Full Text Journal Articles by
Author Robert P Woroniecki

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1912-1922]

Cited: 0 times

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Diabetes Insipidus Complicating Management in a Child with COVID-19 and Multiorgan System Failure: A Novel Use for Furosemide.

Sara D Gungor, Robert P Woroniecki, Erin Hulfish, Katherine V Biagas,

Judicious balance of fluids is needed for optimal management of acute respiratory distress syndrome (ARDS). Achieving optimal fluid balance is difficult in patients with disorders of fluid homeostasis such as diabetes insipidus (DI). There is little data on the use of Furosemide to aid in balancing fluid and electrolytes in ... Read more >>

Case Rep Crit Care (Case reports in critical care)
[2021, 2021:5942431]

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Weight as a Risk Factor for Mortality in Critically Ill Patients.

Itay Ayalon, Jessica G Woo, Rajit K Basu, Ahmad Kaddourah, Stuart L Goldstein, Jennifer M Kaplan, ,

<h4>Objectives</h4>To explore the hypothesis that obesity is associated with increased mortality and worse outcomes in children who are critically ill.<h4>Methods</h4>Secondary analysis of the Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology study, a prospective, multinational observational study. Patients between 3 months and 25 years across Asia, Australia, Europe, ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(2):]

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Pediatric Immunization Practices in Nephrotic Syndrome: An Assessment of Provider and Parental Knowledge.

Cheryl L Tran, David T Selewski, Gia J Oh, Jonathan P Troost, Susan F Massengill, Samhar I Al-Akash, Shefali Mahesh, Rasheda Amin, Isa F Ashoor, Rahul Chanchlani, Mahmoud Kallash, Robert P Woroniecki, Debbie S Gipson,

<b>Background:</b> Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine-preventable infections. Immunization practices in ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:619548]

Cited: 0 times

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Hypertension in Childhood Nephrotic Syndrome.

Ibrahim F Shatat, Lauren J Becton, Robert P Woroniecki,

Arterial hypertension (HTN) is commonly encountered by clinicians treating children with steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS). Although the prevalence of HTN in SSNS is less documented than in SRNS, recent studies reported high prevalence in both. Studies have estimated the prevalence of HTN in different patient ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:287]

Cited: 3 times

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Oliguria and Acute Kidney Injury in Critically Ill Children: Implications for Diagnosis and Outcomes.

Ahmad Kaddourah, Rajit K Basu, Stuart L Goldstein, Scott M Sutherland, ,

<h4>Objectives</h4>Consensus definitions for acute kidney injury are based on changes in serum creatinine and urine output. Although the creatinine criteria have been widely applied, the contribution of the urine output criteria remains poorly understood. We evaluated these criteria individually and collectively to determine their impact on the diagnosis and outcome ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(4):332-339]

Cited: 13 times

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Editorial: Nephrotic Syndrome in Pediatric Patients.

Robert P Woroniecki, Agnieszka Swiatecka-Urban, Frederick J Kaskel,

Front Pediatr (Frontiers in pediatrics)
[2017, 5:167]

Cited: 1 time

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Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review.

Robert P Woroniecki, Andrew Kahnauth, Laurie E Panesar, Katarina Supe-Markovina,

Adults with arterial hypertension (HTN) have stroke, myocardial infarction, end-stage renal disease (ESRD), or die at higher rates than those without. In children, HTN leads to target organ damage, which includes kidney, brain, eye, blood vessels, and heart, which precedes "hard outcomes" observed in adults. Left ventricular hypertrophy (LVH) or ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2017, 5:101]

Cited: 3 times

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APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts.

Derek K Ng, Catherine C Robertson, Robert P Woroniecki, Sophie Limou, Christopher E Gillies, Kimberly J Reidy, Cheryl A Winkler, Sangeeta Hingorani, Keisha L Gibson, Rebecca Hjorten, Christine B Sethna, Jeffrey B Kopp, Marva Moxey-Mims, Susan L Furth, Bradley A Warady, Matthias Kretzler, John R Sedor, Frederick J Kaskel, Matthew G Sampson,

<h4>Background</h4>Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2017, 32(6):983-990]

Cited: 28 times

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Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults.

Ahmad Kaddourah, Rajit K Basu, Sean M Bagshaw, Stuart L Goldstein, ,

<h4>Background</h4>The epidemiologic characteristics of children and young adults with acute kidney injury have been described in single-center and retrospective studies. We conducted a multinational, prospective study involving patients admitted to pediatric intensive care units to define the incremental risk of death and complications associated with severe acute kidney injury.<h4>Methods</h4>We used ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 376(1):11-20]

Cited: 233 times

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Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.

