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Author Robert P Hasserjian

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JAK2 Rearrangements Are a Recurrent Alteration in CD30+ Systemic T-Cell Lymphomas With Anaplastic Morphology.

Megan J Fitzpatrick, Lucas R Massoth, Chelsea Marcus, Jo-Anne Vergilio, Eric Severson, Daniel Duncan, Shakti H Ramkissoon, Robert P Hasserjian, Annette S Kim, Aliyah R Sohani, Erik A Williams, Valentina Nardi,

Peripheral T-cell lymphoma (PTCL) comprises a heterogenous group of rare mature T-cell neoplasms. While some PTCL subtypes are well-characterized by histology, immunophenotype, and recurrent molecular alterations, others remain incompletely defined. In particular, the distinction between CD30+ PTCL, not otherwise specified and anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma can ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):895-904]

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Distinguishing AML from MDS: a fixed blast percentage may no longer be optimal.

Elihu H Estey, Robert P Hasserjian, Hartmut Döhner,

Patients with acute myeloid leukemia (AML) have conventionally received more "intense" therapy than patients with myelodysplastic syndromes (MDS). Although less intense therapies are being used more often in AML, the AML-MDS dichotomy remains, with the presence of ≥ 20% myeloblasts in marrow or peripheral blood generally regarded as defining AML. ... Read more >>

Blood (Blood)
[2021, :]

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Multiorgan failure in a fatal case of autoimmune hemolytic anemia.

Annabelle J Anandappa, Jonathan A Stefely, Robert P Hasserjian, Walter H Dzik, Anem Waheed,

<h4>Background</h4>Autoimmune hemolytic anemia (AIHA) results in red blood cell destruction by auto-antibodies directed against surface antigens and is rarely fatal. Here we describe a case of AIHA, refractory to both standard and experimental therapies, complicated by multiorgan failure, and rapidly leading to death.<h4>Case report and results</h4>A 65 year-old man who ... Read more >>

Transfusion (Transfusion)
[2021, :]

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Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML.

Damodaran Narayanan, Olga Pozdnyakova, Robert P Hasserjian, Sanjay S Patel, Olga K Weinberg,

The clinicopathologic features of DNA methyltransferase 3A (DNMT3A)-mutated de novo acute myeloid leukemia (AML), and the significance of variant type, variant allele frequency (VAF), and multiple concomitant DNMT3A mutations, remain poorly defined. We examined 104 DNMT3A-mutated de novo AML patients from 2 major centers. Most (82%) had normal karyotype (NK); ... Read more >>

Blood Adv (Blood advances)
[2021, 5(11):2539-2549]

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Myeloid/lymphoid neoplasms with FLT3 rearrangement.

Guilin Tang, Wayne Tam, Nicholas J Short, Prithviraj Bose, David Wu, Stephanie N Hurwitz, Adam Bagg, Heesun J Rogers, Eric D Hsi, Andres E Quesada, Wei Wang, Roberto N Miranda, Carlos E Bueso-Ramos, L Jeffrey Medeiros, Valentina Nardi, Robert P Hasserjian, Daniel A Arber, Attilio Orazi, Kathryn Foucar, Sa A Wang,

Myeloid/lymphoid neoplasms (M/LN) with 13q12/FLT3 rearrangement have been suggested as candidates for possible inclusion in the World Health Organization classification group of M/LN with eosinophilia (M/LN-eo). We report 12 patients with confirmed FLT3 rearrangement, six with t(12;13)/ETV6-FLT3; one with ins(13;22)/BCR-FLT3; and five with an unconfirmed partner gene located on chromosome ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomic Alterations Distinct from Follicular Dendritic Cell Sarcoma.

