Full Text Journal Articles by
Author Robert J Boyle

Advertisement

Find full text journal articles






Cardiovascular changes during peanut-induced allergic reactions in human subjects.

Monica Ruiz-Garcia, Joan Bartra, Olaya Alvarez, Ashna Lakhani, Shalinee Patel, Alistair Tang, Marcus Sim, Mohamed H Shamji, Isabel Skypala, E N Clare Mills, Alexander R Lyon, Carl Hayward, Stephen R Durham, Paul J Turner, Robert J Boyle,

BACKGROUND:Food allergy is the commonest cause of anaphylaxis. Changes in posture during acute reactions can trigger fatal outcomes, but the impact of allergic reactions on the cardiovascular system in non-fatal reactions remains poorly understood. OBJECTIVE:To systematically evaluate changes in cardiovascular function during acute allergic reactions to peanut. METHODS:Participants underwent double-blind ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Reactions on re-exposure following negative and inconclusive follow-up food challenges in children with acute FPIES.

Laura Argiz, Sonsoles Infante, Adrianna Machinena, Mariona Pascal, Luis Echeverria, Simona Barni, Teresa Garriga-Baraut, Stefania Arasi, Jose Domingo Moure, Alberto Gomez-Carballa, Federico Martinon-Torres, Robert J Boyle, Marta Vazquez-Ortiz, ,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Outcomes for clinical trials of food allergy treatments.

Kathleen Sim, Dragan Mijakoski, Sasho Stoleski, Pablo Rodriguez Del Rio, Patrick Sammut, Thuy-My Le, Daniel Munblit, Robert J Boyle,

OBJECTIVE:Food allergy is a common condition that can have a significant impact on the quality of life of affected individuals and their caregivers. Recent years have witnessed an increased effort to identify new treatments for food allergy. Here, we review the need to identify core outcomes for measurement in clinical ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Assessment of Evidence About Common Infant Symptoms and Cow's Milk Allergy.

Daniel Munblit, Michael R Perkin, Debra J Palmer, Katie J Allen, Robert J Boyle,

Sales of specialized formula for managing cow's milk allergy (CMA) have increased, triggering concern that attribution of common infant symptoms, such as crying, vomiting, and rashes, to CMA may be leading to overdiagnosis, which could undermine breastfeeding. To understand whether CMA guideline recommendations might promote CMA overdiagnosis or undermine breastfeeding. ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Guidance for the Conduct and Reporting of Clinical Trials of Breast Milk Substitutes.

Katharine Jarrold, Bartosz Helfer, Mona Eskander, Helen Crawley, Jillian Trabulsi, Laura E Caulfield, Gillian Duffy, Vanessa Garcia-Larsen, Deborah Hayward, Matthew Hyde, Suzan Jeffries, Mikael Knip, Jo Leonardi-Bee, Elizabeth Loder, Caroline J Lodge, Adrian J Lowe, William McGuire, David Osborn, Hildegard Przyrembel, Mary J Renfrew, Paula Trumbo, John Warner, Barbara Schneeman, Robert J Boyle,

Importance:Breast milk substitutes (BMS) are important nutritional products evaluated in clinical trials. Concerns have been raised about the risk of bias in BMS trials, the reliability of claims that arise from such trials, and the potential for BMS trials to undermine breastfeeding in trial participants. Existing clinical trial guidance does ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Health and nutrition claims for infant formula are poorly substantiated and potentially harmful.

Daniel Munblit, Helen Crawley, Richard Hyde, Robert J Boyle,

BMJ (BMJ (Clinical research ed.))
[2020, 369:m875]

Cited: 0 times

View full text PDF listing >>



Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.

Joanne R Chalmers, Rachel H Haines, Lucy E Bradshaw, Alan A Montgomery, Kim S Thomas, Sara J Brown, Matthew J Ridd, Sandra Lawton, Eric L Simpson, Michael J Cork, Tracey H Sach, Carsten Flohr, Eleanor J Mitchell, Richard Swinden, Stella Tarr, Susan Davies-Jones, Nicola Jay, Maeve M Kelleher, Michael R Perkin, Robert J Boyle, Hywel C Williams, ,

BACKGROUND:Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. METHODS:We did a multicentre, pragmatic, parallel-group, randomised controlled trial in 12 hospitals and four primary care sites across the UK. Families were approached via antenatal or postnatal ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10228):962-972]

Cited: 0 times

View full text PDF listing >>



An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.

Maeve M Kelleher, Nicola Jay, Michael R Perkin, Rachel H Haines, Rebecca Batt, Lucy E Bradshaw, Alan A Montgomery, Joanne R Chalmers, Hywel C Williams, Robert J Boyle,

BACKGROUND:Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore, not be acceptable to all study participants. OBJECTIVE:To design and evaluate an algorithm for detecting IgE-mediated food allergy in clinical study participants who do not undergo OFC. METHODS:An algorithm ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2020, 50(3):334-342]

Cited: 1 time

View full text PDF listing >>



Reaction phenotypes in IgE-mediated food allergy and anaphylaxis.

