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Author Risa Shorr

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The COVID-19 pandemic: An opportunity to rethink and harmonise the frequency of follow-up visits for patients with early stage breast cancer.

Julian Surujballi, Hely Shah, Brian Hutton, Mashari Alzahrani, Ana-Alicia Beltran-Bless, Risa Shorr, Gail Larocque, Sharon McGee, Katherine Cole, Mohammed F K Ibrahim, Ricardo Fernandes, Angel Arnaout, Carol Stober, Michelle Liu, Marta Sienkiewicz, Deanna Saunders, Lisa Vandermeer, Mark Clemons,

<h4>Purpose</h4>While routine, in-person follow-up of early-stage breast cancer patients (EBC) after completion of initial treatment is common, the COVID-19 pandemic has resulted in unprecedented changes in clinical practice. A systematic review was performed to evaluate the evidence supporting different frequencies of routine follow-up.<h4>Methods</h4>MEDLINE and the Cochrane Collaboration Library were searched ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2021, 97:102188]

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Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta-analysis of preclinical studies.

Harinad B Maganti, Adrian J M Bailey, Aidan M Kirkham, Risa Shorr, Nicolas Pineault, David S Allan,

Gene editing blood-derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of edited cells following reinfusion. All studies identified in our systematic search (to 20 October 2020) examining the use of CRISPR/Cas9 ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2021, :]

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Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review.

Gauruv Bose, Justin Graveline, Vignan Yogendrakumar, Risa Shorr, Dean A Fergusson, Gregoire Le Gal, Jonathan Coutinho, Marcelo Mendonça, Miguel Viana-Baptista, Simon Nagel, Dar Dowlatshahi,

<h4>Objectives</h4>Current guidelines do not recommend direct oral anticoagulants (DOACs) to treat cerebral venous thrombosis (CVT) despite their benefits over standard therapy. We performed a systematic review to summarise the published experience of DOAC therapy in CVT.<h4>Data sources</h4>MEDLINE, Embase and COCHRANE databases up to 18 November 2020.<h4>Eligibility criteria</h4>All published articles of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e040212]

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Optimising weight-loss interventions in cancer patients-A systematic review and network meta-analysis.

Nathalie LeVasseur, Wei Cheng, Sasha Mazzarello, Mark Clemons, Lisa Vandermeer, Lee Jones, Anil Abraham Joy, Pauline Barbeau, Dianna Wolfe, Nadera Ahmadzai, Mona Hersi, Carol Stober, Risa Shorr, John Hilton, Brian Hutton,

<h4>Background</h4>Excess weight has been associated with increased morbidity and a worse prognosis in adult patients with early-stage cancer. The optimal lifestyle interventions to optimize anthropometric measures amongst cancer patients and survivors remain inconsistent.<h4>Objective</h4>To conduct a systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs) comparing the effects of ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0245794]

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Efficacy and safety of CD22 chimeric antigen receptor (CAR) T cell therapy in patients with B cell malignancies: a protocol for a systematic review and meta-analysis.

Komal Adeel, Nathan J Fergusson, Risa Shorr, Harold Atkins, Kevin A Hay,

<h4>Background</h4>Chimeric antigen receptor (CAR) T cell therapy has had great success in treating patients with relapsed or refractory B cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fails to respond or relapse after CD19 CAR T cell therapy, in part due to antigen ... Read more >>

Syst Rev (Systematic reviews)
[2021, 10(1):35]

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Effects of living kidney donation on arterial stiffness: a systematic review protocol

Rosendo A Rodriguez, Mayra Trentin Sonoda, Mohsen Agharazii, Risa Shorr, Kevin D Burns,

<h4>Introduction</h4> Kidney donors have been reported to have accelerated progression of aortic stiffness and decreased glomerular filtration compared with healthy non-donors. This is a concern because increased aortic stiffness is an independent predictor of overall cardiovascular disease and all-cause mortality in the general population. To confirm if arterial stiffness increases ... Read more >>

BMJ Open (BMJ open)
[2021, 11(3):]

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Protocol for a scoping review of outcomes in clinical studies of interventions for venous thromboembolism in adults.

Tobias Tritschler, Nicole Langlois, Brian Hutton, Beverley J Shea, Risa Shorr, Sara Ng, Suzanne Dubois, Carol West, Alfonso Iorio, Peter Tugwell, Grégoire Le Gal,

<h4>Introduction</h4>Venous thromboembolism (VTE) is a common, potentially fatal yet treatable disease. Several advances in treatment of VTE have been made over the past decades, but definition and reporting of outcomes across those studies are inconsistent. Development of an international core outcome set for clinical studies of interventions for VTE addresses ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e040122]

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A scoping review characterizing "Choosing Wisely®" recommendations for breast cancer management.

