Full Text Journal Articles by
Author Richard H Smith


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Advances in subcutaneous injections: PRECISE II: a study of safety and subject preference for an innovative needle-free injection system.

E Lynne Kelley, Richard H Smith, Gillian Corcoran, Sandra Nygren, Mary V Jacoski, Andrea Fernandes,

Needle-free injection is a desirable goal for many reasons, including reducing pain, anxiety, and eliminating safety risks associated with needle-stick injuries. However, development of a safe, reliable needle-free device optimized for at-home use has been met with many challenges. Portal Instruments Inc. has been developing needle-free medication delivery using a ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1915-1922]

Cited: 0 times

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NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.

Daisuke Araki, Jian Fei Fu, Heather Huntsman, Stefan Cordes, Fayaz Seifuddin, Luigi J Alvarado, Patali S Cheruku, Ayla Cash, Javier Traba, Yuesheng Li, Mehdi Pirooznia, Richard H Smith, Andre Larochelle,

Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1<sup>ext-IgG</sup> [DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopulating hematopoietic stem cells (LTR-HSCs) remains uncertain. Here, we demonstrate that ex vivo culture of human adult HSPCs with DXI ... Read more >>

Stem Cell Reports (Stem cell reports)
[2021, 16(9):2336-2350]

Cited: 0 times

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Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia.

Husam Qanash, Yongqin Li, Richard H Smith, Kaari Linask, Sara Young-Baird, Waleed Hakami, Keyvan Keyvanfar, John S Choy, Jizhong Zou, Andre Larochelle,

Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin synthesis, resulting in excess toxic free heme in erythroid progenitors, early differentiation arrest, and pure red cell aplasia. In this study, DBA induced pluripotent stem cell (iPSC) lines were generated from blood ... Read more >>

Cells (Cells)
[2021, 10(4):]

Cited: 1 time

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Reducing Spread of Infections with a Photocatalytic Reactor-Potential Applications in Control of Hospital Staphylococcus aureus and Clostridioides difficile Infections and Inactivation of RNA Viruses.

Abeer Gharaibeh, Richard H Smith, Michael J Conway,

Contaminated surfaces and indoor environments are important sources of infectious spread within hospital and non-hospital facilities. Bacterial infections such as infections with <i>Clostridioides</i> (formerly <i>Clostridium</i>) <i>difficile</i> (<i>C. difficile</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and its antibiotic resistant strains continue to pose a significant risk to healthcare workers and patients. Additionally, ... Read more >>

Infect Dis Rep (Infectious disease reports)
[2021, 13(1):58-71]

Cited: 0 times

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Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones.

Richard H Smith, Yun-Ching Chen, Fayaz Seifuddin, Daniel Hupalo, Camille Alba, Robert Reger, Xin Tian, Daisuke Araki, Clifton L Dalgard, Richard W Childs, Mehdi Pirooznia, Andre Larochelle,

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9)-mediated genome editing holds remarkable promise for the treatment of human genetic diseases. However, the possibility of off-target Cas9 activity remains a concern. To address this issue using clinically relevant target cells, we electroporated Cas9 ribonucleoprotein (RNP) complexes (independently targeted to two ... Read more >>

Genes (Basel) (Genes)
[2020, 11(12):]

Cited: 2 times

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Genome editing in human hematopoietic stem and progenitor cells via CRISPR-Cas9-mediated homology-independent targeted integration.

Hanan Bloomer, Richard H Smith, Waleed Hakami, Andre Larochelle,

Ex vivo gene correction of hematopoietic stem and progenitor cells (HSPCs) has emerged as a promising therapeutic approach for treatment of inherited human blood disorders. Use of engineered nucleases to target therapeutic transgenes to their endogenous genetic loci addresses many of the limitations associated with viral vector-based gene replacement strategies, such ... Read more >>

Mol Ther (Molecular therapy : the journal of the American Society of Gene Therapy)
[2021, 29(4):1611-1624]

Cited: 1 time

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IFN-γ directly inhibits the activity of erythropoietin in human erythroid progenitors.

