Full Text Journal Articles by
Author Robert Macarthur


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The Rockefeller Team Science Leadership training program: Curriculum, standardized assessment of competencies, and impact of returning assessments.

Roger Vaughan, Michelle Romanick, Donna Brassil, Rhonda Kost, Maija Neville-Williams, Riva Gottesman, Rita Devine, Prasanth Manukonda, Andrea Ronning, Barbara O'Sullivan, Bernadette Capili, Robert Macarthur, Jonathan N Tobin, Tesheia Johnson, Eugene D Shapiro, Emma Meagher, James Krueger, Sarah Schlesinger, Barry S Coller,

The ability to effectively lead an interdisciplinary translational team is a crucial component of team science success. Most KL2 Clinical Scholars have been members of scientific teams, but few have been team science leaders. There is a dearth of literature and outcome measures of effective Team Science Leadership in clinical ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
[2021, 5(1):e165]

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Compounded bioidentical hormone products, a path forward.

Robert B MacArthur, Donald Mattison, Ruth M Parker,

<h4>Objective</h4>To describe the widespread use of compounded bioidentical hormone therapies (cBHT). To define the term clinical utility and present why there is insufficient evidence to support the overall clinical utility of cBHT products. To recommend actions that pharmacists and regulators can take to promote safer cBHT use.<h4>Summary</h4>Nationwide, millions of men ... Read more >>

J Am Pharm Assoc (2003) (Journal of the American Pharmacists Association : JAPhA)
[2021, :]

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Excess dietary fructose does not alter gut microbiota or permeability in humans: A pilot randomized controlled study.

José O Alemán, Wendy A Henderson, Jeanne M Walker, Andrea Ronning, Drew R Jones, Peter J Walter, Scott G Daniel, Kyle Bittinger, Roger Vaughan, Robert MacArthur, Kun Chen, Jan L Breslow, Peter R Holt,

<h4>Introduction</h4>Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver disease that accompanies obesity and the metabolic syndrome. Excess fructose consumption can initiate or exacerbate NAFLD in part due to a consequence of impaired hepatic fructose metabolism. Preclinical data emphasized that fructose-induced altered gut microbiome, increased gut permeability, ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
[2021, 5(1):e143]

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Dive Performance and Aquatic Thermoregulation of the World’s Smallest Mammalian Diver, the American Water Shrew (Sorex palustris)

Roman Gusztak, Robert MacArthur, Kevin Campbell,

<h4>ABSTRACT</h4> Allometry predicts that the 12–17 g American water shrew ( Sorex palustris )—the world’s smallest mammalian diver—will have the highest diving metabolic rate coupled with the lowest total body oxygen storage capacity, skeletal muscle buffering capacity, and glycolytic potential of any endothermic diver. Consistent with expectations, and potentially owing ... Read more >>

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Obesity Related Glomerulopathy: weighing in the effect of Body Surface Area

Bielopolski Dana, Singh Neha, Bentur Ohad, Renert-Yuval Yael, MacArthur Robert, Vasquez Kimberly, Moftah Dena, Vaughan Roger, Kost Rhonda, Tobin Jonathan,

<h4>Importance</h4> Obesity-related glomerulopathy (ORG), part of the cardio-renal spectrum, has an early reversible stage of hyperfiltration. Early identification in the obese adolescent population provides an opportunity to reverse the damage. <h4>Objective</h4> Age-appropriate formulae for estimated glomerular filtration rate (eGFR), are standardized to ideal body surface area (BSA) and provide assessment ... Read more >>

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CTSA pharmacies: Contribution to research and public health during the COVID-19 pandemic.

Robert B MacArthur, Ohad S Bentur, Ian C MacArthur, Anna S Bartoo, Donna L Capozzi, Jason A Christensen, Amber L Johnson, Kuldip Patel, Barry S Coller,

<h4>Introduction</h4>In March 2020, academic medical center (AMC) pharmacies were compelled to implement practice changes in response to the COVID-19 pandemic. These changes were described by survey data collected by the Clinical and Translational Science Awards (CTSA) program which were interpreted by a multi-institutional team of AMC pharmacists and physician investigators.<h4>Methods</h4>The ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
[2021, 5(1):e108]

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Phase 1 Randomized Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate – A Potential Treatment for COVID-19

Ohad Bentur, Richard Hutt, Donna Brassil, Per Bäckman, Igor Gonda, Homer Boushey, B. Cahrous, Barry Coller, Robert MacArthur,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, 147(2):AB237-AB237]

