Full Text Journal Articles by
Author Robert F Tamburro

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Survival and Cardiopulmonary Resuscitation Hemodynamics Following Cardiac Arrest in Children With Surgical Compared to Medical Heart Disease.

Andrew R Yates, Robert M Sutton, Ron W Reeder, Kathleen L Meert, John T Berger, Richard Fernandez, David Wessel, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen, Rick E Harrison, Frank W Moler, Murray M Pollack, Todd C Carpenter, Daniel A Notterman, J Michael Dean, Vinay M Nadkarni, Robert A Berg, ,

OBJECTIVES:To assess the association of diastolic blood pressure cutoffs (≥ 25 mm Hg in infants and ≥ 30 mm Hg in children) during cardiopulmonary resuscitation with return of spontaneous circulation and survival in surgical cardiac versus medical cardiac patients. Secondarily, we assessed whether these diastolic blood pressure targets were feasible to achieve ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(12):1126-1136]

Cited: 0 times

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A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

Athena F Zuppa, Nicole R Zane, Ganesh Moorthy, Heidi J Dalton, Alan Abraham, Ron W Reeder, Joseph A Carcillo, Andrew R Yates, Kathleen L Meert, Robert A Berg, Anil Sapru, Peter Mourani, Daniel A Notterman, J Michael Dean, Marc R Gastonguay, ,

OBJECTIVES:Limited data exist on the effects of extracorporeal membrane oxygenation on pharmacokinetics of cefepime in critically ill pediatric patients. The objective was to describe cefepime disposition in children treated with extracorporeal membrane oxygenation using population pharmacokinetic modeling. DESIGN:Multicenter, prospective observational study. SETTING:The pediatric and cardiac ICUs of six sites of ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(1):62-70]

Cited: 0 times

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Acute Respiratory Failure in Pediatric Hematopoietic Cell Transplantation: A Multicenter Study.

Courtney M Rowan, Jennifer McArthur, Deyin D Hsing, Shira J Gertz, Lincoln S Smith, Ashley Loomis, Julie C Fitzgerald, Mara E Nitu, Elizabeth A S Moser, Christine N Duncan, Kris M Mahadeo, Jerelyn Moffet, Mark W Hall, Emily L Pinos, Robert F Tamburro, Ira M Cheifetz, ,

OBJECTIVES:Acute respiratory failure is common in pediatric hematopoietic cell transplant recipients and has a high mortality. However, respiratory prognostic markers have not been adequately evaluated for this population. Our objectives are to assess respiratory support strategies and indices of oxygenation and ventilation in pediatric allogeneic hematopoietic cell transplant patients receiving ... Read more >>

Crit. Care Med. (Critical care medicine)
[2018, 46(10):e967-e974]

Cited: 2 times

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No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.

Katie Park, Lindsay C Trout, Cong Xu, Ming Wang, Robert F Tamburro, E Scott Halstead,

OBJECTIVES:To determine the relationship between theophylline trough levels and urine output in critically ill children administered aminophylline as adjunctive diuretic therapy. DESIGN:Retrospective cohort study. SETTING:The PICU of a tertiary care children's hospital. PATIENTS:A mixed population of medical/surgical including postoperative cardiothoracic surgery patients less than 18 years old. INTERVENTIONS:Electronic medical records ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):e425-e432]

Cited: 0 times

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CALIPSO: A Randomized Controlled Trial of Calfactant for Acute Lung Injury in Pediatric Stem Cell and Oncology Patients.

Neal J Thomas, Debbie Spear, Emily Wasserman, Steven Pon, Barry Markovitz, Aalok R Singh, Simon Li, Shira J Gertz, Courtney M Rowan, Allen Kunselman, Robert F Tamburro, ,

To assess if calfactant reduces mortality among children with leukemia/lymphoma or after hematopoietic cell transplantation (HCT) with pediatric acute respiratory distress syndrome (PARDS), we conducted a multicenter, randomized, placebo-controlled, double-blinded trial in 17 pediatric intensive care units (PICUs) of tertiary care children's hospitals. Patients ages 18 months to 25 years ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2018, 24(12):2479-2486]

Cited: 2 times

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RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support.

