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Author Renzo Colombo

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Is There a Detrimental Effect of Antibiotic Therapy in Patients with Muscle-invasive Bladder Cancer Treated with Neoadjuvant Pembrolizumab?

Filippo Pederzoli, Marco Bandini, Daniele Raggi, Laura Marandino, Giuseppe Basile, Massimo Alfano, Renzo Colombo, Andrea Salonia, Alberto Briganti, Andrea Gallina, Francesco Montorsi, Andrea Necchi,

In locally advanced and metastatic malignancies, antibiotic (ATB) therapy has a negative effect on immunotherapy efficacy. Therefore, we aimed to evaluate whether ATB therapy and use of specific ATB classes with concomitant neoadjuvant pembrolizumab affected pathologic complete response (ypT0N0) and relapse-free survival (RFS) for patients with clinical T2-4N0M0 bladder cancer ... Read more >>

Eur Urol (European urology)
[2021, :]

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Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guérin immunotherapy for T1G3/HG bladder cancer.

David D'Andrea, Francesco Soria, Anne J Grotenhuis, Eugene K Cha, Nuria Malats, Savino Di Stasi, Steven Joniau, Tommaso Cai, Bas W G van Rhijn, Jaques Irani, Jeffrey Karnes, John Varkarakis, Jack Baniel, Joan Palou, Marek Babjuk, Martin Spahn, Peter Ardelt, Renzo Colombo, Vincenzo Serretta, Guido Dalbagni, Paolo Gontero, Riccardo Bartoletti, Stephane Larré, Per-Uno Malmstrom, Richard Sylvester, Shahrokh F Shariat,

<h4>Purpose</h4>To investigate the association of patients' sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette-Guérin (BCG) for T1G3/HG urinary bladder cancer (UBC).<h4>Materials and methods</h4>We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Protocol of the Italian Radical Cystectomy Registry (RIC): a non-randomized, 24-month, multicenter study comparing robotic-assisted, laparoscopic, and open surgery for radical cystectomy in bladder cancer.

Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis, Ottavio De Cobelli, Fabrizio Di Maida, Amelio Ercolino, Franco Gaboardi, Antonio Galfano, Andrea Gallina, Michele Gallucci, Carlo Introini, Ettore Mearini, Andrea Minervini, Francesco Montorsi, Gennaro Musi, Giovannalberto Pini, Riccardo Schiavina, Silvia Secco, Sergio Serni, Claudio Simeone, Giovanni Tasso, Daniele D'Agostino,

<h4>Background</h4>Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radical cystectomy. The aim ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):51]

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Predicting the Pathologic Complete Response After Neoadjuvant Pembrolizumab in Muscle-Invasive Bladder Cancer.

Marco Bandini, Jeffrey S Ross, Daniele Raggi, Andrea Gallina, Maurizio Colecchia, Roberta Lucianò, Patrizia Giannatempo, Elena Farè, Filippo Pederzoli, Marco Bianchi, Renzo Colombo, Giorgio Gandaglia, Nicola Fossati, Laura Marandino, Umberto Capitanio, Federico Deho', Siraj M Ali, Russell Madison, Jon H Chung, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Andrea Necchi,

<h4>Background</h4>In the PURE-01 study (NCT02736266), we aimed to evaluate the ability to predict the pathologic complete response (pT0N0) after pembrolizumab by using clinical and tumor biomarkers.<h4>Methods</h4>In an open-label, single-arm, phase 2 study, 3 courses of 200 mg pembrolizumab preceding radical cystectomy were administered in patients with T2-4aN0M0 muscle-invasive bladder cancer. The ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, 113(1):48-53]

Cited: 2 times

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Perioperative and oncologic outcomes of open radical nephrectomy and inferior vena cava thrombectomy with liver mobilization and Pringle maneuver for Mayo III level tumor thrombus: single institution experience.

Alessandro Nini, Fabio Muttin, Francesco Cianflone, Cristina Carenzi, Roberta Lucianó, Marco Catena, Alessandro Larcher, Marco Salvioni, Walter Cazzaniga, Filippo Pederzoli, Rayan Matloob, Renzo Colombo, Michele Paganelli, Andrea Salonia, Alberto Briganti, Claudio Doglioni, Alberto Zangrillo, Francesco De Cobelli, Patrizio Rigatti, Massimo Freschi, Guglielmo Cornero, Roberto Nicoletti, Luca Aldrighetti, Francesco Montorsi, Umberto Capitanio, Roberto Bertini,

<h4>Background</h4>Scarce data are available regarding the technique and outcomes for patients with RCC and Mayo III caval thrombi. To report surgical and oncological outcomes of RCC patients with Mayo III thrombi treated with radical nephrectomy and thrombectomy after liver mobilization (LM) and Pringle Manoeuvre (PM).<h4>Methods</h4>Retrospective analysis of surgical technique, outcomes ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, :]

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Prediction of the Need for an Extended Lymphadenectomy at the Time of Radical Cystectomy in Patients with Bladder Cancer.

