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Author Reetta Huttunen

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Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements.

Juha Rannikko, Ville Holmberg, Matti Karppelin, Pertti Arvola, Reetta Huttunen, Eero Mattila, Niina Kerttula, Teija Puhto, Ülle Tamm, Irma Koivula, Risto Vuento, Jaana Syrjänen, Ulla Hohenthal,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):]

Cited: 0 times

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Healthcare-associated blood stream infections in hematological patients in Finland during the years 2006-2016.

Emilia Åttman, Jaana Syrjänen, Outi Lyytikäinen, Jukka Ollgren, Marjatta Sinisalo, Risto Vuento, Erja Mattila, Reetta Huttunen,

<h4>Objectives</h4>The aim was to identify the clinical characteristics, outcome, and antimicrobial susceptibility of healthcare-associated bloodstream infections (BSIs) in hematological patients.<h4>Methods</h4>This retrospectively collected laboratory-based surveillance data include 3404 healthcare-associated BSIs in 2296 patients with a hematological malignancy in hospitals participating in the Finnish Hospital Infection Program from January 1, 2006, to ... Read more >>

Eur J Haematol (European journal of haematology)
[2021, :]

Cited: 0 times

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Plasma suPAR may help to distinguish between chronic pancreatitis and pancreatic cancer.

Anu Aronen, Janne Aittoniemi, Reetta Huttunen, Anssi Nikkola, Irina Rinta-Kiikka, Jussi Nikkola, Olli Limnell, Isto Nordback, Juhani Sand, Johanna Laukkarinen,

<h4>Objectives</h4>SuPAR (soluble urokinase-type plasminogen activator receptor) is a biomarker reflecting the inflammatory state of the human body. Earlier studies suggest that urinary suPAR/creatinine ratio levels are elevated in chronic pancreatitis (CP), and that plasma suPAR (P-suPAR) level is elevated in pancreatic cancer (PC). Our aim was to study the levels ... Read more >>

Scand J Gastroenterol (Scandinavian journal of gastroenterology)
[2021, 56(1):81-85]

Cited: 1 time

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Shopping Detail Information and Home Freezer Sampling Confirmed the Role of Commercial, Modified-Atmosphere Packaged Meatballs as a Vehicle for Listeriosis in Finland.

Riikka Keto-Timonen, Annukka Markkula, Jani Halkilahti, Reetta Huttunen, Sirpa Räsänen, Saara Salmenlinna, Anne Heikkilä, Mia Puisto, Maria Närhinen, Marjaana Hakkinen, Hannu Korkeala, Katri Jalava,

In November 2016, an elderly patient was diagnosed with <i>Listeria monocytogenes</i> bacteremia in Finland. Grocery store loyalty card records and microbiological investigation of foods found in the home fridge and freezer of the patient revealed commercial, modified-atmosphere packaged meatballs as the source of the infection. Investigation of the meatball production ... Read more >>

Front Public Health (Frontiers in public health)
[2019, 7:216]

Cited: 1 time

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Plasma level of soluble urokinase plasminogen activator receptor (suPAR) predicts long-term mortality after first acute alcohol-induced pancreatitis.

Anu Aronen, Janne Aittoniemi, Reetta Huttunen, Anssi Nikkola, Jussi Nikkola, Olli Limnell, Isto Nordback, Juhani Sand, Johanna Laukkarinen,

<h4>Background</h4>Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker associated with inflammatory and certain malignancies. Earlier we have shown that plasma suPAR (P-suPAR) predicts severity of acute alcohol-induced pancreatitis (AAP) on admission. Our aim was to investigate whether P-suPAR levels predict AAP recurrences or mortality during long-term follow-up after first ... Read more >>

Eur J Intern Med (European journal of internal medicine)
[2019, 64:72-75]

Cited: 1 time

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Periprosthetic Joint Infections as a Consequence of Bacteremia.

