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The preterm infant-parent programme for attachment-PIPPA Study: a randomised controlled trial.

Aoife Twohig, John F Murphy, Anthony McCarthy, Ricardo Segurado, Angela Underdown, Anna Smyke, Fiona McNicholas, Eleanor J Molloy,

<h4>Background</h4>There is increasing recognition of adverse mental health consequences of preterm birth and the impact on social-emotional development. However, the quality of the developing parent-infant relationship may be protective, with enhanced maternal sensitivity to infants' cues associated with improved outcomes.<h4>Methods</h4>Eighty mothers and their preterm infants born <32 weeks gestation were ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Sexual dimorphism and the placenta - results from the ROLO kids study.

Jean M T Donnelly, Mary Horan, Ricardo Segurado, Eoghan E Mooney, Shannon French, Eleanor J Molloy, Fionnuala M McAuliffe,

<h4>Background/aims</h4>To assess the association between placental morphology and neonatal and infant anthropometry, including analysis by sex.<h4>Study design</h4>Data from the ROLO Kids [Randomized COntrol Trial of LOw Glycaemic Index in Pregnancy] study were analyzed including placental weight and morphology. Placental, anthropometric and skinfold measurements were recorded as markers of adiposity in ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-7]

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[email protected]: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol

Linda O'Neill, Emer Guinan, Suzanne Doyle, Louise O'Connor, Grainne Sheill, Emily Smyth, Ciaran Fairman, Ricardo Segurado, Deirdre Connolly, Jacintha O'Sullivan, John Reynolds, Juliette Hussey,

<ns5:p><ns5:bold>Background:</ns5:bold> Exercise rehabilitation programmes, traditionally involving supervised exercise sessions, have had to rapidly adapt to virtual delivery in response to the coronavirus disease 2019 (COVID-19) pandemic to minimise patient contacts. In the absence of an effective vaccine, the pandemic is likely to persist in the medium term and during this ... Read more >>

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Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT)

Linda O'Neill, Peter Knapp, Suzanne Doyle, Emer Guinan, Adwoa Parker, Ricardo Segurado, Deirdre Connolly, Jacintha O'Sullivan, John Reynolds, Juliette Hussey,

<ns3:p> <h4>Background: </h4> Whilst the potential benefits of exercise rehabilitation in cancer survivorship are plentiful, recruitment to survivorship rehabilitation trials remains suboptimal. There is growing evidence that Public and Patient Involvement (PPI) initiatives can increase the rate of recruitment to research. This study within a trial (SWAT) will examine if ... Read more >>

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Multidisciplinary-based Rehabilitation (MBR) Compared With Active Physical Interventions for Pain and Disability in Adults With Chronic Pain: A Systematic Review and Meta-analysis.

Máire-Bríd Casey, Keith M Smart, Ricardo Segurado, Catherine Doody,

<h4>Objective</h4>This systematic review and meta-analysis examined the effectiveness of multidisciplinary-based rehabilitation (MBR) in comparison with active physical interventions for adults with chronic pain.<h4>Materials and methods</h4>The review was conducted in line with the recommendations provided in the Cochrane Handbook for Systematic Reviews and is reported in accordance with the Preferred Reporting ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, 36(11):874-886]

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Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS).

Deirdre A Hurley, Isabelle Jeffares, Amanda M Hall, Alison Keogh, Elaine Toomey, Danielle McArdle, Suzanne M McDonough, Suzanne Guerin, Ricardo Segurado, James Matthews,

<h4>Background</h4>The self-management of osteoarthritis (OA) and low back pain (LBP) through activity and skills (SOLAS) theory-driven group-based complex intervention was developed primarily for the evaluation of its acceptability to patients and physiotherapists and the feasibility of trial procedures, to inform the potential for a definitive trial.<h4>Methods</h4>This assessor-blinded multicentre two-arm parallel ... Read more >>

Trials (Trials)
[2020, 21(1):807]

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Sedative Load in Community-Dwelling Older Adults with Mild-Moderate Alzheimer's Disease: Longitudinal Relationships with Adverse Events, Delirium and Falls.

