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A Provider Perspective of Psychosocial Predictors of Upper-Extremity Vascularized Composite Allotransplantation Success.

Sarah E Kinsley, Emma E Williams, Nora K Lenhard, Sejal B Shah, Robert R Edwards, Jeffrey N Katz, Simon G Talbot,

<h4>Purpose</h4>We performed a qualitative study to understand the psychosocial factors associated with success in upper-extremity vascularized composite allotransplantation from the perspective of transplant providers.<h4>Methods</h4>We recruited 13 providers actively involved in upper-extremity vascularized composite allotransplantation. Participants included physicians, nurses, social workers, occupational therapists, and research administrators. We conducted semistructured face-to-face focus ... Read more >>

J Hand Surg Am (The Journal of hand surgery)
[2021, :]

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Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement.

Akila Weerasekera, Erin Morrissey, Minhae Kim, Atreyi Saha, Yang Lin, Zeynab Alshelh, Angel Torrado-Carvajal, Daniel Albrecht, Oluwaseun Akeju, Young-Min Kwon, Hany Bedair, Antonia F Chen, Vitaly Napadow, Kristin Schreiber, Eva-Maria Ratai, Robert R Edwards, Marco L Loggia,

<h4>Abstract</h4>The weak association between disability levels and "peripheral" (ie, knee) findings suggests that central nervous system alterations may contribute to the pathophysiology of knee osteoarthritis (KOA). Here, we evaluated brain metabolite alterations in patients with KOA, before and after total knee arthroplasty (TKA), using 1H-magnetic resonance spectroscopy (MRS). Thirty-four presurgical ... Read more >>

Pain (Pain)
[2021, 162(7):2014-2023]

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The Combination of Preoperative Pain, Conditioned Pain Modulation, and Pain Catastrophizing Predicts Postoperative Pain 12 Months After Total Knee Arthroplasty.

Dennis Boye Larsen, Mogens Laursen, Robert R Edwards, Ole Simonsen, Lars Arendt-Nielsen, Kristian Kjær Petersen,

<h4>Objectives</h4>Approximately 20% of knee osteoarthritis patients undergoing total knee arthroplasty (TKA) report chronic postoperative pain. Studies suggest that preoperative variables such as impaired descending pain control, catastrophizing, function, and neuropathic pain-like symptoms may predict postoperative pain 12 months after TKA, but the combined prediction value of these factors has not been ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(7):1583-1590]

Cited: 1 time

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Individual variation in diurnal cortisol in patients with knee osteoarthritis: Clinical correlates.

Myrella Paschali, Asimina Lazaridou, Theodoros Paschalis, Julia R Moradian, Jason Sadora, Eric S Vilsmark, Robert R Edwards,

<h4>Background</h4>The cortisol awakening response (CAR) is a core biomarker of hypothalamic-pituitary-adrenal (HPA) axis regulation. To date, however, studies of HPA-axis function among patients with chronic pain are scarce and show equivocal results. The objectives of this study were to investigate the association between CAR and pain-related outcomes and to investigate ... Read more >>

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2021, 167:1-6]

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3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia.

Jeungchan Lee, Ovidiu C Andronesi, Angel Torrado-Carvajal, Eva-Maria Ratai, Marco L Loggia, Akila Weerasekera, Michael P Berry, Dan-Mikael Ellingsen, Laura Isaro, Asimina Lazaridou, Myrella Paschali, Arvina Grahl, Ajay D Wasan, Robert R Edwards, Vitaly Napadow,

<h4>Background</h4>Fibromyalgia is a centralized multidimensional chronic pain syndrome, but its pathophysiology is not fully understood.<h4>Methods</h4>We applied 3D magnetic resonance spectroscopic imaging (MRSI), covering multiple cortical and subcortical brain regions, to investigate the association between neuro-metabolite (e.g. combined glutamate and glutamine, Glx; myo-inositol, mIno; and combined (total) N-acetylaspartate and N-acetylaspartylglutamate, tNAA) ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2021, :]

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Chronic pain severity, impact, and opioid use among patients with cancer: An analysis of biopsychosocial factors using the CHOIR learning health care system.

