Full Text Journal Articles by
Author Robert Voswinckel


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Correction to: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

Sevdalina Nikolova, Andreas Guenther, Rajkumar Savai, Norbert Weissmann, Hossein A Ghofrani, Melanie Konigshoff, Oliver Eickelberg, Walter Klepetko, Robert Voswinckel, Werner Seeger, Friedrich Grimminger, Ralph T Schermuly, Soni S Pullamsetti,

Respir Res (Respiratory research)
[2022, 23(1):2]

Cited: 0 times

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Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature.

Daniel O Thomas-Rüddel, Peter Hoffmann, Daniel Schwarzkopf, Christian Scheer, Friedhelm Bach, Marcus Komann, Herwig Gerlach, Manfred Weiss, Matthias Lindner, Hendrik Rüddel, Philipp Simon, Sven-Olaf Kuhn, Reinhard Wetzker, Michael Bauer, Konrad Reinhart, Frank Bloos, ,

<h4>Background</h4>Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.<h4>Methods</h4>We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):368]

Cited: 1 time

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Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model.

Vandana S Nikam, Sandeep Nikam, Akyl Sydykov, Katrin Ahlbrecht, Rory E Morty, Werner Seeger, Robert Voswinckel,

<h4>Background and purpose</h4>Recruitment and involvement of bone-/blood-derived circulating fibrocytes (CF) in the promotion of fibrotic tissue remodelling processes have been shown. However, their direct contribution to pathological changes is not clear. The present study investigates the causal role of CF in the pathogenesis of pulmonary hypertension (PH).<h4>Experimental approach</h4>For selective ablation ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(13):2974-2990]

Cited: 2 times

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Validation of the German Version of Functional Oral Intake Scale (FOIS-G) for Flexible Endoscopic Evaluation of Swallowing (FEES).

Samra Hamzic, Tobias Braun, Martin Juenemann, Marius Butz, Robert Voswinckel, Michael Belly, Oliver Vogelbusch, Susanne Weber, Hasan Khilan, Manfred Kaps, Tibo Gerriets,

The Functional Oral Intake Scale (FOIS) is the most frequently used scale for the evaluation of functional oral intake by dysphagia patients. FOIS was validated using data from Videofluoroscopic Swallowing Study (VFSS). Until now, a validated German version of FOIS for Flexible Endoscopic Evaluation of Swallowing (FEES) is lacking. The ... Read more >>

Dysphagia (Dysphagia)
[2021, 36(1):130-139]

Cited: 2 times

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Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice.

Felix Hempel, Martin Roderfeld, Rajkumar Savai, Akylbek Sydykov, Karuna Irungbam, Ralph Schermuly, Robert Voswinckel, Kernt Köhler, Yury Churin, Ladislau Kiss, Jens Bier, Jörn Pons-Kühnemann, Elke Roeb,

Bone marrow-derived fibrocytes (FC) represent a unique cell type, sharing features of both mesenchymal and hematopoietic cells. FC were shown to specifically infiltrate the injured liver and participate in fibrogenesis. Moreover, FC exert a variety of paracrine functions, thus possibly influencing the disease progression. However, the overall contribution of FC ... Read more >>

Cells (Cells)
[2019, 8(10):]

Cited: 8 times

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Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage.

Luca Giordano, Antoine Farnham, Praveen K Dhandapani, Laura Salminen, Jahnavi Bhaskaran, Robert Voswinckel, Peter Rauschkolb, Susan Scheibe, Natascha Sommer, Christoph Beisswenger, Norbert Weissmann, Thomas Braun, Howard T Jacobs, Robert Bals, Christian Herr, Marten Szibor,

Cigarette smoke (CS) exposure is the predominant risk factor for the development of chronic obstructive pulmonary disease (COPD) and the third leading cause of death worldwide. We aimed to elucidate whether mitochondrial respiratory inhibition and oxidative stress are triggers in its etiology. In different models of CS exposure, we investigated ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2019, 60(5):515-522]

Cited: 9 times

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Resident cell lineages are preserved in pulmonary vascular remodeling.

Slaven Crnkovic, Leigh M Marsh, Elie El Agha, Robert Voswinckel, Bahil Ghanim, Walter Klepetko, Elvira Stacher-Priehse, Horst Olschewski, Wilhelm Bloch, Saverio Bellusci, Andrea Olschewski, Grazyna Kwapiszewska,

Pulmonary vascular remodeling is the main pathological hallmark of pulmonary hypertension disease. We undertook a comprehensive and multilevel approach to investigate the origin of smooth muscle actin-expressing cells in remodeled vessels. Transgenic mice that allow for specific, inducible, and permanent labeling of endothelial (Cdh5-tdTomato), smooth muscle (Acta2-, Myh11-tdTomato), pericyte (Cspg4-tdTomato), ... Read more >>

J Pathol (The Journal of pathology)
[2018, 244(4):485-498]

Cited: 15 times

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A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung.