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Excess Dietary Fructose Does Not Alter Gut Microbiota or Permeability in Humans: A Randomized Controlled Pilot Study

Jose Aleman, Wendy Henderson, Jeanne Walker, Andrea Ronning, Drew Jones, Peter Walter, Scott Daniel, Kyle Bittinger, Roger Vaughan, Robert MacArthur, Kun Chen, Jan Breslow, Peter Holt,

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver disease that accompanies obesity and the metabolic syndrome. Excess fructose consumption can initiate or exacerbate NAFLD due in part to a consequence of impaired hepatic fructose metabolism. Pre-clinical data have emphasized that fructose-induced altered ... Read more >>

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2145 Drug formulation strategies: A vital but nearly invisible component in translational education

Robert B. MacArthur, Roger Vaughan, Barry S. Coller,

OBJECTIVES/SPECIFIC AIMS: To develop a KL2 curriculum on the science and art of drug formulation. METHODS/STUDY POPULATION: Develop training materials for KL2 scholars that outline the art of formulation development. Materials will include syllabi, reading materials, and course work. RESULTS/ANTICIPATED RESULTS: This will enhance the training of KL2 scholars by ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
[2018, 2(Suppl 1):54-54]

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Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension.

Nadine Al-Naamani, Harold I Palevsky, David J Lederer, Evelyn M Horn, Stephen C Mathai, Kari E Roberts, Russell P Tracy, Paul M Hassoun, Reda E Girgis, Daichi Shimbo, Wendy S Post, Steven M Kawut, ,

<h4>Rationale</h4>Pulmonary arterial hypertension (PAH) is a rare progressive disease of the pulmonary vasculature that is characterized by endothelial dysfunction, inflammation, and right ventricular dysfunction.<h4>Objectives</h4>The main objective was to determine whether endothelial, inflammatory, and cardiac biomarkers would be associated with the World Health Organization functional assessment and survival in patients with ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2016, 13(1):25-30]

Cited: 21 times

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The association of nurse practitioners' mortality risk assessments and advance care planning discussions on nursing home patients' clinical outcomes.

Susan E Mullaney, Karen Devereaux Melillo, A James Lee, Robert MacArthur,

<h4>Purpose</h4>To investigate the impact nurse practitioners' (NPs) documented mortality risk assessments (MRAs) and advance care planning (ACP) discussions have on clinical outcomes for newly enrolled Medicare Advantage nursing home patients.<h4>Methods</h4>Data collection in this mixed-method study consisted of quantitative data from a convenience sample of NPs' MRAs and medical record reviews ... Read more >>

J Am Assoc Nurse Pract (Journal of the American Association of Nurse Practitioners)
[2016, 28(6):304-310]

Cited: 4 times

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An Algorithm to Identify Compounded Non-Sterile Products that Can Be Formulated on a Commercial Scale or Imported to Promote Safer Medication Use in Children.

Varsha Bhatt-Mehta, Robert B MacArthur, Raimar Löbenberg, Jeffrey J Cies, Ibolja Cernak, Richard H Parrish Ii,

The lack of commercially-available pediatric drug products and dosage forms is well-known. A group of clinicians and scientists with a common interest in pediatric drug development and medicines-use systems developed a practical framework for identifying a list of active pharmaceutical ingredients (APIs) with the greatest market potential for development to ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2015, 3(4):284-294]

Cited: 3 times

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A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma.

Giselle L Saulnier Sholler, Eugene W Gerner, Genevieve Bergendahl, Robert B MacArthur, Alyssa VanderWerff, Takamaru Ashikaga, Jeffrey P Bond, William Ferguson, William Roberts, Randal K Wada, Don Eslin, Jacqueline M Kraveka, Joel Kaplan, Deanna Mitchell, Nehal S Parikh, Kathleen Neville, Leonard Sender, Timothy Higgins, Masao Kawakita, Kyoko Hiramatsu, Shun-Suke Moriya, André S Bachmann,

<h4>Background</h4>Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients. This study investigated safety, response, pharmacokinetics, genetic and metabolic factors associated with ODC in a ... Read more >>

PLoS One (PloS one)
[2015, 10(5):e0127246]

Cited: 56 times

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A dosing algorithm for erythropoietin alpha in older adults with heart failure and a preserved ejection fraction.

