Full Text Journal Articles by
Author Richard E Peterson

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Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor.

Hao Wu, Binkai Liu, Ka Yang, Gabrielle N Winston-McPherson, Eric D Leisten, Chad M Vezina, William A Ricke, Richard E Peterson, Weiping Tang,

The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3,2-b) carbazole (FICZ, 2), a series of analogues has been designed, synthesized and evaluated by cell-based ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2020, 30(5):126959]

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Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: urethral histology.

Hannah Ruetten, Kyle A Wegner, Conner L Kennedy, Anne Turco, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The National Institutes of Health leveled new focus on sex as a biological variable with the goal of understanding sex-specific differences in health and physiology. We previously published a functional assessment of the impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology (Ruetten H, Wegner KA, Zhang ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2020, 318(3):F617-F627]

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Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration.

Andrew J Schneider, Joseph Gawdzik, Chad M Vezina, Tracie R Baker, Richard E Peterson,

Previous studies identified Sox9 as a critical mediator of prostate development but the precise stage when Sox9 acts had not been determined. A genetic approach was used to delete Sox9 from mouse urogenital sinus epithelium (UGE) prior to prostate specification. All prostatic bud types (anterior, dorsolateral and ventral) were stunted ... Read more >>

Gene Expr Patterns (Gene expression patterns : GEP)
[2019, 34:119075]

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Insight and Resources From a Study of the "Impact of Sex, Androgens, and Prostate Size on C57BL/6J Mouse Urinary Physiology.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The purpose of this symposium report is to summarize information from a session 3 oral presentation at the Society of Toxicologic Pathology Annual Symposium in Raleigh, North Carolina. Mice are genetically tractable and are likely to play an important role in elucidating environmental, genetic, and aging-related mechanisms of urinary dysfunction ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2019, 47(8):1038-1042]

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Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

Laboratory mice are used to identify causes of urinary dysfunction including prostate-related mechanisms of lower urinary tract symptoms. Effective use of mice for this purpose requires a clear understanding of molecular, cellular, anatomic, and endocrine contributions to voiding function. Whether the prostate influences baseline voiding function has not been specifically ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2019, 317(4):F996-F1009]

Cited: 0 times

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A temporal and spatial map of axons in developing mouse prostate.

Anne E Turco, Mark T Cadena, Helen L Zhang, Jaskiran K Sandhu, Steven R Oakes, Thrishna Chathurvedula, Richard E Peterson, Janet R Keast, Chad M Vezina,

Prostate autonomic and sensory axons control glandular growth, fluid secretion, and smooth muscle contraction and are remodeled during cancer and inflammation. Morphogenetic signaling pathways reawakened during disease progression may drive this axon remodeling. These pathways are linked to proliferative activities in prostate cancer and benign prostate hyperplasia. However, little is ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2019, 152(1):35-45]

Cited: 1 time

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Pro-NP™ protect against TiO2 nanoparticle-induced phototoxicity in zebrafish model: exploring potential application for skin care.

Min-Sik Kim, Melinda Stees, Bala Vamsi K Karuturi, Sivakumar Vijayaraghavalu, Richard E Peterson, Gary L Madsen, Vinod Labhasetwar,

Titanium dioxide nanoparticles (TiO2NPs) are used in sunscreen products to protect the skin from the sun's ultraviolet rays. However, following exposure to sunlight, the photocatalytic activity of TiO2NPs can produce an excess of reactive oxygen species (ROS), causing skin cell damage, triggering an inflammatory response. In zebrafish model, we evaluated ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2017, 7(3):372-382]

Cited: 3 times

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ToF-SIMS imaging of capsaicinoids in Scotch Bonnet peppers (Capsicum chinense).

Bonnie J Tyler, Richard E Peterson, Therese G Lee, Felix Draude, Andreas Pelster, Heinrich F Arlinghaus,

Peppers (Capsicum spp.) are well known for their ability to cause an intense burning sensation when eaten. This organoleptic response is triggered by capsaicin and its analogs, collectively called capsaicinoids. In addition to the global popularity of peppers as a spice, there is a growing interest in the use of ... Read more >>

Biointerphases (Biointerphases)
[2016, 11(2):02A327]

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Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish.

Daisuke Nijoukubo, Yasuaki Tanaka, Yuki Okuno, Guojun Yin, Takio Kitazawa, Richard E Peterson, Akira Kubota, Hiroki Teraoka,

The role of prostaglandin pathways has been suggested in some toxicological responses to dioxins. Cyclooxygenase type 2b (COX2b), thromboxane synthase, and the thromboxane receptor (TP) pathway have been implicated in mediating 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced pre-cardiac edema in developing zebrafish at 55 h post fertilization (hpf). Pre-cardiac edema refers to edema located in ... Read more >>

Chemosphere (Chemosphere)
[2016, 156:111-117]

Cited: 2 times

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In Utero and Lactational TCDD Exposure Increases Susceptibility to Lower Urinary Tract Dysfunction in Adulthood.

