Full Text Journal Articles by
Author Richard Roberts

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Test-Retest Reliability of the Dizziness Symptom Profile.

Renee L Landon-Lane, Erin G Piker, Gary P Jacobson, Kelsey Hatton, Richard A Roberts,

OBJECTIVES:This investigation was conducted to measure the test-retest reliability of the Dizziness Symptom Profile (DSP). The DSP was developed to assist primary care providers, general otolaryngologists, and other health care providers in the development of a differential diagnosis for patients who present with dizziness, vertigo, or unsteadiness. The DSP yields ... Read more >>

Ear Hear (Ear and hearing)
[2020, :]

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Mechanism underlying the vasodilation induced by diosmetin in porcine coronary artery.

Taseer Ahmad, Abdul Jabbar Shah, Taous Khan, Richard Roberts,

Diosmetin is a flavonoid present naturally in citrus fruit. Plants containing diosmetin have been reported to have anti-hypertensive and vasorelaxant effects. Therefore, experiments were carried out to study the effects of diosmetin in segments of the porcine coronary artery (PCA). PCA rings were mounted for isometric tension recording in isolated ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2020, :173400]

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Multiple Co-Occurring Vestibular Disorders Identified Using the Dizziness Symptom Profile.

Richard A Roberts, Gary P Jacobson, Kelsey Hatton,

Purpose The purpose of the current investigation was to determine the interrelations among vestibular disorders from a data set generated from the patient perspective as compared to previous data generated from the physician's perspective. Method The data for the current investigation originated from a previously published study describing the development ... Read more >>

Am J Audiol (American journal of audiology)
[2020, :1-9]

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Enabling Flow-Based Kinetic Off-Rate Selections Using a Microfluidic Enrichment Device.

William E Evenson, Wan-Zhen Sophie Lin, Kenmond Pang, Alexander T Czaja, Farzad Jalali-Yazdi, Terry T Takahashi, Noah Malmstadt, Richard W Roberts,

Modern genomic sequencing efforts are identifying potential diagnostic and therapeutic targets more rapidly than existing methods can generate the peptide- and protein-based ligands required to study them. To address this problem, we have developed a microfluidic enrichment device (MFED) enabling kinetic off-rate selection without the use of exogenous competitor. We ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, :]

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Complete Genome Sequences and Methylome Analyses of Cutibacterium acnes subsp. acnes Strains DSM 16379 and DSM 1897T.

Paulina Deptula, Pia Laine, Lars Paulin, Petri Auvinen, Richard J Roberts, Christopher D Johnston, Pekka Varmanen,

Cutibacterium acnes is a member of the normal human skin microbiome. However, it is also associated with skin disorders and persistent infections of orthopedic implants. Here, we announce complete genome sequences and methylomes of the C. acnes subsp. acnes strains DSM 1897T and DSM 16379 together with their active restriction-modification ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(29):]

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Uphold the nuclear weapons test moratorium.

Jonathan King, Martin Chalfie, Noam Chomsky, Joseph Cirincione, Sean Decatur, Melissa Franklin, Joseph Gerson, David P Goldenberg, Gary Goldstein, William Hartung, Ira Helfand, Daniel Holz, Peter C Kahn, Sheldon Krimsky, Edward Loechler, Val Moghadam, Stuart A Newman, David Ozonoff, Prasannan Parthasarathi, William Phillips, H David Politzer, Robert P Redwine, Richard J Roberts, Alan Robock, Catherine Ann Royer, Suzanne Scarlata, Elaine Scarry, George F Smoot, Robert Socolow, Susan Solomon, Andrew Strominger, Eric J Sundberg, Mriganka Sur, Max Tegmark, John F Tierney, Cornelia van der Ziel, Michael VanElzakker, Frank N von Hippel, Lawrence Wittner, Henry H Wortis,

Science (Science (New York, N.Y.))
[2020, 369(6501):262]

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SAT-054 Gigantism and Hypothalamic Obesity: Rare Endocrine Manifestations of Neurofibromatosis Type 1.

