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Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.

Anoop D Shah, Niall S MacCallum, Steve Harris, David A Brealey, Edward Palmer, James Hetherington, Sinan Shi, David Perez-Suarez, Ari Ercole, Peter J Watkinson, Andrew Jones, Simon Ashworth, Richard Beale, Stephen J Brett, Mervyn Singer,

<h4>Objectives</h4>To describe the epidemiology of sepsis in critical care by applying the Sepsis-3 criteria to electronic health records.<h4>Design</h4>Retrospective cohort study using electronic health records.<h4>Setting</h4>Ten ICUs from four U.K. National Health Service hospital trusts contributing to the National Institute for Health Research Critical Care Health Informatics Collaborative.<h4>Patients</h4>A total of 28,456 critical ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1883-1894]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

Cited: 0 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

Cited: 0 times

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.

James J McNamee, Michael A Gillies, Nicholas A Barrett, Gavin D Perkins, William Tunnicliffe, Duncan Young, Andrew Bentley, David A Harrison, Daniel Brodie, Andrew J Boyle, Jonathan E Millar, Tamas Szakmany, Jonathan Bannard-Smith, Redmond P Tully, Ashley Agus, Clíona McDowell, Colette Jackson, Daniel F McAuley, ,

<h4>Importance</h4>In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.<h4>Objective</h4>To determine whether lower tidal volume mechanical ventilation using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxemic respiratory failure.<h4>Design, setting, and participants</h4>This ... Read more >>

JAMA (JAMA)
[2021, 326(11):1013-1023]

Cited: 0 times

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An impedance pneumography signal quality index: Design, assessment and application to respiratory rate monitoring.

Peter H Charlton, Timothy Bonnici, Lionel Tarassenko, David A Clifton, Richard Beale, Peter J Watkinson, Jordi Alastruey,

Impedance pneumography (ImP) is widely used for respiratory rate (RR) monitoring. However, ImP-derived RRs can be imprecise. The aim of this study was to develop a signal quality index (SQI) for the ImP signal, and couple it with a RR algorithm, to improve RR monitoring. An SQI was designed which ... Read more >>

Biomed Signal Process Control (Biomedical signal processing and control)
[2021, 65:102339]

Cited: 1 time

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The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study.

Edward Palmer, Benjamin Post, Roman Klapaukh, Giampiero Marra, Niall S MacCallum, David Brealey, Ari Ercole, Andrew Jones, Simon Ashworth, Peter Watkinson, Richard Beale, Stephen J Brett, J Duncan Young, Claire Black, Aasiyah Rashan, Daniel Martin, Mervyn Singer, Steve Harris,

<b>Rationale:</b> There is conflicting evidence on harm related to exposure to supraphysiologic Pa<sub>O<sub>2</sub></sub> (hyperoxemia) in critically ill patients.<b>Objectives:</b> To examine the association between longitudinal exposure to hyperoxemia and mortality in patients admitted to ICUs in five United Kingdom university hospitals.<b>Methods:</b> A retrospective cohort of ICU admissions between January 31, 2014, ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(11):1373-1380]

Cited: 10 times

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Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.

Ewan C Goligher, Alain Combes, Daniel Brodie, Niall D Ferguson, Antonio M Pesenti, V Marco Ranieri, Arthur S Slutsky, ,

<h4>Purpose</h4>To describe the variability and determinants of the effect of extracorporeal CO<sub>2</sub> removal (ECCO<sub>2</sub>R) on tidal volume (V<sub>t</sub>), driving pressure (ΔP), and mechanical power (Power<sub>RS</sub>) and to determine whether highly responsive patients can be identified for the purpose of predictive enrichment in ECCO<sub>2</sub>R trial design.<h4>Methods</h4>Using data from the SUPERNOVA trial ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(9):1219-1230]

Cited: 12 times

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Enough Is As Good As a Feast.

Richard Beale,

Crit Care Med (Critical care medicine)
[2019, 47(7):1004-1006]

Cited: 0 times

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Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa.

