Full Text Journal Articles by
Author Richelle Mychasiuk

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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, :]

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

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Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury.

William T O'Brien, Louise Pham, Rhys D Brady, Jesse Bain, Glenn R Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald,

There is a widely recognized need for blood biomarkers to assist clinical decisions surrounding mild traumatic brain injury (mTBI). Serum neurofilament light (NfL), an indicator of neuroaxonal damage, is one such candidate, with early mTBI clinical investigations demonstrating significant promise. To facilitate the translation of pre-clinical mTBI findings, clinically relevant ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 341:113698]

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Paternal exposure to exercise and/or caffeine and alcohol modify offspring behavioral and pathophysiological recovery from repetitive mild traumatic brain injury in adolescence.

Eric Eyolfson, Dhyey Bhatt, Melinda Wang, Alexander W Lohman, Richelle Mychasiuk,

Only recently has the scope of parental research expanded to include the paternal sphere with epidemiological studies implicating stress, nutrition and alcohol consumption in the neurobiological and behavioral characteristics of offspring. This study was designed to determine if paternal exposure to caffeine, alcohol and exercise prior to conception would improve ... Read more >>

Genes Brain Behav (Genes, brain, and behavior)
[2021, :egbb12736]

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Adverse Childhood Experiences (ACEs) and Internalizing Mental Health, Pain, and Quality of Life in Youth With Chronic Pain: A Longitudinal Examination.

Sarah Nelson, Jaimie K Beveridge, Richelle Mychasiuk, Melanie Noel,

The aims of this longitudinal study were to 1) identify categories of adverse childhood experiences (ACEs) (ie, neglect, abuse, household dysfunction in childhood) that increase risk for internalizing mental health problems, pain-related impairment, and poorer quality of life and 2) examine the moderating role of posttraumatic stress symptoms (PTSS) in ... Read more >>

J Pain (The journal of pain)
[2021, :]

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The ketogenic diet raises brain oxygen levels, attenuates postictal hypoxia, and protects against learning impairments.

Renaud C Gom, Dhyey Bhatt, Bianca R Villa, Antis G George, Alexander W Lohman, Richelle Mychasiuk, Jong M Rho, G Campbell Teskey,

<h4>Objectives</h4>A prolonged vasoconstriction/hypoperfusion/hypoxic event follows self-terminating focal seizures. The ketogenic diet (KD) has demonstrated efficacy as a metabolic treatment for intractable epilepsy and other disorders but its effect on local brain oxygen levels is completely unknown. This study investigated the effects of the KD on tissue oxygenation in the hippocampus ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 154:105335]

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Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.

Sabrina Salberg, Glenn R Yamakawa, Yannick Griep, Jesse Bain, Jaimie K Beveridge, Mujun Sun, Stuart J McDonald, Sandy R Shultz, Rhys D Brady, David K Wright, Melanie Noel, Richelle Mychasiuk,

Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma-pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of ... Read more >>

Cereb Cortex Commun (Cerebral cortex communications)
[2021, 2(2):tgab014]

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Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies.

Ker Rui Wong, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald, Rhys D Brady,

Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or spinal cord. This abnormal formation of bone can result in nerve impingement, pain, contractures and impaired movement. Patients are often diagnosed ... Read more >>

Bone Res (Bone research)
[2020, 8(1):42]

Cited: 1 time

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Adverse childhood experiences in parents of youth with chronic pain: prevalence and comparison with a community-based sample.

Jaimie K Beveridge, Keith S Dobson, Sheri Madigan, Keith O Yeates, Amanda L Stone, Anna C Wilson, Sabrina Salberg, Richelle Mychasiuk, Melanie Noel,

<h4>Introduction</h4>Adverse childhood experiences (ACEs) are common occurrences that are related to poor health outcomes, including chronic pain, in youth and adults. Research suggests that children of parents exposed to ACEs are also at risk of poor outcomes. However, little is known about the risk that ACEs confer for chronic pain ... Read more >>

Pain Rep (Pain reports)
[2020, 5(6):e866]

Cited: 2 times

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Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model.

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald,

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of repeated mTBI in rats to characterize the acute and chronic neuropathological ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 148:105151]

Cited: 3 times

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Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties.

Jennaya Christensen, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

Until recently, both the purpose of the biological need for sleep and the mechanism by which the central nervous system eliminated metabolic waste products were unknown. The glymphatic system is the recently discovered macroscopic waste clearance system for the CNS, which predominantly functions during sleep states. Important implications for the ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2021, 198:101917]

Cited: 2 times

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Examining changes in rodent temperament following repetitive mild traumatic brain injury in adolescence.

Ali Hazari, Sabrina Salberg, Yannick Griep, Glenn R Yamakawa, Richelle Mychasiuk,

Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes in day-to-day behavior or temperament, which although not meeting criteria for postconcussive diagnosis, does cause ... Read more >>

Behav Neurosci (Behavioral neuroscience)
[2020, 134(5):384-393]

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Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration.

Nicole A Cho, Alissa C Nicolucci, Teja Klancic, Weilan Wang, Keith A Sharkey, Richelle Mychasiuk, Raylene A Reimer,

Microbial colonization of the gut early in life is crucial for the development of the immune and nervous systems, as well as influencing metabolism and weight gain. While early life exposure to antibiotics can cause microbial dysbiosis, prebiotics are non-digestible substrates that selectively promote the growth of beneficial gut microbiota. ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(7):]

Cited: 1 time

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The Development of Adolescent Chronic Pain following Traumatic Brain Injury and Surgery: The Role of Diet and Early Life Stress.