Meeri Honkanen, Esa Jämsen, Matti Karppelin, Reetta Huttunen, Antti Eskelinen, Jaana Syrjänen,

<h4>Background</h4>The risk for developing a periprosthetic joint infection (PJI) during bacteremia is unclear, except for <i>Staphylococcus aureus</i> bacteremia. The aim of this study was to examine the risk for developing a PJI during bacteremia and to identify possible risk factors leading to it.<h4>Methods</h4>Patients with a primary knee or hip joint ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(6):ofz218]

Cited: 3 times

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Spa type distribution in MRSA and MSSA bacteremias and association of spa clonal complexes with the clinical characteristics of bacteremia.

Elina Jokinen, Laura Lindholm, Reetta Huttunen, Heini Huhtala, Risto Vuento, Jaana Vuopio, Jaana Syrjänen,

The genetic distribution of invasive methicillin-susceptible (MSSA) and resistant S. aureus (MRSA) strains has to be addressed in order to target infection control strategies. A large MRSA epidemic caused by a certain MRSA strain (spa type 067) broke out in 2001 in our health district. We wanted to investigate the ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2018, 37(5):937-943]

Cited: 2 times

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Trends in incidence and resistance patterns of Staphylococcus aureus bacteremia.

Elina Jokinen, Janne Laine, Reetta Huttunen, Outi Lyytikäinen, Risto Vuento, Jaana Vuopio, Jaana Syrjänen,

BACKGROUND:Staphylococcus aureus bacteremia (SAB) causes a significant burden on the population. Several infection control measures have been implemented in Pirkanmaa county to combat a local epidemic with methicillin-resistant Staphylococcus aureus (MRSA). We aimed to study the epidemiology of SAB and antibiotic resistance of S. aureus and the possible influence of ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2018, 50(1):52-58]

Cited: 7 times

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A Serratia marcescens outbreak in a neonatal intensive care unit was successfully managed by rapid hospital hygiene interventions and screening.

Emilia Åttman, Päivi Korhonen, Outi Tammela, Risto Vuento, Janne Aittoniemi, Jaana Syrjänen, Erja Mattila, Monica Österblad, Reetta Huttunen,

AIM:Serratia marcescens is a rare, but important, pathogen in hospital-acquired infections, especially in neonatal units. Outbreaks may cause significant mortality among neonates. This study describes how an outbreak of S. marcescens was handled in a neonatal intensive care unit in Finland in June 2015. METHODS:Tampere University Hospital is the only ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2018, 107(3):425-429]

Cited: 3 times

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Bloodstream infections in acute myeloid leukemia patients treated according to the Finnish Leukemia Group AML-2003 protocol - a prospective nationwide study.

Aarne Kolonen, Marjatta Sinisalo, Reetta Huttunen, Jaana Syrjänen, Janne Aittoniemi, Heini Huhtala, Marja Sankelo, Hannele Rintala, Riikka Räty, Esa Jantunen, Tapio Nousiainen, Marjaana Säily, Marjut Kauppila, Maija Itälä-Remes, Hanna Ollikainen, Auvo Rauhala, Pirjo Koistinen, Erkki Elonen, ,

<h4>Background</h4>Infections greatly influence the outcome of acute myeloid leukemia (AML) patients receiving intensive treatment. The aim of this study was to establish the incidence, microbial etiology, risk factors and prognosis of bloodstream infections (BSIs) in patients with AML and compare the results with the previous treatment protocol (AML-92).<h4>Methods</h4>Registery data were ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2017, 49(11-12):799-808]

Cited: 4 times

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Concordance between the old and new diagnostic criteria for periprosthetic joint infection.

Meeri Honkanen, Esa Jämsen, Matti Karppelin, Reetta Huttunen, Outi Lyytikäinen, Jaana Syrjänen,

<h4>Purpose</h4>There is no uniform definition for periprosthetic joint infection (PJI). New diagnostic criteria were formulated in an international consensus meeting in 2013 and adopted by Centers for Disease Control (CDC) in 2016. The purpose of this study is to compare the new diagnostic criteria with the old CDC criteria from ... Read more >>

Infection (Infection)
[2017, 45(5):637-643]

Cited: 6 times

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Comparison of outcome and clinical characteristics of bacteremia caused by methicillin-resistant, penicillin-resistant and penicillin-susceptible Staphylococcus aureus strains.