Lucas R Massoth, Yin P Hung, Judith A Ferry, Robert P Hasserjian, Valentina Nardi, G Petur Nielsen, Sam Sadigh, Vinayak Venkataraman, Martin Selig, Alison M Friedmann, Wesley Samore, Jonathan Keith Killian, Riza Milante, Joseph Giessinger, Kathleen Foley-Peres, Chelsea Marcus, Eric Severson, Daniel Duncan, Smruthy Sivakumar, Jeffrey S Ross, Vikram Desphande, Shakti H Ramkissoon, Jo-Anne Vergilio, Abner Louissaint, Lawrence R Zukerberg, Erik A Williams,

<h4>Background</h4>Histiocytic and dendritic cell neoplasms are a diverse group of tumors arising from monocytic or dendritic cell lineage. Whereas the genomic features for Langerhans cell histiocytosis and Erdheim-Chester disease have been well described, other less common and often aggressive tumors in this broad category remain poorly characterized, and comparison studies ... Read more >>

Oncologist (The oncologist)
[2021, 26(7):e1263-e1272]

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Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Elsa Bernard, Yasuhito Nannya, Robert P Hasserjian, Sean M Devlin, Heinz Tuechler, Juan S Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F Levine, Juan E Arango, Yangyu Zhou, Francesc Solé, Catherine A Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A van de Loosdrecht, Martin Jädersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y Follo, Felicitas Thol, Ronald F Pinheiro, Valeria Santini, Ioannis Kotsianidis, Jacqueline Boultwood, Fabio P S Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori-Kondo, Toru Kiguchi, Chantana Polprasert, John M Bennett, Virginia M Klimek, Michael R Savona, Monika Belickova, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Ades, Matteo Giovanni Della Porta, Harold K Elias, Alexandra G Smith, Yesenia Werner, Minal Patel, Agnès Viale, Katelynd Vanness, Donna S Neuberg, Kristen E Stevenson, Kamal Menghrajani, Kelly L Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H Jansen, José Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L Ebert, Rafael Bejar, Peter L Greenberg, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Elli Papaemmanuil,

Nat Med (Nature medicine)
[2021, 27(5):927]

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A novel differentiation response with combination IDH inhibitor and intensive induction therapy for AML.

Emily F Mason, Olga Pozdnyakova, Mikhail Roshal, Amir T Fathi, Eytan M Stein, P Brent Ferrell, Aaron C Shaver, Mark Frattini, Hongfang Wang, Lei Hua, Jimmy Mu, Sung Choe, Rengyi Xu, Caroline Almon, Michael Cooper, Richard M Stone, Robert P Hasserjian, Michael R Savona,

Blood Adv (Blood advances)
[2021, 5(8):2279-2283]

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Navigating Myelodysplastic and Myelodysplastic/Myeloproliferative Overlap Syndromes.

Robert P Hasserjian, Rena Buckstein, Mrinal M Patnaik,

Myelodysplastic syndromes (MDS) and MDS/myeloproliferative neoplasms (MPNs) are clonal diseases that differ in morphologic diagnostic criteria but share some common disease phenotypes that include cytopenias, propensity to acute myeloid leukemia evolution, and a substantially shortened patient survival. MDS/MPNs share many clinical and molecular features with MDS, including frequent mutations involving ... Read more >>

Am Soc Clin Oncol Educ Book (American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting)
[2021, 41:328-350]

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Flow cytometry reveals the nuances of clonal haematopoiesis.

Robert P Hasserjian,

Br J Haematol (British journal of haematology)
[2021, 192(6):949-950]

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Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Elsa Bernard, Yasuhito Nannya, Robert P Hasserjian, Sean M Devlin, Heinz Tuechler, Juan S Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F Levine, Juan E Arango, Yangyu Zhou, Francesc Solé, Catherine A Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A van de Loosdrecht, Martin Jädersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y Follo, Felicitas Thol, Ronald F Pinheiro, Valeria Santini, Ioannis Kotsianidis, Jacqueline Boultwood, Fabio P S Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori-Kondo, Toru Kiguchi, Chantana Polprasert, John M Bennett, Virginia M Klimek, Michael R Savona, Monika Belickova, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Ades, Matteo Giovanni Della Porta, Alexandra G Smith, Yesenia Werner, Minal Patel, Agnès Viale, Katelynd Vanness, Donna S Neuberg, Kristen E Stevenson, Kamal Menghrajani, Kelly L Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H Jansen, José Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L Ebert, Rafael Bejar, Peter L Greenberg, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Elli Papaemmanuil,

Nat Med (Nature medicine)
[2021, 27(3):562]

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Clinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group.

