Full Text Journal Articles by
Author Reinhard W Holl

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Diabetes in the Hospital—A Nationwide Analysis of all Hospitalized Cases in Germany With and Without Diabetes, 2015-2017.

Marie Auzanneau, Andreas Fritsche, Andrea Icks, Erhard Siegel, Reinhold Kilian, Wolfram Karges, Stefanie Lanzinger, Reinhard W Holl,

<h4>Background</h4>Comprehensive data on the frequency of diabetes mellitus among hospitalized patients in Germany have not been published to date.<h4>Methods</h4>Among all inpatient cases aged ≥20 years that were documented in the German DRG statistics for 2015-2017, we analyzed the frequencies of five types of diabetes (type 1, type 2, other/pancreatic diabetes, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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A Comparison of Familial and Sporadic Type 1 Diabetes Among Young Patients.

Beate Karges, Nicole Prinz, Kerstin Placzek, Nicolin Datz, Matthias Papsch, Ursula Strier, Dirk Agena, Walter Bonfig, Heiner Kentrup, Reinhard W Holl,

<h4>Objective</h4>To investigate natural course, treatment, and outcomes in familial versus sporadic type 1 diabetes.<h4>Research design and methods</h4>In a population-based study, we compared patients with onset of type 1 diabetes before the age of 20 years who had a first-degree relative with type 1 diabetes (familial diabetes) with patients with type ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Hydrocortisone dosing in children with classic congenital adrenal hyperplasia: results of the German/Austrian registry.

Heike Hoyer-Kuhn, Angela Huebner, Annette Richter-Unruh, Markus Bettendorf, Tilman Rohrer, Klaus Kapelari, Stefan Riedl, Klaus Mohnike, Helmuth-Günther Dörr, Friedrich-Wilhelm Roehl, Katharina Fink, Reinhard W Holl, Joachim Woelfle,

<h4>Objective</h4>Treatment in classic congenital adrenal hyperplasia (CAH) is necessary to compensate for glucocorticoid/mineralocorticoid deficiencies and to suppress androgen excess. Hydrocortisone (HC) is preferred in growing children with classic CAH, but recommendations regarding dosage/administration are inconsistent. Aim of the study was to evaluate HC dosing in children with CAH in relation ... Read more >>

Endocr Connect (Endocrine connections)
[2021, :]

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Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort.

Thomas Reinehr, Sascha R Tittel, Rolf Holle, Susanna Wiegand, Ines Gellhaus, Johannes Hebebrand, Susanne Greber-Platzer, Christian Denzer, Sabine Linke, Wieland Kiess, Reinhard W Holl,

<h4>Objective</h4>Obesity is associated with many cardiovascular risk factors (CVRF) in childhood. There is an ongoing discussion whether there is a linear relationship between degree of overweight and deterioration of CVRFs justifying body mass index (BMI) cut-offs for treatment decisions.<h4>Methods</h4>We studied the impact of BMI-SDS on blood pressure, lipids, and glucose ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2021, 45(5):1061-1073]

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Predictors of transient congenital primary hypothyroidism: data from the German registry for congenital hypothyroidism (AQUAPE "HypoDok").

Nicola Matejek, Sascha R Tittel, Holger Haberland, Tilman Rohrer, Eva-Maria Busemann, Norbert Jorch, Karl-Otfried Schwab, Joachim Wölfle, Reinhard W Holl, Markus Bettendorf,

Neonatal screening for congenital primary hypothyroidism (CH) may not distinguish between transient (TCH) and permanent dysfunction (PCH), causing potential overtreatment and concerns in affected families. To specify the indication for interruption of therapy, we analysed the German registry "HypoDok" for infants with CH, which oversees 1625 patients from 49 participating ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, :]

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Intermittently Scanned Glucose Values for Continuous Monitoring: Cross-Sectional Analysis of Glycemic Control and Hypoglycemia in 1809 Children and Adolescents with Type 1 Diabetes.

