Full Text Journal Articles by
Author Robert H Mak

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Clinical characteristics and risk factors for death among hospitalised children and adolescents with COVID-19 in Brazil: an analysis of a nationwide database

Eduardo A Oliveira, Enrico A Colosimo, Ana Cristina Simões e Silva, Robert H Mak, Daniella B Martelli, Ludmila R Silva, Hercílio Martelli-Júnior, Maria Christina L Oliveira,

<h4>Background</h4> COVID-19 is usually less severe and has lower case fatality in children than in adults. We aimed to characterise the clinical features of children and adolescents hospitalised with laboratory-confirmed SARS-CoV-2 infection and to evaluate the risk factors for COVID-19-related death in this population. <h4>Methods</h4> We did an analysis of ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2021, :]

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Evaluation of Urinary Tract Dilation Classification System for Prediction of Long-Term Outcomes in Isolated Antenatal Hydronephrosis: A Cohort Study.

Fernanda F Melo, Robert H Mak, Ana Cristina Simões E Silva, Mariana A Vasconcelos, Cristiane S Dias, Ludmila C Rosa, Gabriela Y Shiomatsu, Camila Storch, Maria Christina L Oliveira, Eduardo A Oliveira,

<h4>Purpose</h4>The aim of this study was to evaluate the performance of the new classification of urinary tract dilatation (UTD) to predict long-term clinical outcomes in infants with isolated antenatal hydronephrosis (AHN).<h4>Patients and methods</h4>Between 1989 and 2019, 447 infants diagnosed with isolated severe AHN and were prospectively followed. The main predictive ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001899]

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Standardized urine biomarkers in assessing neonatal kidney function: are we there yet?

Robert H Mak, Carolyn L Abitbol,

J Pediatr (Rio J) (Jornal de pediatria)
[2021, :]

Cited: 0 times

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Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.

Wai W Cheung, Wei Ding, Hal M Hoffman, Zhen Wang, Sheng Hao, Ronghao Zheng, Alex Gonzalez, Jian-Ying Zhan, Ping Zhou, Shiping Li, Mary C Esparza, Richard L Lieber, Robert H Mak,

Patients with chronic kidney disease (CKD) are often 25(OH)D<sub>3</sub> and 1,25(OH)<sub>2</sub>D<sub>3</sub> insufficient. We studied whether vitamin D repletion could correct aberrant adipose tissue and muscle metabolism in a mouse model of CKD-associated cachexia. Intraperitoneal administration of 25(OH)D<sub>3</sub> and 1,25(OH)<sub>2</sub>D<sub>3</sub> (75 μg/kg/day and 60 ng/kg/day respectively for 6 weeks) normalized serum concentrations of 25(OH)D<sub>3</sub> ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14175]

Cited: 1 time

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Editorial: Developmental Disorders of the Kidney and Urinary Tract: Recent Insights From Clinical and Molecular Studies.

Eduardo A Oliveira, Robert H Mak, Ana Cristina Simões E Silva,

Front Pediatr (Frontiers in pediatrics)
[2020, 8:348]

Cited: 0 times

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Low Serum Bicarbonate and CKD Progression in Children.

Denver D Brown, Jennifer Roem, Derek K Ng, Kimberly J Reidy, Juhi Kumar, Matthew K Abramowitz, Robert H Mak, Susan L Furth, George J Schwartz, Bradley A Warady, Frederick J Kaskel, Michal L Melamed,

<h4>Background and objectives</h4>Studies of adults have demonstrated an association between metabolic acidosis, as measured by low serum bicarbonate levels, and CKD progression. We evaluated this relationship in children using data from the Chronic Kidney Disease in Children study.<h4>Design, setting, participants, & measurements</h4>The relationship between serum bicarbonate and a composite end ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 15(6):755-765]

Cited: 2 times

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Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity.

Uwe Querfeld, Robert H Mak, Axel Radlach Pries,

Chronic kidney disease (CKD) is a relentlessly progressive disease with a very high mortality mainly due to cardiovascular complications. Endothelial dysfunction is well documented in CKD and permanent loss of endothelial homeostasis leads to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2020, 134(12):1333-1356]

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Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis.

Sean N Avedissian, Shannon M Skochko, Jennifer Le, Sara Hingtgen, Helen Harvey, Edmund V Capparelli, Andrew Richardson, Jeremiah Momper, Robert H Mak, Michael Neely, John S Bradley,

<h4>Objectives</h4>The objectives of this study were to 1) define extent and potential clinical impact of increased or decreased renal elimination of meropenem in children with sepsis, based on analysis of renal function during the first 2 days of PICU stay; and 2) estimate the risk of subtherapeutic meropenem exposure attributable ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(5):413-422]

Cited: 2 times

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Urinary tract infection in pediatrics: an overview.