William A Ricke, Calvin W Lee, Tyler R Clapper, Andrew J Schneider, Robert W Moore, Kimberly P Keil, Lisa L Abler, Jalissa L Wynder, Arnaldo López Alvarado, Isaac Beaubrun, Jenny Vo, Tyler M Bauman, Emily A Ricke, Richard E Peterson, Chad M Vezina,

Benign prostatic hyperplasia, prostate cancer, and changes in the ratio of circulating testosterone and estradiol often occur concurrently in aging men and can lead to lower urinary tract (LUT) dysfunction. To explore the possibility of a fetal basis for the development of LUT dysfunction in adulthood, Tg(CMV-cre);Nkx3-1(+/-);Pten(fl/+) mice, which are ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2016, 150(2):429-440]

Cited: 10 times

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2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice.

Robert W Moore, Wayne A Fritz, Andrew J Schneider, Tien-Min Lin, Amanda M Branam, Stephen Safe, Richard E Peterson,

It is well established that the prototypical aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can both cause and protect against carcinogenesis in non-transgenic rodents. But because these animals almost never develop prostate cancer with old age or after carcinogen exposure, whether AHR activation can affect cancer of the prostate remained ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2016, 305:242-249]

Cited: 7 times

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Expression and colocalization of β-catenin and lymphoid enhancing factor-1 in prostate cancer progression.

Tyler M Bauman, Chad M Vezina, Emily A Ricke, Richard B Halberg, Wei Huang, Richard E Peterson, William A Ricke,

The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic intraepithelial neoplasia (HGPIN; n = 25), localized PCa (n ... Read more >>

Hum Pathol (Human pathology)
[2016, 51:124-133]

Cited: 5 times

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A co-culture assay of embryonic zebrafish hearts to assess migration of epicardial cells in vitro.

Monica S Yue, Jessica S Plavicki, Xin-yi Li, Richard E Peterson, Warren Heideman,

The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms from epicardial progenitor cells (EPCs), which migrate to the myocardium during early development. Disruptions in EPC migration and epicardium formation result ... Read more >>

BMC Dev. Biol. (BMC developmental biology)
[2015, 15:50]

Cited: 4 times

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Analysis of the zebrafish sox9b promoter: Identification of elements that recapitulate organ-specific expression of sox9b.

Felipe R Burns, Kevin A Lanham, Kong M Xiong, Alex J Gooding, Richard E Peterson, Warren Heideman,

The SRY-related high-mobility box 9 (SOX9) gene is expressed in many different tissues. To better understand the DNA elements that control tissue-specific expression, we cloned and sequenced a 2.5 kb fragment lying 5' to the zebrafish sox9b gene transcriptional start site. Three regions of this clone contained stable secondary structures ... Read more >>

Gene (Gene)
[2016, 578(2):281-289]

Cited: 3 times

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Dioxin disrupts cranial cartilage and dermal bone development in zebrafish larvae.

Felipe R Burns, Richard E Peterson, Warren Heideman,

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) disrupts craniofacial development in zebrafish larvae. However, the cellular changes responsible for the decreased jaw size remain poorly understood. We show that smaller jaw size is due to a decrease in both the size and number of chondrocytes in the developing craniofacial cartilages. TCDD was found ... Read more >>

Aquat Toxicol (Aquatic toxicology (Amsterdam, Netherlands))
[2015, 164:52-60]

Cited: 8 times

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Dioxin inhibition of swim bladder development in zebrafish: is it secondary to heart failure?

Monica S Yue, Richard E Peterson, Warren Heideman,

The swim bladder is a gas-filled organ that is used for regulating buoyancy and is essential for survival in most teleost species. In zebrafish, swim bladder development begins during embryogenesis and inflation occurs within 5 days post fertilization (dpf). Embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) before 96 h post fertilization (hpf) ... Read more >>

Aquat Toxicol (Aquatic toxicology (Amsterdam, Netherlands))
[2015, 162:10-17]

Cited: 5 times

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Beta-catenin is elevated in human benign prostatic hyperplasia specimens compared to histologically normal prostate tissue.