Torben Biester, Julia M Grimsmann, Bettina Heidtmann, Birgit Rami-Merhar, Uwe Ermer, Johannes Wolf, Markus Freff, Beate Karges, Dirk Agena, Peter Bramlage, Thomas Danne, Reinhard W Holl,

<b><i>Background and Objective:</i></b> Intermittent scanning continuous glucose monitoring (iscCGM) is increasingly used for glycemic monitoring in diabetes care. In this cross-sectional real-world analysis, iscCGM data were compared to traditional parameters of glycemic control in young people with type 1 diabetes. <b><i>Methods:</i></b> Using the DPV registry, most recent data from children ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2021, 23(3):160-167]

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Involving patients' perspective in the development of an internet- and mobile-based CBT intervention for adolescents with chronic medical conditions: Findings from a qualitative study.

Agnes Geirhos, Frederike Lunkenheimer, Reinhard W Holl, Kirsten Minden, Andreas Schmitt, Svenja Temming, Harald Baumeister, Matthias Domhardt,

<h4>Objective</h4>A user-centered approach is critical for increasing the adherence to and effectiveness of an internet- and mobile-based intervention program. Therefore, potential future intervention users were involved in the development of an internet- and mobile-based cognitive behavioral therapy program (iCBT) for adolescents and young adults (AYA) with chronic medical conditions and ... Read more >>

Internet Interv (Internet interventions)
[2021, 24:100383]

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Guideline Adherence and Registry Recruitment of Congenital Primary Hypothyroidism: Data from the German Registry for Congenital Hypothyroidism (HypoDok).

Julia Thomann, Sascha R Tittel, Egbert Voss, Rudolf Oeverink, Katja Palm, Susanne Fricke-Otto, Klaus Kapelari, Reinhard W Holl, Joachim Woelfle, Markus Bettendorf,

Neonatal screening for congenital primary hypothyroidism (CH) is mandatory in Germany but medical care thereafter remains inconsistent. Therefore, the registry HypoDok of the German Society of Pediatric Endocrinology and Diabetology (DGKED) was analyzed to evaluate the implementation of evidence-based guidelines and to assess the number of included patients. Inclusion criteria ... Read more >>

Int J Neonatal Screen (International journal of neonatal screening)
[2021, 7(1):]

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Previous diabetic ketoacidosis as a risk factor for recurrence in a large prospective contemporary pediatric cohort: Results from the DPV initiative.

Johanna Hammersen, Sascha R Tittel, Katharina Warncke, Maria Fritsch, Kerstin Placzek, Danièle Pacaud, Beate Karges, Joachim Woelfle, Reinhard W Holl, ,

<h4>Objective</h4>To assess the role of previous episodes of diabetic ketoacidosis (DKA) and their time-lag as risk factors for recurring DKA in youth with type 1 diabetes (T1D).<h4>Research design and methods</h4>In a population-based analysis, data from 29,325 children and adolescents with T1D and at least 5 years of continuous follow-up were retrieved ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):455-462]

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Worse glycemic control, higher rates of diabetic ketoacidosis, and more hospitalizations in children, adolescents, and young adults with type 1 diabetes and anxiety disorders.

Angela Galler, Sascha R Tittel, Harald Baumeister, Christina Reinauer, Burkhard Brosig, Marianne Becker, Holger Haberland, Dörte Hilgard, Marcelus Jivan, Joaquina Mirza, Julia Schwab, Reinhard W Holl,

The aim of the study was to explore the metabolic characteristics and outcome parameters in youth with type 1 diabetes and anxiety disorders. HbA1c levels, rates of severe hypoglycemia, diabetic ketoacidosis (DKA), and hospital admission in children, adolescents, and young adults with type 1 diabetes and an anxiety disorder from ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):519-528]

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Non-suicidal self-injury in adolescents and young adults with type 1 diabetes: clinical characteristics from a German diabetes-patient registry (DPV).

Alexander Eckert, Matthias Domhardt, Christina Reinauer, Gabriele Berger, Angela Galler, Andreas Böckmann, Martina Henn, Thomas Haak, Reinhard W Holl,

The aim was to examine the relations between non-suicidal self-injury (NSSI) and clinical parameters as well as other psychiatric comorbidities in adolescents and young adults with type 1 diabetes mellitus (T1D). Patients aged 8-<=25 years with T1D and documented NSSI from the DPV database (n=167) were compared to a control ... Read more >>

Psychiatry Res (Psychiatry research)
[2021, 297:113733]

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[Is it possible to prevent diabetic ketoacidosis at diagnosis of pediatric type 1 diabetes? Lessons from the COVID-19 pandemic].