Adam H Dyer, Claire Murphy, Brian Lawlor, Sean P Kennelly, ,

<h4>Background</h4>Older adults are frequently prescribed medications with sedative effects, which are associated with numerous adverse consequences. However, the prevalence and longitudinal associations of sedative medication use in community-dwelling older adults with mild-moderate Alzheimer's disease (AD) has not been explored to date.<h4>Objectives</h4>Our objective was to assess the prevalence of sedative medication ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(11):829-837]

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Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Deirdre Hurley, Isabelle Jeffares, Amanda Hall, Alison Keogh, Elaine Toomey, Danielle McArdle, Suzanne McDonough, Suzanne Guerin, Ricardo Segurado, James Matthews,

<h4>Background: </h4> The Self-management of Osteoarthritis (OA) and Low back pain (LBP) through Activity and Skills (SOLAS) theory-driven group-based complex intervention was developed primarily for the evaluation of its acceptability to patients and physiotherapists and the feasibility of trial procedures, to inform the potential for a definitive trial. <h4>Methods: </h4> ... Read more >>

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The impact of introducing nurse-led analgesia and sedation guidelines in ventilated infants following cardiac surgery.

Claire Magner, Abraham J Valkenburg, Dermot Doherty, Monique van Dijk, Brendan O'Hare, Ricardo Segurado, Seamus Cowman,

INTRODUCTION:Enhanced clinical outcomes in the Paediatric Intensive Care Unit following standardisation of analgesia and sedation practice are reported. Little is known about the impact of standardisation of analgesia and sedation practice including incorporation of a validated distress assessment instrument on infants post cardiac surgery, a subset of whom have Trisomy ... Read more >>

Intensive Crit Care Nurs (Intensive & critical care nursing)
[2020, 60:102879]

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Rehabilitation strategies following oesophagogastric and Hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomized controlled trial.

Linda O'Neill, Emer Guinan, Suzanne Doyle, Deirdre Connolly, Jacintha O'Sullivan, Annemarie Bennett, Grainne Sheill, Ricardo Segurado, Peter Knapp, Ciaran Fairman, Charles Normand, Justin Geoghegan, Kevin Conlon, John V Reynolds, Juliette Hussey,

BACKGROUND:Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With advancing survival rates, there is an emergent cohort of UGI and HPB cancer survivors with physical and nutritional deficits, resultant from both the cancer and its treatments. Therefore, rehabilitation ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):415]

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Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?

Adam H Dyer, Claire Murphy, Ricardo Segurado, Brian Lawlor, Sean P Kennelly, ,

<h4>Background</h4>Use of anticholinergic medication is associated with an increased risk of cognitive impairment and/or dementia. Despite this, the impact of continuing medication with anticholinergic properties in those diagnosed with Alzheimer's Disease (AD) is not clear.<h4>Methods</h4>Analysis of data from NILVAD, an 18-month randomized controlled trial of Nilvadipine in AD. Effects of ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2020, 75(5):987-994]

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Gait speed, cognition and falls in people living with mild-to-moderate Alzheimer disease: data from NILVAD.

Adam H Dyer, Brian Lawlor, Sean P Kennelly, ,

<h4>Background</h4>Previous evidence suggests that slower gait speed is longitudinally associated with cognitive impairment, dementia and falls in older adults. Despite this, the longitudinal relationship between gait speed, cognition and falls in those with a diagnosis of dementia remains poorly explored. We sought to assess this longitudinal relationship in a cohort ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):117]

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Challenges in assessing contamination levels and novel decontamination technologies in the critical care setting.

Aoife D Kearney, Maria A Boyle, Sharath K Babu, Muireann Fallon, Ricardo Segurado, Mary Codd, James O'Rourke, Niall T Stevens, Philip C Carling, Stephen Daniels, Hilary Humphreys,

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2020, 41(5):622-623]

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Limited Impact of Fetal Sex and Maternal Body Mass Index on Fetal and Maternal Insulin Resistance and Lipid Metabolism: Findings from the PEARs Study.

Anthony R Rafferty, Aisling A Geraghty, Maria A Kennelly, Eileen C O'Brien, Reshma Merin Reji, John Mehegan, Ricardo Segurado, Thomas Smith, Orla Maguire, Martina Cronin, Fionnuala M McAuliffe,

The intrauterine environment can have a significant impact on fetal and maternal well-being, both during pregnancy and in later life. We aimed to identify how fetal sex and maternal body mass index (BMI) influence insulin resistance and metabolic function during pregnancy with maternal BMI > 25 kg/m<sup>2</sup>. This secondary analysis assessed data ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2020, 27(2):513-522]

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Is there an app for that? A cluster randomised controlled trial of a mobile app-based mental health intervention.