Hely Shah, Julian Surujballi, Arif Ali Awan, Brian Hutton, Angel Arnaout, Risa Shorr, Lisa Vandermeer, Mashari Jemaan Alzahrani, Mark Clemons,

<h4>Purpose</h4>Choosing Wisely (CW)® was created by the American Board of Internal Medicine (ABIM) to promote patient-physician conversations about unnecessary medical interventions. Similarly, other countries created their own panels of experts called "CW® campaigns" which review recommendations submitted by that country's oncology societies. We performed a scoping review to consolidate CW® ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2021, 185(3):533-547]

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Exploring Peaks in Hospital Blood Component Utilization: A 10-Year Retrospective Study at a Large Multisite Academic Centre.

Iris Perelman, Dean Fergusson, Jacinthe Lampron, Johnathan Mack, Fraser Rubens, Antonio Giulivi, Melanie Tokessy, Risa Shorr, Alan Tinmouth,

Peak demand analysis is common in industries such as the energy sector, but can also be applied to the field of transfusion to characterize the nature and timing of peak days in hospital blood utilization. This information can be used to forecast future peak days or to inform hospital emergency ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(1):37-45]

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Transcatheter Mitral Valve Repair in Cardiogenic Shock and Mitral Regurgitation: A Patient-Level, Multicenter Analysis.

Richard G Jung, Trevor Simard, Christopher Kovach, Kelsey Flint, Creighton Don, Pietro Di Santo, Marianna Adamo, Luca Branca, Francesca Valentini, Tomás Benito-González, Felipe Fernández-Vázquez, Rodrigo Estévez-Loureiro, Alessandra Berardini, Nicolina Conti, Claudio Rapezzi, Elena Biagini, Simon Parlow, Risa Shorr, Amos Levi, Ana Manovel, Rosa Cardenal-Piris, Jose Diaz Fernandez, Mony Shuvy, Dan Haberman, Alessandra Sala, Mohamad A Alkhouli, Claudia Marini, Marta Bargagna, Davide Schiavi, Paolo Denti, Sinisa Markovic, Nicola Buzzatti, Vincent Chan, Mark Hynes, Thierry Mesana, Marino Labinaz, Federico Pappalardo, Maurizio Taramasso, Benjamin Hibbert,

<h4>Objectives</h4>The aim of this study was to evaluate the outcome of transcatheter mitral valve repair (TMVr) in patients with cardiogenic shock and significant mitral regurgitation (MR).<h4>Background</h4>Patients in cardiogenic shock with severe MR have a poor prognosis in the setting of conventional medical therapy. Because of its favorable safety profile, TMVr ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(1):1-11]

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Prevalence of non-contrast CT abnormalities in adults with reversible cerebral vasoconstriction syndrome: protocol for a systematic review and meta-analysis.

Ryan Daniel Gotesman, Naomi Niznick, Brian Dewar, Dean A Fergusson, Risa Shorr, Michel Shamy, Dar Dowlatshahi,

<h4>Introduction</h4>Reversible cerebral vasoconstriction syndrome (RCVS) is characterised by severe, recurrent thunderclap headaches (TCHs) and vasoconstriction of cerebral arteries that resolve within 3 months. Abnormalities on non-contrast CT (NCCT) such as ischaemic strokes, intracerebral haemorrhage and subarachnoid haemorrhages are frequently observed on brain imaging of patients with RCVS though their prevalence ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e041776]

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Educational interventions are associated with improvements in colonoscopy quality indicators: a systematic review and meta-analysis.

Natalia S Causada-Calo, Emmanuel I Gonzalez-Moreno, Kirles Bishay, Risa Shorr, Catherine Dube, Steven J Heitman, Robert J Hilsden, Alaa Rostom, Catharine Walsh, John T Anderson, Rajesh N Keswani, Michael A Scaffidi, Samir C Grover, Nauzer Forbes,

<b>Background and study aims</b>  The quality of screening-related colonoscopy depends on several physician- and patient-related factors. Adenoma detection rate (ADR) varies considerably between endoscopists. Educational interventions aim to improve endoscopists' ADRs, but their overall impact is uncertain. We aimed to assess whether there is an association between educational interventions and ... Read more >>

Endosc Int Open (Endoscopy international open)
[2020, 8(10):E1321-E1331]

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Association Between Time to Colonoscopy After Positive Fecal Testing and Colorectal Cancer Outcomes: A Systematic Review.