Elina Jokinen, Janne Laine, Reetta Huttunen, Pekka Rahikka, Heini Huhtala, Risto Vuento, Jaana Vuopio, Jaana Syrjänen,

<h4>Background</h4>The aim of this study was to assess the association of methicillin resistance and penicillinase production with clinical characteristics and outcome of Staphylococcus aureus bacteremia.<h4>Methods</h4>For 126 patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, 378 age- and gender-matched controls with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia were selected. Of controls, 126 had ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2017, 49(7):493-500]

Cited: 7 times

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Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis.

Anssi Nikkola, Janne Aittoniemi, Reetta Huttunen, Linnea Rajala, Isto Nordback, Juhani Sand, Johanna Laukkarinen,

<h4>Objectives</h4>Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP).<h4>Methods</h4>From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during ... Read more >>

Pancreas (Pancreas)
[2017, 46(1):77-82]

Cited: 1 time

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Sepsis-related mortality in 497 cases with blood culture-positive sepsis in an emergency department.

Juha Rannikko, Jaana Syrjänen, Tapio Seiskari, Janne Aittoniemi, Reetta Huttunen,

<h4>Objective</h4>Few studies have sought to establish how often death after sepsis is related to the sepsis and how often underlying diseases have a major role in case fatality.<h4>Methods</h4>In this retrospective cohort study, data were collected on 497 cases with blood culture-positive sepsis in an emergency department (ED).<h4>Results</h4>Sepsis was categorized as ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2017, 58:52-57]

Cited: 12 times

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Etiology, clinical course and outcome of healthcare-associated bloodstream infections in patients with hematological malignancies: a retrospective study of 350 patients in a Finnish tertiary care hospital.

Emilia Åttman, Janne Aittoniemi, Marjatta Sinisalo, Risto Vuento, Outi Lyytikäinen, Tommi Kärki, Jaana Syrjänen, Reetta Huttunen,

This retrospectively collected laboratory-based surveillance data includes 575 healthcare-associated bloodstream infections (BSIs) in 350 patients with hematological malignancy in Tampere University Hospital, Finland, during 1999-2001 and 2005-2010. The most common underlying diseases were acute myelogenous leukemia (n=283, 49%), followed by myeloma (n=87, 15%) and acute lymphocytic leukemia (n=76, 13%). The ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2015, 56(12):3370-3377]

Cited: 12 times

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Smoking is associated with aggravated kidney injury in Puumala hantavirus-induced haemorrhagic fever with renal syndrome.

Laura Tervo, Satu Mäkelä, Jaana Syrjänen, Reetta Huttunen, Arja Rimpelä, Heini Huhtala, Olli Vapalahti, Antti Vaheri, Jukka Mustonen,

<h4>Background</h4>Previous studies indicate that smoking affects the outcome of some infections and is a risk factor for Puumala virus (PUUV) infection. The aim of this study was to assess the effect of smoking on the clinical severity of PUUV infection and the prevalence of smoking in patients with PUUV infection.<h4>Methods</h4>A ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2015, 30(10):1693-1698]

Cited: 14 times

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Combined interventions are effective in MRSA control.

Elina Jokinen, Janne Laine, Reetta Huttunen, Pertti Arvola, Jaana Vuopio, Laura Lindholm, Risto Vuento, Jaana Syrjänen,

<h4>Background</h4>A large healthcare-associated epidemic mainly caused by one methicillin-resistant Staphylococcus aureus (MRSA) strain broke out in Pirkanmaa County, Finland, in 2001. This study describes the impact of infection control and screening practices on the epidemic.<h4>Methods</h4>The number of hospital-acquired (HA)-MRSA findings obtained from clinical and screening samples during the epidemic was ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2015, 47(11):801-807]

Cited: 6 times

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Predictors of recurrent cellulitis in five years. Clinical risk factors and the role of PTX3 and CRP.

