Full Text Journal Articles by
Author Reinhard Berner

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Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany.

Florens Lohrmann, Angela Berg, Esther Wicker, Anita Imm, Gérard Krause, Katharina Zürn, Reinhard Berner, Markus Hufnagel, Fabian Lander,

For neonates, group B Streptococcus is life threatening. Current prevention strategies remain insufficient, especially for cases of late-onset sepsis, where intrapartum antibiotic prophylaxis has demonstrated no benefit. One promising approach is the vaccination of pregnant women, which offers protective immunity via transplacental transmission of neutralizing antibodies. Our nationwide, prospective surveillance ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):76-82]

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[Use of masks by children to prevent infection with SARS-CoV-2].

Hans-Iko Huppertz, Reinhard Berner, Renate Schepker, Matthias Kopp, Andreas Oberle, Thomas Fischbach, Burkhard Rodeck, Markus Knuf, Matthias Keller, Arne Simon, Johannes Hübner,

After initial reluctance masks have emerged as an important means of restricting the spread of SARS-CoV‑2, the new coronavirus causing COVID-19. Other simple measures are keeping a distance of at least 1 ½ m from other persons and observing hygiene recommendations, including washing or even disinfecting the hands, coughing into the crook of ... Read more >>

Monatsschr Kinderheilkd (Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde)
[2020, :1-5]

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Interferon signature guiding therapeutic decision making: ruxolitinib as first-line therapy for severe juvenile dermatomyositis?

André Heinen, Anja Schnabel, Normi Brück, Martin Smitka, Christine Wolf, Nadja Lucas, Stefanie Dollinger, Gabriele Hahn, Claudia Günther, Reinhard Berner, Min Ae Lee-Kirsch, Catharina Schuetz,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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[Children with acute respiratory tract infections in pediatric hospitals in autumn/winter 2020/2021].

Reinhard Berner, Johannes Huebner, Hans-Iko Huppertz, Arne Simon, Peter Walger, , ,

Due to the shortage of pediatric hospital beds in general and due to the large annual burden of hospital admissions for common respiratory tract infections, such as influenza or RSV [respiratory syncytial virus] in particular, it can be expected that hospitalization of children with suspected or confirmed SARS-CoV‑2 infections will ... Read more >>

Monatsschr Kinderheilkd (Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde)
[2020, :1-4]

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Hospitalization for Acute Respiratory Tract Infection in a Low-Antibiotic-Prescribing Setting: Cross-Sectional Data from General Practice.

Christin Löffler, Attila Altiner, Annette Diener, Reinhard Berner, Gregor Feldmeier, Christian Helbig, Winfried V Kern, Anna Köchling, Michaela Schmid, Gerhard Schön, Helmut Schröder, Karl Wegscheider, Anja Wollny,

<h4>Background</h4>Acute respiratory tract infections (ARTI) are the main cause of inappropriate antibiotic prescribing. To date, there is limited evidence concerning whether low levels of antibiotic prescribing may impact patient safety. We investigate whether antibiotic prescribing for patients seeking primary care for ARTI correlates with the odds for hospitalization.<h4>Methods</h4>Analysis of patient ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2020, 9(10):]

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Severe Bleeding Diathesis in Siblings with Platelet Dysfunction due to a Novel Nonsense RASGRP2 Mutation.

Julia Körholz, Nadja Lucas, Franziska Boiti, Karina Althaus, Oliver Tiebel, Mingyan Fang, Reinhard Berner, Min Ae Lee-Kirsch, Ralf Knöfler,

Next-generation sequencing is increasingly applied during the diagnostic work-up of patients with bleeding diathesis and has facilitated the diagnosis of rare bleeding disorders such as inherited platelet function disorders. Mutations in RAS guanyl releasing protein 2 (RasGRP2), also known as calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), underlie ... Read more >>

TH Open (TH open : companion journal to thrombosis and haemostasis)
[2020, 4(4):e413-e416]

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Measures to maintain regular operations and prevent outbreaks of SARS-CoV-2 in childcare facilities or schools under pandemic conditions and co-circulation of other respiratory pathogens.

Arne Simon, Johannes Huebner, Reinhard Berner, Alasdair P S Munro, Martin Exner, Hans-Iko Huppertz, Peter Walger,

After the lockdown and the end of the summer holidays, day-cares and schools need to be reopened and (despite the continued circulation of the new coronavirus SARS-CoV-2) kept open. The need for opening up arises from the right of children to education, participation, support and care. This is possible if ... Read more >>

GMS Hyg Infect Control (GMS hygiene and infection control)
[2020, 15:Doc22]

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Group B streptococcus vaccines: one step further.

