Full Text Journal Articles by
Author Robert Davis

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Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients.

Annie M Racine, Douglas Tommet, Madeline L D'Aquila, Tamara G Fong, Yun Gou, Patricia A Tabloski, Eran D Metzger, Tammy T Hshieh, Eva M Schmitt, Sarinnapha M Vasunilashorn, Lisa Kunze, Kamen Vlassakov, Ayesha Abdeen, Jeffrey Lange, Brandon Earp, Bradford C Dickerson, Edward R Marcantonio, Jon Steingrimsson, Thomas G Travison, Sharon K Inouye, Richard N Jones, ,

BACKGROUND:Our objective was to assess the performance of machine learning methods to predict post-operative delirium using a prospective clinical cohort. METHODS:We analyzed data from an observational cohort study of 560 older adults (≥ 70 years) without dementia undergoing major elective non-cardiac surgery. Post-operative delirium was determined by the Confusion Assessment Method supplemented ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2020, :]

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Safety, Tolerability, and Outcomes of Enteral Nutrition in Extracorporeal Membrane Oxygenation.

Robert C Davis, Lucian A Durham, Laszlo Kiraly, Jayshil J Patel,

Extracorporeal membrane oxygenation (ECMO) is a supportive care system for patients with respiratory or cardiac failure. Patients requiring ECMO are at risk for significant inflammation, prolonged hospitalization, and acquired malnutrition and sarcopenia. Societal guidelines recommend early enteral nutrition in critically ill patients; however, in this population, optimal timing and dose ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2020, :]

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Temporal Differential Expression of Physiomarkers Predicts Sepsis in Critically Ill Adults.

Akram Mohammed, Franco Van Wyk, Lokesh K Chinthala, Anahita Khojandi, Robert L Davis, Craig M Coopersmith, Rishikesan Kamaleswaran,

BACKGROUND:Sepsis is a life-threatening condition with high mortality rates. Early detection and treatment are critical to improving outcomes. Our primary objective was to develop artificial intelligence capable of predicting sepsis earlier using a minimal set of streaming physiological data in real-time. METHODS AND FINDINGS:A total of 29,552 adult patients were ... Read more >>

Shock (Shock (Augusta, Ga.))
[2020, :]

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TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.

Franz Meitinger, Midori Ohta, Kian-Yong Lee, Sadanori Watanabe, Robert L Davis, John V Anzola, Ruth Kabeche, David A Jenkins, Andrew K Shiau, Arshad Desai, Karen Oegema,

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus1. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs. 2,3). When PLK4 is chemically inhibited, cell division proceeds without centrosome duplication, generating centrosome-less cells that exhibit ... Read more >>

Nature (Nature)
[2020, 585(7825):440-446]

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Qualitative descriptions of patient perceptions about fall risks, prevention strategies and self-identity: Analysis of fall prevention Motivational Interviewing conversations.

Hiroko Kiyoshi-Teo, Kathlynn Northrup-Snyder, Mary Robert Davis, Ellen Garcia, Amy Leatherwood, Shigeko Seiko Izumi,

BACKGROUND:Older adults are often reluctant to engage in fall prevention activities. OBJECTIVES:To understand how older adults respond to fall prevention and identify attributes that affect their responses to fall prevention. METHODS:Qualitative content analysis of Fall Prevention Motivational Interviewing conversations that were conducted as an intervention for a fall prevention study ... Read more >>

J Clin Nurs (Journal of clinical nursing)
[2020, :]

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Lighting Control in Patient Rooms: Understanding Nurses' Perceptions of Hospital Lighting Using Qualitative Methods.

Lindsay J McCunn, Sarah Safranek, Andrea Wilkerson, Robert G Davis,

PURPOSE:This study differs in its methodological approach from previously published research by interpreting qualitative results against existing literature to understand how nurses conceptualize medical-surgical patient rooms as productive settings in relation to lighting, as well as the ways in which nurses believe these spaces could be enhanced for patient satisfaction. ... Read more >>

HERD (HERD)
[2020, :1937586720946669]

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A comparison of the effect of weather and climate on emergency department visitation in Roanoke and Charlottesville, Virginia.

