Full Text Journal Articles by
Author Reid A Phelps

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New perspectives on APC control of cell fate and proliferation in colorectal cancer.

Reid A Phelps, Talmage J Broadbent, Diana M Stafforini, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence for this model has come from mouse models of Apc truncation where nuclear beta-catenin is detectable soon after loss of Apc. However, examination of tumors from familial adenomatous ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2009, 8(16):2549-2556]

Cited: 49 times

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A two-step model for colon adenoma initiation and progression caused by APC loss.

Reid A Phelps, Stephanie Chidester, Somaye Dehghanizadeh, Jason Phelps, Imelda T Sandoval, Kunal Rai, Talmage Broadbent, Sharmistha Sarkar, Randall W Burt, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal ... Read more >>

Cell (Cell)
[2009, 137(4):623-634]

Cited: 166 times

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The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Peter W Peterson, Reid A Phelps, Stephanie Chidester, Diana M Stafforini, Stephen M Prescott, David A Jones,

Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest stages of colorectal carcinogenesis. Cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers and plays an important role in colorectal tumorigenesis; however, the mechanisms by which APC mutations result ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(29):20474-20482]

Cited: 31 times

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