Aglaia Ntokou, Marten Szibor, José Alberto Rodríguez-Castillo, Jennifer Quantius, Susanne Herold, Elie El Agha, Saverio Bellusci, Isabelle Salwig, Thomas Braun, Robert Voswinckel, Werner Seeger, Rory E Morty, Katrin Ahlbrecht,

Pulmonary diseases such as chronic obstructive pulmonary disease, lung fibrosis, and bronchopulmonary dysplasia are characterized by the destruction or malformation of the alveolar regions of the lung. The underlying pathomechanisms at play are an area of intense interest since these mechanisms may reveal pathways suitable for interventions to drive reparative ... Read more >>

Genesis (Genesis (New York, N.Y. : 2000))
[2017, 55(12):]

Cited: 10 times

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The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups.

Henning Gall, Janine F Felix, Franziska K Schneck, Katrin Milger, Natascha Sommer, Robert Voswinckel, Oscar H Franco, Albert Hofman, Ralph T Schermuly, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Hossein A Ghofrani,

<h4>Background</h4>Pulmonary hypertension (PH) is a severe, progressive disease. Although 5 PH subgroups are recognized, reports on survival have focused mainly on pulmonary arterial hypertension (PAH).<h4>Methods</h4>Long-term transplant-free survival and its determinants were investigated in patients with PH (diagnosed by right heart catheterization) within a prospective registry at a single referral center ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2017, 36(9):957-967]

Cited: 66 times

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Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational study.

Henning Gall, Natascha Sommer, Katrin Milger, Manuel J Richter, Robert Voswinckel, Dirk Bandorski, Werner Seeger, Friedrich Grimminger, Hossein-Ardeschir Ghofrani,

<h4>Background</h4>Combination therapy is frequently used to treat patients with pulmonary hypertension but few studies have compared treatment regimens. This study examined the long-term effect of different combination regimens of inhaled iloprost and oral sildenafil on survival and disease progression.<h4>Methods</h4>This was a retrospective study of patients in the Giessen Pulmonary Hypertension ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2016, 16:5]

Cited: 5 times

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The prognostic relevance of oxygen uptake in inoperable chronic thromboembolic pulmonary hypertension.

Manuel Jonas Richter, Philip Pader, Henning Gall, Frank Reichenberger, Werner Seeger, Eckhard Mayer, Stefan Guth, Thorsten Kramm, Friedrich Grimminger, Hossein A Ghofrani, Robert Voswinckel,

<h4>Background</h4>Patients with chronic thromboembolic pulmonary hypertension (CTEPH) present with a decreased oxygen uptake, however, the prognostic relevance of oxygen uptake (VO<sub>2</sub> ) in inoperable CTEPH is unknown.<h4>Methods</h4>Patients with inoperable CTEPH were retrospectively analyzed. All patients were assessed by means of right heart catheterisation and cardio pulmonary exercise testing in semisupine ... Read more >>

Clin Respir J (The clinical respiratory journal)
[2017, 11(6):682-690]

Cited: 3 times

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Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development.

Aglaia Ntokou, Friederike Klein, Daria Dontireddy, Sven Becker, Saverio Bellusci, William D Richardson, Marten Szibor, Thomas Braun, Rory E Morty, Werner Seeger, Robert Voswinckel, Katrin Ahlbrecht,

A reduced number of alveoli is the structural hallmark of diseases of the neonatal and adult lung, where alveoli either fail to develop (as in bronchopulmonary dysplasia), or are progressively destroyed (as in chronic obstructive pulmonary disease). To correct the loss of alveolar septa through therapeutic regeneration, the mechanisms of ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2015, 309(9):L942-58]

Cited: 40 times

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Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension.

Katrin Milger, Janine F Felix, Robert Voswinckel, Natascha Sommer, Oscar H Franco, Friedrich Grimminger, Frank Reichenberger, Werner Seeger, Hossein A Ghofrani, Henning Gall,

Vasoreactivity testing with inhaled NO is recommended for pulmonary arterial hypertension (PAH) because of its therapeutic and prognostic value. Sildenafil has acute pulmonary vasodilating properties, but its diagnostic and prognostic impact in PAH is unknown. Our objective was to compare acute vasodilating responses to sildenafil and those to NO during ... Read more >>

Pulm Circ (Pulmonary circulation)
[2015, 5(2):305-312]

Cited: 4 times

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New potential diagnostic biomarkers for pulmonary hypertension.