Kok Wee Chong, Monica Ruiz-Garcia, Nandinee Patel, Robert J Boyle, Paul J Turner,

OBJECTIVE:Food allergy encompasses a range of food hypersensitivities. Different clinical phenotypes for food allergy likely exist in much the same way as endotype discovery is now a major research theme in asthma. We discuss the emerging evidence for different reaction phenotypes (ie, symptoms experienced after allergen exposure in food allergic ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2020, 124(5):473-478]

Cited: 2 times

View full text PDF listing >>



Prevention of food allergy - skin barrier interventions.

Maeve M Kelleher, Lien Tran, Robert J Boyle,

The relationship between infant skin health and food allergy pathogenesis is the focus of intense research activity, on the basis that interventions to improve infant skin health may potentially lead to the prevention of food allergy. Current evidence does not provide conclusive findings on the mechanisms of food allergy development ... Read more >>

Allergol Int (Allergology international : official journal of the Japanese Society of Allergology)
[2020, 69(1):3-10]

Cited: 0 times

View full text PDF listing >>



Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review.

Oleg Blyuss, Ka Yan Cheung, Jessica Chen, Callum Parr, Loukia Petrou, Alina Komarova, Maria Kokina, Polina Luzan, Egor Pasko, Alina Eremeeva, Dmitrii Peshko, Vladimir I Eliseev, Sindre Andre Pedersen, Meghan B Azad, Kirsi M Jarvinen, Diego G Peroni, Valerie Verhasselt, Robert J Boyle, John O Warner, Melanie R Simpson, Daniel Munblit,

A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight pitfalls and unmet needs. A comprehensive literature search in MEDLINE and Embase retrieved 13,607 unique records. Following ... Read more >>

Nutrients (Nutrients)
[2019, 11(10):]

Cited: 0 times

View full text PDF listing >>



Transforming growth factor beta in human milk and allergic outcomes in children: A systematic review.

Ekaterina Khaleva, Zoya Gridneva, Donna T Geddes, Wendy H Oddy, Silvia Colicino, Oleg Blyuss, Robert J Boyle, John O Warner, Daniel Munblit,

BACKGROUND:Human milk (HM) transforming growth factor beta (TGF-β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF-β levels are associated with allergic outcomes. OBJECTIVE:We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF-β and ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(9):1201-1213]

Cited: 7 times

View full text PDF listing >>



Therapy competence in delivering a brief cognitive behavioural therapy intervention to reduce maternal anxiety associated with child food allergy.

Bea Vickers, Robert J Boyle, Thisanayagam Umasunthar, Jared G Smith, Matthew Hodes,

Child food allergy is increasingly prevalent, and caring for such children is associated with elevated parental anxiety. We previously carried out a randomized-controlled trial (RCT) of brief cognitive behavioural therapy (CBT) for parental anxiety associated with child food allergy which found that treatment to be effective. This study describes the ... Read more >>

J Child Health Care (Journal of child health care : for professionals working with children in the hospital and community)
[2019, 23(3):446-457]

Cited: 0 times

View full text PDF listing >>



TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study.

Matthew J Ridd, Louisa Edwards, Miriam Santer, Joanne R Chalmers, Lisa Waddell, Deborah Marriage, Ingrid Muller, Kirsty Roberts, Kirsty Garfield, Joanna Coast, Lucy Selman, Clare Clement, Alison R G Shaw, Elizabeth Angier, Peter S Blair, Nicholas L Turner, Jodi Taylor, Joe Kai, Robert J Boyle,

BACKGROUND:Early onset eczema is associated with food allergy, and allergic reactions to foods can cause acute exacerbations of eczema. Parents often pursue dietary restrictions as a way of managing eczema and seek allergy testing for their children to guide dietary management. However, it is unclear whether test-guided dietary management improves ... Read more >>

BMJ Open (BMJ open)
[2019, 9(5):e028428]

Cited: 0 times

View full text PDF listing >>



Oral Immunotherapy for Peanut Allergy.

Mimi L K Tang, Robert J Boyle,

N. Engl. J. Med. (The New England journal of medicine)
[2019, 380(7):690-691]

Cited: 0 times

View full text PDF listing >>



Probiotics for treating eczema.

Areti Makrgeorgou, Jo Leonardi-Bee, Fiona J Bath-Hextall, Dedee F Murrell, Mimi Lk Tang, Amanda Roberts, Robert J Boyle,

BACKGROUND:Eczema is a common chronic skin condition. Probiotics have been proposed as an effective treatment for eczema; their use is increasing, as numerous clinical trials are under way. This is an update of a Cochrane Review first published in 2008, which suggested that probiotics may not be an effective treatment ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 11:CD006135]

Cited: 2 times

View full text PDF listing >>



Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy.