Reinhard Berner,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Anti-SARS-CoV-2 IgG antibodies in adolescent students and their teachers in Saxony, Germany (SchoolCoviDD19): very low seropraevalence and transmission rates

Jakob Armann, Manja Unrath, Carolin Kirsten, Christian Lück, Alexander Dalpke, Reinhard Berner,

<h4>Background</h4> School closures are part of the SARS-CoV-2 pandemic control measures in many countries, based on the assumption that children play a similar role in transmitting SARS-CoV-2 as they do in transmitting influenza. We therefore performed a SARS-CoV-2 seropraevalence-study in students and teachers to assess their role in the SARS-CoV-2 ... Read more >>

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Management of Care for Neonates Born to SARS-CoV-2 Positive Women with or without Clinical Symptoms (COVID-19).

Arne Simon, Johannes Hübner, Markus Knuf, Markus Hufnagel, Reinhard Berner,

Klin Padiatr (Klinische Padiatrie)
[2020, 232(4):173-177]

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Neonatal and young infant sepsis by Group B Streptococci and Escherichia coli: a single-center retrospective analysis in Germany-GBS screening implementation gaps and reduction in antibiotic resistance.

Maren Doenhardt, Barbara Seipolt, Lars Mense, Jennifer Lucia Winkler, Alexander Thürmer, Mario Rüdiger, Reinhard Berner, Jakob Armann,

The last nationwide surveillance study on neonatal and young infant sepsis due to Group B Streptococci (GBS) and Escherichia coli in Germany was conducted between 2009 and 2010. The aim of this study is to provide longitudinal epidemiological data on neonatal and young infant sepsis caused by GBS and E. ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2020, 179(11):1769-1777]

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Hospital Admission in Children and Adolescents With COVID-19.

Jakob Peter Armann, Natalie Diffloth, Arne Simon, Maren Doenhardt, Markus Hufnagel, Andreas Trotter, Dominik Schneider, Johannes Hübner, Reinhard Berner,

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2020, 117(21):373-374]

Cited: 5 times

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Survival of Group A Streptococcus (GAS) is Enhanced Under Desiccated Culture Conditions.

Leonhard Menschner, Uta Falke, Peter Konrad, Nicole Toepfner, Reinhard Berner,

Streptococcus pyogenes or Group A Streptococcus (GAS) infections are the leading cause of bacterial tonsillopharyngitis. The bacterium can survive and persist within the human host for a long time as it is observed in up to 40% of the population who are considered as carriers. Recurrent tonsillopharyngitis is a particular ... Read more >>

Curr Microbiol (Current microbiology)
[2020, 77(8):1518-1524]

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Microarray Analysis of Group B Streptococci Causing Invasive Neonatal Early- and Late-onset Infection.

Katharina Zürn, Fabian Lander, Markus Hufnagel, Stefan Monecke, Reinhard Berner,

BACKGROUND:Group B Streptococcus is the leading cause of meningitis and sepsis in newborns. Until now, there is no data of fast and simple typing of group B Streptococcus virulence factors using a genetic microarray and comparing these data to clinical manifestations. METHODS:A prospective active surveillance study was conducted via 2 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(5):449-453]

Cited: 1 time

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Janus kinase inhibition in complement component 1 deficiency.

Christine Wolf, Normi Brück, Sarah Koss, Constanze Griep, Michael Kirschfink, Katharina Palm-Beden, Mingyan Fang, Nadja Röber, Stefan Winkler, Reinhard Berner, Eike Latz, Claudia Günther, Min Ae Lee-Kirsch,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2020, 146(6):1439-1442.e5]

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Update on the "Choosing Wisely" initiative in infectious diseases in Germany.

Rika Draenert, Norma Jung, ,

PURPOSE:The Choosing Wisely® initiative is an international campaign addressing over- and underuse of diagnostic and therapeutic measures in infectious diseases among others. Since 2016, the German Society for Infectious Diseases (DGI) has constantly designed new items in this regard. Here we report the most recent recommendations. METHODS:The recommendations of the ... Read more >>

Infection (Infection)
[2020, 48(3):317-321]

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Social inequalities in the participation and activity of children and adolescents with leukemia, brain tumors, and sarcomas (SUPATEEN): a protocol for a multicenter longitudinal prospective observational study.

Julia Roick, Reinhard Berner, Toralf Bernig, Bernhard Erdlenbruch, Gabriele Escherich, Jörg Faber, Christoph Klein, Konrad Bochennek, Christian Kratz, Joachim Kühr, Alfred Längler, Holger N Lode, Markus Metzler, Hermann Müller, Dirk Reinhardt, Axel Sauerbrey, Florian Schepper, Wolfram Scheurlen, Dominik Schneider, Georg Christof Schwabe, Matthias Richter,

BACKGROUND:About 2000 children and adolescents under the age of 18 are diagnosed with cancer each year in Germany. Because of current medical treatment methods, a high survival rate can be reached for many types of the disease. Nevertheless, patients face a number of long-term effects related to the treatment. As ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):48]

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Orbital inflammation and colitis in pediatric IgG4-related disease: A case report and review of the literature.

