Full Text Journal Articles by
Author Rihab Nasr

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Knowledge, beliefs, and practices related to cancer screening and prevention in Lebanon: community and social media users' perspectives.

Talar Telvizian, Yasmina Al Ghadban, Jude Alawa, Deborah Mukherji, Nathalie K Zgheib, Bisher Sawaf, Rihab Nasr, Marco Bardus,

<h4>Objective</h4>Common to many countries in the Middle East, Lebanon has an increasing cancer burden; however, national screening programs are limited to breast cancer. The literature on cancer screening practices and beliefs is scarce. This cross-sectional study investigates the knowledge, beliefs, and practices related to the prevention and screening for breast, ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):341-349]

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A Signature of Four Circulating microRNAs as Potential Biomarkers for Diagnosing Early-Stage Breast Cancer.

Maha M Itani, Farah J Nassar, Arafat H Tfayli, Rabih S Talhouk, Ghada K Chamandi, Abdul Rahman S Itani, Joelle Makoukji, Rose-Mary N Boustany, Lifang Hou, Nathalie K Zgheib, Rihab R Nasr,

Breast cancer (BC) is the most predominant type of cancer among women. The aim of this study is to find new biomarkers that can help in early detection of BC, especially for those who are too young to be screened using mammography as per guidelines. Using microRNA microarray, we previously ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction.

Farah J Nassar, Zahraa S Msheik, Rihab R Nasr, Sally N Temraz,

Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second among cancers though its incidence ranks third. Early CRC detection is key and is associated with improved survival outcomes. However, existing tests for CRC diagnosis have several weaknesses thus rendering them inefficient. Moreover, reliable prognostic tests that ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2021, 13(1):111]

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LINE-1 methylation mediates the inverse association between body mass index and breast cancer risk: A pilot study in the Lebanese population.

Zainab Awada, Liacine Bouaoun, Rihab Nasr, Arafat Tfayli, Cyrille Cuenin, Reem Akika, Rose-Mary Boustany, Joelle Makoukji, Hani Tamim, Nathalie K Zgheib, Akram Ghantous,

<h4>Introduction</h4>Lebanon is among the top countries worldwide in combined incidence and mortality of breast cancer, which raises concern about risk factors peculiar to this country. The underlying molecular mechanisms of breast cancer require elucidation, particularly epigenetics, which is recognized as a molecular sensor to environmental exposures.<h4>Purpose</h4>We aim to explore whether ... Read more >>

Environ Res (Environmental research)
[2021, 197:111094]

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Primary care and pulmonary physicians' knowledge and practice concerning screening for lung cancer in Lebanon, a middle-income country.

Imad Bou Akl, Nathalie K Zgheib, Maroun Matar, Deborah Mukherji, Marco Bardus, Rihab Nasr,

<h4>Background</h4>Screening for lung cancer with low-dose computed tomography (LDCT) was shown to reduce lung cancer incidence and overall mortality, and it has been recently included in international guidelines. Despite the rising burden of lung cancer in low and middle-income countries (LMICs) such as Lebanon, little is known about what primary ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(8):2877-2884]

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Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis.

Farah J Nassar, Zahraa S Msheik, Maha M Itani, Remie El Helou, Ruba Hadla, Firas Kreidieh, Rachelle Bejjany, Deborah Mukherji, Ali Shamseddine, Rihab R Nasr, Sally N Temraz,

Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Stage IV CRC patients have poor prognosis with a five-year survival rate of 14%. Liver metastasis is the main cause of mortality in CRC patients. Since current screening tests have several drawbacks, effective stable non-invasive biomarkers such as ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(2):]

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A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.

Nataly Naser Al Deen, Nadia Atallah Lanman, Shirisha Chittiboyina, Sophie Lelièvre, Rihab Nasr, Farah Nassar, Heinrich Zu Dohna, Mounir AbouHaidar, Rabih Talhouk,

mRNA-circRNA-miRNAs axes have been characterized in breast cancer, but not as risk-assessment axes for tumor initiation in early-onset breast cancer that is increasing drastically worldwide. To address this gap, we performed circular RNA (circRNA) microarrays and microRNA (miRNA) sequencing on acini of HMT-3522 S1 (S1) breast epithelial risk-progression culture model ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2626]

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Nutrition and Breast Cancer Research in Arab Countries: Gaps, Opportunities, and Recommendations.

Hibeh Shatila, Zaynab Fatfat, Rabih Talhouk, Salpy Naalbandian, Michele R Forman, Rihab Nasr, Farah Naja,

According to the WHO, Arab countries have the highest relative increase in Breast Cancer (BC) rates worldwide. Current shifts in dietary patterns in these countries are postulated as important modifiable risk factors of the disease. The objectives of this review were to examine the gaps and opportunities in the extent, ... Read more >>

Nutr Cancer (Nutrition and cancer)
[2020, :1-17]

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The Crosstalk between Microbiome and Immune Response in Gastric Cancer.