Kirsten Mönkemöller, Clemens Kamrath, Johanna Hammersen, Torben Biester, Katharina Warncke, Angeliki Pappa, Katharina Fink, Klemens Raile, Tilman R Rohrer, Reinhard W Holl, ,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a life-threatening emergency in children and adolescents with manifestation of type 1 diabetes mellitus (DM1) and often associated with delayed diagnosis or previous diagnostic errors. During the coronavirus disease 2019 (COVID-19) lockdown period in Germany, less patients presented at emergency departments and private practices<b>.</b><h4>Objective</h4>The aim of this study ... Read more >>

Monatsschr Kinderheilkd (Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde)
[2021, :1-8]

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Personal glycation factors and calculated HbA1c for diabetes management: Real-world data from the DPV registry.

Yongjin Xu, Julia M Grimsmann, Beate Karges, Sabine E Hofer, Thomas Danne, Reinhard W Holl, Ramzi A Ajjan, Timothy D Dunn,

Background Glycated hemoglobin A1c (HbA1c) is a key biomarker in the glycemic management of individuals with diabetes but the relationship with glucose levels can be variable. A recent kinetic model has described a calculated HbA1c (cHbA1c) that is individual-specific. Our aim was to validate the routine clinical use of this ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2021, :]

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Association of family structure with type 1 diabetes management and outcomes in adolescents: A population-based cross-sectional survey.

Christina Baechle, Anna Stahl-Pehe, Katty Castillo, Silvia Selinski, Reinhard W Holl, Joachim Rosenbauer,

<h4>Background</h4>Diabetes therapies have enormously changed during past decades, but only few studies have analyzed the association between family structure and diabetes management and outcomes.<h4>Objective</h4>To analyze cross-sectionally the associations of family structure with type 1 diabetes (T1D) management and various diabetes outcomes.<h4>Methods</h4>A total of 1635 11- to 17-year-old participants and their ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):482-494]

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Transition from gynaecomastia to lipomastia in pubertal boys.

Thomas Reinehr, Alexandra Kulle, Andre Barth, Jonas Ackermann, Reinhard W Holl, Paul-Martin Holterhus,

<h4>Objective</h4>Gynaecomastia is frequent in pubertal boys and is regarded as a self-limiting abnormality. However, longitudinal studies proving this hypothesis are scarce.<h4>Design</h4>Longitudinal follow-up study (median 2.4, range 1.0-4.8 years).<h4>Methods</h4>The regression of breast diameter was analysed in 31 pubertal boys aged 11.7-16.1 (median 13.2) years with gynaecomastia. Furthermore, weight changes (as BMI-SDS) and pubertal ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, 94(4):583-589]

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Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.

Roberto Bizzotto, Christopher Jennison, Angus G Jones, Azra Kurbasic, Andrea Tura, Gwen Kennedy, Jimmy D Bell, E Louise Thomas, Gary Frost, Rebeca Eriksen, Robert W Koivula, Soren Brage, Jane Kaye, Andrew T Hattersley, Alison Heggie, Donna McEvoy, Leen M 't Hart, Joline W Beulens, Petra Elders, Petra B Musholt, Martin Ridderstråle, Tue H Hansen, Kristine H Allin, Torben Hansen, Henrik Vestergaard, Agnete T Lundgaard, Henrik S Thomsen, Federico De Masi, Konstantinos D Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J McDonald, Tarja Kokkola, Ian M Forgie, Giuseppe N Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil Dermitzakis, Mark I McCarthy, Oluf Pedersen, Jochen M Schwenk, Jerzy Adamski, Paul W Franks, Mark Walker, Ewan R Pearson, Andrea Mari, ,

<h4>Objective</h4>We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D).<h4>Research design and methods</h4>A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(2):511-518]

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Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes.

Marie Auzanneau, Beate Karges, Andreas Neu, Thomas Kapellen, Stefan A Wudy, Corinna Grasemann, Gabriele Krauch, Eva Maria Gerstl, Gerhard Däublin, Reinhard W Holl,

In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, 180(2):597-606]

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Early versus delayed insulin pump therapy in children with newly diagnosed type 1 diabetes: results from the multicentre, prospective diabetes follow-up DPV registry.