Marco Moschini, Luca Afferi, Giorgio Gandaglia, David D'Andrea, Stefania Zamboni, Carlo Di Bona, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Alberto Martini, Giusy Burgio, Shahrokh F Shariat, Rafael Sanchez-Salas, Xavier Cathelineau, Armando Stabile, Emanuele Zaffuto, Andrea Salonia, Renzo Colombo, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Andrea Gallina,

<h4>Background</h4>A prospective randomized trial (LEA AUO AB 25/02) found no survival benefit in extended compared with limited pelvic lymph node dissection (PLND) templates in bladder cancer (BCa) patients treated with radical cystectomy (RC). However, the rate of lymph node invasion (LNI) in the standard and extended templates was lower than ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Adjuvant chemotherapy is ineffective in patients with bladder cancer and variant histology treated with radical cystectomy with curative intent.

Stefania Zamboni, Luca Afferi, Francesco Soria, Atiqullah Aziz, Mohammad Abufaraj, Cedric Poyet, Andrea Necchi, David D'Andrea, Giuseppe Simone, Mariaconsiglia Ferriero, Ettore Di Trapani, Claudio Simeone, Alessandro Antonelli, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Giorgio Gandaglia, Agostino Mattei, Philipp Baumeister, Livio Mordasini, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Shahrokh F Shariat, Evanguelous Xylinas, Marco Moschini,

<h4>Objectives</h4>Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT on survival outcomes in ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The Value of Multiparametric Magnetic Resonance Imaging Sequences to Assist in the Decision Making of Muscle-invasive Bladder Cancer.

Marco Bandini, Giuseppina Calareso, Daniele Raggi, Laura Marandino, Maurizio Colecchia, Andrea Gallina, Patrizia Giannatempo, Filippo Pederzoli, Giorgio Gandaglia, Nicola Fossati, Umberto Capitanio, Renzo Colombo, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Francesco De Cobelli, Antonella Messina, Andrea Necchi,

Interim data from the PURE-01 study, using pembrolizumab before radical cystectomy in muscle-invasive bladder cancer (MIBC), suggested that multiparametric magnetic resonance imaging (mpMRI) was able to predict the pathologic response. Owing to the availability of novel effective therapies in MIBC, the possibility to assess tumor response easily has become exceedingly ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

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Hospital care in Departments defined as COVID-free: A proposal for a safe hospitalization protecting healthcare professionals and patients not affected by COVID-19.

Rosario Leonardi, Piera Bellinzoni, Luigi Broglia, Renzo Colombo, Davide De Marchi, Lorenzo Falcone, Guido Giusti, Vincenzo Grasso, Guglielmo Mantica, Giovanni Passaretti, Silvia Proietti, Antonio Russo, Giuseppe Saitta, Salvatore Smelzo, Nazareno Suardi, Franco Gaboardi,

The COVID-19 pandemic influenced the normal course of clinical practice leading to significant delays in the delivery of healthcare services for patients non affected by COVID-19. In the near future, it will be crucial to identify facilities capable of providing health care in compliance with the safety of healthcare professionals, ... Read more >>

Arch Ital Urol Androl (Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica)
[2020, 92(2):]

Cited: 3 times

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Sex-specific Alterations in the Urinary and Tissue Microbiome in Therapy-naïve Urothelial Bladder Cancer Patients.

Filippo Pederzoli, Roberto Ferrarese, Virginia Amato, Irene Locatelli, Elisa Alchera, Roberta Lucianò, Manuela Nebuloni, Alberto Briganti, Andrea Gallina, Renzo Colombo, Andrea Necchi, Massimo Clementi, Francesco Montorsi, Nicasio Mancini, Andrea Salonia, Massimo Alfano,

Comprehensive characterization of the urinary and urothelium-bound microbiomes in bladder cancer (BCa) and healthy state is essential to understand how these local microbiomes may play a role in BCa tumorigenesis and response to therapy, as well as to explain sex-based differences in BCa pathobiology. Performing 16 s rDNA microbiome analysis on ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):784-788]

Cited: 3 times

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Impact of Molecular Subtyping and Immune Infiltration on Pathological Response and Outcome Following Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer.