Ana Cristina Simões E Silva, Eduardo A Oliveira, Robert H Mak,

<h4>Objective</h4>This review aimed to provide a critical overview on the pathogenesis, clinical findings, diagnosis, imaging investigation, treatment, chemoprophylaxis, and complications of urinary tract infection in pediatric patients.<h4>Source of data</h4>Data were obtained independently by two authors, who carried out a comprehensive and non-systematic search in public databases.<h4>Summary of findings</h4>Urinary tract infection ... Read more >>

J Pediatr (Rio J) (Jornal de pediatria)
[2020, 96 Suppl 1:65-79]

Cited: 1 time

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Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.

Wai W Cheung, Sheng Hao, Zhen Wang, Wei Ding, Ronghao Zheng, Alex Gonzalez, Jian-Ying Zhan, Ping Zhou, Shiping Li, Mary C Esparza, Hal M Hoffman, Richard L Lieber, Robert H Mak,

<h4>Background</h4>Ctns<sup>-/-</sup> mice, a mouse model of infantile nephropathic cystinosis, exhibit hypermetabolism with adipose tissue browning and profound muscle wasting. Ctns<sup>-/-</sup> mice are 25(OH)D<sub>3</sub> and 1,25(OH)<sub>2</sub> D<sub>3</sub> insufficient. We investigated whether vitamin D repletion could ameliorate adipose tissue browning and muscle wasting in Ctns<sup>-/-</sup> mice.<h4>Methods</h4>Twelve-month-old Ctns<sup>-/-</sup> mice and wild-type controls were ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2020, 11(1):120-134]

Cited: 5 times

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A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis.

Fernanda P Costa, Ana C Simões E Silva, Robert H Mak, Joachim H Ix, Mariana A Vasconcelos, Cristiane S Dias, Carolina C Fonseca, Maria Christina L Oliveira, Eduardo A Oliveira,

<h4>Background</h4>Antenatal hydronephrosis (ANH) affects ∼1-5% of pregnancies. The aim of this study was to develop a clinical prediction model of renal injury in a large cohort of infants with isolated ANH.<h4>Methods</h4>This is a longitudinal cohort study of 447 infants with ANH admitted since birth between 1989 and 2015 at a ... Read more >>

Clin Kidney J (Clinical kidney journal)
[2020, 13(5):834-841]

Cited: 0 times

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Cachexia/Protein energy wasting syndrome in CKD: Causation and treatment.

Eduardo A Oliveira, Ronghao Zheng, Caitlin E Carter, Robert H Mak,

Cachexia is a multifactorial syndrome defined by significant body weight loss, fat and muscle mass reduction, and increased protein catabolism. Protein energy wasting (PEW) is characterized as a syndrome of adverse changes in nutrition and body composition being highly prevalent in patients with CKD, especially in those undergoing dialysis, and ... Read more >>

Semin Dial (Seminars in dialysis)
[2019, 32(6):493-499]

Cited: 4 times

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A Predictive Model of Postnatal Surgical Intervention in Children With Prenatally Detected Congenital Anomalies of the Kidney and Urinary Tract.

Mariana A Vasconcelos, Eduardo A Oliveira, Ana Cristina Simões E Silva, Cristiane S Dias, Robert H Mak, Carolina C Fonseca, Ana Paula M Campos, Ewout W Steyerberg, Yvonne Vergouwe,

The aim of this study was to identify predictive factors and develop a model to assess individualized risk of postnatal surgical intervention in patients with antenatal hydronephrosis. This is a retrospective cohort study of 694 infants with prenatally detected congenital anomalies of kidney and urinary tract with a median follow-up ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:120]

Cited: 1 time

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Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.

Tatiana Lobry, Roy Miller, Nathalie Nevo, Celine J Rocca, Jinzhong Zhang, Sergio D Catz, Fiona Moore, Lucie Thomas, Daniel Pouly, Anne Bailleux, Ida Chiara Guerrera, Marie-Claire Gubler, Wai W Cheung, Robert H Mak, Tristan Montier, Corinne Antignac, Stephanie Cherqui,

Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Cystinosis is a lysosomal storage disorder and, despite ... Read more >>

Kidney Int (Kidney international)
[2019, 96(2):350-362]

Cited: 7 times

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A clinical predictive model of renal injury in children with congenital solitary functioning kidney.

Isabel V Poggiali, Ana Cristina Simões E Silva, Mariana A Vasconcelos, Cristiane S Dias, Izabella R Gomes, Rafaela A Carvalho, Maria Christina L Oliveira, Sergio V Pinheiro, Robert H Mak, Eduardo A Oliveira,

<h4>Background</h4>Solitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK.<h4>Methods</h4>In this retrospective cohort study, 162 patients with SFK ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(3):465-474]

Cited: 4 times

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A clinical predictive model of chronic kidney disease in children with posterior urethral valves.

