Full Text Journal Articles by
Author Robert L Grubb

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Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder.

Young H Lee, Molly M Lee, Dinuka M De Silva, Arpita Roy, Cara E Wright, Tiffany K Wong, Rene Costello, Oluwole Olaku, Robert L Grubb, Piyush K Agarwal, Andrea B Apolo, Donald P Bottaro,

Comprehensive characterizations of bladder cancer (BCa) have established molecular phenotype classes with distinct alterations and survival trends. Extending these studies within the tyrosine kinase (TK) family to identify disease drivers could improve our use of TK inhibitors to treat specific patient groups or individuals. We examined the expression distribution of ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0241766]

Cited: 0 times

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One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study.

Lin Yang, Jung Ae Lee, Emily Heer, Claire Pernar, Graham A Colditz, Ratna Pakpahan, Kellie R Imm, Eric H Kim, Robert L Grubb, Kathleen Y Wolin, Adam S Kibel, Siobhan Sutcliffe,

<h4>Background</h4>To examine one-year trajectories of urinary and sexual outcomes, and correlates of these trajectories, among prostate cancer patients treated by radical prostatectomy (RP).<h4>Methods</h4>Study participants were recruited from 2011 to 2014 at two US institutions. Self-reported urinary and sexual outcomes were measured at baseline before surgery, and 5 weeks, 6 months and 12 months ... Read more >>

BMC Urol (BMC urology)
[2021, 21(1):81]

Cited: 0 times

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Intraoperative MRI for newly diagnosed supratentorial glioblastoma: a multicenter-registry comparative study to conventional surgery.

Amar S Shah, Peter T Sylvester, Alexander T Yahanda, Ananth K Vellimana, Gavin P Dunn, John Evans, Keith M Rich, Joshua L Dowling, Eric C Leuthardt, Ralph G Dacey, Albert H Kim, Robert L Grubb, Gregory J Zipfel, Mark Oswood, Randy L Jensen, Garnette R Sutherland, Daniel P Cahill, Steven R Abram, John Honeycutt, Mitesh Shah, Yu Tao, Michael R Chicoine,

<h4>Objective</h4>Intraoperative MRI (iMRI) is used in the surgical treatment of glioblastoma, with uncertain effects on outcomes. The authors evaluated the impact of iMRI on extent of resection (EOR) and overall survival (OS) while controlling for other known and suspected predictors.<h4>Methods</h4>A multicenter retrospective cohort of 640 adult patients with newly diagnosed ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2020, :1-10]

Cited: 1 time

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Recurrent Hemispheric Stroke Syndromes in Symptomatic Atherosclerotic Internal Carotid Artery Occlusions: The Carotid Occlusion Surgery Study Randomized Trial.

Fadi Nahab, Michael Liu, Haseeb A Rahman, Srikant Rangaraju, Daniel Barrow, C Michael Cawley, Robert L Grubb, Colin P Derdeyn, Harold P Adams, Tom O Videen, M Bridget Zimmerman, William J Powers,

<h4>Background</h4>There are limited data on outcomes of extracranial-intracranial (EC-IC) bypass in patients with recurrent hemispheric syndromes due to atherosclerotic internal carotid artery occlusion (AICAO).<h4>Objective</h4>To compare clinical outcomes and efficacy of EC-IC bypass surgery in patients with and without recurrent hemispheric syndromes associated with AICAO in the Carotid Occlusion Surgery Study ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 87(1):137-141]

Cited: 1 time

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Risk of Prostate Cancer-related Death Following a Low PSA Level in the PLCO Trial.

Rebecca Landy, Lauren C Houghton, Christine D Berg, Robert L Grubb, Hormuzd A Katki, Amanda Black,

Longer-than-annual screening intervals have been suggested to improve the balance of benefits and harms in prostate cancer screening. Many researchers, societies, and guideline committees have suggested that screening intervals could depend on the prostate-specific antigen (PSA) result. We analyzed data from men (<i>N</i> = 33,897) ages 55-74 years with a ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2020, 13(4):367-376]

Cited: 1 time

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Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer.