Andrea Necchi, Daniele Raggi, Andrea Gallina, Jeffrey S Ross, Elena Farè, Patrizia Giannatempo, Laura Marandino, Maurizio Colecchia, Roberta Lucianò, Marco Bianchi, Renzo Colombo, Andrea Salonia, Giorgio Gandaglia, Nicola Fossati, Marco Bandini, Filippo Pederzoli, Umberto Capitanio, Francesco Montorsi, Joep J de Jong, Ryan Dittamore, Yang Liu, Elai Davicioni, Joost L Boormans, Alberto Briganti, Peter C Black, Ewan A Gibb,

BACKGROUND:The PURE-01 study (NCT02736266) evaluated the use of pembrolizumab before radical cystectomy (RC) in muscle-invasive bladder cancer (MIBC). OBJECTIVE:To evaluate the ability of molecular signatures to predict the pathological complete response (CR: ypT0N0) and progression-free survival (PFS) after pembrolizumab and RC. DESIGN, SETTING, AND PARTICIPANTS:We analyzed the expression data from ... Read more >>

Eur Urol (European urology)
[2020, 77(6):701-710]

Cited: 16 times

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Surgical Safety of Radical Cystectomy and Pelvic Lymph Node Dissection Following Neoadjuvant Pembrolizumab in Patients with Bladder Cancer: Prospective Assessment of Perioperative Outcomes from the PURE-01 Trial.

Alberto Briganti, Giorgio Gandaglia, Simone Scuderi, Andrea Gallina, Renzo Colombo, Nicola Fossati, Francesco Barletta, Antony Pellegrino, Luigi Nocera, Francesco Montorsi, Andrea Necchi,

No data are available on the surgical safety of radical cystectomy (RC) and pelvic lymph node dissection (PLND) after the administration of checkpoint inhibitors. We aimed at reporting the first prospective rigorous assessment of perioperative outcomes after RC and extended PLND following neoadjuvant pembrolizumab in a contemporary cohort of patients ... Read more >>

Eur Urol (European urology)
[2020, 77(5):576-580]

Cited: 1 time

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Multiparametric Magnetic Resonance Imaging as a Noninvasive Assessment of Tumor Response to Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer: Preliminary Findings from the PURE-01 Study.

Andrea Necchi, Marco Bandini, Giuseppina Calareso, Daniele Raggi, Filippo Pederzoli, Elena Farè, Maurizio Colecchia, Laura Marandino, Marco Bianchi, Andrea Gallina, Renzo Colombo, Nicola Fossati, Giorgio Gandaglia, Umberto Capitanio, Federico Dehò, Patrizia Giannatempo, Roberta Lucianò, Andrea Salonia, Russell Madison, Siraj M Ali, Jon H Chung, Jeffrey S Ross, Alberto Briganti, Francesco Montorsi, Francesco De Cobelli, Antonella Messina,

<h4>Background</h4>In the PURE-01 study, pembrolizumab was given preoperatively before radical cystectomy in clinical T2-4aN0M0 patients. An accurate clinical response assessment may be useful for developing new perioperative strategies in these patients.<h4>Objective</h4>To evaluate the association between bladder multiparametric magnetic resonance imaging (mpMRI) findings after pembrolizumab and the pathological complete response (CR; ... Read more >>

Eur Urol (European urology)
[2020, 77(5):636-643]

Cited: 4 times

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Updated Results of PURE-01 with Preliminary Activity of Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Carcinoma with Variant Histologies.

Andrea Necchi, Daniele Raggi, Andrea Gallina, Russell Madison, Maurizio Colecchia, Roberta Lucianò, Rodolfo Montironi, Patrizia Giannatempo, Elena Farè, Filippo Pederzoli, Marco Bandini, Marco Bianchi, Renzo Colombo, Giorgio Gandaglia, Nicola Fossati, Laura Marandino, Umberto Capitanio, Federico Dehò, Siraj M Ali, Jon H Chung, Jeffrey S Ross, Andrea Salonia, Alberto Briganti, Francesco Montorsi,

<h4>Background</h4>Patients with predominant variant histology (VH) of bladder tumors, defined as involving >50 % of the tumor specimens, are typically excluded from clinical trials, and for these patients, the efficacy of standard chemotherapy is limited.<h4>Objective</h4>To evaluate the activity of preoperative pembrolizumab in patients with muscle-invasive bladder carcinoma (MIBC) and VH, ... Read more >>

Eur Urol (European urology)
[2020, 77(4):439-446]

Cited: 16 times

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Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases.

