Full Text Journal Articles by
Author Robert H Miller

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Graduating Otolaryngology Residents' Ideal Practice Expectations: A Longitudinal Analysis.

Robert H Miller, Richard K Gurgel, Hilary C McCrary,

<h4>Objective</h4>Prior literature has indicated that the number of trained otolaryngologists required to meet the need of our growing population may be insufficient. Therefore, identifying trends in the subspecialty composition of future otolaryngology practices will elucidate workforce needs.<h4>Study design</h4>One-page anonymous questionnaire.<h4>Setting</h4>The survey was completed by examinees at the conclusion of their American ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2022, :1945998211069505]

Cited: 0 times

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B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights.

Julie J Ahn, Mohammad Abu-Rub, Robert H Miller,

In recent years, the role of B cells in neurological disorders has substantially expanded our perspectives on mechanisms of neuroinflammation. The success of B cell-depleting therapies in patients with CNS diseases such as neuromyelitis optica and multiple sclerosis has highlighted the importance of neuroimmune crosstalk in inflammatory processes. While B ... Read more >>

Cells (Cells)
[2021, 10(7):]

Cited: 2 times

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Assessing Trends in Fellowship Training Among Otolaryngology Residents: A National Survey Study.

Robert H Miller, Hilary Caitlyn McCrary, Richard K Gurgel,

<h4>Objective</h4>To summarize trends in otolaryngology fellowship applications, fellowships selected, and reasons for pursuing a fellowship.<h4>Study design</h4>One-page anonymous questionnaire.<h4>Setting</h4>A survey was completed by examinees at the conclusion of their American Board of Otolaryngology-Head and Neck Surgery oral examination from 2011 to 2019.<h4>Methods</h4>Data included age, gender, fellowship type, reasons for doing a ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2021, 165(5):655-661]

Cited: 0 times

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Developmental ablation of mature oligodendrocytes exacerbates adult CNS demyelination.

Ahdeah Pajoohesh-Ganji, Molly Karl, Eric Garrison, Nana Adwoa Osei-Bonsu, Cheryl Clarkson-Paredes, Julie Ahn, Robert H Miller,

Multiple sclerosis (MS) is a CNS neurodegenerative autoimmune disease characterized by loss of oligodendrocytes and myelin in the brain and the spinal cord that results in localized functional deficits. Several risk factors have been associated with MS, however none fully explain the enhanced susceptibility seen in older individuals. Epidemiological data, ... Read more >>

Brain Behav Immun Health (Brain, behavior, & immunity - health)
[2020, 7:100110]

Cited: 0 times

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Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity.

Reshmi Tognatta, Molly T Karl, Sharyl L Fyffe-Maricich, Anastas Popratiloff, Eric D Garrison, Jessica K Schenck, Mohammad Abu-Rub, Robert H Miller,

Astrocytes have been implicated in regulating oligodendrocyte development and myelination in vitro, although their functions in vivo remain less well defined. Using a novel approach to locally ablate GFAP+ astrocytes, we demonstrate that astrocytes are required for normal CNS myelin compaction during development, and for maintaining myelin integrity in the ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2020, 14:74]

Cited: 5 times

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Evaluating gender parity in operative experience for otolaryngology residencies in the United States.

Richard K Gurgel, Brandon R Cardon, Chelsea McCarty Allen, Angela P Presson, Brenna C Kelly, Harriet W Hopf, Sukgi S Choi, Robert H Miller,

<h4>Objectives</h4>Gender disparity exists in medicine, such as differences in pay and promotion opportunities. We hypothesize that there is also a gender difference in graduate medical education as manifested by operative case volume. This study compares surgical case volume by gender for graduating US otolaryngology residents.<h4>Study design</h4>Cohort study.<h4>Methods</h4>With data use approval ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, 130(7):1651-1656]

Cited: 2 times

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Targeted Oligodendrocyte Apoptosis in Optic Nerve Leads to Persistent Demyelination.

Ahdeah Pajoohesh-Ganji, Robert H Miller,

The optic nerve represents one of the simplest regions of the CNS and has been useful in developing an understanding of glial development and myelination. While the visual system is frequently affected in demyelinating conditions, utilizing the optic nerve to model demyelination/remyelination studies has been difficult due to its accessibility, ... Read more >>

Neurochem Res (Neurochemical research)
[2020, 45(3):580-590]

Cited: 3 times

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The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation.

John K Hermann, Shushen Lin, Arielle Soffer, Chun Wong, Vishnupriya Srivastava, Jeremy Chang, Smrithi Sunil, Shruti Sudhakar, William H Tomaszewski, Grace Protasiewicz, Stephen M Selkirk, Robert H Miller, Jeffrey R Capadona,

We have recently demonstrated that partial inhibition of the cluster of differentiation 14 (CD14) innate immunity co-receptor pathway improves the long-term performance of intracortical microelectrodes better than complete inhibition. We hypothesized that partial activation of the CD14 pathway was critical to a neuroprotective response to the injury associated with initial ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2018, 6:113]

Cited: 6 times

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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.