Daisuke Araki, Luigi J Alvarado, Heather D Huntsman, Richard H Smith, Andre Larochelle,

Blood Cells Mol Dis (Blood cells, molecules & diseases)
[2020, 85:102488]

Cited: 0 times

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Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia.

Haydar Çelik, Katherine E Lindblad, Bogdan Popescu, Gege Gui, Meghali Goswami, Janet Valdez, Christin DeStefano, Catherine Lai, Julie Thompson, Jack Y Ghannam, Giovanna Fantoni, Angélique Biancotto, Julián Candia, Foo Cheung, Gauthaman Sukumar, Clifton L Dalgard, Richard H Smith, Andre Larochelle, Laura W Dillon, Christopher S Hourigan,

Acute myeloid leukemia (AML) is a genetically heterogeneous disease that is characterized by abnormal clonal proliferation of myeloid progenitor cells found predominantly within the bone marrow (BM) and blood. Recent studies suggest that genetic and phenotypic alterations in the BM microenvironment support leukemogenesis and allow leukemic cells to survive and ... Read more >>

Blood Adv (Blood advances)
[2020, 4(2):367-379]

Cited: 9 times

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Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells.

Kacey L Guenther, Patali S Cheruku, Ayla Cash, Richard H Smith, Luigi J Alvarado, Sandra Burkett, Danielle M Townsley, Thomas Winkler, Andre Larochelle,

A causal link between hematopoietic stem/progenitor cell (HSPC) dysfunction and DNA damage accrual has been proposed. Clinically relevant strategies to maintain genome integrity in these cells are needed. Here we report that eltrombopag, a small molecule agonist of the thrombopoietin (TPO) receptor used in the clinic, promotes DNA double-strand break ... Read more >>

Exp Hematol (Experimental hematology)
[2019, 73:1-6.e6]

Cited: 6 times

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A Novel Electromagnetic-Neurobiologic Interface for Functional Animation of Dormant Motor Nerve Roots in Spinal Cord Injury via Neuromodulation.

Jawad Shah, Richard H Smith, Abeer Al-Gharaibeh,

Complete spinal cord injury is a devastating occurrence afflicting millions of people worldwide with no available treatment for functional motor recovery. In this report, we describe a procedure in which we used parts of a device available for chronic pain treatment to provide a neuromodulation of motor nerve roots in ... Read more >>

Front Surg (Frontiers in surgery)
[2019, 6:73]

Cited: 0 times

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Intraprocedural predictors of post-stent retriever thrombectomy subarachnoid hemorrhage in middle cerebral artery stroke.

Perry P Ng, Theodore C Larson, Christopher W Nichols, Mark M Murray, Karen L Salzman, Richard H Smith,

<h4>Background</h4>Stent retriever thrombectomy (SRT) in acute thromboembolic stroke can result in post-thrombectomy subarachnoid hemorrhage (PTSAH). Intraprocedural findings associated with PTSAH are not well defined.<h4>Objective</h4>To identify angiographic findings and procedural factors during SRT that are associated with PTSAH.<h4>Materials and methods</h4>This was a retrospective, observational cohort study of consecutive patients with middle ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2019, 11(2):127-132]

Cited: 3 times

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Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.

Richard H Smith, Claus V Hallwirth, Michael Westerman, Nicola A Hetherington, Yu-Shan Tseng, Sylvain Cecchini, Tamas Virag, Mona-Larissa Ziegler, Igor B Rogozin, Eugene V Koonin, Mavis Agbandje-McKenna, Robert M Kotin, Ian E Alexander,

Germline endogenous viral elements (EVEs) genetically preserve viral nucleotide sequences useful to the study of viral evolution, gene mutation, and the phylogenetic relationships among host organisms. Here, we describe a lineage-specific, adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely related marsupial species. Molecular screening ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:28965]

Cited: 13 times

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When envy leads to schadenfreude.

Niels van de Ven, Charles E Hoogland, Richard H Smith, Wilco W van Dijk, Seger M Breugelmans, Marcel Zeelenberg,

Previous research has yielded inconsistent findings concerning the relationship between envy and schadenfreude. Three studies examined whether the distinction between benign and malicious envy can resolve this inconsistency. We found that malicious envy is related to schadenfreude, while benign envy is not. This result held both in the Netherlands where ... Read more >>

Cogn Emot (Cognition & emotion)
[2015, 29(6):1007-1025]

Cited: 10 times

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Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients.