Robert E Davis, Erin S Markle, Sara Windoloski, Margaret E Houck, Kyle B Enfield, Hyojung Kang, Robert C Balling, Damon R Kuehl, John H Burton, Wilson Farthing, Edmundo R Rubio, Wendy M Novicoff,

Compared with mortality, the impact of weather and climate on human morbidity is less well understood, especially in the cold season. We examined the relationships between weather and emergency department (ED) visitation at hospitals in Roanoke and Charlottesville, Virginia, two locations with similar climates and population demographic profiles. Using patient-level ... Read more >>

Environ Res (Environmental research)
[2020, 191:110065]

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Effects of health beliefs, social support, and self-efficacy on sun protection behaviors among medical students: testing of an extended health belief model.

Ross L Pearlman, Vaidehi Patel, Robert E Davis, Taylor S Ferris, Karen Gruszynski, Timothy Elledge, Kaustuv Bhattacharya, Vinayak K Nahar,

Sun protection behaviors (SPB) are important modifiable risk factors for skin cancer. As the most common malignancies in the world, skin cancers account for significant morbidity, mortality, and economic burden. Physicians play a key role in educating patients about proper SPB. Medical education provides the foundation for physician understanding of ... Read more >>

Arch. Dermatol. Res. (Archives of dermatological research)
[2020, :]

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Commentary: Making lungs great again-introducing new modifications to the Toronto ex vivo lung perfusion protocol.

Samuel J Kesseli, Robert Patrick Davis, Matthew G Hartwig,

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2020, :]

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Sensitivity of Clinical Pediatric Obesity Diagnosis Documented in Electronic Health Records.

Christine B San Giovanni, Myla Ebeling, Robert A Davis, C Shaun Wagner, William T Basco,

Objective. This study tested the sensitivity of obesity diagnosis in electronic health records (EHRs) using body mass index (BMI) classification and identified variables associated with obesity diagnosis. Methods. Eligible children aged 2 to 18 years had a calculable BMI in 2017 and had at least 1 visit in 2016 and ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2020, 59(14):1274-1281]

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Electrocardiographic changes predate Parkinson's disease onset.

Oguz Akbilgic, Rishikesan Kamaleswaran, Akram Mohammed, G Webster Ross, Kamal Masaki, Helen Petrovitch, Caroline M Tanner, Robert L Davis, Samuel M Goldman,

Autonomic nervous system involvement precedes the motor features of Parkinson's disease (PD). Our goal was to develop a proof-of-concept model for identifying subjects at high risk of developing PD by analysis of cardiac electrical activity. We used standard 10-s electrocardiogram (ECG) recordings of 60 subjects from the Honolulu Asia Aging ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11319]

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A mid-South chronic disease registry and practice-based research network to address disparities.

Satya Surbhi, Ian M Brooks, Sohul A Shuvo, Parya Zareie, Elizabeth A Tolley, Ronald Cossman, Cardella Leak, Robert L Davis, Altha J Stewart, James E Bailey,

OBJECTIVES:To describe an innovative health information technology (HIT) model for supporting community-wide health improvement through multiprovider collaboration in a regional population health registry and practice-based research network (PBRN). STUDY DESIGN:Case study. METHODS:We describe the HIT data structure and governance of the Diabetes Wellness and Prevention Coalition (DWPC) Registry and PBRN ... Read more >>

Am J Manag Care (The American journal of managed care)
[2020, 26(7):e211-e218]

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Veterinarians' attitudes and practices regarding opioid-related vet shopping practices in tri-state Appalachian counties: an exploratory study.