Arman Altincatal, Robert B Macarthur, Sergio Teruya, Stephen Helmke, Mathew S Maurer,

<h4>Aims</h4>Erythropoietin stimulating agents (ESAs) is an active area of clinical investigation in heart failure (HF) but can cause hypertension and higher hemoglobin concentrations (Hb) that have been associated with adverse outcomes. We evaluated a dosing algorithm and potential confounders' effect on Hb and blood pressure (BP) in a clinical trial.<h4>Methods</h4>In ... Read more >>

Cardiovasc Ther (Cardiovascular therapeutics)
[2013, 31(2):92-99]

Cited: 1 time

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High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART).

Mitchell S V Elkind, Ralph L Sacco, Robert B Macarthur, Ellinor Peerschke, Greg Neils, Howard Andrews, Joshua Stillman, Tania Corporan, Dana Leifer, Rui Liu, Ken Cheung,

<h4>Background</h4>Hydroxymethylglutaryl coenzyme A reductase inhibitors ('statins') reduce the neuronal injury in dose-dependent fashion in rodent stroke models. We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic stroke.<h4>Methods</h4>We conducted a phase 1B dose-finding study using an adaptive ... Read more >>

Cerebrovasc Dis (Cerebrovascular diseases (Basel, Switzerland))
[2009, 28(3):266-275]

Cited: 32 times

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An evaluation of student and clinician perception of digital and conventional implant impressions.

Sang J Lee, Robert X Macarthur, German O Gallucci,

<h4>Statement of problem</h4>The accuracy and efficiency of digital implant impressions should match conventional impressions. Comparisons should be made with clinically relevant data.<h4>Purpose</h4>The purpose of this study was to evaluate the difficulty level and operator's perception between dental students and experienced clinicians when making digital and conventional implant impressions.<h4>Material and methods</h4>Thirty ... Read more >>

J Prosthet Dent (The Journal of prosthetic dentistry)
[2013, 110(5):420-423]

Cited: 12 times

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A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS.

Paul H Gordon, Ying-Kuen Cheung, Bruce Levin, Howard Andrews, Carolyn Doorish, Robert B Macarthur, Jacqueline Montes, Kate Bednarz, Julaine Florence, Julie Rowin, Kevin Boylan, Tahseen Mozaffar, Rup Tandan, Hiroshi Mitsumoto, Elizabeth A Kelvin, John Chapin, Richard Bedlack, Michael Rivner, Leo F McCluskey, Alan Pestronk, Michael Graves, Eric J Sorenson, Richard J Barohn, Jerry M Belsh, Jau-Shin Lou, Todd Levine, David Saperstein, Robert G Miller, Stephen N Scelsa, ,

Combining agents with different mechanisms of action may be necessary for meaningful results in treating ALS. The combinations of minocycline-creatine and celecoxib-creatine have additive effects in the murine model. New trial designs are needed to efficiently screen the growing number of potential neuroprotective agents. Our objective was to assess two ... Read more >>

Amyotroph Lateral Scler (Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases)
[2008, 9(4):212-222]

Cited: 46 times

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Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT.

Steven M Kawut, Emilia Bagiella, David J Lederer, Daichi Shimbo, Evelyn M Horn, Kari E Roberts, Nicholas S Hill, R Graham Barr, Erika B Rosenzweig, Wendy Post, Russell P Tracy, Harold I Palevsky, Paul M Hassoun, Reda E Girgis, ,

<h4>Background</h4>Pulmonary arterial hypertension (PAH) is a progressive disease that causes exercise limitation, heart failure, and death. We aimed to determine the safety and efficacy of aspirin and simvastatin in PAH.<h4>Methods and results</h4>We performed a randomized, double-blind, placebo-controlled 2×2 factorial clinical trial of aspirin and simvastatin in patients with PAH receiving ... Read more >>

Circulation (Circulation)
[2011, 123(25):2985-2993]

Cited: 66 times

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Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design.

Bruce Levin, John L P Thompson, Bibhas Chakraborty, Gilberto Levy, Robert MacArthur, E Clarke Haley,

<h4>Background</h4>TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III.<h4>Purpose</h4>(1) To review the trial design and comprehensive type I error rate simulations and (2) to discuss issues raised ... Read more >>

Clin Trials (Clinical trials (London, England))
[2011, 8(4):398-407]

Cited: 5 times

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Rationale and design of a phase II clinical trial of aspirin and simvastatin for the treatment of pulmonary arterial hypertension: ASA-STAT.

