff, Jan Balzer, Tienush Rassaf, Thomas Lauer, Malte Kelm, Christian Heiss,

<h4>Background</h4>Endothelial dysfunction is a key factor in the development of atherosclerosis. Commonly, endothelial function is determined in the brachial artery, whereas patients with peripheral artery disease (PAD) present with lower limb atherosclerosis. We hypothesized that in PAD, a segmental or local association exists between endothelial dysfunction and atherosclerotic structural changes.<h4>Methods ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2015, 4(2):]

Cited: 10 times

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Macrovascular and microvascular function after implantation of left ventricular assist devices in end-stage heart failure: Role of microparticles.

Roberto Sansone, Beate Stanske, Stefanie Keymel, Dominik Schuler, Patrick Horn, Diyar Saeed, Udo Boeken, Ralf Westenfeld, Artur Lichtenberg, Malte Kelm, Christian Heiss,

<h4>Background</h4>The hemodynamic vascular consequences of implanting left ventricular assist devices (LVADs) have not been studied in detail. We investigated the effect of LVAD implantation compared with heart transplant (HTx) on microvascular and macrovascular function in patients with end-stage heart failure and evaluated whether microparticles may play a role in LVAD-related ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2015, 34(7):921-932]

Cited: 22 times

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Measurement of endothelium-dependent vasodilation in mice--brief report.

Dominik Schuler, Roberto Sansone, Till Freudenberger, Ana Rodriguez-Mateos, Gesine Weber, Tony Y Momma, Christine Goy, Joachim Altschmied, Judith Haendeler, Jens W Fischer, Malte Kelm, Christian Heiss,

<h4>Objective</h4>Endothelium-dependent, flow-mediated vasodilation after an increase in shear stress at the endothelial lining of conduit arteries during reactive hyperemia after ischemia is a fundamental principle of vascular physiology adapting blood flow to demand of supplied tissue. Flow-mediated vasodilation measurements have been performed in human studies and are of diagnostic and ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2014, 34(12):2651-2657]

Cited: 24 times

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Early and late response-to-injury in patients undergoing transradial coronary angiography: arterial remodeling in smokers.

Roberto Sansone, Emilia Stegemann, Göksen Ozaslan, Dominik Schuler, Margarete Lukosz, Ana Rodriguez-Mateos, Thomas Lauer, Ralf Westenfeld, Malte Kelm, Christian Heiss,

OBJECTIVES:To investigate the effect of smoking on vascular response to transradial coronary angiography (TCA). BACKGROUND:Cigarette smoking is the most important modifiable cardiovascular risk factor associated with endothelial dysfunction. METHODS:Radial artery flow-mediated vasodilation (RA-FMD), local stiffness (fractional diameter change), intima-media thickness (IMT), luminal and external arterial diameter were measured in 40 ... Read more >>

Am J Cardiovasc Dis (American journal of cardiovascular disease)
[2014, 4(2):47-57]

Cited: 5 times

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Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients.

Patrick Horn, Nicolas Amabile, Franca S Angeli, Roberto Sansone, Berthold Stegemann, Malte Kelm, Matthew L Springer, Yerem Yeghiazarians, Hagen Schroeter, Christian Heiss,

Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of ... Read more >>

Br J Nutr (The British journal of nutrition)
[2014, 111(7):1245-1252]

Cited: 17 times

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