Tyler M Bauman, Chad M Vezina, Wei Huang, Paul C Marker, Richard E Peterson, William A Ricke,

Benign prostatic hyperplasia (BPH) is linked to lower urinary tract symptoms (LUTS) such as incomplete bladder emptying, urinary frequency and urgency. Mechanisms responsible for BPH are not fully known. Here, we tested whether beta-catenin (CTNNB1) immunostaining intensity and distribution differ in human glandular BPH tissue specimens compared to normal prostate ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2014, 2(4):313-322]

Cited: 10 times

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Cardiac myocyte-specific AHR activation phenocopies TCDD-induced toxicity in zebrafish.

Kevin A Lanham, Jessica Plavicki, Richard E Peterson, Warren Heideman,

Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. AHR is found in the heart; however, AHR activation by TCDD is not confined to the heart and occurs throughout the organism. In order to understand the cause of ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 141(1):141-154]

Cited: 19 times

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Intersection of AHR and Wnt signaling in development, health, and disease.

Andrew J Schneider, Amanda M Branam, Richard E Peterson,

The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site) signaling pathways have been conserved throughout evolution. Appropriately regulated signaling through each pathway is necessary for normal development and health, while dysregulation can lead to developmental defects and disease. Though both pathways have been vigorously studied, there is relatively ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2014, 15(10):17852-17885]

Cited: 36 times

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Dioxin induction of transgenerational inheritance of disease in zebrafish.

Tracie R Baker, Tisha C King-Heiden, Richard E Peterson, Warren Heideman,

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) is an aryl hydrocarbon receptor (AHR) agonist, an endocrine disruptor, and a potent global pollutant. TCDD exposure is associated with diseases of almost every organ system, and its toxicity is highly conserved across vertebrates. While the acute developmental effects of dioxin exposure have been extensively studied, the ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2014, 398(1-2):36-41]

Cited: 18 times

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In utero exposure to TCDD alters Wnt signaling during mouse prostate development: linking ventral prostate agenesis to downregulated β-catenin signaling.

Andrew J Schneider, Robert W Moore, Amanda M Branam, Lisa L Abler, Kimberly P Keil, Vatsal Mehta, Chad M Vezina, Richard E Peterson,

In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes ventral prostate agenesis in C57BL/6J mice by preventing ventral prostatic budding in the embryonic urogenital sinus (UGS). TCDD (5 μg/kg, po) administered to pregnant dams on embryonic day 15.5 (E15.5) activates the aryl hydrocarbon receptor in the UGS mesenchyme, disrupting the mesenchymally derived ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 141(1):176-187]

Cited: 5 times

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Multiple modes of proepicardial cell migration require heartbeat.

Jessica S Plavicki, Peter Hofsteen, Monica S Yue, Kevin A Lanham, Richard E Peterson, Warren Heideman,

The outermost layer of the vertebrate heart, the epicardium, forms from a cluster of progenitor cells termed the proepicardium (PE). PE cells migrate onto the myocardium to give rise to the epicardium. Impaired epicardial development has been associated with defects in valve development, cardiomyocyte proliferation and alignment, cardiac conduction system ... Read more >>

BMC Dev. Biol. (BMC developmental biology)
[2014, 14:18]

Cited: 17 times

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Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish.

Tracie R Baker, Richard E Peterson, Warren Heideman,

There is strong evidence indicating that disease in adult humans stems from a combination of genetic and environmental factors. A problem in identifying environmental factors is that subacute exposures during early life are often unnoticed, or exposures are variable among a diverse population. This leads to a confusing pattern in ... Read more >>

(Endocrine disruptors (Austin, Tex.))
[2014, 2(1):]

Cited: 0 times

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Construction and characterization of a sox9b transgenic reporter line.

Jessica S Plavicki, Tracie R Baker, Felipe R Burns, Kong M Xiong, Alex J Gooding, Peter Hofsteen, Richard E Peterson, Warren Heideman,

The transcription factor SOX9 is a member of the SRY-related high-mobility-group box (SOX) superfamily of genes. In mammals, Sox9 plays important roles in many developmental processes including craniofacial, skeletal and heart morphogenesis, retinal and brain development, and gonad differentiation. Human mutations in SOX9 or the SOX9 promoter result in campomelic ... Read more >>

Int J Dev Biol (The International journal of developmental biology)
[2014, 58(9):693-699]

Cited: 8 times

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Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish.

Hiroki Teraoka, Yuki Okuno, Daisuke Nijoukubo, Ayumi Yamakoshi, Richard E Peterson, John J Stegeman, Takio Kitazawa, Takeo Hiraga, Akira Kubota,

The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR nuclear translocator type 1 (ARNT1) is still limited. In the ... Read more >>

Aquat Toxicol (Aquatic toxicology (Amsterdam, Netherlands))
[2014, 154:19-26]

Cited: 9 times

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