Nauzer Forbes, Robert J Hilsden, Myriam Martel, Yibing Ruan, Catherine Dube, Alaa Rostom, Risa Shorr, Charles Menard, Darren R Brenner, Alan N Barkun, Steven J Heitman,

<h4>Background & aims</h4>Colonoscopy is required following a positive fecal screening test for colorectal cancer (CRC). It remains unclear to what extent time to colonoscopy is associated with CRC-related outcomes. We performed a systematic review to elucidate this relationship.<h4>Methods</h4>An electronic search was performed through April 2020 for studies reporting associations between time from ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, :]

Cited: 1 time

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Efficacy and Safety of CD22 Chimeric Antigen Receptor (CAR) T-cell Therapy in Patients With B-cell Malignancies: A Protocol for a Systematic Review and Meta-analysis

Komal Adeel, Nathan Fergusson, Risa Shorr, Harry Atkins, Kevin Anthony Hay,

<h4>Background: </h4> Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, ... Read more >>

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Plerixafor in combination with chemotherapy and/or hematopoietic cell transplantation to treat acute leukemia: A systematic review and metanalysis of preclinical and clinical studies.

Harinad Maganti, Alissa Visram, Risa Shorr, Jill Fulcher, Mitchell Sabloff, David S Allan,

Leukemia-initiating cells localize to bone marrow niches via cell surface CXCR4 binding to stromal-derived factor 1 (SDF-1). Plerixafor, a CXCR4 antagonist, can mobilize and sensitize leukemia cells to cytotoxic therapy, and/or enhance the engraftment of healthy donor stem cells in the context of hematopoietic cell transplantation (HCT). A systematic review ... Read more >>

Leuk Res (Leukemia research)
[2020, 97:106442]

Cited: 2 times

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Human endothelial colony-forming cells in regenerative therapy: A systematic review of controlled preclinical animal studies.

Gary Liao, Katina Zheng, Risa Shorr, David S Allan,

Endothelial colony-forming cells (ECFCs) hold significant promise as candidates for regenerative therapy of vascular injury. Existing studies remain largely preclinical and exhibit marked design heterogeneity. A systematic review of controlled preclinical trials of human ECFCs is needed to guide future study design and to accelerate clinical translation. A systematic search ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2020, 9(11):1344-1352]

Cited: 1 time

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Associations between endoscopist feedback and improvements in colonoscopy quality indicators: a systematic review and meta-analysis.

Kirles Bishay, Natalia Causada-Calo, Michael A Scaffidi, Catharine M Walsh, John T Anderson, Alaa Rostom, Catherine Dube, Rajesh N Keswani, Steven J Heitman, Robert J Hilsden, Risa Shorr, Samir C Grover, Nauzer Forbes,

<h4>Background and aims</h4>Colonoscopy quality indicators such as adenoma detection rate (ADR) are surrogates for the effectiveness of screening-related colonoscopy. It is unclear whether endoscopist feedback on these indicators improves performance. We performed a meta-analysis to determine whether associations exist between endoscopist feedback and colonoscopy performance.<h4>Methods</h4>We conducted a search through May ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2020, 92(5):1030-1040.e9]

Cited: 2 times

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The safety and efficacy of hypovolemic phlebotomy on blood loss and transfusion in liver surgery: a systematic review and meta-analysis.

Lily Park, Richard Gilbert, Laura Baker, Risa Shorr, Aklile Workneh, Simon Turcotte, Kimberley A Bertens, Jad Abou-Khalil, Fady K Balaa, Guillaume Martel,

<h4>Background</h4>Hypovolemic phlebotomy (HP) is a novel intervention that involves intraoperative removal of whole blood (7-10 mL/kg) without volume replacement. The subsequent central venous pressure (CVP) reduction is hypothesized to decrease blood loss and the need for blood transfusion. The objective was to conduct a systematic assessment of the safety and efficacy ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, 22(3):340-350]

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Systematic review of controlled clinical studies using umbilical cord blood for regenerative therapy: Identifying barriers to assessing efficacy.

Joseph Aziz, Gary Liao, Zach Adams, Mina Rizk, Risa Shorr, David S Allan,

Clinical use of umbilical cord blood (UCB) for novel indications in regenerative therapy continues to rise, however, whether new indications are proven is less clear. An updated systematic search of the literature, focusing only on controlled clinical studies, is needed to properly assess potential efficacy. After updating our systematic search ... Read more >>

Cytotherapy (Cytotherapy)
[2019, 21(11):1112-1121]

Cited: 1 time

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Endoscopic ultrasound-guided transmural approach versus ERCP-guided transpapillary approach for primary decompression of malignant biliary obstruction: a meta-analysis.