Olga K Weinberg, Karen M Chisholm, Chi Young Ok, Yuri Fedoriw, Bartosz Grzywacz, Jason H Kurzer, Emily F Mason, Karen A Moser, Siddharth Bhattacharya, Mina Xu, Daniel Babu, Kathryn Foucar, Wayne Tam, Adam Bagg, Attilio Orazi, Tracy I George, Wei Wang, Sa A Wang, Daniel A Arber, Robert P Hasserjian,

Natural killer (NK) cells are lymphocytes of the native immune system that play a pivotal role in host defense and immune surveillance. While the conceptual view of NK-neoplasms is evolving, little is known about the rare NK lymphoblastic leukemia (NK-LL), which remains as a provisional entity in the 2016 WHO ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, 34(7):1358-1366]

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Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells.

Madhu M Ouseph, Robert P Hasserjian, Paola Dal Cin, Scott B Lovitch, David P Steensma, Valentina Nardi, Olga K Weinberg,

Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in hematopoietic cells in men. However, due to the high prevalence of LOY as the sole cytogenetic finding in the healthy older population, differentiating isolated LOY associated with clonal hematologic processes from aging-associated mosaicism can ... Read more >>

Haematologica (Haematologica)
[2021, 106(2):555-564]

Cited: 2 times

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Controversies in the recent (2016) World Health Organization classification of acute myeloid leukemia.

Robert P Hasserjian,

The current World Health Organization (WHO) Classification of acute myeloid leukemia (AML), developed in 2016 and published in 2017, codifies the defining features of AML and recognizes several subtypes based on clinical, morphologic, and genetic features. This classification is widely used for the purposes of assigning patients to specific therapeutic ... Read more >>

Best Pract Res Clin Haematol (Best practice & research. Clinical haematology)
[2021, 34(1):101249]

Cited: 1 time

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Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.

Peter G Miller, Adam S Sperling, Christopher J Gibson, Kaushik Viswanathan, Cecilia Castellano, Marie McConkey, John Ceremsak, Martin S Taylor, Sebastian Birndt, Florian Perner, Jon Arnason, Mridul Agrawal, Alison M Schram, Sarah Nikiforow, German Pihan, Robert P Hasserjian, Jon C Aster, Paul La Rosée, Elizabeth A Morgan, Nancy Berliner, Benjamin L Ebert,

Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. Unlike pediatric HLH, adult HLH is rarely driven by germline genetic variants. Although numerous precipitating etiologies have been identified, the reason that HLH occurs in only a subset of individuals and how other factors contribute to the disease ... Read more >>

Blood (Blood)
[2020, 136(26):3051-3055]

Cited: 2 times

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Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Elsa Bernard, Yasuhito Nannya, Robert P Hasserjian, Sean M Devlin, Heinz Tuechler, Juan S Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F Levine, Juan E Arango, Yangyu Zhou, Francesc Solé, Catherine A Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A van de Loosdrecht, Martin Jädersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y Follo, Felicitas Thol, Ronald F Pinheiro, Valeria Santini, Ioannis Kotsianidis, Jacqueline Boultwood, Fabio P S Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori-Kondo, Toru Kiguchi, Chantana Polprasert, John M Bennett, Virginia M Klimek, Michael R Savona, Monika Belickova, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Ades, Matteo Giovanni Della Porta, Harold K Elias, Alexandra G Smith, Yesenia Werner, Minal Patel, Agnès Viale, Katelynd Vanness, Donna S Neuberg, Kristen E Stevenson, Kamal Menghrajani, Kelly L Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H Jansen, José Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L Ebert, Rafael Bejar, Peter L Greenberg, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Elli Papaemmanuil,