Desiree R Azizoddin, Kristin Schreiber, Meghan R Beck, Andrea C Enzinger, Valerie Hruschak, Beth D Darnall, Robert R Edwards, Matthew J Allsop, James A Tulsky, Edward Boyer, Sean Mackey,

<h4>Background</h4>Despite the biopsychosocial underpinnings of chronic noncancer pain, relatively little is known about the contribution of psychosocial factors to chronic cancer pain. The authors aimed to characterize associations between biopsychosocial factors and pain and opioid use among individuals with chronic pain and cancer.<h4>Methods</h4>The authors conducted a retrospective, cross-sectional study of ... Read more >>

Cancer (Cancer)
[2021, :]

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Higher Pain Sensitivity Predicts Efficacy of a Wearable Transcutaneous Electrical Nerve Stimulation Device for Persons With Fibromyalgia: A Randomized Double-Blind Sham-Controlled Trial.

Robert N Jamison, Samantha Curran, Limeng Wan, Edgar L Ross, Christopher J Gilligan, Robert R Edwards,

<h4>Objectives</h4>This study investigated the efficacy of a transcutaneous electrical nerve stimulation (TENS) device (Quell®) for persons with symptoms due to fibromyalgia (FM).<h4>Materials and methods</h4>One hundred nineteen (N = 119) subjects were randomly assigned to use an active (N = 62) or sham (N = 57) TENS for three months. All subjects completed baseline questionnaires and were administered ... Read more >>

Neuromodulation (Neuromodulation : journal of the International Neuromodulation Society)
[2021, :]

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Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone.

Gabrielle Agin-Liebes, Andrew S Huhn, Eric C Strain, George E Bigelow, Michael T Smith, Robert R Edwards, Valerie A Gruber, D Andrew Tompkins,

<h4>Objectives</h4>Acute pain management in patients with opioid use disorder who are maintained on methadone presents unique challenges due to high levels of opioid tolerance in this population. This randomized controlled study assessed the analgesic and abuse liability effects of escalating doses of acute intravenous (IV) hydromorphone versus placebo utilizing a ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2021, 226:108869]

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A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity.

Dan-Mikael Ellingsen, Florian Beissner, Tawfik Moher Alsady, Asimina Lazaridou, Myrella Paschali, Michael Berry, Laura Isaro, Arvina Grahl, Jeungchan Lee, Ajay D Wasan, Robert R Edwards, Vitaly Napadow,

<h4>Abstract</h4>Pain catastrophizing is prominent in chronic pain conditions such as fibromyalgia and has been proposed to contribute to the development of pain widespreadness. However, the brain mechanisms responsible for this association are unknown. We hypothesized that increased resting salience network (SLN) connectivity to nodes of the default mode network (DMN), ... Read more >>

Pain (Pain)
[2021, 162(5):1352-1363]

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Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations.

Jennifer S Gewandter, Shannon M Smith, Robert H Dworkin, Dennis C Turk, Tong J Gan, Ian Gilron, Sharon Hertz, Nathaniel P Katz, John D Markman, Srinivasa N Raja, Michael C Rowbotham, Brett R Stacey, Eric C Strain, Denham S Ward, John T Farrar, Kurt Kroenke, James P Rathmell, Richard Rauck, Colville Brown, Penney Cowan, Robert R Edwards, James C Eisenach, McKenzie Ferguson, Roy Freeman, Roy Gray, Kathryn Giblin, Hanna Grol-Prokopczyk, Jennifer Haythornthwaite, Robert N Jamison, Marc Martel, Ewan McNicol, Michael L Oshinsky, Friedhelm Sandbrink, Joachim Scholz, Richard Scranton, Lee S Simon, Deborah Steiner, Kenneth Verburg, Ajay D Wasan, Kerry Wentworth,

<h4>Abstract</h4>Randomized clinical trials have demonstrated the efficacy of opioid analgesics for the treatment of acute and chronic pain conditions, and for some patients, these medications may be the only effective treatment available. Unfortunately, opioid analgesics are also associated with major risks (eg, opioid use disorder) and adverse outcomes (eg, respiratory ... Read more >>

Pain (Pain)
[2021, :]

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Cancer pain self-management in the context of a national opioid epidemic: Experiences of patients with advanced cancer using opioids.

Desiree R Azizoddin, Robert Knoerl, Rosalind Adam, Daniela Kessler, James A Tulsky, Robert R Edwards, Andrea C Enzinger,

<h4>Background</h4>The US opioid epidemic has prompted dramatic changes in public attitudes and regulations governing opioid prescribing. Little is known about the experiences of patients with advanced cancer using opioids in the context of the epidemic.<h4>Methods</h4>Semistructured interviews of 26 patients with advanced cancer were conducted between May 2019 and April 2020; ... Read more >>

Cancer (Cancer)
[2021, :]

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Perceived Success in Upper-Extremity Vascularized Composite Allotransplantation: A Qualitative Study.