Robert P Woroniecki, Derek K Ng, Sophie Limou, Cheryl A Winkler, Kimberly J Reidy, Mark Mitsnefes, Matthew G Sampson, Craig S Wong, Bradley A Warady, Susan L Furth, Jeffrey B Kopp, Frederick J Kaskel,

<h4>Background and objectives</h4>African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how <i>APOL1</i> genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children.<h4>Design setting participants and measurements</h4>We examined the prevalence of <i>APOL1</i> genotypes and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2016, 4:122]

Cited: 16 times

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Assessment of Left Ventricular Mass and Hypertrophy by Cardiovascular Magnetic Resonance Imaging in Pediatric Hypertension.

Katarina Supe-Markovina, James C Nielsen, Muzammil Musani, Laurie E Panesar, Robert P Woroniecki,

Cardiovascular magnetic resonance (CMR) imaging in adults is considered the gold standard for assessment of left ventricular mass (LVM) and left ventricular hypertrophy (LVH). The authors aimed to evaluate agreement of LVM measurements and LVH determination between echocardiography (ECHO) and CMR imaging in children with hypertension (HTN) confirmed by 24-hour ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2016, 18(10):976-981]

Cited: 3 times

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Rituximab in post-transplant pediatric recurrent focal segmental glomerulosclerosis.

Juhi Kumar, Ibrahim F Shatat, Amy L Skversky, Robert P Woroniecki, Marcela Del Rio, Eduardo M Perelstein, Valerie L Johnson, Shefali Mahesh,

<h4>Background</h4>Focal segmental glomerulosclerosis (FSGS) recurs in 20-40 % of allografts. Plasmapheresis (TPE) has been one of the mainstays of treatment with variable results. Rituximab (RTX), a monoclonal antibody to the protein CD20, is being used for treatment of recurrent FSGS (recFSGS) but pediatric experience is limited.<h4>Methods</h4>We conducted a retrospective review ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2013, 28(2):333-338]

Cited: 21 times

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Hypertension, chronic kidney disease, and renal pathology in a child with hermansky-pudlak syndrome.

Roberto Gordillo, Marcela Del Rio, David B Thomas, Joseph T Flynn, Robert P Woroniecki,

We report a child with Hermansky-Pudlak Syndrome (HPS) and chronic kidney disease (stage II) with histological diagnosis of focal segmental glomerulosclerosis (FSGS). A 15-year-old male of Puerto Rico ancestry with history of HPS, hypertension (HTN), asthma, obesity, and chronic kidney disease (CKD) stage II presented with new-onset proteinuria without edema. ... Read more >>

Int J Nephrol (International journal of nephrology)
[2011, 2011:324916]

Cited: 4 times

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Recurrent focal segmental glomerulosclerosis in renal allograft recipients: role of human leukocyte antigen mismatching and other clinical variables.

Shimi Sharief, Shefali Mahesh, Marcela Del Rio, Vivian Telis, Robert P Woroniecki,

Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation impacts long-term graft survival and limits access to transplantation. We hypothesized that HLA donor/recipient matching could be used as a surrogate marker of recurrence. In a retrospective study of 42 pediatric and 77 adult subjects with primary FSGS, transplanted from 1990 ... Read more >>

Int J Nephrol (International journal of nephrology)
[2011, 2011:506805]

Cited: 4 times

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Progression of glomerular and tubular disease in pediatrics.

Robert P Woroniecki, H William Schnaper,

Chronic kidney disease may be stimulated by many different etiologies, but its progression involves a common, yet complex, series of events that lead to the replacement of normal tissue with scar. These events include altered physiology within the kidney leading to abnormal hemodynamics, chronic hypoxia, inflammation, cellular dysfunction, and activation ... Read more >>

Semin Nephrol (Seminars in nephrology)
[2009, 29(4):412-424]

Cited: 3 times

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Outcome of dialysis in children with human immunodeficiency virus infection.

Roberto Gordillo, Juhi Kumar, Marcela Del Rio, Joseph T Flynn, Robert P Woroniecki,

Human immunodeficiency virus (HIV) infection accounts for an unknown percentage of children with end-stage kidney disease (ESKD). Our objective was to compare the outcome of renal replacement therapy (RRT) in subjects with ESKD due to HIV and other diagnoses and to examine the prevalence of ESKD due to HIV. We ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2009, 24(1):171-175]

Cited: 4 times

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Laser capture microdissection of kidney tissue.