Svenja L Tiede, Henning Gall, Oliver Dörr, Marina dos Santos Guilherme, Christian Troidl, Christoph Liebetrau, Sandra Voss, Robert Voswinckel, Ralph T Schermuly, Werner Seeger, Friedrich Grimminger, Andreas M Zeiher, Stefanie Dimmeler, Helge Möllmann, Christian W Hamm, Christian W Hamm, Hossein Ardeschir Ghofrani, Holger M Nef,

This study aimed to determine whether the vascular endothelial growth factor (VEGF) family members soluble VEGF receptor 1 (also called soluble fms-like tyrosine kinase 1 (sFlt-1)) and placental growth factor (PlGF) could be used as biomarkers for pulmonary hypertension (PH). Consecutive patients undergoing right heart catheterisation were enrolled (those with ... Read more >>

Eur Respir J (The European respiratory journal)
[2015, 46(5):1390-1396]

Cited: 14 times

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Acute hemodynamic effects of nebulized iloprost via the I-neb Adaptive Aerosol Delivery system in pulmonary hypertension.

Manuel J Richter, Hossein A Ghofrani, Robert Voswinckel, Werner Seeger, Richard Schulz, Frank Reichenberger, Henning Gall,

Inhaled iloprost has proven to be an effective therapy in patients with pulmonary hypertension (PH). However, the acute hemodynamic effect of nebulized iloprost delivered via the I-neb Adaptive Aerosol Delivery (AAD) system remains unclear and needs to be assessed. In this study, 126 patients with PH were classified according to ... Read more >>

Pulm Circ (Pulmonary circulation)
[2015, 5(1):162-170]

Cited: 7 times

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Pulmonary Hemodynamic Response to Exercise in Chronic Thromboembolic Pulmonary Hypertension before and after Pulmonary Endarterectomy.

Manuel Jonas Richter, Natascha Sommer, Henning Gall, Robert Voswinckel, Werner Seeger, Eckhard Mayer, Christoph B Wiedenroth, Andreas Rieth, Friedrich Grimminger, Stefan Guth, Hossein A Ghofrani,

Pulmonary endarterectomy (PEA) is the treatment of choice in surgically accessible chronic thromboembolic pulmonary hypertension (CTEPH). An important predictor of outcome is postsurgical residual pulmonary hypertension.We aimed to use the hemodynamic response during exercise before PEA as a measurement for the hemodynamic outcome 1 year after PEA.Between January 2011 and ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2015, 90(1):63-73]

Cited: 7 times

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The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie-restricted mouse heart.

Julia Schipke, Ewgenija Banmann, Sandeep Nikam, Robert Voswinckel, Karin Kohlstedt, Annemarieke E Loot, Ingrid Fleming, Christian Mühlfeld,

Changes in body mass due to varying amounts of calorie intake occur frequently with obesity and anorexia/cachexia being at opposite sides of the scale. Here, we tested whether a high-fat diet or calorie restriction (CR) decreases the number of cardiac myocytes and affects their volume. Ten 6-8-week-old mice were randomly ... Read more >>

J Anat (Journal of anatomy)
[2014, 225(5):539-547]

Cited: 9 times

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Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung.

Celimene Galiger, Sawa Kostin, Anita Golec, Katrin Ahlbrecht, Sven Becker, Mihaela Gherghiceanu, Laurentiu M Popescu, Rory E Morty, Werner Seeger, Robert Voswinckel,

Octamer binding trascription factor 4 (Oct4) is a transcription factor of POU family specifically expressed in embryonic stem cells (ESCs). A role for maintaining pluripotency and self-renewal of ESCs is assigned to Oct4 as a pluripotency marker. Oct4 can also be detected in adult stem cells such as bone marrow-derived ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2014, 18(7):1321-1333]

Cited: 19 times

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The prognostic significance of inspiratory capacity in pulmonary arterial hypertension.

Manuel Jonas Richter, Henning Tiede, Rory E Morty, Robert Voswinckel, Werner Seeger, Richard Schulz, Hossein Ardeschir Ghofrani, Frank Reichenberger,

<h4>Background</h4>Patients with pulmonary arterial hypertension (PAH) present with an altered inspiratory capacity (IC) reflecting dynamic hyperinflation (DH) that leads to mechanical constraints and excessive ventilatory demand, particularly during exercise, resulting in exertional dyspnea.<h4>Objectives</h4>Assessment of the long-term consequences of altered IC and DH in PAH.<h4>Methods</h4>50 patients with newly diagnosed PAH were ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2014, 88(1):24-30]

Cited: 4 times

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Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease.