Paolo Gontero, Francesca Pisano, Joan Palou, Steven Joniau, Maarten Albersen, Renzo Colombo, Alberto Briganti, Federico Pellucchi, Oscar Rodriguez Faba, Bas W van Rhijn, Elies Fransen van de Putte, Marko Babjuk, Hanz Martin Fritsche, Roman Mayr, Peter Albers, Gunter Niegisch, Julien Anract, Alexandra Masson-Lecomte, Alexandre De la Taille, Morgan Roupret, Benoit Peyronnet, Tomaso Cai, Alfred J Witjes, Max Bruins, Jack Baniel, Roy Mano, Alberto Lapini, Francesco Sessa, Jaques Irani, Maurizio Brausi, Arnulf Stenzl, Jeffrey R Karnes, Douglas Scherr, Padraic O'Malley, Benjamin Taylor, Shahrokh F Shariat, Peter Black, Hamidreza Abdi, Vsevolod B Matveev, Olga Samuseva, Dipen Parekh, Mark Gonzalgo, Malte W Vetterlein, Atiqullah Aziz, Margit Fisch, James Catto, Karl H Pang, Evanguelos Xylinas, Michael Rink, ,

<h4>Purpose</h4>Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies.<h4>Methods</h4>Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum ... Read more >>

World J Urol (World journal of urology)
[2020, 38(8):1959-1968]

Cited: 2 times

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Predictive factors of the absence of residual disease at repeated transurethral resection of the bladder. Is there a possibility to avoid it in well-selected patients?

Francesco Soria, David D'Andrea, Marco Moschini, Andrea Giordano, Simone Mazzoli, Giuseppe Pizzuto, Rodolfo Hurle, Renzo Colombo, Alberto Briganti, Vincenzo Altieri, Shahrokh F Shariat, Paolo Gontero,

<h4>Purpose</h4>To evaluate the predictive factors of pT0 at repeated transurethral resection of the bladder (re-TURB) in pT1 high-grade (HG) nonmuscle invasive bladder cancer in order to explore the possibility to avoid it in well-selected patients.<h4>Methods</h4>This multicenter retrospective study included patients with pT1HG nonmuscle invasive bladder cancer from 4 different centers ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(3):77.e1-77.e7]

Cited: 1 time

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How to improve patient selection for neoadjuvant chemotherapy in bladder cancer patients candidate for radical cystectomy and pelvic lymph node dissection.

Stefania Zamboni, Marco Moschini, Alessandro Antonelli, Claudio Simeone, Sandra Belotti, Luca Cristinelli, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Andrea Salonia, Renzo Colombo, Livio Mordasini, Agostino Mattei, Philipp Baumeister,

<h4>Purpose</h4>To improve patient selection for neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in bladder cancer patients (BCa).<h4>Methods</h4>Retrospective evaluation of 1057 patients with cT2-4N0M0 BCa treated with RC and pelvic lymph node dissection between 1990 and 2018 at 3 referral centers. Adverse pathologic features (APF) were defined as pT3-pT4/pN + disease at RC. ... Read more >>

World J Urol (World journal of urology)
[2020, 38(5):1229-1233]

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The impact of completeness of last transurethral resection of bladder tumors on the outcomes of radical cystectomy.

Stefania Zamboni, Marco Moschini, Andrea Gallina, Renzo Colombo, Francesco Montorsi, Alberto Briganti, Andrea Salonia, Alessandro Antonelli, Claudio Simeone, Sandra Belotti, Luca Cristinelli, Agostino Mattei, Philipp Baumeister,

PURPOSE:To evaluate the role of a complete transurethral resection of bladder tumors (c-TURBT) on oncological outcomes after radical cystectomy (RC) and its relationship with adverse pathological features. METHODS:We retrospectively analyzed data of 727 patients treated with RC and bilateral pelvic lymph node dissection at three tertiary referral centers. Possible c-TURBT ... Read more >>

World J Urol (World journal of urology)
[2019, 37(12):2707-2714]

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Radical Cystectomy in Pathological T4a and T4b Bladder Cancer Patients: Is There Any Space for Sub Stratification?

Marco Moschini, Stefania Zamboni, Agostino Mattei, Philipp Baumeister, Carlo Di Bona, Julian Cornelius, Shahrokh F Shariat, Massimo Freschi, Emanuele Zaffuto, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina, ,

INTRODUCTION:According to TNM staging, pathological T4ab are comprehensive of the invasion of prostate, seminal vesicles, uterus or vagina and pelvic or abdominal wall. However, few data are available on the perioperative and oncological outcomes of specific organ invasion. MATERIALS AND METHODS:A total of 917 consecutive bladder cancer (BCa) patients treated ... Read more >>

Urol Int (Urologia internationalis)
[2019, 102(3):269-276]

Cited: 0 times

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Translation and cultural adaptation of the Computer Vision Syndrome Questionnaire (CVS-Q) into Italian.