Rihab Nasr, Ali Shamseddine, Deborah Mukherji, Farah Nassar, Sally Temraz,

Gastric cancer is the end result of a complex interplay between host genetics, environmental factors, and microbial factors. The link between gut microbiome and gastric cancer has been attributed to persistent activation of the host's immune system by gut microbiota. The end result of this dysregulated interaction between host epithelium ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(18):]

Cited: 2 times

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Diagnostic Approaches and Established Treatments for Adult T Cell Leukemia Lymphoma.

Kunihiro Tsukasaki, Ambroise Marçais, Rihab Nasr, Koji Kato, Takahiro Fukuda, Olivier Hermine, Ali Bazarbachi,

Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy caused by human T-cell leukemia/lymphotropic virus type I (HTLV-1) endemic in some areas in the world. HTLV-1 transmits through mother-to-child infection via breastfeeding, sexual intercourses, and blood transfusions. Early HTLV-1 infection, presumably through mother's milk, is crucial in developing ATL. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1207]

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Effect of bisphenols on telomerase expression and activity in breast cancer cell lines.

Zainab Awada, Rihab Nasr, Reem Akika, Akram Ghantous, Lifang Hou, Nathalie K Zgheib,

Bisphenol A (BPA), a monomer of polycarbonates and resins, was shown to induce the expression of telomerase enzyme which has been associated with breast cancer development and progression. However, the effects of BPA analogues, bisphenol F (BPF) and bisphenol S (BPS) on telomere-linked pathway have not been evaluated. Herein, MCF-7 ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2020, 47(5):3541-3549]

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miRNA expression in advanced Algerian breast cancer tissues.

Mohamad Ali Tfaily, Farah Nassar, Leila-Sarah Sellam, Zine-Charaf Amir-Tidadini, Fatima Asselah, Mehdi Bourouba, Nasr Rihab,

Breast cancer is one of the commonest cancers among Algerian females. Compared to Western populations, the median age of diagnosis of breast cancer is much lower in Algeria. The objective of this study is to explore the expression of several miRNAs reported to be deregulated in breast cancer. The miRNAs ... Read more >>

PLoS One (PloS one)
[2020, 15(2):e0227928]

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The role of candidate genetic polymorphisms in the interaction between voriconazole and cyclosporine in patients undergoing allogeneic hematopoietic cell transplantation: An explorative study.

Nathalie Khoueiry Zgheib, Raafat Alameddine, Radwan Massoud, Rihab Nasr, Ammar Zahreddine, Jean El Cheikh, Rami Mahfouz, Ali Bazarbachi,

PURPOSE:To evaluate polymorphisms in genes of drug metabolizing enzymes and transporters involved in cyclosporine and/or voriconazole disposition among patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). METHODS:DNA from forty patients was genotyped using the DMETPlus array. The average ratio of cyclosporine concentration/dose (C/D in (ng/mL)/(mg/kg)) per participant's weight was computed using ... Read more >>

Curr Res Transl Med (Current research in translational medicine)
[2020, 68(2):51-58]

Cited: 1 time

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Giant Inflatable Colon Model Enhances Lebanese Community Knowledge and Intention for Colorectal Cancer Screening.

Amro Baassiri, Mohammad El-Harakeh, Abdulrahman Itani, Farah J Nassar, Remi Safi, Zeina Dassouki, Maya Romani, Nathalie Zgheib, Rihab Nasr,

PURPOSE:To assess the knowledge and intention for colorectal cancer (CRC) screening within the Lebanese community before and after a guided tour through an inflatable colon model. METHODS:The Cancer Prevention and Control Program, Naef K. Basile Cancer Institute at the American University of Beirut Medical Center in collaboration with AMALOUNA educational ... Read more >>

JCO Glob Oncol (JCO global oncology)
[2020, 6:167-173]

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Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening.

Amani Al Outa, Dana Abubaker, Ali Bazarbachi, Marwan El Sabban, Margret Shirinian, Rihab Nasr,

Chronic myeloid leukemia is caused by a balanced chromosomal translocation resulting in the formation of <i>BCR-ABL1</i> fusion gene encoding a constitutively active BCR-ABL1 tyrosine kinase, which activates multiple signal transduction pathways leading to malignant transformation. Standard treatment of chronic myeloid leukemia is based on tyrosine kinase inhibitors; however, some mutations ... Read more >>

Haematologica (Haematologica)
[2020, 105(2):387-397]

Cited: 4 times

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Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer.

Sally Temraz, Farah Nassar, Rihab Nasr, Maya Charafeddine, Deborah Mukherji, Ali Shamseddine,

Research has been driven towards finding therapy predictive biomarkers for colorectal cancer (CRC) with a special interest in studying the gut microbiome. Gut microbiome acts not only as a barrier to prevent bacterial invasion and infection, but it also affects the efficacy of hematopoietic-cell transplantation, chemotherapy, and immunotherapy. Recently, immunotherapy, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(17):]

Cited: 10 times

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Antitumor efficacy of arsenic/interferon in preclinical models of chronic myeloid leukemia resistant to tyrosine kinase inhibitors.