Mariana A Vasconcelos, Ana Cristina Simões E Silva, Izabella R Gomes, Rafaela A Carvalho, Sergio V Pinheiro, Enrico A Colosimo, Peter Yorgin, Robert H Mak, Eduardo A Oliveira,

<h4>Background</h4>Posterior urethral valves (PUVs) are associated with severe consequences to the urinary tract and are a common cause of chronic kidney disease (CKD). The aim of this study was to develop clinical predictive model of CKD in a cohort of patients with PUVs.<h4>Methods</h4>In this retrospective cohort study, 173 patients with ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(2):283-294]

Cited: 2 times

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Progression of chronic kidney disease in children - role of glomerular hemodynamics and interstitial fibrosis.

Eduardo A Oliveira, Robert H Mak,

PURPOSE OF REVIEW:The aim of this review is to provide an overview of the current advances in the understanding of the mechanisms involved in the progression of chronic kidney disease (CKD) with emphasis on the role of glomerular hemodynamics and tubulointerstitial fibrosis. RECENT FINDINGS:Despite the varied causes of CKD, the ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2018, 30(2):220-227]

Cited: 0 times

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Unacylated ghrelin and obestatin in pediatric CKD: are they important in protein energy wasting?

Zhen Wang, Eduardo A Oliveira, Robert H Mak,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2018, 33(5):741-743]

Cited: 1 time

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Preparation of Potent Leptin Receptor Antagonists and Their Therapeutic Use in Mouse Models of Uremic Cachexia and Kidney Fibrosis.

Robert H Mak, Wai W Cheung, Gili Solomon, Arieh Gertler,

Leptin antagonists (L39A/D40A/F4lA mutants) of mouse, human, rat and ovine leptins were developed in our laboratory by rational mutagenesis, expressed in Escherichia coli, refolded and purified to homogeneity. Pegylation of these antagonists resulted in long-acting reagents suitable for in-vivo studies. Further selection of high-affinity leptin antagonists was achieved by random ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2018, 24(9):1012-1018]

Cited: 1 time

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Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study.

Elaine Ku, Joel D Kopple, Charles E McCulloch, Bradley A Warady, Susan L Furth, Robert H Mak, Barbara A Grimes, Mark Mitsnefes,

<h4>Background</h4>Anorexia and malnutrition are associated with poor outcomes in children with chronic kidney disease (CKD).<h4>Study design</h4>Observational cohort study.<h4>Setting & participants</h4>We assessed changes in body mass index (BMI) as kidney function declines and its association with risk for end-stage renal disease (ESRD) among 854 participants followed between 2005 to 2013 in ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2018, 71(5):648-656]

Cited: 4 times

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MicroRNA as Novel Exercise Mimetic for Muscle Wasting in CKD.

Robert H Mak, Wai W Cheung,

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2017, 28(9):2557-2559]

Cited: 1 time

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Emerging roles of nuclear phosphatase SCP4 in CKD-associated muscle wasting.

Wai W Cheung, Sheng Hao, Robert H Mak,

Cachexia with wasting of muscle protein is a serious complication of chronic kidney disease (CKD). Muscle protein phosphorylation is a potential therapeutic target. Liu et al. reported that small C-terminal domain phosphatase (SCP) 4 was increased in muscles of patients and mice with CKD. Importantly, knockdown of SCP4 significantly ameliorated muscle ... Read more >>

Kidney Int (Kidney international)
[2017, 92(2):281-283]

Cited: 0 times

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Muscle wasting in chronic kidney disease.

Eduardo A Oliveira, Wai W Cheung, Kalodiah G Toma, Robert H Mak,

Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2018, 33(5):789-798]

Cited: 9 times

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Steroid-resistant nephrotic syndrome: past and current perspectives.

Noureddin Nourbakhsh, Robert H Mak,

Patients with steroid-resistant nephrotic syndrome (SRNS) represent a challenging subset of patients with nephrotic syndrome who often fail standard immunosuppression and have a higher likelihood of progressing to end-stage renal disease. Appropriate treatment of SRNS requires an adequate understanding of the historical treatment, renal histopathology, and genetics associated with the ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2017, 8:29-37]

Cited: 10 times

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Cachexia in children with chronic kidney disease: challenges in diagnosis and treatment.

Robert H Mak,

<h4>Purpose of review</h4>Although cachexia is highly prevalent in adult patients with chronic kidney disease (CKD), it is understudied and less well characterized in children. Recent evidence suggests that cachexia is also prevalent in children with CKD but presents challenges in diagnosis and treatment.<h4>Recent findings</h4>A study from the CKD in children ... Read more >>

Curr Opin Support Palliat Care (Current opinion in supportive and palliative care)
[2016, 10(4):293-297]

Cited: 5 times

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