Clemens Kamrath, Sascha R Tittel, Thomas M Kapellen, Thekla von dem Berge, Bettina Heidtmann, Katrin Nagl, Ulrike Menzel, Simone Pötzsch, Katja Konrad, Reinhard W Holl,

<h4>Background</h4>Although continuous subcutaneous insulin infusion therapy (ie, insulin pump therapy) is associated with improved metabolic control compared with multiple daily insulin injections in children with type 1 diabetes, it is unclear when it is best to start it after diagnosis. In this study, we aimed to compare the outcomes between ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2021, 5(1):17-25]

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Demographic characteristics and acute complications among adults with type 1 diabetes: Comparison of two multicentre databases from Germany and the United States.

Alexander J Eckert, Fang L Zhou, Julia M Grimsmann, Jeremy H Pettus, Wolfgang Kerner, Kellee M Miller, Lars Stechemesser, Steven V Edelman, Carsten Spies, Reinhard W Holl, Angela M Ibald-Mulli,

<h4>Background</h4>Studies on acute complications in adult T1D were previously reported from the United States (U.S.) and from Germany. The aim was to compare demographic characteristics and patterns of severe hypoglycaemia (SH) and diabetic ketoacidosis (DKA) between Germany and the U.S.<h4>Methods</h4>Descriptive comparison on individuals aged ≥18 years, with T1D duration ≥2 years were ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2021, 35(3):107812]

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Comorbidity of inflammatory bowel disease in children and adolescents with type 1 diabetes.

Hildegard Jasser-Nitsche, Susanne Bechtold-Dalla Pozza, Elisabeth Binder, Esther Bollow, Bettina Heidtmann, Young Hee Lee-Barkley, Klemens Raile, Gideon de Sousa, Ursula Schramm, Reinhard W Holl,

<h4>Aim</h4>To determine the prevalence of inflammatory bowel disease (IBD) in patients with type 1 diabetes (T1D) and to characterise patients with both diseases.<h4>Methods</h4>Data of 65.147 patients with T1D ≤18 years of 379 centres in Germany and Austria participating in the DPV initiative were analysed. A total of 63 children had comorbid ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2021, 110(4):1353-1358]

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Type 2 diabetes in older patients: an analysis of the DPV and DIVE databases.

Gesine van Mark, Sascha R Tittel, Stefan Sziegoleit, Franz Josef Putz, Mesut Durmaz, Michaela Bortscheller, Ivo Buschmann, Jochen Seufert, Reinhard W Holl, Peter Bramlage,

<h4>Background</h4>The clinical profile differs between old and young patients with type 2 diabetes mellitus (T2DM). We explored, based on a large real-world database, patient and disease characteristics and actual treatment patterns by age.<h4>Methods</h4>The analysis was based on the DIVE and DPV registries of patients with T2DM. Patients were analyzed by ... Read more >>

Ther Adv Endocrinol Metab (Therapeutic advances in endocrinology and metabolism)
[2020, 11:2042018820958296]

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A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Transatlantic Comparison.

Ananta Addala, Marie Auzanneau, Kellee Miller, Werner Maier, Nicole Foster, Thomas Kapellen, Ashby Walker, Joachim Rosenbauer, David M Maahs, Reinhard W Holl,

<h4>Objective</h4>As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>). We hypothesized that an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA<sub>1c</sub> disparities.<h4>Research design and methods</h4>Participants aged <18 years with diabetes duration ≥1 year ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):133-140]

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Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany.

Clemens Kamrath, Kirsten Mönkemöller, Torben Biester, Tilman R Rohrer, Katharina Warncke, Johanna Hammersen, Reinhard W Holl,

JAMA (JAMA)
[2020, 324(8):801-804]

Cited: 20 times

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Psychological care in children and adolescents with type 1 diabetes in a real-world setting and associations with metabolic control.

Angela Galler, Dörte Hilgard, Esther Bollow, Thomas Hermann, Nicole Kretschmer, Berthold Maier, Kirsten Mönkemöller, Ralf Schiel, Reinhard W Holl,

BACKGROUND:International guidelines recommend psychosocial care for children and adolescents with type 1 diabetes. OBJECTIVE:To assess psychological care in children and adolescents with type 1 diabetes in a real-world setting and to evaluate associations with metabolic outcome. METHODS:Delivery of psychological care, HbA1c, and rates of severe hypoglycemia and diabetic ketoacidosis (DKA) ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, 21(6):1050-1058]

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