Maria Del Mar Seguí-Crespo, Natalia Cantó Sancho, Elena Ronda, Renzo Colombo, Stefano Porru, Angela Carta,

<h4>Background</h4>The original Spanish version of the Computer Vision Syndrome Questionnaire (CVS-Q©) is a validated instrument with good psychometric properties to measure the Computer Visual Syndrome (CVS) in workers exposed to video display terminals (VDT). The Italian version would facilitate research and its use in clinical practice the prevention of occupational ... Read more >>

Med Lav (La Medicina del lavoro)
[2019, 110(1):37-45]

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Evaluation of Cause of Death After Radical Cystectomy for Patients With Bladder Cancer: The Impact of Age at the Time of Surgery.

Marco Moschini, Alberto Martini, Stefania Zamboni, Agostino Mattei, Philipp Baumeister, Carlo Di Bona, Paolo Dell'Oglio, Emanuele Zaffuto, Giusy Burgio, Shahrokh F Shariat, Rafael Sanchez-Salas, Xavier Cathelineau, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo,

<h4>Introduction</h4>Patients with bladder cancer treated with radical cystectomy (RC) have heterogeneous results in term of cancer-specific (CSM) and other cause mortality (OCM). Our aim is to assess the impact of age on cause of death after RC.<h4>Patients and methods</h4>We retrospectively analyzed the data of 1222 patients treated with RC and ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(3):e541-e548]

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Corrigendum re "Neoadjuvant Short-term Intensive Intravesical Mitomycin C Regimen Compared with Weekly Schedule for Low-grade Recurrent Non-muscle-invasive Bladder Cancer: Preliminary Results of a Randomised Phase 2 Study" [Eur Urol 2012;62:797-802].

Renzo Colombo, Lorenzo Rocchini, Nazareno Suardi, Fabio Benigni, Giorgia Colciago, Arianna Bettiga, Federico Pellucchi, Carmen Maccagnano, Alberto Briganti, Andrea Salonia, Patrizio Rigatti, Francesco Montorsi,

Eur Urol (European urology)
[2019, 75(3):e81]

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Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.

Andrea Necchi, Andrea Anichini, Daniele Raggi, Alberto Briganti, Simona Massa, Roberta Lucianò, Maurizio Colecchia, Patrizia Giannatempo, Roberta Mortarini, Marco Bianchi, Elena Farè, Francesco Monopoli, Renzo Colombo, Andrea Gallina, Andrea Salonia, Antonella Messina, Siraj M Ali, Russell Madison, Jeffrey S Ross, Jon H Chung, Roberto Salvioni, Luigi Mariani, Francesco Montorsi,

<h4>Purpose</h4>To determine the activity of pembrolizumab as neoadjuvant immunotherapy before radical cystectomy (RC) for muscle-invasive bladder carcinoma (MIBC) for which standard cisplatin-based chemotherapy is poorly used.<h4>Patients and methods</h4>In the PURE-01 study, patients had a predominant urothelial carcinoma histology and clinical (c)T≤3bN0 stage tumor. They received three cycles of pembrolizumab 200 ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2018, 36(34):3353-3360]

Cited: 67 times

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Development of a Prediction Tool for Exclusive Locoregional Recurrence After Radical Cystectomy in Patients With Muscle-Invasive Bladder Cancer.

Andrea Necchi, Gregory R Pond, Marco Moschini, Elizabeth R Plimack, Gunter Niegisch, Evan Y Yu, Aristotelis Bamias, Neeraj Agarwal, Ulka Vaishampayan, Christine Theodore, Srikala S Sridhar, Jonathan E Rosenberg, Joaquim Bellmunt, Andrea Gallina, Renzo Colombo, Francesco Montorsi, Alberto Briganti, Matthew D Galsky,

<h4>Background</h4>Limited information is available about the pattern of relapse after perioperative chemotherapy with radical cystectomy (RC) vs. RC alone in muscle-invasive bladder cancer.<h4>Patients and methods</h4>Data from 1082 patients of the Retrospective International Study of Invasive/Advanced Cancer of the Urothelium database, treated from February 1990 to December 2013 at 27 centers ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(1):7-14.e3]

Cited: 0 times

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