Jennifer A Muszynski, Ron W Reeder, Mark W Hall, Robert A Berg, Thomas P Shanley, Christopher J L Newth, Murray M Pollack, David Wessel, Joseph Carcillo, Rick Harrison, Kathleen L Meert, J Michael Dean, Tammara Jenkins, Robert F Tamburro, Heidi J Dalton, ,

OBJECTIVES:To determine RBC transfusion practice and relationships between RBC transfusion volume and mortality in infants and children treated with extracorporeal membrane oxygenation. DESIGN:Secondary analysis of a multicenter prospective observational study. SETTING:Eight pediatric institutions within the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Collaborative Pediatric Critical Care ... Read more >>

Crit. Care Med. (Critical care medicine)
[2018, 46(6):e552-e559]

Cited: 3 times

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Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial.

Ron W Reeder, Alan Girling, Heather Wolfe, Richard Holubkov, Robert A Berg, Maryam Y Naim, Kathleen L Meert, Bradley Tilford, Joseph A Carcillo, Melinda Hamilton, Matthew Bochkoris, Mark Hall, Tensing Maa, Andrew R Yates, Anil Sapru, Robert Kelly, Myke Federman, J Michael Dean, Patrick S McQuillen, Deborah Franzon, Murray M Pollack, Ashley Siems, John Diddle, David L Wessel, Peter M Mourani, Carleen Zebuhr, Robert Bishop, Stuart Friess, Candice Burns, Shirley Viteri, David A Hehir, R Whitney Coleman, Tammara L Jenkins, Daniel A Notterman, Robert F Tamburro, Robert M Sutton, ,

BACKGROUND:Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children with an in-hospital arrest will survive to discharge. A single-center before-and-after study demonstrated that outcomes may be improved with a novel training program in which all pediatric intensive ... Read more >>

Trials (Trials)
[2018, 19(1):213]

Cited: 1 time

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High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient.

Courtney M Rowan, Ashley Loomis, Jennifer McArthur, Lincoln S Smith, Shira J Gertz, Julie C Fitzgerald, Mara E Nitu, Elizabeth As Moser, Deyin D Hsing, Christine N Duncan, Kris M Mahadeo, Jerelyn Moffet, Mark W Hall, Emily L Pinos, Robert F Tamburro, Ira M Cheifetz, ,

INTRODUCTION:The effectiveness of high-frequency oscillatory ventilation (HFOV) in the pediatric hematopoietic cell transplant patient has not been established. We sought to identify current practice patterns of HFOV, investigate parameters during HFOV and their association with mortality, and compare the use of HFOV to conventional mechanical ventilation in severe pediatric ARDS. ... Read more >>

Respir Care (Respiratory care)
[2018, 63(4):404-411]

Cited: 3 times

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Viral DNAemia and Immune Suppression in Pediatric Sepsis.

Sam Davila, E Scott Halstead, Mark W Hall, Allan Doctor, Russell Telford, Richard Holubkov, Joseph A Carcillo, Gregory A Storch, ,

OBJECTIVES:Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN:Retrospective analysis of a prospective cohort study. PATIENTS:Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:This study was performed as an ancillary investigation to a single-center ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(1):e14-e22]

Cited: 2 times

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Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival.

Robert A Berg, Robert M Sutton, Ron W Reeder, John T Berger, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen, Kathleen L Meert, Andrew R Yates, Rick E Harrison, Frank W Moler, Murray M Pollack, Todd C Carpenter, David L Wessel, Tammara L Jenkins, Daniel A Notterman, Richard Holubkov, Robert F Tamburro, J Michael Dean, Vinay M Nadkarni, ,

BACKGROUND:On the basis of laboratory cardiopulmonary resuscitation (CPR) investigations and limited adult data demonstrating that survival depends on attaining adequate arterial diastolic blood pressure (DBP) during CPR, the American Heart Association recommends using blood pressure to guide pediatric CPR. However, evidence-based blood pressure targets during pediatric CPR remain an important ... Read more >>

Circulation (Circulation)
[2018, 137(17):1784-1795]

Cited: 9 times

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Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status.

Matt S Zinter, Richard Holubkov, Martina A Steurer, Christopher C Dvorak, Christine N Duncan, Anil Sapru, Robert F Tamburro, Patrick S McQuillen, Murray M Pollack,

The number of pediatric hematopoietic cell transplant (HCT) patients who survive pediatric intensive care unit (PICU) admission is increasing, yet little is known about their functional morbidity after PICU discharge. We hypothesized that relative to control subjects, pediatric HCT patients who survive PICU admission would have greater rates of new ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2018, 24(2):330-336]

Cited: 4 times

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Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation.