Richard Ogden Roberts, Christina Chambers,

Abstract Background: Neurofibromatosis type 1 (NF-1) is a heritable, autosomal dominant, multisystem disorder caused by mutations or deletions in NF1, with approximately 30-50% of cases arising from de novo mutations. In the pediatric population, growth hormone deficiency is among one of the most commonly described endocrine sequelae, although aberrations of ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Development of high affinity monobodies recognizing SARS-CoV-2 antigen

Yushen Du, Tian-hao Zhang, Xiangzhi Meng, Yuan Shi, Menglong Hu, Shuofeng Yuan, Chit Ying La, Shu-xing Li, Siwei Liu, Jiayan Li, Haigen Huang, Hong Jian, Dongdong Chen, Li Sheng, Mengying Hong, Anders Olson, Hsiang-I Liao, Xiaojiang Chen, Xinmin Li, Gexin Zhao, Richard Roberts, Jasper Chan, Dong-Yan Jin, Irvin SY Chen, Honglin Chen, Kwok-Yung Yuen, Quan Hao, Ren Sun,

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a threat to global public health. Prompt patient identification and quarantine is the most effective way to control its rapid transmission, which can be facilitated by early detection of viral antigens. Here ... Read more >>

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mRNA Display Discovery of a Novel Programmed Death Ligand 1 (PD-L1) Binding Peptide (a Peptide Ligand for PD-L1).

Golnaz Kamalinia, Brian J Engel, Anupallavi Srinivasamani, Brian J Grindel, Justin N Ong, Michael A Curran, Terry T Takahashi, Steven W Millward, Richard W Roberts,

Programmed death ligand 1 (PD-L1) is a critical immune checkpoint ligand whose overexpression on tumor cells provides a mechanism of escape from immune surveillance. The interaction between PD-L1 and PD-1 on T cell lymphocytes suppresses both T cell activation and effector function and is engaged by cancers to dampen antitumor ... Read more >>

ACS Chem. Biol. (ACS chemical biology)
[2020, 15(6):1630-1641]

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A new approach to assessing emotional understanding.

Susan Hellwig, Richard D Roberts, Ralf Schulze,

This article describes (a) the origins of, (b) rationale underlying, and (c) preliminary validity evidence for, a new ability measure of emotional understanding (EU), a major component of emotional intelligence. A novel conceptual approach-the empathic agent paradigm (EAP)-provided the theoretical foundation. The EAP results in a veridical, logically defensible scoring ... Read more >>

Psychol Assess (Psychological assessment)
[2020, 32(7):649-662]

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Complete Genome Sequences and Methylome Analysis of Two Environmental Spirochaetes.

Alexey Fomenkov, Margarita Y Grabovich, Galina Dubinina, Natalia Leshcheva, Natalia Mikheeva, Tamas Vincze, Richard J Roberts,

Here, we report the finished closed genomes of two environmental bacteria, Oceanispirochaeta crateria K2 and Thiospirochaeta perfilievii P (formally known as Spirochaeta perfilievii P). In addition, we provide methylation data and the associated enzymes predicted and confirmed to be responsible for each modified motif. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(15):]

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Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease.

Bianca Stenmark, Odile B Harrison, Lorraine Eriksson, Brian P Anton, Alexey Fomenkov, Richard J Roberts, Ave Tooming-Klunderud, Holly B Bratcher, James E Bray, Sara Thulin-Hedberg, Martin C J Maiden, Paula Mölling,

Invasive meningococcal disease (IMD) due to serogroup Y Neisseria meningitidis emerged in Europe during the 2000s. Draft genomes of serogroup Y isolates in Sweden revealed that although the population structure of these isolates was similar to other serogroup Y isolates internationally, a distinct strain (YI) and more specifically a sublineage ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3644]

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Human occupation of northern India spans the Toba super-eruption ~74,000 years ago.

Chris Clarkson, Clair Harris, Bo Li, Christina M Neudorf, Richard G Roberts, Christine Lane, Kasih Norman, Jagannath Pal, Sacha Jones, Ceri Shipton, Jinu Koshy, M C Gupta, D P Mishra, A K Dubey, Nicole Boivin, Michael Petraglia,

India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):961]

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Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å.