Tumor protein p53 (TP53) is the most frequently mutated gene in cancer<sup>1,2</sup>. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease<sup>3,4</sup>, rapid transformation to acute myeloid leukemia (AML)<sup>5</sup>, resistance to conventional therapies<sup>6-8</sup> and dismal outcomes<sup>9</sup>. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- ... Read more >>

Nat Med (Nature medicine)
[2020, 26(10):1549-1556]

Cited: 30 times

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Chronic myeloid neoplasms harboring concomitant mutations in myeloproliferative neoplasm driver genes (JAK2/MPL/CALR) and SF3B1.

Chi Young Ok, Kevin T Trowell, Kyle G Parker, Karen Moser, Olga K Weinberg, Heesun J Rogers, Kaaren K Reichard, Tracy I George, Eric D Hsi, Carlos E Bueso-Ramos, Wayne Tam, Attilio Orazi, Adam Bagg, Daniel A Arber, Robert P Hasserjian, Sa A Wang,

JAK2, CALR, and MPL are myeloproliferative neoplasm (MPN)-driver mutations, whereas SF3B1 is strongly associated with ring sideroblasts (RS) in myelodysplastic syndrome (MDS). Concomitant mutations of SF3B1 and MPN-driver mutations out of the context of MDS/MPN with RS and thrombocytosis (MDS/MPN-RS-T) are not well-studied. From the cases (<5% blasts) tested by ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, 34(1):20-31]

Cited: 2 times

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How I Diagnose Low-Grade Myelodysplastic Syndromes.

Alexa J Siddon, Robert P Hasserjian,

OBJECTIVES:Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms that are often difficult to diagnose due to their pathologic and clinical heterogeneity. The key features of MDS are peripheral blood cytopenias, ineffective hematopoiesis manifesting as morphologic dysplasia, and clonal genetic abnormalities. The most difficult diagnostic dilemmas often arise in low-grade ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2020, 154(1):5-14]

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Pan-sarcoma genomic analysis of KMT2A rearrangements reveals distinct subtypes defined by YAP1-KMT2A-YAP1 and VIM-KMT2A fusions.

Lucas R Massoth, Yin P Hung, Valentina Nardi, G Petur Nielsen, Robert P Hasserjian, Abner Louissaint, Adam S Fisch, Vikram Deshpande, Lawrence R Zukerberg, Jochen K Lennerz, Martin Selig, Krzysztof Glomski, Parth J Patel, Kevin Jon Williams, Ethan S Sokol, Brian M Alexander, Jo-Anne Vergilio, Jeffrey S Ross, Dean C Pavlick, Ivan Chebib, Erik A Williams,

Sarcomas are driven by diverse pathogenic mechanisms, including gene rearrangements in a subset of cases. Rare soft tissue sarcomas containing KMT2A fusions have recently been reported, characterized by a predilection for young adults, sclerosing epithelioid fibrosarcoma-like morphology, and an often aggressive course. Nonetheless, clinicopathologic and molecular descriptions of KMT2A-rearranged sarcomas ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(11):2307-2317]

Cited: 3 times

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Comparison of therapy-related and de novo core binding factor acute myeloid leukemia: A bone marrow pathology group study.

Heesun J Rogers, Xiaoqiong Wang, Yan Xie, Adam R Davis, Beenu Thakral, Sa A Wang, Gautam Borthakur, Miguel D Cantu, Elizabeth M Margolskee, John K S Philip, Madina Sukhanova, Adam Bagg, Carlos E Bueso-Ramos, Attilio Orazi, Daniel A Arber, Eric D Hsi, Robert P Hasserjian,

This multi-institutional study retrospectively evaluated clinicopathologic and genetic characteristics in 351 patients with core-binding-factor acute myeloid leukemia (CBF-AML), comprising 69 therapy-related (t-CBF-AML) and 282 de novo cases. The T-CBF-AML patients were older, had lower WBC counts, and slightly higher hemoglobin than patients with de novo disease. Secondary cytogenetic abnormalities were ... Read more >>

Am J Hematol (American journal of hematology)
[2020, 95(7):799-808]

Cited: 3 times

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Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia.