Benjamin W Fischer-Valuck, Jeff M Michalski, Nandita Mitra, John P Christodouleas, Todd A DeWees, Eric Kim, Zachary L Smith, Gerald L Andriole, Vivek Arora, Arnold Bullock, Ruben Carmona, Robert S Figenshau, Robert L Grubb, Thomas J Guzzo, Eric M Knoche, S Bruce Malkowicz, Ronac Mamtani, Russell K Pachynski, Bruce J Roth, Mohamed S Zaghloul, Hiram A Gay, Brian C Baumann,

<h4>Background</h4>Local-regional failure (LF) for locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity/mortality. Postoperative radiotherapy (PORT) can reduce LF and may enhance overall survival (OS) but has no defined role. We hypothesized that the addition of PORT would improve ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(8):3698-3709]

Cited: 2 times

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Self-Management in Long-Term Prostate Cancer Survivors: A Randomized, Controlled Trial.

Ted A Skolarus, Tabitha Metreger, Daniela Wittmann, Soohyun Hwang, Hyungjin Myra Kim, Robert L Grubb, Jeffrey R Gingrich, Hui Zhu, John D Piette, Sarah T Hawley,

PURPOSE:This randomized clinical trial compared a personally tailored, automated telephone symptom management intervention to improve self-management among long-term survivors of prostate cancer with usual care enhanced with a nontailored newsletter about symptom management. We hypothesized that intervention-group participants would have more confident symptom self-management and reduced symptom burden. METHODS:A total ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(15):1326-1335]

Cited: 4 times

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Levels and patterns of self-reported and objectively-measured free-living physical activity among prostate cancer survivors: A prospective cohort study.

Lee Smith, Jung Ae Lee, Junbae Mun, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Adam S Kibel, Graham A Colditz, Robert L Grubb, Kathleen Y Wolin, Siobhan Sutcliffe, Lin Yang,

<h4>Background</h4>No prior study has measured or compared self-reported and objectively measured physical activity trajectories in prostate cancer survivors before and after treatment.<h4>Methods</h4>Clinically localized prostate cancer patients treated with radical prostatectomy were recruited between 2011 and 2014. Of the 350 participants enrolled at the main site, 310 provided self-reported physical activity ... Read more >>

Cancer (Cancer)
[2019, 125(5):798-806]

Cited: 3 times

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Heterogeneity in Definitions of High-risk Prostate Cancer and Varying Impact on Mortality Rates after Radical Prostatectomy.

Matthew Mossanen, Kenneth G Nepple, Robert L Grubb, Gerald L Androile, Dorina Kallogjeri, Eric A Klein, Andrew J Stephenson, Adam S Kibel,

<h4>Background</h4>Multiple definitions of high-risk prostate cancer (PC) exist in clinical practice. Prior studies have primarily evaluated the variability in prediction of biochemical recurrence.<h4>Objective</h4>To examine the impact of different definitions on mortality after radical prostatectomy (RP).<h4>Design, setting, and participants</h4>Retrospective study of 6477 men with clinically localized disease undergoing RP at Barnes-Jewish ... Read more >>

Eur Urol Oncol (European urology oncology)
[2018, 1(2):143-148]

Cited: 4 times

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Prostate Cancer: Update on Early Detection and New Biomarkers.

Robert L Grubb,

Screening and early treatment of prostate cancer (PCa) has recently come under scrutiny due to the rates of overdiagnosis of low risk cancer. Randomized trials, including ERSPC and PLCO, have informed our understanding of the survival benefit provided by systematic PCa screening with serum prostate-specific antigen (PSA). To reduce the ... Read more >>

Mo Med (Missouri medicine)
[2018, 115(2):132-134]

Cited: 1 time

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Prostate Magnetic Resonance Imaging Provides Limited Incremental Value Over the Memorial Sloan Kettering Cancer Center Preradical Prostatectomy Nomogram.

John K Weaver, Eric H Kim, Joel M Vetter, Anup Shetty, Robert L Grubb, Seth A Strope, Gerald L Andriole,

<h4>Objective</h4>To examine the incremental value of prostate magnetic resonance imaging (MRI) when used in combination with the currently available preoperative risk stratification tool, the Memorial Sloan Kettering Cancer Center (MSKCC) preradical prostatectomy nomogram.<h4>Materials and methods</h4>We reviewed our institutional database of prostate MRI performed before radical prostatectomy between December 2014 and ... Read more >>

Urology (Urology)
[2018, 113:119-128]

Cited: 8 times

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Trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race/ethnicity in the PLCO Trial.