Rachel Kenny, Amanda Fitzgerald, Ricardo Segurado, Barbara Dooley,

Demand for the use of mobile apps in mental health interventions has grown in recent years, particularly among adolescents who experience elevated levels of distress. However, there is a scarcity of evidence for the effectiveness of these tools within this population. The aim of this study was to test the ... Read more >>

Health Informatics J (Health informatics journal)
[2020, 26(3):1538-1559]

Cited: 2 times

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Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT).

Linda O'Neill, Peter Knapp, Suzanne L Doyle, Emer Guinan, Adwoa Parker, Ricardo Segurado, Deirdre Connolly, Jacintha O'Sullivan, John V Reynolds, Juliette Hussey,

Background: Whilst the potential benefits of exercise rehabilitation in cancer survivorship are plentiful, recruitment to survivorship rehabilitation trials remains suboptimal. There is growing evidence that Public and Patient Involvement (PPI) initiatives can increase the rate of recruitment to research. This study within a trial (SWAT) will examine if participant information ... Read more >>

HRB Open Res (HRB open research)
[2019, 2:27]

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Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD.

Adam H Dyer, Claire Murphy, Brian Lawlor, Sean P Kennelly, ,

<h4>Objective</h4>Benzodiazepines and related drugs (BDZRs) have been associated with an increased risk of Alzheimer's disease (AD) in later life. Despite this, it remains unclear whether ongoing BDZR use may further accelerate cognitive decline in those diagnosed with mild to moderate AD.<h4>Design</h4>This study was embedded within NILVAD, a randomized controlled trial ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, 21(2):194-200]

Cited: 1 time

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Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: individual participant data meta-analysis.

Eileen C O'Brien, Ricardo Segurado, Aisling A Geraghty, Goiuri Alberdi, Ewelina Rogozinska, Arne Astrup, Rubenomar Barakat Carballo, Annick Bogaerts, Jose Guilherme Cecatti, Arri Coomarasamy, Christianne J M de Groot, Roland Devlieger, Jodie M Dodd, Nermeen El Beltagy, Fabio Facchinetti, Nina Geiker, Kym Guelfi, Lene Haakstad, Cheryce Harrison, Hans Hauner, Dorte M Jensen, Khalid Khan, Tarja Inkeri Kinnunen, Riitta Luoto, Ben Willem Mol, Siv Mørkved, Narges Motahari-Tabari, Julie A Owens, Maria Perales, Elisabetta Petrella, Suzanne Phelan, Lucilla Poston, Kathrin Rauh, Girish Rayanagoudar, Kristina M Renault, Anneloes E Ruifrok, Linda Sagedal, Kjell Å Salvesen, Tania T Scudeller, Gary Shen, Alexis Shub, Signe N Stafne, Fernanda G Surita, Shakila Thangaratinam, Serena Tonstad, Mireille N M van Poppel, Christina Vinter, Ingvild Vistad, SeonAe Yeo, Fionnuala M McAuliffe, ,

<h4>Objectives</h4>To identify if maternal educational attainment is a prognostic factor for gestational weight gain (GWG), and to determine the differential effects of lifestyle interventions (diet based, physical activity based or mixed approach) on GWG, stratified by educational attainment.<h4>Design</h4>Individual participant data meta-analysis using the previously established International Weight Management in Pregnancy ... Read more >>

BMJ Open (BMJ open)
[2019, 9(8):e025620]

Cited: 0 times

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Community first responders for out-of-hospital cardiac arrest in adults and children.

Tomas Barry, Maeve C Doheny, Siobhán Masterson, Niall Conroy, Jan Klimas, Ricardo Segurado, Mary Codd, Gerard Bury,

<h4>Background</h4>Mobilization of community first responders (CFRs) to the scene of an out-of-hospital cardiac arrest (OHCA) event has been proposed as a means of shortening the interval from occurrence of cardiac arrest to performance of cardiopulmonary resuscitation (CPR) and defibrillation, thereby increasing patient survival.<h4>Objectives</h4>To assess the effect of mobilizing community first ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 7:CD012764]

Cited: 4 times

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Exploring Covariation between Traditional Markers of Metabolic Health and the Plasma Metabolomic Profile: A Classic Twin Design.

