Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,
<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>
Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]
Cited: 0 times
Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Hayato Takihara, Shujiro Okuda, Akihiko Saitoh,
BACKGROUND:Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are ... Read more >>
J Infect Dis (The Journal of infectious diseases)
[2020, 222(4):681-689]
Cited: 1 time
Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh,
BACKGROUND:Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES:To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring ... Read more >>
J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104256]
Cited: 0 times
Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,
AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]
Cited: 0 times
Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,
<h4>Background</h4>Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants.<h4>Methods</h4>In this prospective study, we evaluated stool ... Read more >>
J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):501-506]
Cited: 2 times
Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Akihiko Saitoh,
AbstractBackgroundParechovirus-A3 (PeV-A3) and enteroviruses (EVs) are the most common viral causes of neonatal and infantile sepsis. We previously reported that the clinical manifestations of PeV-A3 infection—e.g., high body temperature, tachycardia, and poor peripheral circulation, but not cerebrospinal fluid (CSF) pleocytosis—tend be more severe than those of EV infection. We tested ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S74-S74]
Cited: 0 times
Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,
Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]
Cited: 0 times
Kosuke Nagai, Hisanori Domon, Tomoki Maekawa, Takumi Hiyoshi, Hikaru Tamura, Daisuke Yonezawa, Rie Habuka, Akihiko Saitoh, Yutaka Terao,
Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However, it has been reported that PPSV ... Read more >>
Vaccine (Vaccine)
[2019, 37(1):160-168]
Cited: 2 times
Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,
AbstractBackgroundHuman parechovirus type 3 (HPeV3) and enteroviruses (EVs) are the major viral pathogens causing severe diseases in neonates and young infants. Although two infections typically occur in summer, and initial clinical presentations are similar, differences in clinical and laboratory characteristics of HPeV3- and EV- infections are not well described.MethodsFrom January ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S693-S693]
Cited: 0 times
Kosuke Nagai, Hisanori Domon, Tomoki Maekawa, Masataka Oda, Takumi Hiyoshi, Hikaru Tamura, Daisuke Yonezawa, Yoshiaki Arai, Mai Yokoji, Koichi Tabeta, Rie Habuka, Akihiko Saitoh, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao,
Streptococcus pneumoniae is a leading cause of bacterial pneumonia. Our previous study suggested that S. pneumoniae autolysis-dependently releases intracellular pneumolysin, which subsequently leads to lung injury. In this study, we hypothesized that pneumococcal autolysis induces the leakage of additional intracellular molecules that could increase the pathogenicity of S. pneumoniae. Liquid ... Read more >>
Cell Immunol (Cellular immunology)
[2018, 325:14-22]
Cited: 4 times