Miguelle Marous, Wen-Yi Huang, Charles S Rabkin, Richard B Hayes, John F Alderete, Bernard Rosner, Robert L Grubb, Anke C Winter, Siobhan Sutcliffe,

<h4>Purpose</h4>Results from previous sero-epidemiologic studies of Trichomonas vaginalis infection and prostate cancer (PCa) support a positive association between this sexually transmitted infection and aggressive PCa. However, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between T. vaginalis seropositivity and PCa in African-American ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2017, 28(8):889-898]

Cited: 7 times

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Caution with Use of the EPIC-50 Urinary Bother Scale: How Voiding Dysfunction Modifies its Performance.

Lin Yang, Adam S Kibel, Graham A Colditz, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Robert L Grubb, Kathleen Y Wolin, Siobhan Sutcliffe,

<h4>Purpose</h4>We evaluated agreement between patient reported urinary function and bother, and sexual function and bother in patients treated with radical prostatectomy to help inform possible nonfunctional, modifiable mechanisms for patient bother.<h4>Materials and methods</h4>Patients were recruited from 2011 to 2014 at Washington University, and Brigham and Women's Hospital. Urinary and sexual ... Read more >>

J Urol (The Journal of urology)
[2017, 198(6):1397-1403]

Cited: 1 time

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Baseline Hemodynamic Impairment and Future Stroke Risk in Adult Idiopathic Moyamoya Phenomenon: Results of a Prospective Natural History Study.

Colin P Derdeyn, Gregory J Zipfel, Allyson R Zazulia, Patricia H Davis, Shyam Prabhakaran, Cristina S Ivan, Venkatesh Aiyagari, James R Sagar, Nancy Hantler, Lina Shinawi, John J Lee, Hussain Jafri, Robert L Grubb, J Philip Miller, Ralph G Dacey,

<h4>Background and purpose</h4>The purpose was to test the hypothesis that increased oxygen extraction fraction (OEF), a marker of severe hemodynamic impairment measured by positron emission tomography, is an independent risk factor for subsequent ischemic stroke in this population.<h4>Methods</h4>Adults with idiopathic moyamoya phenomena were recruited between 2005 and 2012 for a ... Read more >>

Stroke (Stroke)
[2017, 48(4):894-899]

Cited: 10 times

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Optimizing veteran-centered prostate cancer survivorship care: study protocol for a randomized controlled trial.

Ted A Skolarus, Tabitha Metreger, Soohyun Hwang, Hyungjin Myra Kim, Robert L Grubb, Jeffrey R Gingrich, Sarah T Hawley,

<h4>Background</h4>Although prostate cancer is the most common cancer among veterans receiving care in the Veterans Health Administration (VA), more needs to be done to understand and improve survivorship care for this large population. This study, funded by VA Health Services Research & Development (HSR&D), seeks to address the need to ... Read more >>

Trials (Trials)
[2017, 18(1):181]

Cited: 5 times

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Author Reply.

Eric H Kim, Anup S Shetty, Kathryn J Fowler, Robert L Grubb, Gerald L Andriole,

Urology (Urology)
[2017, 102:196-197]

Cited: 0 times

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Determination of the Role of Negative Magnetic Resonance Imaging of the Prostate in Clinical Practice: Is Biopsy Still Necessary?

Robert S Wang, Eric H Kim, Joel M Vetter, Kathryn J Fowler, Anup S Shetty, Aaron J Mintz, Niraj G Badhiwala, Robert L Grubb, Gerald L Andriole,

<h4>Objective</h4>To assess the negative predictive value (NPV) of multiparametric magnetic resonance imaging (mpMRI) for detection of prostate cancer (PCa) in routine clinical practice and to identify characteristics of patients for whom mpMRI fails to detect high-grade (Gleason score ≥7) disease.<h4>Materials and methods</h4>We reviewed our prospectively maintained database of consecutive men ... Read more >>

Urology (Urology)
[2017, 102:190-197]

Cited: 8 times

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Extended mortality results for prostate cancer screening in the PLCO trial with median follow-up of 15 years.

Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole,

<h4>Background</h4>Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from ... Read more >>

Cancer (Cancer)
[2017, 123(4):592-599]

Cited: 65 times

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Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes.

Sam Q Sun, Chunyu Cai, Rory K J Murphy, Todd DeWees, Ralph G Dacey, Robert L Grubb, Keith M Rich, Gregory J Zipfel, Joshua L Dowling, Eric C Leuthardt, Joseph R Simpson, Clifford G Robinson, Michael R Chicoine, Richard J Perrin, Jiayi Huang, Albert H Kim,

<h4>Background</h4>Optimal use of stereotactic radiosurgery (SRS) vs external beam radiation therapy (EBRT) for treatment of residual/recurrent atypical meningioma is unclear.<h4>Objective</h4>To analyze features associated with progression after radiation therapy.<h4>Methods</h4>Fifty radiation-naive patients who received SRS or EBRT for residual and/or recurrent atypical meningioma were examined for predictors of progression using Cox regression ... Read more >>

Neurosurgery (Neurosurgery)
[2016, 79(1):23-32]

Cited: 11 times

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Relative Mean Transit Time Predicts Subsequent Stroke in Symptomatic Carotid Occlusion.