John R Horton, Jie Yang, Xing Zhang, Theresa Petronzio, Alexey Fomenkov, Geoffrey G Wilson, Richard J Roberts, Xiaodong Cheng,

HhaI, a Type II restriction endonuclease, recognizes the symmetric sequence 5'-GCG↓C-3' in duplex DNA and cleaves ('↓') to produce fragments with 2-base, 3'-overhangs. We determined the structure of HhaI in complex with cognate DNA at an ultra-high atomic resolution of 1.0 Å. Most restriction enzymes act as dimers with two ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2020, 48(3):1466-1478]

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Genome Sequence of Salarchaeum sp. Strain JOR-1, an Extremely Halophilic Archaeon from the Dead Sea.

Brian P Anton, Priya DasSarma, Fabiana L Martinez, Satyajit L DasSarma, Mohammad Al Madadha, Richard J Roberts, Shiladitya DasSarma,

An extremely halophilic archaeon, Salarchaeum sp. strain JOR-1, was isolated from the east coast of the Dead Sea, Kingdom of Jordan, and sequenced using single-molecule real-time (SMRT) sequencing. The GC-rich 2.5-Mbp genome was composed of a circular chromosome and a megaplasmid. The genome contained 2,633 genes and was incorporated into ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(5):]

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Technical note: validation of an automated feeding system for measuring individual animal feed intake in sheep housed in groups.

Stephanie K Muir, Nick P Linden, Andrew Kennedy, Grace Calder, Gavin Kearney, Richard Roberts, Matthew I Knight, Ralph Behrendt,

The development of feeding systems that can individually measure and control feed intake in a group-housed environment would allow a greater understanding of sheep intake without compromising animal welfare and behavior through the removal of social interactions between sheep. This study validated an automated feeding system for measuring feed intake ... Read more >>

Transl Anim Sci (Translational animal science)
[2020, 4(2):txaa007]

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Short Communication: The Belly-Tendon Derivation Yields Superior Ocular Vestibular Evoked Myogenic Potential Amplitudes in a Normal Pediatric Sample.

Megan Bilodeau, Gary P Jacobson, Richard A Roberts, Kelsey Hatton,

Purpose The purpose of the investigation was to determine whether the "belly-tendon" electrode derivation produced ocular vestibular evoked myogenic potentials (oVEMPs) in children that were superior to those recorded with the infraorbital-chin electrode derivation. Method This was a prospective observational study using a sample of convenience at a tertiary care ... Read more >>

Am J Audiol (American journal of audiology)
[2020, 29(1):88-93]

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Timeliness and equity of infant pertussis vaccination in wales: Analysis of the three dose primary course.

Malorie Perry, Anne McGowan, Richard Roberts, Simon Cottrell,

Infants aged under one year are at the highest risk of severe complications or death from pertussis infection. Prompt vaccination with a three dose course at two, three and four months of age decreases the amount of time they are vulnerable following waning of maternal antibodies. In Wales, uptake of ... Read more >>

Vaccine (Vaccine)
[2020, 38(6):1402-1407]

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Combined organic biomarker and use-wear analyses of stone artefacts from Liang Bua, Flores, Indonesia.

Susan Luong, Matthew W Tocheri, Elspeth Hayes, Thomas Sutikna, Richard Fullagar, E Wahyu Saptomo, Jatmiko, Richard G Roberts,

Organic biomarker and lithic use-wear analyses of archaeological implements manufactured and/or used by hominins in the past offers a means of assessing how prehistoric peoples utilised natural resources. Currently, most studies focus on one of these techniques, rather than using both in sequence. This study aims to assess the potential ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17553]

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Mechanisms mediating the vasodilatory effects of juglone in porcine isolated coronary artery.

Taseer Ahmad, Abdul Jabbar Shah, Richard Roberts,

Juglone (5-hydroxy-1, 4-naphthoquinone), is a natural phenolic compound that has been shown to relax smooth muscle. Therefore the aim of this study was to determine the effect of juglone on vascular tone using porcine coronary artery (PCA). Segments of PCA, with or without endothelium, were mounted for isometric tension recording ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2020, 866:172815]

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Evidence of Systemic Absorption of Enteral Budesonide in Patients with Fontan-Associated Protein-Losing Enteropathy.