Robert P Woroniecki, Erwin P Bottinger,

Kidney tissue laser capture microdissection (LCM) is of great clinical relevance since genome wide studies on total kidney messenger RNA (mRNA) potentially miss important factors involved in the pathogenesis of the disease in glomeruli and tubules. This technique is readily applicable to study mRNA from isolated glomeruli and tubules of ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2009, 466:73-82]

Cited: 5 times

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The role of osteopontin in the development of albuminuria.

Johan Lorenzen, Rajshree Shah, Alisha Biser, Serban A Staicu, Thiruvur Niranjan, Ana Maria Garcia, Antje Gruenwald, David B Thomas, Ibrahim F Shatat, Katarine Supe, Robert P Woroniecki, Katalin Susztak,

Several gene array studies have suggested that osteopontin (Opn) expression strongly correlates with albuminuria and glomerular disease. Urinary Opn concentration and kidney Opn immunoreactivity were found to be increased in patients with steroid-sensitive nephrotic syndrome. In addition, renal Opn mRNA was increased in the Ins2(Akita) mouse model of type 1 ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2008, 19(5):884-890]

Cited: 55 times

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Increased prevalence of renal and urinary tract anomalies in children with congenital hypothyroidism.

Juhi Kumar, Roberto Gordillo, Frederick J Kaskel, Charlotte M Druschel, Robert P Woroniecki,

<h4>Objective</h4>We investigated the prevalence of congenital renal and urologic anomalies in children with congenital hypothyroidism to determine whether further renal and urologic investigations would be of benefit.<h4>Study design</h4>Prevalence of congenital hypothyroidism was obtained from the New York State Congenital Malformation Registry. The occurrence of urinary tract anomalies were calculated for ... Read more >>

J Pediatr (The Journal of pediatrics)
[2009, 154(2):263-266]

Cited: 34 times

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Urinary cytokines and steroid responsiveness in idiopathic nephrotic syndrome of childhood.

Robert P Woroniecki, Ibrahim F Shatat, Katarina Supe, Zhongfang Du, Frederick J Kaskel,

<h4>Background/aim</h4>Steroid-resistant nephrotic syndrome (SRNS) has been associated with activation of TGF-beta(1) and progression to chronic kidney disease. Steroid-sensitive nephrotic syndrome (SSNS) has been associated with activation of T-cells and favorable outcome. Our objective was to distinguish SRNS from SSNS and focal segmental glomerulosclerosis (FSGS) from minimal change disease (MCD) on ... Read more >>

Am J Nephrol (American journal of nephrology)
[2008, 28(1):83-90]

Cited: 12 times

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Genetics of focal segmental glomerulosclerosis.

Robert P Woroniecki, Jeffrey B Kopp,

The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2007, 22(5):638-644]

Cited: 15 times

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Association of steroid and cyclosporin resistance in focal segmental glomerulosclerosis.

Ibrahim F Shatat, Morris Schoeneman, Joseph T Flynn, Robert P Woroniecki,

Given the variable response of steroid-resistant nephrotic syndrome (SRNS) to treatment with cyclosporin (CsA), it may be inappropriate to expose all SR patients to additional immunosuppression. How to determine from which patients to withhold CsA is unclear. We tested the hypothesis that in patients with primary focal segmental glomerulosclerosis (FSGS), ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2007, 22(6):834-839]

Cited: 5 times

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Urinary proteome of steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome of childhood.

Robert P Woroniecki, Tatyana N Orlova, Natasha Mendelev, Ibrahim F Shatat, Susan M Hailpern, Frederick J Kaskel, Michael S Goligorsky, Edmond O'Riordan,

The response to steroid therapy is used to characterize the idiopathic nephrotic syndrome (INS) of childhood as either steroid-sensitive (SSNS) or steroid-resistant (SRNS), a classification with a better prognostic capability than renal biopsy. The majority (approximately 80%) of INS is due to minimal change disease but the percentage of focal ... Read more >>

Am J Nephrol (American journal of nephrology)
[2006, 26(3):258-267]

Cited: 34 times

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Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein.

Robert P Woroniecki, Mario Schiffer, Andrey S Shaw, Frederick J Kaskel, Erwin P Bottinger,

Mice lacking CD2-associated protein (CD2AP-/-) develop glomerular lesions resembling human focal segmental glomerulosclerosis (FSGS) between 3-4 weeks of age and die approximately 2 weeks later from massive proteinuria and renal failure. The mechanisms involved in the glomerular injury in this model are unclear. In this study, we used laser capture ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2006, 21(3):333-338]

Cited: 10 times

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