Heidi J Dalton, Ron Reeder, Pamela Garcia-Filion, Richard Holubkov, Robert A Berg, Athena Zuppa, Frank W Moler, Thomas Shanley, Murray M Pollack, Christopher Newth, John Berger, David Wessel, Joseph Carcillo, Michael Bell, Sabrina Heidemann, Kathleen L Meert, Richard Harrison, Allan Doctor, Robert F Tamburro, J Michael Dean, Tammara Jenkins, Carol Nicholson, ,

Extracorporeal membrane oxygenation (ECMO) is used for respiratory and cardiac failure in children but is complicated by bleeding and thrombosis.(1) To measure the incidence of bleeding (blood loss requiring transfusion or intracranial hemorrhage) and thrombosis during ECMO support; (2) to identify factors associated with these complications; and (3) to determine ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2017, 196(6):762-771]

Cited: 21 times

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End-of-Life and Bereavement Care in Pediatric Intensive Care Units.

Markita L Suttle, Tammara L Jenkins, Robert F Tamburro,

Most childhood deaths in the United States occur in hospitals. Pediatric intensive care clinicians must anticipate and effectively treat dying children's pain and suffering and support the psychosocial and spiritual needs of families. These actions may help family members adjust to their loss, particularly bereaved parents who often experience reduced ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2017, 64(5):1167-1183]

Cited: 4 times

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Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.

Joseph A Carcillo, E Scott Halstead, Mark W Hall, Trung C Nguyen, Ron Reeder, Rajesh Aneja, Bita Shakoory, Dennis Simon, ,

OBJECTIVES:We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis. DESIGN:Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple organ failure (whole blood ex ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(6):513-523]

Cited: 11 times

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Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 1.

Jeffrey S Upperman, Jacques Lacroix, Martha A Q Curley, Paul A Checchia, Daniel W Lee, Kenneth R Cooke, Robert F Tamburro,

OBJECTIVE:To describe a number of the conditions associated with multiple organ dysfunction syndrome presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development multiple organ dysfunction syndrome workshop (March 26-27, 2015). DATA SOURCES:Literature review, research data, and expert opinion. STUDY SELECTION:Not applicable. DATA EXTRACTION:Moderated ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(3_suppl Suppl 1):S50-S57]

Cited: 1 time

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Pediatric Acute Respiratory Distress Syndrome in Pediatric Allogeneic Hematopoietic Stem Cell Transplants: A Multicenter Study.

Courtney M Rowan, Lincoln S Smith, Ashley Loomis, Jennifer McArthur, Shira J Gertz, Julie C Fitzgerald, Mara E Nitu, Elizabeth A S Moser, Deyin D Hsing, Christine N Duncan, Kris M Mahadeo, Jerelyn Moffet, Mark W Hall, Emily L Pinos, Robert F Tamburro, Ira M Cheifetz, ,

OBJECTIVE:Immunodeficiency is both a preexisting condition and a risk factor for mortality in pediatric acute respiratory distress syndrome. We describe a series of pediatric allogeneic hematopoietic stem cell transplant patients with pediatric acute respiratory distress syndrome based on the recent Pediatric Acute Lung Injury Consensus Conference guidelines with the objective ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(4):304-309]

Cited: 11 times

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Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 2.

Jeffrey S Upperman, John C Bucuvalas, Felicia N Williams, Bruce A Cairns, Charles S Cox, Allan Doctor, Robert F Tamburro,

OBJECTIVE:To describe a number of conditions and therapies associated with multiple organ dysfunction syndrome presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Multiple Organ Dysfunction Workshop (March 26-27, 2015). In addition, the relationship between burn injuries and multiple organ dysfunction syndrome is ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(3_suppl Suppl 1):S58-S66]

Cited: 1 time

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Multiple Organ Dysfunction Syndrome: A Challenge for the Pediatric Critical Care Community.

Robert F Tamburro, Tammara L Jenkins,

The multiple organ dysfunction syndrome is highly prevalent among critically ill children both at the time of their admission and throughout their PICU stay. It is associated with a wide variety of clinical conditions and diagnoses. In addition to its prevalence, it is closely associated with mortality, and the risk ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(3_suppl Suppl 1):S1-S3]

Cited: 1 time

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A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis.