Sabrina Salberg, Marissa Sgro, Rhys D Brady, Melanie Noel, Richelle Mychasiuk,

Pain is evolutionarily necessary for survival in that it reduces tissue damage by signaling the body to respond to a harmful stimulus. However, in many circumstances, acute pain becomes chronic, and this is often dysfunctional. Adolescent chronic pain is a growing epidemic with an unknown etiology and limited effective treatment ... Read more >>

Dev Neurosci (Developmental neuroscience)
[2020, 42(1):2-11]

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Aberrant Mitochondrial Morphology and Function in the BTBR Mouse Model of Autism Is Improved by Two Weeks of Ketogenic Diet.

Younghee Ahn, Rasha Sabouny, Bianca R Villa, Nellie C Yee, Richelle Mychasiuk, Golam M Uddin, Jong M Rho, Timothy E Shutt,

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder that exhibits a common set of behavioral and cognitive impairments. Although the etiology of ASD remains unclear, mitochondrial dysfunction has recently emerged as a possible causative factor underlying ASD. The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that augments ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(9):]

Cited: 3 times

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Experimental traumatic brain injury does not lead to lung infection.

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie H Y Wong, Sandy R Shultz, Stuart J McDonald,

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 343:577239]

Cited: 1 time

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A "dyadic dance": pain catastrophizing moderates the daily relationships between parent mood and protective responses and child chronic pain.

Alexandra Neville, Yannick Griep, Tonya M Palermo, Tine Vervoort, Fiona Schulte, Keith Owen Yeates, Janice E Sumpton, Richelle Mychasiuk, Melanie Noel,

Children's experience of chronic pain is influenced by the psychological and behavioural responses of their parents. However, the majority of research has been cross-sectional, precluding examination of how these dynamic relationships unfold over time. This study used a microlongitudinal design to examine the daily relationships between parent mood and protective ... Read more >>

Pain (Pain)
[2020, 161(5):1072-1082]

Cited: 3 times

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Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI). Adolescents are at particularly high risk for experiencing a TBI, particularly mild TBI (mTBI) and repetitive mTBI (RmTBI); however, glymphatic clearance, and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6254]

Cited: 1 time

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Sexually Dimorphic Behavioral and Genetic Outcomes Associated With Administration of TA65 (A Telomerase Activator) Following Repetitive Traumatic Brain Injury: A Pilot Study.

Eric Eyolfson, Haris Malik, Richelle Mychasiuk,

Children and adolescents have the highest rates of traumatic brain injury (TBI), with mild TBI (mTBI) accounting for most of these injuries. This demographic also often suffers from post-injury symptomologies that may persist for months. Telomere length (TL) has previously been used as a marker for outcomes following repetitive mild ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:98]

Cited: 2 times

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Acute Dilation of Venous Sinuses in Animal Models of Mild Traumatic Brain Injury Detected Using 9.4T MRI.

Qandeel Shafqat, Jennaya Christensen, A Max Hamilton, Elizabeth Imhof, Richelle M Mychasiuk, Jeff F Dunn,

Mild traumatic brain injury (mTBI) is a debilitating but extremely common form of brain injury that affects a substantial number of people each year. mTBI is especially common in children and adolescents. Our understanding of mTBI pathophysiology is limited, and there is currently no accepted marker for disease severity. A ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:307]

Cited: 0 times

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Sleep disturbance underlies the co-occurrence of trauma and pediatric chronic pain: a longitudinal examination.

Maria Pavlova, Daniel C Kopala-Sibley, Cara Nania, Richelle Mychasiuk, Jennaya Christensen, Allison McPeak, Lianne Tomfohr-Madsen, Joel Katz, Tonya M Palermo, Melanie Noel,

Epidemiological and cross-sectional studies have shown that post-traumatic stress disorder symptoms (PTSS) are common and impairing in youth with chronic pain. Yet, the co-occurrence of PTSS and pediatric chronic pain has not been examined longitudinally, which has limited understanding of theoretically proposed mechanisms (eg, sleep disturbance) underlying the PTSS-pain relationship ... Read more >>

Pain (Pain)
[2020, 161(4):821-830]

Cited: 5 times

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Administration of diphenyl diselenide (PhSe)2 following repetitive mild traumatic brain injury exacerbates anxiety-like symptomology in a rat model.

Glenn R Yamakawa, Eric Eyolfson, Himanthri Weerawardhena, Richelle Mychasiuk,

Approximately 10-15 % of people that sustain mild traumatic brain injury (mTBI) develop post-concussive syndrome (PCS). PCS is a complex array of symptoms that can result in physical, cognitive and emotional impairments. Following mTBI, there are also complex changes in the oxidative stress system and engagement of the inflammatory system, ... Read more >>

Behav Brain Res (Behavioural brain research)
[2020, 382:112472]

Cited: 1 time

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Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex.

Brendan B McAllister, Nicoline Bihelek, Richelle Mychasiuk, Richard H Dyck,

In certain neurons, zinc ions are stored in synaptic vesicles by zinc transporter 3 (ZnT3). Vesicular zinc can then be released synaptically to modulate myriad targets. In vitro evidence indicates that these targets may include brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB). But the effects ... Read more >>

Neuroscience (Neuroscience)
[2020, 425:90-100]

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Caffeine consumption during development alters spine density and recovery from repetitive mild traumatic brain injury in young adult rats.

Jennaya Christensen, Glenn R Yamakawa, Sabrina Salberg, Melinda Wang, Bryan Kolb, Richelle Mychasiuk,

Caffeine is the most commonly used psychostimulant throughout the world, with its consumption being especially prevalent among adolescents and young adults, as over 75% of this group consumes caffeine daily. Similarly, the adolescent and young adult age group exhibit the highest incidence of traumatic brain injury (TBI). Given that both ... Read more >>

Synapse (Synapse (New York, N.Y.))
[2020, 74(4):e22142]

Cited: 1 time

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A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

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