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Author Reinhard Schnettler

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Surgical treatment outcome after serial debridement of infected nonunion-A retrospective cohort study.

Markus Rupp, Stefanie Kern, Nike Walter, Lydia Anastasopoulou, Reinhard Schnettler, Christian Heiss, Volker Alt,

<h4>Purpose</h4>Reported outcome after multiple staged surgical treatment of infected nonunion is scarce. We, therefore, asked: (1) What is the clinical outcome in infected nonunion patients after multiple staged revision surgery? (2) Are different pathogens evidenced after surgical treatment in patients who have undergone more or less surgeries?<h4>Methods</h4>All enrolled patients were ... Read more >>

Eur J Orthop Surg Traumatol (European journal of orthopaedic surgery & traumatology : orthopedie traumatologie)
[2021, :]

Cited: 0 times

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Comparison of Material-mediated Bone Regeneration Capacities of Sintered and Non-sintered Xenogeneic Bone Substitutes via 2D and 3D Data.

Eleni Kapogianni, Mike Barbeck, Ole Jung, Aylin Arslan, Lennart Kuhnel, Xin Xiong, Rumen Krastev, Reinhard E. Friedrich, Reinhard Schnettler, Tim Fienitz, Daniel Rothamel,

<h4>Background/aim</h4>The aim of this study was the development of a new osteoconductivity index to determine the bone healing capacities of bone substitute materials (BSM) on the basis of 3D microcomputed tomographic (μ-CT) data.<h4>Materials and methods</h4>Sinus biopsies were used for the comparative analysis of the integration behavior of two xenogeneic BSM ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2019, 33(6):2169-2179]

Cited: 6 times

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Polymicrobial infections and microbial patterns in infected nonunions - a descriptive analysis of 42 cases.

Markus Rupp, Stefanie Kern, Tobias Weber, Tamina D Menges, Reinhard Schnettler, Christian Heiß, Volker Alt,

<h4>Background</h4>Frequencies of polymicrobial infection and pathogens evidenced in course of infected nonunion treatment are largely unknown. Therefore, this study aims at investigating microbial patterns in infected nonunions.<h4>Methods</h4>Surgically treated patients with long bone infected nonunion admitted between January 2010 and March 2018 were included in the study. Microbiological culture and polymerase-chain-reaction ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):667]

Cited: 2 times

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An introduction to bone tissue engineering.

Željka Perić Kačarević, Patrick Rider, Said Alkildani, Sujith Retnasingh, Marija Pejakić, Reinhard Schnettler, Martin Gosau, Ralf Smeets, Ole Jung, Mike Barbeck,

Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor ... Read more >>

Int J Artif Organs (The International journal of artificial organs)
[2020, 43(2):69-86]

Cited: 10 times

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Effects of testosterone and 17β-estradiol on osteogenic and adipogenic differentiation capacity of human bone-derived mesenchymal stromal cells of postmenopausal women.

Kristina Glenske, Gerhard Schuler, Stefan Arnhold, Mohamed I Elashry, Alena-Svenja Wagner, Mike Barbeck, Elena Neumann, Ulf Müller-Ladner, Reinhard Schnettler, Sabine Wenisch,

Progressive bone loss is a predominant symptom of aging and osteoporosis. Therefore, the effects of sex steroids (i.e. testosterone and 17β-estradiol) on the differentiation capacity of human bone-derived mesenchymal stromal cells (hMSCs), as progenitors of osteoblasts and adipocytes, are of particular interest. The objectives of the present study were, thus, ... Read more >>

Bone Rep (Bone reports)
[2019, 11:100226]

Cited: 2 times

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The Addition of High Doses of Hyaluronic Acid to a Biphasic Bone Substitute Decreases the Proinflammatory Tissue Response.

Dominik Sieger, Tadas Korzinskas, Ole Jung, Sanja Stojanovic, Sabine Wenisch, Ralf Smeets, Martin Gosau, Reinhard Schnettler, Stevo Najman, Mike Barbeck,

Biphasic bone substitutes (BBS) are currently well-established biomaterials. Through their constant development, even natural components like hyaluronic acid (HY) have been added to improve both their handling and also their regenerative properties. However, little knowledge exists regarding the consequences of the addition of HY to their biocompatibility and the inflammatory ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(8):]

Cited: 11 times

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Improved In Vitro Test Procedure for Full Assessment of the Cytocompatibility of Degradable Magnesium Based on ISO 10993-5/-12.