Robert L Grubb, Colin P Derdeyn, Tom O Videen, David A Carpenter, William J Powers,

<h4>Background</h4>Mean transit time (MTT) measurements to assess cerebral hemodynamics are easily obtained by computed tomography and magnetic resonance imaging. We reviewed hemodynamic and clinical outcome data from the St. Louis Carotid Occlusion Study to determine if increased MTT was associated with an increased risk of stroke in patients with symptomatic ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2016, 25(6):1421-1424]

Cited: 4 times

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Surgical Revascularization in North American Adults with Moyamoya Phenomenon: Long-Term Angiographic Follow-up.

Eric J Arias, Gavin P Dunn, Chad W Washington, Colin P Derdeyn, Michael R Chicoine, Robert L Grubb, Christopher J Moran, DeWitte T Cross, Ralph G Dacey, Gregory J Zipfel,

<h4>Background</h4>North American and Asian forms of moyamoya have distinct clinical characteristics. Asian adults with moyamoya are known to respond better to direct versus indirect revascularization. It is unclear whether North American adults with moyamoya have a similar long-term angiographic response to direct versus indirect bypass.<h4>Methods</h4>A retrospective review of surgical revascularization ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2015, 24(7):1597-1608]

Cited: 12 times

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Screening for cancer: lessons learned from the prostate, lung, colorectal, and ovarian cancer screening trial.

Robert L Grubb, Paul Pinsky, Philip C Prorok, Gerald L Andriole,

While the PLCO Cancer Screening trial demonstrated no observed mortality benefit associated with screening for prostate cancer with prostate-specific antigen and rectal exam, the knowledge gained about prostate cancer and screening and resources developed in completing the trial make the trial a success. ... Read more >>

Eur Urol (European urology)
[2015, 68(4):545-546]

Cited: 2 times

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Earlier prostate-specific antigen testing in African American men--Clinical support for the recommendation.

Amanda F Saltzman, Suhong Luo, Jeffery F Scherrer, Kenneth D Carson, Robert L Grubb, M'Liss A Hudson,

<h4>Background</h4>To determine whether prostate-specific antigen (PSA) testing in African American veterans (AAVs) aged 40 to 54 years is associated with high-risk prostate cancer characteristics compared with AAVs aged 55 to 70 years or white veterans (WVs) aged 40 to 54 years.<h4>Methods</h4>A total of 231,174 healthy veterans aged 40 to 70 ... Read more >>

Urol Oncol (Urologic oncology)
[2015, 33(7):330.e9-17]

Cited: 4 times

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Physical activity and benign prostatic hyperplasia-related outcomes and nocturia.

Kathleen Y Wolin, Robert L Grubb, Ratna Pakpahan, Lawrence Ragard, Jerome Mabie, Gerald L Andriole, Siobhan Sutcliffe,

<h4>Introduction</h4>Benign prostatic hyperplasia (BPH) and its associated lower urinary tract symptoms (LUTS), including nocturia, are extremely common among middle- and older-age American men. Although studies on physical activity (PA) and prevalent BPH-related outcomes suggest that PA may protect against the development of this common condition, only a few studies have ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2015, 47(3):581-592]

Cited: 10 times

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Preliminary evaluation of urinary soluble Met as a biomarker for urothelial carcinoma of the bladder.

Brian K McNeil, Maximiliano Sorbellini, Robert L Grubb, Andrea Apolo, Fabiola Cecchi, Gagani Athauda, Benjamin Cohen, Alessio Giubellino, Haley Simpson, Piyush K Agarwal, Jonathan Coleman, Robert H Getzenberg, George J Netto, Joanna Shih, W Marston Linehan, Peter A Pinto, Donald P Bottaro,

<h4>Background</h4>Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent progression, improve survival rates and reduce health care costs. Among several oncogenic signaling pathways implicated in BCa progression is that of hepatocyte ... Read more >>

J Transl Med (Journal of translational medicine)
[2014, 12:199]

Cited: 9 times

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