Caroline Le Guiner, Marie Montus, Laurent Servais, Yan Cherel, Virginie Francois, Jean-Laurent Thibaud, Claire Wary, Béatrice Matot, Thibaut Larcher, Lydie Guigand, Maeva Dutilleul, Claire Domenger, Marine Allais, Maud Beuvin, Amélie Moraux, Johanne Le Duff, Marie Devaux, Nicolas Jaulin, Mickaël Guilbaud, Virginie Latournerie, Philippe Veron, Sylvie Boutin, Christian Leborgne, Diana Desgue, Jack-Yves Deschamps, Sophie Moullec, Yves Fromes, Adeline Vulin, Richard H Smith, Nicolas Laroudie, Frédéric Barnay-Toutain, Christel Rivière, Stéphanie Bucher, Thanh-Hoa Le, Nicolas Delaunay, Mehdi Gasmi, Robert M Kotin, Gisèle Bonne, Oumeya Adjali, Carole Masurier, Jean-Yves Hogrel, Pierre Carlier, Philippe Moullier, Thomas Voit,

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder caused by mutations in the dystrophin gene, without curative treatment yet available. Our study provides, for the first time, the overall safety profile and therapeutic dose of a recombinant adeno-associated virus vector, serotype 8 (rAAV8) carrying a modified U7snRNA sequence promoting ... Read more >>

Mol Ther (Molecular therapy : the journal of the American Society of Gene Therapy)
[2014, 22(11):1923-1935]

Cited: 66 times

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Justice for the average Joe: the role of envy and the mentalizing network in the deservingness of others' misfortunes.

David S Chester, Caitlin A J Powell, Richard H Smith, Jane E Joseph, Gayannėe Kedia, David J Y Combs, C Nathan DeWall,

The misfortunes of enviable individuals are met by observers with pleasure whereas those of "average", non-enviable individuals elicit pain. These responses are mirrored in deservingness judgments, as enviable individuals' misfortunes are perceived as deserved and those of non-enviable individuals perceived as undeserved. However, the neural underpinnings of these deservingness disparities ... Read more >>

Soc Neurosci (Social neuroscience)
[2013, 8(6):640-649]

Cited: 5 times

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Energetic effects for observed and unobserved HIV-1 reverse transcriptase mutations of residues L100, V106, and Y181 in the presence of nevirapine and efavirenz.

Marilyn B Kroeger Smith, Lenea H Rader, Amanda M Franklin, Emily V Taylor, Katie D Smith, Richard H Smith, Julian Tirado-Rives, William L Jorgensen,

The effect of mutations on amino acid residues L100, V106, and Y181 for unbound HIV-1 reverse transcriptase (RT) and RT bound to nevirapine and efavirenz was investigated using Monte Carlo/free energy perturbation calculations. Using both native and bound crystal structures of RT, mutation of the amino acid residues to both ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2008, 18(3):969-972]

Cited: 4 times

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Chromatography-based purification of adeno-associated virus.

Richard H Smith, Linda Yang, Robert M Kotin,

Virus-mediated gene transfer shows great potential as a therapeutic strategy for the management of various inherited and acquired human diseases. Among the current viral vectors, adeno-associated virus (AAV) has become the vector of choice for numerous gene therapy applications. As AAV-based vectors approach the clinic, the need for scalable methods ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2008, 434:37-54]

Cited: 8 times

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Comprehending envy.

Richard H Smith, Sung Hee Kim,

The authors reviewed the psychological research on envy. The authors examined definitional challenges associated with studying envy, such as the important distinction between envy proper (which contains hostile feelings) and benign envy (which is free of hostile feelings). The authors concluded that envy is reasonably defined as an unpleasant, often ... Read more >>

Psychol Bull (Psychological bulletin)
[2007, 133(1):46-64]

Cited: 65 times

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Relativistic origins of emotional reactions to events happening to others and to ourselves.