Richard Ogden Roberts, Michael V Di Maria, Dania Brigham, Stephanie Hsu,

To evaluate for evidence of systemic glucocorticoid absorption in cases of Fontan-associated protein-losing enteropathy (PLE) treated with enteral budesonide, we reviewed the charts of 27 patients with Fontan-associated PLE followed at Children's Hospital Colorado from 2005 to 2018. Cases were excluded for lack of budesonide thserapy or a treatment duration ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, 41(2):241-250]

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National Partnership for Maternal Safety: Consensus Bundle on Venous Thromboembolism.

Adam C Urato, Elia Abi-Jaoude, John Abramson, Harrison Alter, Louise B Andrew, David Antonuccio, Lisa Bero, Pierre Biron, Laura S Boylan, Alain Braillon, James M Brophy, Shannon Brownlee, Alan Cassels, Robert Cook-Deegan, Lisa Cosgrove, Luca De Fiore, Richard A Deyo, Adam Elshaug, Cindy Farquhar, Daniel M Fatovich, Eileen Fingerman, Juan Gérvas, Peter C Gøtzsche, Rafael Gracia, Iona Heath, David U Himmelstein, Jerome R Hoffman, Teppo Järvinen, Jon Jureidini, Andrew Kotaska, Thomas Kuehlein, Jeanne Lenzer, Susan Levenstein, Joel Lexchin, Barbara Mintzes, Florian Naudet, Manon Niquette, Lusy Paulyna Orellana Navarrete, Cynthia A Pearson, Geneviève Rail, Richard Roberts, Naman Shah, Vera Sharav, Jay Siwek, Stefan Topolski, Alexander C Tsai,

Obstet Gynecol (Obstetrics and gynecology)
[2019, 134(5):1115-1117]

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Complete Genome Sequence and Methylome Analysis of Sphaerotilus natans subsp. sulfidivorans D-507.

Alexey Fomenkov, Margarita Grabovich, Elena Belousova, Dmitry Smolyakov, Galina Dubinina, Richard J Roberts,

Sphaerotilus natans subsp. sulfidivorans D-507 is an environmental isolate from a sulfate spring in the northern Caucasus region of Russia. This heterotrophic bacterium is involved in the oxidation of reduced sulfur derivatives. This report includes the finished genome of this strain. In addition, we provide methylation data and the associated ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2019, 8(46):]

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Red-Brown Pigmentation of Acidipropionibacterium jensenii Is Tied to Haemolytic Activity and cyl-Like Gene Cluster.

Paulina Deptula, Iida Loivamaa, Olli-Pekka Smolander, Pia Laine, Richard J Roberts, Vieno Piironen, Lars Paulin, Kirsi Savijoki, Petri Auvinen, Pekka Varmanen,

The novel Acidipropionibacterium genus encompasses species of industrial importance but also those associated with food spoilage. In particular, Acidipropionibacterium acidipropionici, Acidipropionibacterium thoenii, and Acidipropionibacterium jensenii play an important role in food fermentation, as biopreservatives, or as potential probiotics. Notably, A. jensenii and A. thoenii can cause brown spot defects in ... Read more >>

Microorganisms (Microorganisms)
[2019, 7(11):]

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Lumbar Spine Fusion Rates With Local Bone in Posterolateral and Combined Posterolateral and Interbody Approaches.

Daniel K Park, Richard Roberts, Paul Arnold, David H Kim, Rick Sasso, Kevin C Baker, Jeffrey S Fischgrund,

Posterolateral lumbar fusion (PLF) used to treat degenerative lumbar conditions still faces pseudarthrosis. Bone graft choice is a key factor; a traditional choice has been autologous iliac crest bone graft (ICBG), but complication rates are quoted up to 39%. Local bone from laminectomy eliminates ICBG harvesting complications. Methods:Two hundred forty-one ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(11):e018]

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