Zita Hubler, Dharmaraja Allimuthu, Ilya Bederman, Matthew S Elitt, Mayur Madhavan, Kevin C Allan, H Elizabeth Shick, Eric Garrison, Molly T Karl, Daniel C Factor, Zachary S Nevin, Joel L Sax, Matthew A Thompson, Yuriy Fedorov, Jing Jin, William K Wilson, Martin Giera, Franz Bracher, Robert H Miller, Paul J Tesar, Drew J Adams,

Regeneration of myelin is mediated by oligodendrocyte progenitor cells-an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS underlies a number of neurological diseases, including multiple sclerosis and diverse genetic diseases<sup>1-3</sup>. High-throughput chemical screening ... Read more >>

Nature (Nature)
[2018, 560(7718):372-376]

Cited: 57 times

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Induction of myelinating oligodendrocytes in human cortical spheroids.

Mayur Madhavan, Zachary S Nevin, H Elizabeth Shick, Eric Garrison, Cheryl Clarkson-Paredes, Molly Karl, Benjamin L L Clayton, Daniel C Factor, Kevin C Allan, Lilianne Barbar, Tanya Jain, Panagiotis Douvaras, Valentina Fossati, Robert H Miller, Paul J Tesar,

Cerebral organoids provide an accessible system for investigations of cellular composition, interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we reproducibly generated oligodendrocytes and myelin in 'oligocortical spheroids' derived from human pluripotent stem cells. Molecular features consistent with those of maturing oligodendrocytes ... Read more >>

Nat Methods (Nature methods)
[2018, 15(9):700-706]

Cited: 82 times

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Transcriptional Profiling of Mesenchymal Stem Cells Identifies Distinct Neuroimmune Pathways Altered by CNS Disease.

Alex Sargent, Genevieve Shano, Molly Karl, Eric Garrison, Christian Miller, Robert H Miller,

Background and Objectives:Bone marrow mesenchymal stem cells (BM-MSCs) are an attractive cell based therapy in the treatment of CNS demyelinating diseases such as multiple sclerosis (MS). Preclinical studies demonstrate that BM-MSCs can effectively reduce clinical burden and enhance recovery in experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of ... Read more >>

Int J Stem Cells (International journal of stem cells)
[2018, 11(1):48-60]

Cited: 5 times

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Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination.

Mohammad Abu-Rub, Robert H Miller,

Myelination is critical for the normal functioning of the central nervous system (CNS) in vertebrates. Conditions in which the development of myelin is perturbed result in severely compromised individuals often with shorter lifespans, while loss of myelin in the adult results in a variety of functional deficits. Although some form ... Read more >>

Brain Sci (Brain sciences)
[2018, 8(6):]

Cited: 11 times

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Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory.

Fucheng Luo, Jessie Zhang, Kathryn Burke, Rita R Romito-DiGiacomo, Robert H Miller, Yan Yang,

Myelination of the central nervous system is important for normal motor and sensory neuronal function and recent studies also link it to efficient learning and memory. Cyclin-dependent kinase 5 (Cdk5) is required for normal oligodendrocyte development, myelination and myelin repair. Here we show that conditional deletion of Cdk5 by targeting ... Read more >>

Exp Neurol (Experimental neurology)
[2018, 306:92-104]

Cited: 6 times

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Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.

John K Hermann, Madhumitha Ravikumar, Andrew J Shoffstall, Evon S Ereifej, Kyle M Kovach, Jeremy Chang, Arielle Soffer, Chun Wong, Vishnupriya Srivastava, Patrick Smith, Grace Protasiewicz, Jingle Jiang, Stephen M Selkirk, Robert H Miller, Steven Sidik, Nicholas P Ziats, Dawn M Taylor, Jeffrey R Capadona,

OBJECTIVE:Neuroinflammatory mechanisms are hypothesized to contribute to intracortical microelectrode failures. The cluster of differentiation 14 (CD14) molecule is an innate immunity receptor involved in the recognition of pathogens and tissue damage to promote inflammation. The goal of the study was to investigate the effect of CD14 inhibition on intracortical microelectrode ... Read more >>

J Neural Eng (Journal of neural engineering)
[2018, 15(2):025002]

Cited: 17 times

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Targeting CD14 on blood derived cells improves intracortical microelectrode performance.

Hillary W Bedell, John K Hermann, Madhumitha Ravikumar, Shushen Lin, Ashley Rein, Xujia Li, Emily Molinich, Patrick D Smith, Stephen M Selkirk, Robert H Miller, Steven Sidik, Dawn M Taylor, Jeffrey R Capadona,

Intracortical microelectrodes afford researchers an effective tool to precisely monitor neural spiking activity. Additionally, intracortical microelectrodes have the ability to return function to individuals with paralysis as part of a brain computer interface. Unfortunately, the neural signals recorded by these electrodes degrade over time. Many strategies which target the biological ... Read more >>

Biomaterials (Biomaterials)
[2018, 163:163-173]

Cited: 24 times

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Calcium control of myelin sheath growth.