Joseph A Carcillo, Katherine Sward, E Scott Halstead, Russell Telford, Adria Jimenez-Bacardi, Bita Shakoory, Dennis Simon, Mark Hall, ,

OBJECTIVES:We tested the hypothesis that a C-reactive protein and ferritin-based systemic inflammation contingency table can track mortality risk in pediatric severe sepsis. DESIGN:Prospective cohort study. SETTING:Tertiary PICU. PATIENTS:Children with 100 separate admission episodes of severe sepsis were enrolled. INTERVENTIONS:Blood samples were attained on day 2 of sepsis and bi-weekly for ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(2):143-150]

Cited: 9 times

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Strategic Planning for Research in Pediatric Critical Care.

Robert F Tamburro, Tammara L Jenkins, Patrick M Kochanek,

OBJECTIVE:To summarize the scientific priorities and potential future research directions for pediatric critical care research discussed by a panel of experts at the inaugural Strategic Planning Conference of the Pediatric Trauma and Critical Illness Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. DATA SOURCES:Expert ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2016, 17(11):e539-e542]

Cited: 2 times

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Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial.

Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kanwaljeet J S Anand, Jerry J Zimmerman, Christopher J L Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster, Robert F Tamburro, ,

BACKGROUND AND AIMS:The pediatric Critical Illness Stress-induced Immune Suppression (CRISIS) trial compared the effectiveness of 2 nutraceutical supplementation strategies and found no difference in the development of nosocomial infection and sepsis in the overall population. We performed an exploratory post hoc analysis of interaction between nutraceutical treatments and host immune ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2017, 41(8):1325-1335]

Cited: 1 time

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Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs.

Robert A Berg, Vinay M Nadkarni, Amy E Clark, Frank Moler, Kathleen Meert, Rick E Harrison, Christopher J L Newth, Robert M Sutton, David L Wessel, John T Berger, Joseph Carcillo, Heidi Dalton, Sabrina Heidemann, Thomas P Shanley, Athena F Zuppa, Allan Doctor, Robert F Tamburro, Tammara L Jenkins, J Michael Dean, Richard Holubkov, Murray M Pollack, ,

To determine the incidence of cardiopulmonary resuscitation in PICUs and subsequent outcomes.Multicenter prospective observational study of children younger than 18 years old randomly selected and intensively followed from PICU admission to hospital discharge in the Collaborative Pediatric Critical Care Research Network December 2011 to April 2013.Among 10,078 children enrolled, 139 ... Read more >>

Crit. Care Med. (Critical care medicine)
[2016, 44(4):798-808]

Cited: 33 times

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Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study.

Courtney M Rowan, Shira J Gertz, Jennifer McArthur, Julie C Fitzgerald, Mara E Nitu, Ashley Loomis, Deyin D Hsing, Christine N Duncan, Kris M Mahadeo, Lincoln S Smith, Jerelyn Moffet, Mark W Hall, Emily L Pinos, Ira M Cheifetz, Robert F Tamburro, ,

OBJECTIVE:To establish the current respiratory practice patterns in pediatric hematopoietic stem cell transplant patients and investigate their associations with mortality across multiple centers. DESIGN:Retrospective cohort between 2009 and 2014. SETTING:Twelve children's hospitals in the United States. PATIENTS:Two hundred twenty-two pediatric allogeneic hematopoietic stem cell transplant recipients with acute respiratory failure ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2016, 17(4):294-302]

Cited: 17 times

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Toward a Research Agenda on Pediatric Trauma and Critical Illness.

Valerie Maholmes, Robert F Tamburro, Tammara L Jenkins,

JAMA Pediatr (JAMA pediatrics)
[2016, 170(1):7-8]

Cited: 2 times

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Dexmedetomidine for Sedation during Withdrawal of Support.

Chris O'Hara, Robert F Tamburro, Gary D Ceneviva,

Agents used to control end-of-life suffering are associated with troublesome side effects. The use of dexmedetomidine for sedation during withdrawal of support in pediatrics is not yet described. An adolescent female with progressive and irreversible pulmonary deterioration was admitted. Despite weeks of therapy, she did not tolerate weaning of supplemental ... Read more >>

Palliat Care (Palliative care)
[2015, 9:15-18]

Cited: 4 times

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