Ole Jung, Ralf Smeets, Philip Hartjen, Reinhard Schnettler, Frank Feyerabend, Martin Klein, Nils Wegner, Frank Walther, Dominic Stangier, Anders Henningsen, Carsten Rendenbach, Max Heiland, Mike Barbeck, Alexander Kopp,

Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(2):]

Cited: 12 times

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Anterior intermeniscal ligament: frequency in MRI studies and spatial relationship to the entry point for intramedullary tibial nailing related to the risk of iatrogenic violation.

Joerg Franke, Kersten Mueckner, Volker Alt, Reinhard Schnettler, Anissa Paulina Franke, Sebastian Griewing, Bernd Hohendorff,

<h4>Background</h4>Anterior knee pain is the most common complication after intramedullary tibial nailing. Often, the cause is multifactorial and individually different. Violation of the anterior intermeniscal ligament (AIL) during intramedullary tibial nailing might be a possible origin of postsurgical anterior knee pain. Both the importance and function of the AIL remain ... Read more >>

Eur J Trauma Emerg Surg (European journal of trauma and emergency surgery : official publication of the European Trauma Society)
[2020, 46(5):1085-1092]

Cited: 1 time

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In Vivo Analysis of the Biocompatibility and Macrophage Response of a Non-Resorbable PTFE Membrane for Guided Bone Regeneration.

Tadas Korzinskas, Ole Jung, Ralf Smeets, Sanja Stojanovic, Stevo Najman, Kristina Glenske, Michael Hahn, Sabine Wenisch, Reinhard Schnettler, Mike Barbeck,

The use of non-resorbable polytetrafluoroethylene (PTFE) membranes is indicated for the treatment of large, non-self-containing bone defects, or multi-walled defects in the case of vertical augmentations. However, less is known about the molecular basis of the foreign body response to PTFE membranes. In the present study, the inflammatory tissue responses ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(10):]

Cited: 15 times

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Importance of Mechanoreceptors and Other Neural Structures Within the Anterior Intermeniscal Ligament in the Etiology of Anterior Knee Pain After Tibial Nailing.

Jörg Franke, Alexander Brobeil, Katrin Susanne Lips, Stefan Gattenloehner, Anissa Paulina Franke, Bernd Hohendorff, Volker Alt, Reinhard Schnettler,

<h4>Background</h4>Anterior knee pain is the most common complication after intramedullary tibial nailing. The cause is often multifactorial and varies among individuals. Violation of the anterior intermeniscal ligament (AIL) during intramedullary tibial nailing might be a possible source of postsurgical anterior knee pain. Although there is a certain ambiguity regarding the ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2018, 32(10):526-533]

Cited: 1 time

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Vertical bone augmentation in a single-tooth gap with an allogenic bone ring: Clinical considerations.

Bernhard Giesenhagen, Nathalie Martin, Phil Donkiewicz, Željka Perić Kačarević, Ralf Smeets, Ole Jung, Reinhard Schnettler, Mike Barbeck,

<h4>Objective</h4>The main objective of this case report is to introduce a one-stage bone block augmentation with a cylindrical freeze-dried bone allograft (FDBA) and simultaneous implantation for the reconstruction of a single-tooth bone defect.<h4>Clinical considerations</h4>The report describes this method on the basis of radiographical and clinical images derived from a single ... Read more >>

J Esthet Restor Dent (Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.])
[2018, 30(6):480-483]

Cited: 4 times

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Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration.

Zeljka Perić Kačarević, Faraz Kavehei, Alireza Houshmand, Jörg Franke, Ralf Smeets, Denis Rimashevskiy, Sabine Wenisch, Reinhard Schnettler, Ole Jung, Mike Barbeck,

Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the former bone tissue has to be conducted to ensure the removal of immunogenic components and pathogens. Different physicochemical methods are applied for purification of the donor tissue, and temperature treatment is one ... Read more >>

Int J Artif Organs (The International journal of artificial organs)
[2018, 41(11):789-800]

Cited: 14 times

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Applications of Metals for Bone Regeneration

Kristina Glenske, Phil Donkiewicz, Alexander Köwitsch, Nada Milosevic-Oljaca, Sven Rofall, Jörg Franke, Ole Jung, Reinhard Schnettler, Sabine Wenisch, Mike Barbeck,

The regeneration of bone tissue is a main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a ... Read more >>

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Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.

Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt,

The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy ... Read more >>

Biomaterials (Biomaterials)
[2018, 157:1-16]

Cited: 6 times

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Infrapatellar vs. suprapatellar approach to obtain an optimal insertion angle for intramedullary nailing of tibial fractures.

Joerg Franke, Annika Homeier, Lars Metz, Thilo Wedel, Volker Alt, Sven Spät, Bernd Hohendorff, Reinhard Schnettler,

BACKGROUND:During intramedullary nailing of tibial fractures, the insertion angle of the nail is of great importance. When the nail impacts the posterior cortex due to a large insertion angle with a dorsal target course, higher insertion forces are needed, and the danger of iatrogenic fractures increases. Accordingly, the insertion direction ... Read more >>

Eur J Trauma Emerg Surg (European journal of trauma and emergency surgery : official publication of the European Trauma Society)
[2018, 44(6):927-938]

Cited: 1 time

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Treatment of Severely Resorbed Maxilla Due to Peri-Implantitis by Guided Bone Regeneration Using a Customized Allogenic Bone Block: A Case Report

Oliver Blume, Lisa Hoffmann, Phil Donkiewicz, Sabine Wenisch, Michael Back, Reinhard Schnettler, Mike Barbeck,

The objective of this case report is to introduce a customized CAD/CAM freeze-dried bone allograft (FDBA) block for its use in Guided Bone Regeneration (GBR) procedures for severely deficient maxillary bones. Additionally, a special newly developed remote incision technique is presented to avoid wound dehiscence. The results show an optimal ... Read more >>

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Treatment of Severely Resorbed Maxilla Due to Peri-Implantitis by Guided Bone Regeneration Using a Customized Allogenic Bone Block: A Case Report.

Oliver Blume, Lisa Hoffmann, Phil Donkiewicz, Sabine Wenisch, Michael Back, Jörg Franke, Reinhard Schnettler, Mike Barbeck,

The objective of this case report is to introduce a customized CAD/CAM freeze-dried bone allograft (FDBA) block for its use in Guided Bone Regeneration (GBR) procedures for severely deficient maxillary bones. Additionally, a special newly developed remote incision technique is presented to avoid wound dehiscence. The results show optimal integration ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2017, 10(10):]

Cited: 9 times

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Drug Release as a function of bioactivity, incubation regime, liquid, and initial load: Release of bortezomib from calcium phosphate-containing silica/collagen xerogels.

Benjamin Kruppke, Dirk Hose, Reinhard Schnettler, Anja Seckinger, Sina Rößler, Thomas Hanke, Sascha Heinemann,

The ability of silica-/collagen-based composite xerogels to act as drug delivery systems was evaluated by taking into account the initial drug concentration, bioactivity of the xerogels, liquid, and incubation regime. The proteasome inhibitor bortezomib was chosen as a model drug, used for the systemic treatment of multiple myeloma. Incubation during ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2018, 106(3):1165-1173]

Cited: 3 times

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Cell behavior of human mesenchymal stromal cells in response to silica/collagen based xerogels and calcium deficient culture conditions.

Alena-Svenja Wagner, Kristina Glenske, Anja Henß, Benjamin Kruppke, Sina Rößler, Thomas Hanke, Andreas Moritz, Marcus Rohnke, Monika Kressin, Stefan Arnhold, Reinhard Schnettler, Sabine Wenisch,

Herein, we aim to elucidate osteogenic effects of two silica-based xerogels with different degrees of bioactivity on human bone-derived mesenchymal stromal cells by means of scanning electron microscopy, quantitative PCR enhanced osteogenic effects and the formation of an extracellular matrix which could be ascribed to the sample with lower bioactivity. ... Read more >>

Biomed Mater (Biomedical materials (Bristol, England))
[2017, 12(4):045003]

Cited: 5 times

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TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress.