Robert P Hasserjian, David P Steensma, Timothy A Graubert, Benjamin L Ebert,

Current objectives regarding treatment of acute myeloid leukemia (AML) include achieving complete remission (CR) by clinicopathological criteria followed by interrogation for the presence of minimal/measurable residual disease (MRD) by molecular genetic and/or flow cytometric techniques. Although advances in molecular genetic technologies have enabled highly sensitive detection of AML-associated mutations and ... Read more >>

Blood (Blood)
[2020, 135(20):1729-1738]

Cited: 5 times

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Concordance among hematopathologists in classifying blasts plus promonocytes: A bone marrow pathology group study.

Kathryn Foucar, Eric D Hsi, Sa A Wang, Heesun J Rogers, Robert P Hasserjian, Adam Bagg, Tracy I George, Roland L Bassett, LoAnn C Peterson, William G Morice, Daniel A Arber, Attilio Orazi, Carlos E Bueso-Ramos, ,

Enumeration of blasts and promonocytes is essential for World Health Organization (WHO) classification of myelomonocytic neoplasms. The accuracy of distinguishing blasts, promonocytes and monocytes, including normal vs abnormal monocytes, remains controversial. The objective of this analysis is to assess concordances between experienced hematopathologists in classifying cells as blasts, promonocytes, and ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, 42(4):418-422]

Cited: 2 times

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Bone marrow niches in haematological malignancies.

Simón Méndez-Ferrer, Dominique Bonnet, David P Steensma, Robert P Hasserjian, Irene M Ghobrial, John G Gribben, Michael Andreeff, Daniela S Krause,

Haematological malignancies were previously thought to be driven solely by genetic or epigenetic lesions within haematopoietic cells. However, the niches that maintain and regulate daily production of blood and immune cells are now increasingly being recognized as having an important role in the pathogenesis and chemoresistance of haematological malignancies. Within ... Read more >>

Nat Rev Cancer (Nature reviews. Cancer)
[2020, 20(5):285-298]

Cited: 47 times

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Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.

David B Chou, Viktoras Frismantas, Yuka Milton, Rhiannon David, Petar Pop-Damkov, Douglas Ferguson, Alexander MacDonald, Özge Vargel Bölükbaşı, Cailin E Joyce, Liliana S Moreira Teixeira, Arianna Rech, Amanda Jiang, Elizabeth Calamari, Sasan Jalili-Firoozinezhad, Brooke A Furlong, Lucy R O'Sullivan, Carlos F Ng, Youngjae Choe, Susan Marquez, Kasiani C Myers, Olga K Weinberg, Robert P Hasserjian, Richard Novak, Oren Levy, Rachelle Prantil-Baun, Carl D Novina, Akiko Shimamura, Lorna Ewart, Donald E Ingber,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Biomed Eng (Nature biomedical engineering)
[2020, 4(4):477]

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Multiparametric in situ imaging of NPM1-mutated acute myeloid leukemia reveals prognostically-relevant features of the marrow microenvironment.

Sanjay S Patel, Mikel Lipschitz, Geraldine S Pinkus, Jason L Weirather, Olga Pozdnyakova, Emily F Mason, Giorgio Inghirami, Robert P Hasserjian, Scott J Rodig, Olga K Weinberg,

Ancillary testing during the initial workup of acute myeloid leukemia (AML) is largely performed using aspirated materials. We utilized multiplex immunofluorescence (MIF) imaging with digital image analysis to perform an in situ analysis of the microenvironment in NPM1-mutated AML using diagnostic bone marrow biopsy tissues (N = 17) and correlated these findings ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(7):1380-1388]

Cited: 1 time

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