Sarah E Kinsley, Nora K Lenhard, Emma C Lape, Sejal B Shah, Robert R Edwards, Jeffrey N Katz, Simon G Talbot,

<h4>Purpose</h4>We performed a qualitative study to understand psychosocial factors associated with perceived success of upper-extremity vascularized composite allotransplantation (VCA). We interviewed transplant recipients and their primary caregivers.<h4>Methods</h4>We recruited 4 upper-extremity VCA recipients and primary caregivers for 3 of them. We conducted semistructured face-to-face interviews using a guide that explored participants' ... Read more >>

J Hand Surg Am (The Journal of hand surgery)
[2021, :]

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Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities.

Marc O Martel, Alice Bruneau, Robert R Edwards,

Opioids are commonly prescribed for the management of patients with chronic noncancer pain. Despite the potential analgesic benefits of opioids, long-term opioid therapy (LTOT) may be accompanied by problems such as opioid misuse and opioid use disorder (OUD). In this review, we begin with a description of opioid misuse and ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2021, 234:114-128]

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Perceived Injustice and Anger Reactions in Relation to the Working Alliance.

Junie S Carriere, Robert R Edwards,

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(4):1015-1017]

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Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain.

Angel Torrado-Carvajal, Nicola Toschi, Daniel S Albrecht, Ken Chang, Oluwaseun Akeju, Minhae Kim, Robert R Edwards, Yi Zhang, Jacob M Hooker, Andrea Duggento, Jayashree Kalpathy-Cramer, Vitaly Napadow, Marco L Loggia,

<h4>Abstract</h4>Using positron emission tomography, we recently demonstrated elevated brain levels of the 18 kDa translocator protein (TSPO), a glial activation marker, in chronic low back pain (cLBP) patients, compared to healthy controls (HCs). Here, we first sought to replicate the original findings in an independent cohort (15 cLBP, 37.8 ± ... Read more >>

Pain (Pain)
[2021, 162(4):1241-1249]

Cited: 3 times

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AAAPT Diagnostic Criteria for Acute Neuropathic Pain.

Tina L Doshi, Robert H Dworkin, Rosemary C Polomano, Daniel B Carr, Robert R Edwards, Nanna B Finnerup, Roy L Freeman, Judith A Paice, Steven J Weisman, Srinivasa N Raja,

<h4>Objective</h4>Acute neuropathic pain is a significant diagnostic challenge, and it is closely related to our understanding of both acute pain and neuropathic pain. Diagnostic criteria for acute neuropathic pain should reflect our mechanistic understanding and provide a framework for research on and treatment of these complex pain conditions.<h4>Methods</h4>The Analgesic, Anesthetic, ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(3):616-636]

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Modifiable Psychological Factors Affecting Functioning in Fibromyalgia.

Myrella Paschali, Asimina Lazaridou, Theodoros Paschalis, Vitaly Napadow, Robert R Edwards,

<h4>Objective</h4>To examine the role of several interrelated, potentially modifiable psychological factors (i.e., mindfulness and catastrophizing) in influencing patient-reported functioning.<h4>Methods</h4>In this cross-sectional study, 107 patients with fibromyalgia completed self-report assessments of pain severity, functioning and impact of symptoms, mindfulness, and pain catastrophizing. Linear regression and bootstrapping mediation analyses were performed to ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(4):]

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Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States.

Jamie L Huizinga, Elizabeth E Stanley, James K Sullivan, Shuang Song, David J Hunter, A David Paltiel, Tuhina Neogi, Robert R Edwards, Jeffrey N Katz, Elena Losina,

<h4>Background</h4>Symptomatic knee osteoarthritis (SKOA) is a chronic, disabling condition, requiring long-term pain management; over 800,000 SKOA patients in the USA use opioids chronically. We aim to characterize the societal economic burden of opioid use in this population.<h4>Methods</h4>We used the Osteoarthritis Policy Model, a validated computer simulation of SKOA, to estimate ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2021, :]

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Temporal association of pain catastrophizing and pain severity across the perioperative period: a cross-lagged panel analyses following total knee arthroplasty.

Traci J Speed, Chung Jung Mun, Michael T Smith, Harpal S Khanuja, Robert S Sterling, Janelle E Letzen, Jennifer A Haythornthwaite, Robert R Edwards, Claudia M Campbell,

<h4>Objective</h4>While numerous studies show that preoperative pain catastrophizing is a risk factor for pain following total knee arthroplasty (TKA), little is known regarding the temporal course of the association between perioperative pain catastrophizing and pain severity. The present study investigated temporal changes and their dynamic associations between pain catastrophizing and ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, :]

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Getting Active Mindfully: Rationale and Case Illustration of a Group Mind-body and Activity Program for Chronic Pain.