Kate M Bermingham, Lorraine Brennan, Ricardo Segurado, Rebecca E Barron, Eileen R Gibney, Miriam F Ryan, Michael J Gibney, Aifric M O'Sullivan,

Novel metabolomic profiling techniques combined with traditional biomarkers provide knowledge of mechanisms underlying metabolic health. Twin studies describe the impact of genes and environment on variation in traits. This study aims to identify relationships between traditional markers of metabolic health and the plasma metabolomic profile using a twin modeling approach ... Read more >>

J Proteome Res (Journal of proteome research)
[2019, 18(6):2613-2623]

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Cesarean delivery rates using Robson classification system in Ireland: What can we learn?

David A Crosby, Martina M Murphy, Ricardo Segurado, Fionnuala Byrne, Rhona Mahony, Michael Robson, Fionnuala M McAuliffe,

OBJECTIVE:It has been proposed that the Robson Ten-Group Classification System be used as a global standard for assessing, monitoring and comparing cesarean delivery (CD) rates within and between maternity services. Our objective was to compare the change of CD rates within the 10-Group Classification System in our institution over 10 years. ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 236:121-126]

Cited: 2 times

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Changes in knee joint angle affect torque steadiness differently in young and older individuals.

Rui Wu, Eamonn Delahunt, Massimiliano Ditroilo, Madeleine M Lowery, Ricardo Segurado, Giuseppe De Vito,

<h4>Purpose</h4>This study investigated the effect of knee joint angle and age on torque steadiness of knee extensors (KE) at varying submaximal isometric contractions.<h4>Methods</h4>22 young (24.0 ± 2.6 years; 11 women) and 22 older (69.4 ± 2.4 years; 10 women) healthy men and women participated. Maximal voluntary isometric contraction (MVIC) of the KE and flexors was examined ... Read more >>

J Electromyogr Kinesiol (Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology)
[2019, 47:49-56]

Cited: 0 times

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Fetal growth trajectories and their association with maternal and child characteristics.

Helena C Bartels, Clare O'Connor, Ricardo Segurado, Olivia Mason, John Mehegan, Aisling A Geraghty, Eileen O'Brien, Jennifer Walsh, Fionnuala McAuliffe,

<b>Background:</b> The growth of the fetus is a complex process, influenced by genetic and environmental factors. Longitudinal patterns of fetal growth are required to fully understand this process, however to date, a paucity of data exists in this area.Objective: To identify fetal growth trajectories in-utero and to assess their association ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(14):2427-2433]

Cited: 0 times

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Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 2; peer review: 2 approved]

Linda O'Neill, Peter Knapp, Suzanne L. Doyle, Emer Guinan, Adwoa Parker, Ricardo Segurado, Deirdre Connolly, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey,

Background: Whilst the potential benefits of exercise rehabilitation in cancer survivorship are plentiful, recruitment to survivorship rehabilitation trials remains suboptimal. There is growing evidence that Public and Patient Involvement (PPI) initiatives can increase the rate of recruitment to research. This study within a trial (SWAT) will examine if participant information ... Read more >>

HRB Open Res (HRB open research)
[2019, 2:]

Cited: 0 times

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Maternal protein intake during pregnancy is associated with child growth up to 5 years of age, but not through insulin-like growth factor-1: findings from the ROLO study.

Aisling A Geraghty, Eileen C O'Brien, Goiuri Alberdi, Mary K Horan, Jean Donnelly, Elizabeth Larkin, Ricardo Segurado, John Mehegan, Eleanor J Molloy, Fionnuala M McAuliffe,

Infant protein intake has been associated with child growth, however, research on maternal protein intake during pregnancy is limited. Insulin-like growth factors (IGF) play a role in early fetal development and maternal protein intake may influence child body composition via IGF-1. The aim of this study was to investigate the ... Read more >>

Br J Nutr (The British journal of nutrition)
[2018, 120(11):1252-1261]

Cited: 1 time

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