Daniel Munblit, Priya Abrol, Shreya Sheth, Li Yan Chow, Ekaterina Khaleva, Alan Asmanov, Silvana Lauriola, Ezio M Padovani, Pasquale Comberiati, Attilio L Boner, John O Warner, Robert J Boyle, Diego G Peroni,

Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, ... Read more >>

Nutrients (Nutrients)
[2018, 10(9):]

Cited: 5 times

View full text PDF listing >>



Formula Milk Supplementation on the Postnatal Ward: A Cross-Sectional Analytical Study.

Kirsty V Biggs, Katherine Hurrell, Eleanor Matthews, Ekaterina Khaleva, Daniel Munblit, Robert J Boyle,

Breastfeeding rates are low in the UK, where approximately one quarter of infants receive a breastmilk substitute (BMS) in the first week of life. We investigated the reasons for early BMS use in two large maternity units in the UK, in order to understand the reasons for the high rate ... Read more >>

Nutrients (Nutrients)
[2018, 10(5):]

Cited: 2 times

View full text PDF listing >>



Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis.

Vanessa Garcia-Larsen, Despo Ierodiakonou, Katharine Jarrold, Sergio Cunha, Jennifer Chivinge, Zoe Robinson, Natalie Geoghegan, Alisha Ruparelia, Pooja Devani, Marialena Trivella, Jo Leonardi-Bee, Robert J Boyle,

BACKGROUND:There is uncertainty about the influence of diet during pregnancy and infancy on a child's immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease. METHODS AND FINDINGS:Two authors selected studies, extracted data, and assessed risk of bias. Grading of Recommendations ... Read more >>

PLoS Med. (PLoS medicine)
[2018, 15(2):e1002507]

Cited: 15 times

View full text PDF listing >>



Primary Prevention of Food Allergy: Translating Evidence from Clinical Trials to Population-Based Recommendations.

Paul J Turner, Dianne E Campbell, Robert J Boyle, Michael E Levin,

Given the prevalence and impact of childhood food allergy, there is increasing interest in interventions targeting disease prevention. Although interventions such as early introduction of dietary peanut have demonstrated efficacy in a small number of well-conducted randomized clinical trials, evidence for broader effectiveness and successful implementation at a population level ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2018, 6(2):367-375]

Cited: 4 times

View full text PDF listing >>



Human Milk and Allergic Diseases: An Unsolved Puzzle.

Daniel Munblit, Diego G Peroni, Alba Boix-Amorós, Peter S Hsu, Belinda Van't Land, Melvin C L Gay, Anastasia Kolotilina, Chrysanthi Skevaki, Robert J Boyle, Maria Carmen Collado, Johan Garssen, Donna T Geddes, Ralph Nanan, Carolyn Slupsky, Ganesa Wegienka, Anita L Kozyrskyj, John O Warner,

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It ... Read more >>

Nutrients (Nutrients)
[2017, 9(8):]

Cited: 32 times

View full text PDF listing >>



Fatal Anaphylaxis: Mortality Rate and Risk Factors.

Paul J Turner, Elina Jerschow, Thisanayagam Umasunthar, Robert Lin, Dianne E Campbell, Robert J Boyle,

Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2017, 5(5):1169-1178]

Cited: 23 times

View full text PDF listing >>



Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial.

Joanne R Chalmers, Rachel H Haines, Eleanor J Mitchell, Kim S Thomas, Sara J Brown, Matthew Ridd, Sandra Lawton, Eric L Simpson, Michael J Cork, Tracey H Sach, Lucy E Bradshaw, Alan A Montgomery, Robert J Boyle, Hywel C Williams,

BACKGROUND:Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for health care providers. The purpose of the trial is to investigate whether ... Read more >>

Trials (Trials)
[2017, 18(1):343]

Cited: 12 times

View full text PDF listing >>



Diet and Respiratory Health in Children from 11 Latin American Countries: Evidence from ISAAC Phase III.

Alfonso Mario Cepeda, Sumaiyya Thawer, Robert J Boyle, Sara Villalba, Rodolfo Jaller, Elmy Tapias, Ana María Segura, Rodrigo Villegas, Vanessa Garcia-Larsen, Vanessa Garcia-Larsen, ,

The burden of childhood asthma and its risk factors is an important but neglected public health challenge in Latin America. We investigated the association between allergic symptoms and dietary intake in children from this region.As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase III, questionnaire collected ... Read more >>

Lung (Lung)
[2017, 195(6):683-692]

Cited: 4 times

View full text PDF listing >>



Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis.

Daniel Munblit, Marina Treneva, Diego G Peroni, Silvia Colicino, Li Yan Chow, Shobana Dissanayeke, Alexander Pampura, Attilio L Boner, Donna T Geddes, Robert J Boyle, John O Warner,

The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature ... Read more >>

Nutrients (Nutrients)
[2017, 9(6):]

Cited: 14 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9649 s