Manish Kumar, Werner Seeger, Robert Voswinckel,

Chronic obstructive pulmonary disease (COPD) is a major disease of the lungs. It primarily occurs after a prolonged period of cigarette smoking. Chronic inflammation of airways and the alveolar space as well as lung tissue destruction are the hallmarks of COPD. Recently it has been shown that cellular senescence might ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2014, 51(3):323-333]

Cited: 46 times

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Defective angiogenesis delays thrombus resolution: a potential pathogenetic mechanism underlying chronic thromboembolic pulmonary hypertension.

Sherin Alias, Bassam Redwan, Adelheid Panzenboeck, Max P Winter, Uwe Schubert, Robert Voswinckel, Maria K Frey, Johannes Jakowitsch, Arman Alimohammadi, Lukas Hobohm, Andreas Mangold, Helga Bergmeister, Maria Sibilia, Erwin F Wagner, Eckhard Mayer, Walter Klepetko, Thomas J Hoelzenbein, Klaus T Preissner, Irene M Lang,

<h4>Objective</h4>Restoration of patency is a natural target of vascular remodeling after venous thrombosis that involves vascular endothelial cells and smooth muscle cells, as well as leukocytes. Acute pulmonary emboli usually resolve <6 months. However, in some instances, thrombi transform into fibrous vascular obstructions, resulting in occlusion of the deep veins, ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2014, 34(4):810-819]

Cited: 45 times

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Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling.

Regina T Mukhametshina, Aaron Ruhs, Indrabahadur Singh, Diya Hasan, Adriana Contreras, Aditi Mehta, Vandana S Nikam, Katrin Ahlbrecht, Gianni Carraro, Hector A Cabrera-Fuentes, Dongsheng Jiang, Robert Voswinckel, Werner Seeger, Saverio Bellusci, Karin Scharffetter-Kochanek, Tatyana V Bagaeva, Klaus T Preissner, Thomas Boettger, Thomas Braun, Marcus Krüger, Guillermo Barreto,

Alveolar type-II cells (ATII cells) are lung progenitor cells responsible for regeneration of alveolar epithelium during homeostatic turnover and in response to injury. Characterization of ATII cells will have a profound impact on our understanding and treatment of lung disease. The identification of novel ATII cell-surface proteins can be used ... Read more >>

J Proteome Res (Journal of proteome research)
[2013, 12(12):5598-5608]

Cited: 6 times

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Short-term improvement in pulmonary hemodynamics is strongly predictive of long-term survival in patients with pulmonary arterial hypertension.

Henning Tiede, Natascha Sommer, Katrin Milger, Robert Voswinckel, Dirk Bandorski, Ralph T Schermuly, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Hossein A Ghofrani,

Abstract Hemodynamic measurements provide important parameters for determining prognosis and therapy in patients with pulmonary arterial hypertension (PAH). Current guidelines do not incorporate the possible predictive value of individual changes in hemodynamic variables during the disease time course, and there is no consensus about the time point for hemodynamic reevaluation. ... Read more >>

Pulm Circ (Pulmonary circulation)
[2013, 3(3):523-532]

Cited: 14 times

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17β-estradiol replacement reverses age-related lung disease in estrogen-deficient C57BL/6J mice.

Marilyn K Glassberg, Rhea Choi, Vita Manzoli, Shahriar Shahzeidi, Peter Rauschkolb, Robert Voswinckel, Muddassir Aliniazee, Xiaomei Xia, Sharon J Elliot,

The role that estrogens play in the aging lung is poorly understood. Remodeling of the aging lung with thickening of the alveolar walls and reduction in the number of peripheral airways is well recognized. The present study was designed to address whether estrogen deficiency would affect age-associated changes in the ... Read more >>

Endocrinology (Endocrinology)
[2014, 155(2):441-448]

Cited: 10 times

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Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

Rajkumar Savai, Soni S Pullamsetti, Julia Kolbe, Ewa Bieniek, Robert Voswinckel, Ludger Fink, Axel Scheed, Christin Ritter, Bhola K Dahal, Axel Vater, Sven Klussmann, Hossein A Ghofrani, Norbert Weissmann, Walter Klepetko, Gamal A Banat, Werner Seeger, Friedrich Grimminger, Ralph T Schermuly,

<h4>Rationale</h4>Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and vascular remodeling. Recent studies have revealed that immune and inflammatory responses play a crucial role in pathogenesis of idiopathic PAH.<h4>Objectives</h4>To systematically evaluate the number and cross-sectional distribution of inflammatory cells in different sizes of pulmonary arteries from explanted lungs of patients ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2012, 186(9):897-908]

Cited: 150 times

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