Lissy Tille, Anja Schnabel, Martin W Laass, Gabriele Hahn, Heike Taut, Anna Leszczynska, Jessica Pablik, Reinhard Berner, Normi Brück, Christian M Hedrich,

IgG4-related disease (IgG4-RD) is an inflammatory disorder characterized by tumor-like swelling in one or more organs, elevated serum IgG4 levels, and histological alterations with infiltration of IgG4-positive plasma cells. IgG4-RD is rare and likely underdiagnosed in children. We report a case of a 16-year-old girl with IgG4-positive colitis that developed ... Read more >>

Eur J Rheumatol (European journal of rheumatology)
[2019, :1-7]

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High-dose intravenous methylprednisolone in juvenile non-infectious uveitis: A retrospective analysis.

Anja Schnabel, Elisabeth Unger, Normi Brück, Reinhard Berner, Ursula Range, Annette Holl-Wieden, Henner Morbach, Anna Leszczynska, Viktoria Bau, Christian M Hedrich,

Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis ... Read more >>

Clin Immunol (Clinical immunology (Orlando, Fla.))
[2020, 211:108327]

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Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters.

Peter Konrad, Markus Hufnagel, Reinhard Berner, Nicole Toepfner,

Group A streptococci (GAS) are among the most frequent pathogens in children. Many epidemiological studies focus on specific GAS infections (such as tonsillopharyngitis or invasive disease), on GAS carriers or on post-streptococcal sequelae. By comparison, reports on regional GAS characteristics, particularly circulating non-invasive GAS in Europe, are rare. In a ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, 39(2):273-280]

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Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol.

Anette-Gabriele Ziegler, Peter Achenbach, Reinhard Berner, Kristina Casteels, Thomas Danne, Melanie Gündert, Joerg Hasford, Verena Sophia Hoffmann, Olga Kordonouri, Karin Lange, Helena Elding Larsson, Markus Lundgren, Matthew D Snape, Agnieszka Szypowska, John A Todd, Ezio Bonifacio, ,

<h4>Introduction</h4>The POInT study, an investigator initiated, randomised, placebo-controlled, double-blind, multicentre primary prevention trial is conducted to determine whether daily administration of oral insulin, from age 4.0 months to 7.0 months until age 36.0 months to children with elevated genetic risk for type 1 diabetes, reduces the incidence of beta-cell autoantibodies ... Read more >>

BMJ Open (BMJ open)
[2019, 9(6):e028578]

Cited: 2 times

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Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.

Christiane Winkler, Florian Haupt, Martin Heigermoser, Jose Zapardiel-Gonzalo, Jasmin Ohli, Theresa Faure, Evdokia Kalideri, Angela Hommel, Petrina Delivani, Reinhard Berner, Olga Kordonouri, Frank Roloff, Thekla von dem Berge, Karin Lange, Mariusz Oltarzewski, Ryszard Glab, Agnieszka Szypowska, Matthew D Snape, Manu Vatish, John A Todd, Helena E Larsson, Anita Ramelius, Jeanette Å Kördel, Kristina Casteels, Jasmin Paulus, Anette G Ziegler, Ezio Bonifacio, ,

Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2019, 20(6):720-727]

Cited: 4 times

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Group B Streptococci: Declining Incidence in Infants in Germany.

Esther Wicker, Fabian Lander, Felix Weidemann, Markus Hufnagel, Reinhard Berner, Gérard Krause,

Group B streptococcus (GBS) is a leading cause of morbidity and mortality in newborns worldwide. From 2000 to 2008, national guidelines in Germany recommended intrapartum antibiotic prophylaxis for pregnant women displaying risk factors (eg, perinatal anogenital GBS colonization, rupture of the membranes ≥18 hours before birth) for the vertical transmission ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(5):516-519]

Cited: 1 time

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The prevalence of headache in German pupils of different ages and school types.

Vera Nieswand, Matthias Richter, Reinhard Berner, Maja von der Hagen, Anna Klimova, Ingo Roeder, Thea Koch, Rainer Sabatowski, Gudrun Gossrau,

BACKGROUND/OBJECTIVE:Headache in pupils is underestimated and has a negative impact on learning and life. The aim of this study was to investigate headache prevalence and its collateral effects, in pupils of different ages and school types in a German city. METHODS:Anonymized questionnaires were distributed to 5419 pupils attending primary and ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2019, 39(8):1030-1040]

Cited: 1 time

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Hydrogen Peroxide Production of Group A Streptococci (GAS) is emm-Type Dependent and Increased at Low Temperatures.

Leonhard Menschner, Uta Falke, Peter Konrad, Reinhard Berner, Nicole Toepfner,

Group A streptococcus (GAS) is an important human pathogen whose clinical isolates differ in their ability to produce hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). H<sub>2</sub>O<sub>2</sub> is primarily produced by the enzyme lactate oxidase (LctO), an in depth in silico research revealed that all genome-sequenced GAS possess the required gene lctO. The importance of ... Read more >>

Curr Microbiol (Current microbiology)
[2019, 76(6):698-705]

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