Rabab El Eit, Abdul Rahman Itani, Farah Nassar, Nagham Rasbieh, Mark Jabbour, Ahmad Santina, Ghazi Zaatari, François-Xavier Mahon, Ali Bazarbachi, Rihab Nasr,

<h4>Background</h4>Tyrosine kinase inhibitors (TKIs) are the standard treatment for chronic myeloid leukemia (CML). Despite their clinical success, TKIs are faced with challenges such as treatment resistance, which may be driven by kinase domain mutations, and frequent disease relapse upon the cessation of treatment. The combination of arsenic trioxide (ATO) and ... Read more >>

Cancer (Cancer)
[2019, 125(16):2818-2828]

Cited: 3 times

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Cross-Roads to Drug Resistance and Metastasis in Breast Cancer: miRNAs Regulatory Function and Biomarker Capability.

Nataly Naser Al Deen, Farah Nassar, Rihab Nasr, Rabih Talhouk,

Breast cancer and specifically metastatic breast cancer (mBC) constitutes a major health burden worldwide with the highest number of cancer-related mortality among women across the globe. Despite having similar subtypes, breast cancer patients present with a spectrum of aggressiveness and responsiveness to therapy due to cancer heterogeneity. Drug resistance and ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1152:335-364]

Cited: 5 times

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Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications.

Ibrahim El Halabi, Rachelle Bejjany, Rihab Nasr, Deborah Mukherji, Sally Temraz, Farah J Nassar, Haidar El Darsa, Ali Shamseddine,

Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(9):]

Cited: 5 times

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microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Comparative Analysis.

Farah J Nassar, Rabih Talhouk, Nathalie K Zgheib, Arafat Tfayli, Maya El Sabban, Nagi S El Saghir, Fouad Boulos, Mark N Jabbour, Claude Chalala, Rose-Mary Boustany, Humam Kadara, Zhou Zhang, Yinan Zheng, Brian Joyce, Lifang Hou, Ali Bazarbachi, George Calin, George Calin, Rihab Nasr,

Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adjacent breast ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):16829]

Cited: 7 times

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Overview of Targeted Therapies for Adult T-Cell Leukemia/Lymphoma.

Rihab Nasr, Ambroise Marçais, Olivier Hermine, Ali Bazarbachi,

Adult T-Cell Leukemia/lymphoma (ATL) is the first human malignancy associated with a chronic infection by a retrovirus, the human T-cell lymphotropic virus type I (HTLV-I). ATL occurs, after a long latency period, only in about 5% of 10-20 millions infected individuals. ATL has a dismal prognosis with a median survival ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2017, 1582:197-216]

Cited: 10 times

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MicroRNAs as biomarkers for early breast cancer diagnosis, prognosis and therapy prediction.

Farah J Nassar, Rihab Nasr, Rabih Talhouk,

Breast cancer is a major health problem that affects one in eight women worldwide. As such, detecting breast cancer at an early stage anticipates better disease outcome and prolonged patient survival. Extensive research has shown that microRNA (miRNA) are dysregulated at all stages of breast cancer. miRNA are a class ... Read more >>

Pharmacol Ther (Pharmacology & therapeutics)
[2017, 172:34-49]

Cited: 82 times

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Interactive and collaborative learning in the classroom at the medical school Automated response systems and team-based learning.

Rihab Nasr, Jumana Antoun, Ramzi Sabra, Nathalie K Zgheib,

There has been a pedagogic shift in higher education from the traditional teacher centered to the student centered approach in teaching, necessitating a change in the role of the teacher from a supplier of information to passive receptive students into a more facilitative role. Active learning activities are based on ... Read more >>

J Med Liban (Le Journal medical libanais. The Lebanese medical journal)
[2016, 64(4):217-222]

Cited: 0 times

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The pharmacoepigenetics of drug metabolism and transport in breast cancer: review of the literature and in silico analysis.

Rihab Nasr, Fatima Sleiman, Zeinab Awada, Natalie K Zgheib,

The focus of this manuscript is on DNA methylation and miRNA regulation of drug-metabolizing enzymes and drug transporters involved in the disposition of drugs commonly used in breast cancer. We start with a review of the available scant literature and follow with an in silico analysis of the CpG islands ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2016, 17(14):1573-1585]

Cited: 4 times

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CIRCULATING microRNAs: POTENTIAL BIOMARKERS IN CANCER DETECTION, DIAGNOSIS AND PROGNOSIS.

Nader Makarem, Ahmad Mourad, Farah J Nassar, Rihab Nasr,

A large family of small 18-25 nucleotide long non coding RNA molecules now known as microRNA (miRNA) was described two decades ago, and has been recently es- tablished as post-transcriptional gene regulators. miRNAs were shown to be involved in the regulation of diverse phys- iological and developmental processes. Moreover, dysregula- ... Read more >>

J Med Liban (Le Journal medical libanais. The Lebanese medical journal)
[2016, 64(2):116-122]

Cited: 2 times

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