Robert H Miller,

Nat Neurosci (Nature neuroscience)
[2018, 21(1):2-3]

Cited: 3 times

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Development of a PET radioligand for potassium channels to image CNS demyelination.

Pedro Brugarolas, Jorge E Sánchez-Rodríguez, Hsiu-Ming Tsai, Falguni Basuli, Shih-Hsun Cheng, Xiang Zhang, Andrew V Caprariello, Jerome J Lacroix, Richard Freifelder, Dhanabalan Murali, Onofre DeJesus, Robert H Miller, Rolf E Swenson, Chin-Tu Chen, Peter Herscovitch, Daniel S Reich, Francisco Bezanilla, Brian Popko,

Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions. Quantitative and specific imaging of demyelination would thus provide critical clinical insight. Here, we investigated the possibility of targeting axonal potassium channels to image demyelination by positron emission tomography (PET). These ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):607]

Cited: 13 times

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Neurobiology: A change of fate for nerve repair.

Robert H Miller,

Nature (Nature)
[2017, 551(7678):41-42]

Cited: 1 time

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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Martha S Windrem, Mikhail Osipovitch, Zhengshan Liu, Janna Bates, Devin Chandler-Militello, Lisa Zou, Jared Munir, Steven Schanz, Katherine McCoy, Robert H Miller, Su Wang, Maiken Nedergaard, Robert L Findling, Paul J Tesar, Steven A Goldman,

In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells derived from patients with childhood-onset SCZ. After neonatal implantation into myelin-deficient shiverer mice, SCZ ... Read more >>

Cell Stem Cell (Cell stem cell)
[2017, 21(2):195-208.e6]

Cited: 78 times

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CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells.

Alex Sargent, Lianhua Bai, Genevieve Shano, Molly Karl, Eric Garrison, Lahiru Ranasinghe, Sarah M Planchon, Jeffrey Cohen, Robert H Miller,

Mesenchymal stem cells (MSCs) have emerged as a potentially powerful cellular therapy for autoimmune diseases including multiple sclerosis (MS). Based on their success in treating animal models of MS like experimental autoimmune encephalomyelitis (EAE), MSCs have moved rapidly into clinical trials for MS. The majority of these trials use autologous ... Read more >>

Exp Neurol (Experimental neurology)
[2017, 295:222-232]

Cited: 4 times

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Reliability testing of the Larsen and Sharp classifications for rheumatoid arthritis of the elbow.

Nicholas B Jew, Anthony M Hollins, Benjamin M Mauck, Richard A Smith, Frederick M Azar, Robert H Miller, Thomas W Throckmorton,

<h4>Background</h4>Two popular systems for classifying rheumatoid arthritis affecting the elbow are the Larsen and Sharp schemes. To our knowledge, no study has investigated the reliability of these 2 systems. We compared the intraobserver and interobserver agreement of the 2 systems to determine whether one is more reliable than the other.<h4>Methods</h4>The ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2017, 26(1):140-143]

Cited: 2 times

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Oligodendrocyte ablation as a tool to study demyelinating diseases.

Ahdeah Pajoohesh-Ganji, Robert H Miller,

Multiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause ... Read more >>

Neural Regen Res (Neural regeneration research)
[2016, 11(6):886-889]

Cited: 3 times

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Contribution of the oligodendrocyte lineage to CNS repair and neurodegenerative pathologies.

Reshmi Tognatta, Robert H Miller,

The concept of the oligodendrocyte lineage as simply a source of myelinating cells in the vertebrate CNS is undergoing radical revision. Elucidation of the origins of oligodendrocytes in the CNS has led to identification of important signaling pathways, the timing and mechanism of lineage commitments and overlapping as well as ... Read more >>

Neuropharmacology (Neuropharmacology)
[2016, 110(Pt B):539-547]

Cited: 28 times

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Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin Imaging.

Anand Dev Tiwari, Chunying Wu, Junqing Zhu, Sheng Zhang, Jinle Zhu, William R Wang, Jinming Zhang, Curtis Tatsuoka, Paul M Matthews, Robert H Miller, Yanming Wang,

Myelination is one of the fundamental processes in vertebrates. A major challenge is to quantitatively image myelin distribution in the central nervous system. For this reason, we designed and synthesized a series of fluorinated radioligands that can be radiolabeled as radiotracers for positron emission tomography (PET) imaging of myelin. These ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2016, 59(8):3705-3718]

Cited: 4 times

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MSC Therapeutics in Chronic Inflammation.

Alex Sargent, Robert H Miller,

The utilization of mesenchymal stem cells (also known as mesenchymal stromal cells, or MSCs) as a cell-based therapy for diseases that have ongoing inflammatory damage has become increasingly available. Our understanding of the cell biology of MSCs is still incomplete. However, as a result of increasing numbers of pre-clinical and ... Read more >>

Curr Stem Cell Rep (Current stem cell reports)
[2016, 2(2):168-173]

Cited: 10 times

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