Kirles Bishay, Devon Boyne, Mohammad Yaghoobi, Mouen A Khashab, Risa Shorr, Yervant Ichkhanian, Nauzer Forbes,

<h4>Background</h4>Primary decompression in patients with malignant biliary obstruction can be achieved via endoscopic retrograde cholangiopancreatography (ERCP) with transpapillary stenting, or, more recently, via transmural endoscopic ultrasound-guided biliary drainage (EUS-BD). It is unclear whether either approach is superior in terms of clinical success or adverse events in the primary setting.<h4>Methods</h4>A comprehensive ... Read more >>

Endoscopy (Endoscopy)
[2019, 51(10):950-960]

Cited: 4 times

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De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysis.

Arif Ali Awan, Brian Hutton, John Hilton, Sasha Mazzarello, Catherine Van Poznak, Lisa Vandermeer, Brianne Bota, Carol Stober, Marta Sienkiewicz, Dean Fergusson, Risa Shorr, Mark Clemons,

<h4>Purpose</h4>Bone-modifying agents (BMAs) such as bisphosphonates and denosumab are usually administered every 4 weeks (standard) in patients with bone metastases from breast cancer to prevent skeletal-related events (SREs). Recent randomized controlled trials suggest every 12-week (de-escalated) dosing interval may be non-inferior. The objective of this systematic review and meta-analysis was to ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2019, 176(3):507-517]

Cited: 3 times

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A Systematic Review of the Impact of Surgical Special Care Units on Patient Outcomes and Health Care Resource Utilization.

Nicholas Mendis, Gavin M Hamilton, Daniel I McIsaac, Dean A Fergusson, Hannah Wunsch, Daniel Dubois, Joshua Montroy, Michaël Chassé, Alexis F Turgeon, Lauralyn McIntyre, Heather McDonald, Homer Yang, Sonia D Sampson, Colin J L McCartney, Risa Shorr, André Denault, Manoj M Lalu, ,

Perioperative intermediate care units (termed surgical special care units) have been widely implemented across health systems because they are believed to improve surveillance and management of high-risk surgical patients. Our objective was to conduct a systematic review to investigate the effects of a 3-level model of perioperative care delivery (ie, ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2019, 128(3):533-542]

Cited: 2 times

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Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis.

Manoj M Lalu, Dean A Fergusson, Wei Cheng, Marc T Avey, Dale Corbett, Dar Dowlatshahi, Malcolm R Macleod, Emily S Sena, David Moher, Risa Shorr, Sarah K McCann, Laura J Gray, Michael D Hill, Annette O'Connor, Kristina Thayer, Fatima Haggar, Aditi Dobriyal, Hee Sahng Chung, Nicky J Welton, Brian Hutton,

<b>Introduction:</b> Globally, stroke is the second leading cause of death. Despite the burden of illness and death, few acute interventions are available to patients with ischemic stroke. Over 1,000 potential neuroprotective therapeutics have been evaluated in preclinical models. It is important to use robust evidence synthesis methods to appropriately assess ... Read more >>

F1000Res (F1000Research)
[2019, 8:11]

Cited: 2 times

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Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

Manoj Lalu, Dean Fergusson, Wei Cheng, Marc Avey, Dale Corbett, Dar Dowlatshahi, Malcolm Macleod, Emily Sena, David Moher, Risa Shorr, Sarah McCann, Laura Gray, Michael Hill, Annette O'Connor, Kristina Thayer, Fatima Haggar, Aditi Dobriyal, Hee Sahng Chung, Nicky Welton, Brian Hutton,

Introduction: Globally, stroke is the second leading cause of death. Despite the burden of illness and death, few acute interventions are available to patients with ischemic stroke. Over 1,000 potential neuroprotective therapeutics have been evaluated in preclinical models. It is important to use robust evidence synthesis methods to appropriately assess ... Read more >>

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Optimal vascular access strategies for patients receiving chemotherapy for early-stage breast cancer: a systematic review.

Andrew Robinson, Osama Souied, A Brianne Bota, Nathalie Levasseur, Carol Stober, John Hilton, Dalia Kamel, Brian Hutton, Lisa Vandermeer, Sasha Mazzarello, Anil A Joy, Dean Fergusson, Sheryl McDiarmid, Mathew McInnes, Risa Shorr, Mark Clemons,

<h4>Importance</h4>Systemic chemotherapy can be administered either through a peripheral vein (IV), or centrally through peripherally inserted central catheter (PICC), totally implanted vascular access devices (PORTs) or tunnelled cuffed catheters. Despite the widespread use of systemic chemotherapy in patients with breast cancer, the optimal choice of vascular access is unknown.<h4>Objective</h4>This systematic ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2018, 171(3):607-620]

Cited: 1 time

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