Richard H Smith, Heidi L Eyre, Caitlin A J Powell, Sung Hee Kim,

The purpose of the present study was to show that people's emotional reactions to both good and bad events happening to others can be influenced by how their own experiences compare with these events. Female undergraduate students took a test of intellectual ability and received false feedback suggesting that they ... Read more >>

Br J Soc Psychol (The British journal of social psychology)
[2006, 45(Pt 2):357-371]

Cited: 3 times

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Assault on resistance: the use of computational chemistry in the development of anti-HIV drugs.

Marilyn B Kroeger Smith, Richard H Smith, William L Jorgensen,

While many inhibitors of the Human Immunodeficiency Virus (HIV), the causative agent of Acquired Immunodeficiency Syndrome (AIDS), have been developed, the problem of drug resistance has continued to plague the fight against the disease. The ability of computers to aid in the drug discovery process, and by default the resistance ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2006, 12(15):1843-1856]

Cited: 3 times

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Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues.

Marilyn B Kroeger Smith, Brian M Hose, Arie Hawkins, James Lipchock, David W Farnsworth, Robert C Rizzo, Julian Tirado-Rives, Edward Arnold, Wanyi Zhang, Stephen H Hughes, William L Jorgensen, Christopher J Michejda, Richard H Smith,

The energies and physical descriptors for the binding of 20 novel 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)benzimidazole analogues (BPBIs) to HIV-1 reverse transcriptase (RT) have been determined using Monte Carlo (MC) simulations. The crystallographic structure of the lead compound, 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole, was used as a starting point to model the inhibitors in both the bound and ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2003, 46(10):1940-1947]

Cited: 14 times

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The roles of praise and social comparison information in the experience of pride.

J Matthew Webster, Jamieson Duvall, Leslie M Gaines, Richard H Smith,

The authors examined the roles of social comparisons, publicity of success, and praise on the experience of pride in an experiment in which college students successfully completed a timed intelligence task in private and later received 1 of 4 types of feedback from the experimenter: no feedback (private), mere public ... Read more >>

J Soc Psychol (The Journal of social psychology)
[2003, 143(2):209-232]

Cited: 8 times

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HIV-1 reverse transcriptase variants: molecular modeling of Y181C, V106A, L100I, and K103N mutations with nonnucleoside inhibitors using Monte Carlo simulations in combination with a linear response method.

Marilyn B Kroeger Smith, Sandra Ruby, Stanislav Horouzhenko, Bryan Buckingham, Julia Richardson, Ina Puleri, Emily Potts, William L Jorgensen, Edward Arnold, Wanyi Zhang, Stephen H Hughes, Christopher J Michejda, Richard H Smith,

The energies and physical descriptors for the binding of 21 novel 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole (BPBI) analogs to HIV-1 reverse transcriptase (RT) variants Y181C, L100I, V106A, and K103N have been determined using Monte Carlo (MC) simulations. The crystallographic structure of the lead compound, 4-methyl BPBI, was used as a starting point to model ... Read more >>

Drug Des Discov (Drug design and discovery)
[2003, 18(4):151-163]

Cited: 2 times

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Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid.

Richard H Smith, Sandra A Afione, Robert M Kotin,

Adeno-associated viruses (AAVs) are replication-defective parvoviruses that require helper virusfunctionsfor efficient productive replication. The AAVs are currently premier candidates as vectors for human gene therapy applications. In particular; much recent interest has been expressed concerning recombinant AAV serotype 5 (rAAV-5) vectors, as they appear to utilize cellular receptors distinctfrom those ... Read more >>

Biotechniques (BioTechniques)
[2002, 33(1):204-6, 208, 210-1]

Cited: 17 times

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Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.

Robert C Rizzo, Marina Udier-Blagović, De-Ping Wang, Edward K Watkins, Marilyn B Kroeger Smith, Richard H Smith, Julian Tirado-Rives, William L Jorgensen,

Results of Monte Carlo (MC) simulations for more than 200 nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) representing eight diverse chemotypes have been correlated with their anti-HIV activities in an effort to establish simulation protocols and methods that can be used in the development of more effective drugs. Each inhibitor ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2002, 45(14):2970-2987]

Cited: 32 times

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