Falguni C Patel, Jeffrey A Raines, Richard W Kim, Karen Gruszynski, Robert E Davis, Manoj Sharma, Gilbert Patterson, Jason W Johnson, Vinayak K Nahar,

BACKGROUND:The opioid crisis continues to grow in the United States with 46,700 drug overdose deaths due to opioids in 2017 alone. Vet shopping, the practice of soliciting veterinarians for prescription medications, has been receiving national media attention in recent years. A 2014 review of Prescription Monitoring Drug Programs found less ... Read more >>

BMC Vet. Res. (BMC veterinary research)
[2020, 16(1):210]

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Impact of Polymer-Constrained Annealing on the Properties of DNA Origami-Templated Gold Nanowires.

Tyler R Westover, Basu R Aryal, Dulashani R Ranasinghe, Bibek Uprety, John N Harb, Adam T Woolley, Robert C Davis,

DNA origami-templated fabrication enables bottom-up fabrication of nanoscale structures from a variety of functional materials, including metal nanowires. We studied the impact of low-temperature annealing on the morphology and conductance of DNA-templated nanowires. Nanowires were formed by selective seeding of gold nanorods on DNA origami and gold electroless plating of ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, 36(24):6661-6667]

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M205. LONG-TERM SAFETY OF LUMATEPERONE (ITI-007): METABOLIC EFFECTS IN A 1-YEAR STUDY.

Andrew Satlin, Suresh Durgam, Kimberly E Vanover, Robert E Davis, Jason Huo, Sharon Mates, Christoph Correll,

AbstractBackgroundStandard of care (SOC) treatments for schizophrenia are often associated with a spectrum of metabolic adverse effects including weight gain and increased risk of diabetes, hyperlipidemia, and hypertension. Identifying new schizophrenia treatments with a favorable weight gain and metabolic side effect profile is important in reducing patient morbidity, mortality, and ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S214-S214]

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The Personal Health Library: A Single Point of Secure Access to Patient Digital Health Information.

Nariman Ammar, James E Bailey, Robert L Davis, Arash Shaban-Nejad,

Traditionally, health data management has been EMR-based and mostly handled by health care providers. Mechanisms are needed to give patients more control over their health conditions. Personal Health Libraries (PHLs) provide a single point of secure access to patients' digital health information that can help empower patients to make better-informed ... Read more >>

Stud Health Technol Inform (Studies in health technology and informatics)
[2020, 270:448-452]

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Using Machine Learning to Predict Early Onset Acute Organ Failure in Critically Ill Intensive Care Unit Patients With Sickle Cell Disease: Retrospective Study.

Akram Mohammed, Pradeep S B Podila, Robert L Davis, Kenneth I Ataga, Jane S Hankins, Rishikesan Kamaleswaran,

BACKGROUND:Sickle cell disease (SCD) is a genetic disorder of the red blood cells, resulting in multiple acute and chronic complications, including pain episodes, stroke, and kidney disease. Patients with SCD develop chronic organ dysfunction, which may progress to organ failure during disease exacerbations. Early detection of acute physiological deterioration leading ... Read more >>

J. Med. Internet Res. (Journal of medical Internet research)
[2020, 22(5):e14693]

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CPNP 2020 Annual Meeting Poster Abstracts.

(The mental health clinician)
[2020, 10(3):104-206]

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S221. THE EFFICACY OF LUMATEPERONE 42 MG IN THE TREATMENT OF SCHIZOPHRENIA SYMPTOMS ASSOCIATED WITH SOCIAL FUNCTIONING: POST HOC ANALYSIS OF AN ACUTE PLACEBO- AND ACTIVE-CONTROLLED TRIAL.

Kimberly Vanover, Robert Davis, Suresh Durgam, Jason Huo, Sharon Mates, Andrew Satlin, Philip D Harvey,

AbstractBackgroundDeficits in social functioning are a core feature of schizophrenia and may be due to the interaction of multiple factors including negative symptoms, depression symptoms, and deficits in social cognition. Social and functional impairment in schizophrenia can be difficult to treat, may not correlate with improvements in psychotic symptoms, and ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S123-S123]

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T205. LUMATEPERONE IN THE TREATMENT OF SCHIZOPHRENIA: EVALUATION OF EXTRAPYRAMIDAL AND MOTOR SYMPTOMS IN 4 LATE-PHASE CLINICAL TRIALS.