Jonathan D Edgeworth, Domenico Merante, Sanjay Patel, Christopher Young, Paul Jones, Seema Vithlani, Duncan Wyncoll, Peter Roberts, Andrew Jones, Tsutae Den Nagata, Mari Ariyasu, David M Livermore, Richard Beale,

Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(11):1932-1934]

Cited: 14 times

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Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.

Alain Combes, Vito Fanelli, Tai Pham, V Marco Ranieri, ,

<h4>Purpose</h4>We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) to facilitate ultra-protective ventilation (V<sub>T</sub> 4 mL/kg and P<sub>PLAT</sub> ≤ 25 cmH<sub>2</sub>O) in patients with moderate acute respiratory distress syndrome (ARDS).<h4>Methods</h4>Prospective multicenter international phase 2 study. Primary endpoint was the proportion of patients achieving ultra-protective ventilation with PaCO<sub>2</sub> not increasing more than 20% ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(5):592-600]

Cited: 46 times

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COUNTERPOINT: Should the Surviving Sepsis Campaign Guidelines Be Retired? No.

Mitchell M Levy, Andrew Rhodes, Laura E Evans, ,

Chest (Chest)
[2019, 155(1):14-17]

Cited: 5 times

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Rebuttal From Drs Levy, Rhodes, and Evans.

Mitchell M Levy, Andrew Rhodes, Laura E Evans, ,

Chest (Chest)
[2019, 155(1):19-20]

Cited: 1 time

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Optimal intensive care outcome prediction over time using machine learning.

Christopher Meiring, Abhishek Dixit, Steve Harris, Niall S MacCallum, David A Brealey, Peter J Watkinson, Andrew Jones, Simon Ashworth, Richard Beale, Stephen J Brett, Mervyn Singer, Ari Ercole,

<h4>Background</h4>Prognostication is an essential tool for risk adjustment and decision making in the intensive care unit (ICU). Research into prognostication in ICU has so far been limited to data from admission or the first 24 hours. Most ICU admissions last longer than this, decisions are made throughout an admission, and ... Read more >>

PLoS One (PloS one)
[2018, 13(11):e0206862]

Cited: 15 times

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Too Much Pressure at the Bedside...

Richard Beale,

Crit Care Med (Critical care medicine)
[2018, 46(10):1698-1700]

Cited: 0 times

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Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database.

Steve Harris, Sinan Shi, David Brealey, Niall S MacCallum, Spiros Denaxas, David Perez-Suarez, Ari Ercole, Peter Watkinson, Andrew Jones, Simon Ashworth, Richard Beale, Duncan Young, Stephen Brett, Mervyn Singer,

<h4>Objective</h4>To build and curate a linkable multi-centre database of high resolution longitudinal electronic health records (EHR) from adult Intensive Care Units (ICU). To develop a set of open-source tools to make these data 'research ready' while protecting patient's privacy with a particular focus on anonymisation.<h4>Materials and methods</h4>We developed a scalable ... Read more >>

Int J Med Inform (International journal of medical informatics)
[2018, 112:82-89]

Cited: 14 times

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Correction to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study.

Yasser Sakr, Ricard Ferrer, Konrad Reinhart, Richard Beale, Andrew Rhodes, Rui Moreno, Jean Francois Timsit, Laurent Brochard, B Taylor Thompson, Ederlon Rezende, Jean Daniel Chiche, ,

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(1):144-152]

Cited: 0 times

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Breathing Rate Estimation From the Electrocardiogram and Photoplethysmogram: A Review.

Peter H Charlton, Drew A Birrenkott, Timothy Bonnici, Marco A F Pimentel, Alistair E W Johnson, Jordi Alastruey, Lionel Tarassenko, Peter J Watkinson, Richard Beale, David A Clifton,

Breathing rate (BR) is a key physiological parameter used in a range of clinical settings. Despite its diagnostic and prognostic value, it is still widely measured by counting breaths manually. A plethora of algorithms have been proposed to estimate BR from the electrocardiogram (ECG) and pulse oximetry (photoplethysmogram, PPG) signals. ... Read more >>

IEEE Rev Biomed Eng (IEEE reviews in biomedical engineering)
[2018, 11:2-20]

Cited: 26 times

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Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis.