Jonathan Greenberg, Ann Lin, Paula J Popok, Ronald J Kulich, Robert R Edwards, Ana-Maria Vranceanu,

Chronic pain is associated with substantial decreases in physical and emotional health. Psychosocial and physical restoration interventions, although potentially helpful, typically show small-to-moderate improvements that are limited to the short term, and often exhibit problematic adherence. Here, we present GetActive-Fitbit, a novel 10-week group program that integrates mind-body skills, pain coping ... Read more >>

J Clin Psychol Med Settings (Journal of clinical psychology in medical settings)
[2021, :]

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Cross-sectional study of psychosocial and pain-related variables among patients with chronic pain during a time of social distancing imposed by the coronavirus disease 2019 pandemic.

Valerie Hruschak, K Mikayla Flowers, Desiree R Azizoddin, Robert N Jamison, Robert R Edwards, Kristin L Schreiber,

<h4>Abstract</h4>The COVID-19 pandemic has had a tremendous impact, including on individuals with chronic pain. The social distancing policies necessary to slow the spread of SARS-CoV-2 have involved increased levels of social isolation. This cross-sectional survey study examined pain severity and interference among individuals with chronic pain during an early phase ... Read more >>

Pain (Pain)
[2021, 162(2):619-629]

Cited: 4 times

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Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.

Anna Xu, Bart Larsen, Alina Henn, Erica B Baller, J Cobb Scott, Vaishnavi Sharma, Azeez Adebimpe, Allan I Basbaum, Gregory Corder, Robert H Dworkin, Robert R Edwards, Clifford J Woolf, Simon B Eickhoff, Claudia R Eickhoff, Theodore D Satterthwaite,

<h4>Importance</h4>Functional neuroimaging is a valuable tool for understanding how patients with chronic pain respond to painful stimuli. However, past studies have reported heterogenous results, highlighting opportunities for a quantitative meta-analysis to integrate existing data and delineate consistent associations across studies.<h4>Objective</h4>To identify differential brain responses to noxious stimuli in patients with ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2032236]

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The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review.

Bethea A Kleykamp, McKenzie C Ferguson, Ewan McNicol, Ida Bixho, Lesley M Arnold, Robert R Edwards, Roger Fillingim, Hanna Grol-Prokopczyk, Dennis C Turk, Robert H Dworkin,

Fibromyalgia (FM) is a chronic widespread pain condition that overlaps with multiple comorbid health conditions and contributes to considerable patient distress. The aim of this review was to provide a systematic overview of psychiatric and chronic pain comorbidities among patients diagnosed with FM and to inform the development of recommendations ... Read more >>

Semin Arthritis Rheum (Seminars in arthritis and rheumatism)
[2021, 51(1):166-174]

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Increased Salience Network Connectivity Following Manual Therapy is Associated with Reduced Pain in Chronic Low Back Pain Patients.

Kylie Isenburg, Ishtiaq Mawla, Marco L Loggia, Dan-Mikael Ellingsen, Ekaterina Protsenko, Matthew H Kowalski, David Swensen, Deanna O'Dwyer-Swensen, Robert R Edwards, Vitaly Napadow, Norman Kettner,

Chronic low back pain (cLBP) has been associated with changes in brain plasticity. Nonpharmacological therapies such as Manual Therapy (MT) have shown promise for relieving cLBP. However, translational neuroimaging research is needed to understand potential central mechanisms supporting MT. We investigated the effect of MT on resting-state salience network (SLN) ... Read more >>

J Pain (The journal of pain)
[2021, 22(5):545-555]

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Does screening for depressive symptoms help optimize duloxetine use in knee OA patients with moderate pain? A cost-effectiveness analysis.

Nora K Lenhard, James K Sullivan, Eric L Ross, Shuang Song, Robert R Edwards, David J Hunter, Tuhina Neogi, Jeffrey N Katz, Elena Losina,

<h4>Objective</h4>Duloxetine is an FDA-approved treatment for both osteoarthritis (OA) pain and depression, but uptake of duloxetine in knee OA management varies. We examined the cost-effectiveness of adding duloxetine to knee OA care with or without depression screening.<h4>Methods</h4>We used the Osteoarthritis Policy Model, a validated computer microsimulation of knee OA, to ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2020, :]

Cited: 0 times

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