Suresh Durgam, Andrew Satlin, Robert E Davis, Kimberly E Vanover, Sharon Mates, John M Kane,

AbstractBackgroundStandard of care (SOC) antipsychotics exhibit efficacy at high dopamine D2 receptor occupancy (60%-80%), which is associated with increased risk of extrapyramidal symptoms (EPS). Lumateperone (lumateperone tosylate, ITI-007) is a mechanistically novel antipsychotic that simultaneously modulates serotonin, dopamine, and glutamate neurotransmission. Efficacy of lumateperone 42 mg (ITI-007 60 mg) has ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S310-S310]

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A cross-sectional survey of prevalence and correlates of sunscreen use among a rural Tri-State Appalachian population.

James Luong, Robert E Davis, Anjali Chandra, Ashley E White, Ira D Harber, Alexa A Engel, Nicole P Shields, Timothy J York, Vinayak K Nahar,

Over five million people are diagnosed with skin cancers each year. With the sun's ultraviolet radiation exposure being the major risk factor for all skin cancers, sunscreen use is a vital preventative measure. However, in the US, sunscreen use remains inadequate. Furthermore, research regarding sunscreen use amongst rural populations has ... Read more >>

Arch. Dermatol. Res. (Archives of dermatological research)
[2020, :]

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Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial.

Christoph U Correll, Robert E Davis, Michal Weingart, Jelena Saillard, Cedric O'Gorman, John M Kane, Jeffrey A Lieberman, Carol A Tamminga, Sharon Mates, Kimberly E Vanover,

Importance:Individuals living with schizophrenia are affected by cardiometabolic, endocrine, and motor adverse effects of current antipsychotic medications. Lumateperone is a serotonin, dopamine, and glutamate modulator with the potential to treat schizophrenia with few adverse effects. Objective:To examine the efficacy and safety of lumateperone for the short-term treatment of schizophrenia. Design, ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, 77(4):349-358]

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Draft Genome Sequence of ‘Candidatus Phytoplasma pini’-Related Strain MDPP: A Resource for Comparative Genomics of Gymnosperm-Infecting Phytoplasmas

Weili Cai, Jonathan Shao, Yan Zhao, Robert E Davis, Stefano Costanzo,

‘Candidatus Phytoplasma pini’-related strain MDPP, the reference strain of subgroup 16SrXXI-B, is a pathogen associated with witches’ broom disease of Pinus spp. in North America. Here, we report the first draft genome sequence of ‘Ca. Phytoplasma pini’ strain MDPP, which consists of 474,136 bases, with a G + C content ... Read more >>

Plant Dis. (Plant disease)
[2020, 104(4):1009-1010]

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Impact on child vaccination completion rates of short message services (SMS) reminders in developing countries.

Robert Davis,

Introduction:The Expanded Programme on Immunization has, since its inception, struggled to achieve high completion rates for child immunizations. The introduction of 2YL (second year of life) immunizations presents the programme with fresh challenges to assuring high completion rates. Methods:Using the same procedures as those employed in the 2017 article on ... Read more >>

Pan Afr Med J (The Pan African medical journal)
[2020, 35(Suppl 1):12]

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Heartfulness meditation improves sleep in chronic insomnia.

Jayaram Thimmapuram, Deborah Yommer, Luminita Tudor, Theodore Bell, Cristian Dumitrescu, Robert Davis,

Background: Chronic insomnia is characterized by disturbed sleep that occurs despite adequate opportunity and circumstances to sleep. Many patients with chronic insomnia have comorbid mental illnesses or medical illnesses that contribute and precipitate insomnia. Hallmark of chronic insomnia treatment includes non-pharmacological measures such as Cognitive Behavioral Therapy for Insomnia (CBT-I). ... Read more >>

(Journal of community hospital internal medicine perspectives)
[2020, 10(1):10-15]

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