Walid Mohamed, Eugen Domann, Trinad Chakraborty, Gopala Mannala, Katrin S Lips, Christian Heiss, Reinhard Schnettler, Volker Alt,

<h4>Background</h4>Staphylococcus aureus is the principle causative pathogen of osteomyelitis and implant-associated bone infections. It is able to invade and to proliferate inside osteoblasts thus avoiding antibiotic therapy and the host immune system. Therefore, development of alternative approaches to stimulate host innate immune responses could be beneficial in prophylaxis against S. ... Read more >>

BMC Microbiol (BMC microbiology)
[2016, 16(1):230]

Cited: 11 times

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A novel intramedullary callus distraction system for the treatment of femoral bone defects.

Konstantin Horas, Reinhard Schnettler, Gerrit Maier, Uwe Horas,

An intramedullary device has some advantages over external fixation in callus distraction for bone defect reconstruction. There are difficulties controlling motorized intramedullary devices and monitoring the distraction rate which may lead to poor results. The aim of this study was to design a fully implantable and non-motorized simple distraction nail ... Read more >>

Strategies Trauma Limb Reconstr (Strategies in trauma and limb reconstruction)
[2016, 11(2):113-121]

Cited: 2 times

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Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats.

Seemun Ray, Ulrich Thormann, Ursula Sommer, Thaqif El Khassawna, Marvin Hundgeburth, Anja Henß, Marcus Rohnke, Katrin S Lips, Christian Heiss, Sascha Heinemann, Thomas Hanke, Lutz Dürselen, Reinhard Schnettler, Volker Alt,

New bone formation was studied in a metaphyseal fracture-defect in ovariectomized rats stimulated by a plain and a strontium-enriched macroporous silica/collagen scaffold (ScB30 and ScB30Sr20) and a compact silica/collagen xerogel (B30). 45 female Sprague-Dawley rats were randomly assigned to three different treatment groups: (1) ScB30 (n=15), (2) ScB30Sr20 (n=15), and ... Read more >>

Injury (Injury)
[2016, 47 Suppl 1:S52-61]

Cited: 11 times

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Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.

Thaqif El Khassawna, Wolfgang Böcker, Katharina Brodsky, David Weisweiler, Parameswari Govindarajan, Marian Kampschulte, Ulrich Thormann, Anja Henss, Marcus Rohnke, Natali Bauer, Robert Müller, Andreas Deutsch, Anita Ignatius, Lutz Dürselen, Alexander Langheinrich, Katrin S Lips, Reinhard Schnettler, Christian Heiss,

Bone loss is a symptom related to disease and age, which reflects on bone cells and ECM. Discrepant regulation affects cell proliferation and ECM localization. Rat model of osteoporosis (OVX) was investigated against control rats (Sham) at young and old ages. Biophysical, histological and molecular techniques were implemented to examine ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2015, 144(5):491-507]

Cited: 10 times

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Bone status of acetylcholinesterase-knockout mice.

Vivien Kauschke, Mathias Kneffel, Wolfgang Floel, Sonja Hartmann, Marian Kampschulte, Lutz Dürselen, Anita Ignatius, Reinhard Schnettler, Christian Heiss, Katrin Susanne Lips,

Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh) to acetate and choline and thereby terminates nerve impulse transmission. ACh is also expressed in bone tissue and enhances here proliferation and differentiation of osteoblasts, which makes it interesting to investigate effects of AChE deficiency on bone. To our knowledge, this is the first study ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2015, 29(1):222-230]

Cited: 7 times

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Impact of prophylactic CpG Oligodeoxynucleotide application on implant-associated Staphylococcus aureus bone infection.

Shneh Sethi, Ulrich Thormann, Ursula Sommer, Sabine Stötzel, Walid Mohamed, Reinhard Schnettler, Eugen Domann, Trinad Chakraborty, Volker Alt,

TLR-9 ligand CpG oligodeoxynucleotide type B (CpG ODN) induces a proinflammatory environment. We evaluated the effects of a preoperative CpG ODN application in an implant-associated Staphylococcus aureus bone infection model by monitoring bacterial loads and cytokine and chemokine levels. A total of 95 rats were used in four different groups: ... Read more >>

Bone (Bone)
[2015, 78:194-202]

Cited: 4 times

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