Manu Shankar-Hari, David Fear, Paul Lavender, Tracey Mare, Richard Beale, Chad Swanson, Mervyn Singer, Jo Spencer,

<h4>Objective</h4>Sepsis is life-threatening organ dysfunction due to dysregulated host responses to infection. Current knowledge of human B-cell alterations in sepsis is sparse. We tested the hypothesis that B-cell loss in sepsis involves distinct subpopulations of B cells and investigated mechanisms of B-cell depletion.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Critical care units.<h4>Patients</h4>Adult sepsis patients without ... Read more >>

Crit Care Med (Critical care medicine)
[2017, 45(5):875-882]

Cited: 23 times

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Extraction of respiratory signals from the electrocardiogram and photoplethysmogram: technical and physiological determinants.

Peter H Charlton, Timothy Bonnici, Lionel Tarassenko, Jordi Alastruey, David A Clifton, Richard Beale, Peter J Watkinson,

<h4>Objective</h4>Breathing rate (BR) can be estimated by extracting respiratory signals from the electrocardiogram (ECG) or photoplethysmogram (PPG). The extracted respiratory signals may be influenced by several technical and physiological factors. In this study, our aim was to determine how technical and physiological factors influence the quality of respiratory signals.<h4>Approach</h4>Using a ... Read more >>

Physiol Meas (Physiological measurement)
[2017, 38(5):669-690]

Cited: 17 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuck Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger,

<h4>Objective</h4>To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012."<h4>Design</h4>A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was ... Read more >>

Crit Care Med (Critical care medicine)
[2017, 45(3):486-552]

Cited: 809 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger,

<h4>Objective</h4>To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012".<h4>Design</h4>A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was ... Read more >>

Intensive Care Med (Intensive care medicine)
[2017, 43(3):304-377]

Cited: 1460 times

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Short-term and medium-term survival of critically ill patients with solid tumours admitted to the intensive care unit: a retrospective analysis.

Richard Fisher, Carole Dangoisse, Siobhan Crichton, Craig Whiteley, Luigi Camporota, Richard Beale, Marlies Ostermann,

<h4>Objectives</h4>Patients with cancer frequently require unplanned admission to the intensive care unit (ICU). Our objectives were to assess hospital and 180-day mortality in patients with a non-haematological malignancy and unplanned ICU admission and to identify which factors present on admission were the best predictors of mortality.<h4>Design</h4>Retrospective review of all patients ... Read more >>

BMJ Open (BMJ open)
[2016, 6(10):e011363]

Cited: 14 times

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Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.

Anthony C Gordon, Alexina J Mason, Neeraja Thirunavukkarasu, Gavin D Perkins, Maurizio Cecconi, Magda Cepkova, David G Pogson, Hollmann D Aya, Aisha Anjum, Gregory J Frazier, Shalini Santhakumaran, Deborah Ashby, Stephen J Brett, ,

<h4>Importance</h4>Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative.<h4>Objective</h4>To compare the effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock.<h4>Design, setting, and participants</h4>A factorial (2×2), double-blind, randomized clinical trial conducted in 18 general ... Read more >>

JAMA (JAMA)
[2016, 316(5):509-518]

Cited: 136 times

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Targeting cytokines as a treatment for patients with sepsis: A lost cause or a strategy still worthy of pursuit?

K Alun Brown, Geraint A Brown, Sion M Lewis, Richard Beale, David F Treacher,

Despite often knowing the aetiology of sepsis and its clinical course there has not been the anticipated advances in treatment strategies. Cytokines are influential mediators of immune/inflammatory reactions and in patients with sepsis high circulating levels are implicated in the onset and perpetuation of organ failure. Antagonising the activities of ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2016, 36:291-299]

Cited: 12 times

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