Steven M Kawut, Emilia Bagiella, Daichi Shimbo, David J Lederer, Nadine Al-Naamani, Kari E Roberts, R Graham Barr, Wendy Post, Evelyn M Horn, Russell Tracy, Paul Hassoun, Reda Girgis, ,

<h4>Background</h4>Pulmonary arterial hypertension (PAH) is a progressive disease which causes exercise limitation, heart failure, and death. Aspirin and simvastatin are highly effective and safe therapies for other cardiovascular diseases characterized by platelet activation and endothelial dysfunction, but have not been formally studied in PAH.<h4>Methods</h4>ASA-STAT is a phase II, randomized, double-blind, ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2011, 32(2):280-287]

Cited: 7 times

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Determination of naproxen using DBS: evaluation & pharmacokinetic comparison of human plasma versus human blood DBS.

Nikolay Youhnovski, Josée Michon, Sylvain Latour, Jean-Nicholas Mess, Annik Bergeron, Milton Furtado, Marianne Rufiange, Pascal Guibord, Marc Lefebvre, Robert B Macarthur, Fabio Garofolo,

<h4>Background</h4>Dried blood spots (DBS) sampling is a well-known technology for qualitative determination such as DNA analysis and screening of newborn metabolic disorders. The scientific community has recently expressed interest in applying the DBS technique for quantitative determination of drugs in biological fluid.<h4>Results</h4>Two new bioanalytical assays were developed and validated for ... Read more >>

Bioanalysis (Bioanalysis)
[2010, 2(8):1501-1513]

Cited: 8 times

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Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands.

Narayanam V Rao, Brian Argyle, Xiaoyu Xu, Paul R Reynolds, Jeanine M Walenga, Margaret Prechel, Glenn D Prestwich, Robert B MacArthur, Bradford B Walters, John R Hoidal, Thomas P Kennedy,

While heparin has been used almost exclusively as a blood anticoagulant, important literature demonstrates that it also has broad anti-inflammatory activity. Herein, using low anti-coagulant 2-O,3-O-desulfated heparin (ODSH), we demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2010, 299(1):C97-110]

Cited: 80 times

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Role of glutathione transferases in the mechanism of brostallicin activation.

Silvia Pezzola, Giovanni Antonini, Cristina Geroni, Italo Beria, Maristella Colombo, Massimo Broggini, Sergio Marchini, Nicola Mongelli, Loris Leboffe, Robert MacArthur, Alessia Francesca Mozzi, Giorgio Federici, Anna Maria Caccuri,

Brostallicin is a novel and unique glutathione transferase-activated pro-drug with promising anticancer activity, currently in phase I and II clinical evaluation. In this work, we show that, in comparison with the parental cell line showing low GST levels, the cytotoxic activity of brostallicin is significantly enhanced in the human breast ... Read more >>

Biochemistry (Biochemistry)
[2010, 49(1):226-235]

Cited: 10 times

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The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke.

Mitchell S V Elkind, Ralph L Sacco, Robert B MacArthur, Daniel J Fink, Ellinor Peerschke, Howard Andrews, Greg Neils, Josh Stillman, Tania Corporan, Dana Leifer, Ken Cheung,

There is growing experimental and clinical evidence that by reducing downstream products of the mevalonate pathway other than cholesterol, HMG-CoA reductase inhibitors ('statins') have beneficial effects on endothelial function, coronary and cerebral blood flow, inflammation, and hemostasis. Statins have been shown in rodent models of acute ischemic stroke to reduce ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2008, 3(3):210-218]

Cited: 28 times

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O-desulfated heparin improves outcome after rat cerebral ischemia/reperfusion injury.

J Mocco, Corbett E Shelton, Paulina Sergot, Andrew F Ducruet, Ricardo J Komotar, Marc L Otten, Sergei A Sosunov, Robert B Macarthur, Thomas P Kennedy, E Sander Connolly,

<h4>Objective</h4>Inflammatory cascades play a significant role in progressive neurological injury after transient cerebral ischemia. It has been demonstrated that heparin, a potent anticoagulant, also possesses anti-inflammatory properties that diminish postreperfusion damage after stroke. However, the potential for heparin to induce hemorrhagic transformation of an infarct has deterred its use in ... Read more >>

Neurosurgery (Neurosurgery)
[2007, 61(6):1297-303; discussion 1303-4]

Cited: 15 times

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