Matti Karppelin, Tuula Siljander, Janne Aittoniemi, Mikko Hurme, Reetta Huttunen, Heini Huhtala, Juha Kere, Jaana Vuopio, Jaana Syrjänen,

<h4>Objectives</h4>To identify risk factors for recurrence of cellulitis, and to assess the predictive value of pentraxin 3 (PTX3) and C-reactive protein (CRP) measured at baseline.<h4>Methods</h4>A follow up study of 90 hospitalised patients with acute non-necrotising cellulitis was conducted. Clinical risk factors were assessed and PTX3 and CRP values were measured ... Read more >>

J Infect (The Journal of infection)
[2015, 70(5):467-473]

Cited: 4 times

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Nosocomial bloodstream infections in a Finnish tertiary care hospital: a retrospective cohort study of 2175 episodes during the years 1999-2001 and 2005-2010.

Reetta Huttunen, Emilia Åttman, Janne Aittoniemi, Tuula Outinen, Jaana Syrjänen, Tommi Kärki, Outi Lyytikäinen,

<h4>Background</h4>Nosocomial infections are major causes of morbidity in hospitalized patients.<h4>Methods</h4>Retrospective laboratory-based surveillance during 1999-2001 and 2005-2010 identified 2175 cases of nosocomial bloodstream infections (BSIs) in Tampere University Hospital (TAUH), Finland.<h4>Results</h4>Analysis revealed that 57% of BSIs were caused by a gram-positive organism, 27% by a gram-negative organism, 5% by a fungal ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2015, 47(1):20-26]

Cited: 8 times

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Urine soluble urokinase-type plasminogen activator receptor levels correlate with proteinuria in Puumala hantavirus infection.

T K Outinen, S Mäkelä, R Huttunen, N Mäenpää, D Libraty, A Vaheri, J Mustonen, J Aittoniemi,

<h4>Objectives</h4>Urokinase-type plasminogen activator receptor (uPAR) is upregulated during inflammation and known to bind to β3 -integrins, receptors used by pathogenic hantaviruses to enter endothelial cells. It has been proposed that soluble uPAR (suPAR) is a circulating factor that causes focal segmental glomerulosclerosis and proteinuria by activating β3 -integrin in kidney ... Read more >>

J Intern Med (Journal of internal medicine)
[2014, 276(4):387-395]

Cited: 10 times

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Plasma levels of soluble urokinase-type plasminogen activator receptor associate with the clinical severity of acute Puumala hantavirus infection.

Tuula K Outinen, Laura Tervo, Satu Mäkelä, Reetta Huttunen, Niina Mäenpää, Heini Huhtala, Antti Vaheri, Jukka Mustonen, Janne Aittoniemi,

<h4>Objectives</h4>Urokinase-type plasminogen activator receptor is a multifunctional glycoprotein, the expression of which is increased during inflammation. It is known to bind to β3-integrins, which are elementary for the cellular entry of hantaviruses. Plasma soluble form of the receptor (suPAR) levels were evaluated as a predictor of severe Puumala hantavirus (PUUV) ... Read more >>

PLoS One (PloS one)
[2013, 8(8):e71335]

Cited: 22 times

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High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment.

Erik Forsblom, Janne Aittoniemi, Eeva Ruotsalainen, Visa Helmijoki, Reetta Huttunen, Juulia Jylhävä, Mikko Hurme, Asko Järvinen,

<h4>Introduction</h4>Among patients with bacteraemia or sepsis the plasma cell-free DNA (cf-DNA) biomarker has prognostic value and Pitt bacteraemia scores predict outcome. We evaluated the prognostic value of plasma cf-DNA in patients with Staphylococcus aureus bacteraemia (SAB) treated in the ICU or in the general ward.<h4>Methods</h4>418 adult patients with positive blood ... Read more >>

PLoS One (PloS one)
[2014, 9(2):e87741]

Cited: 25 times

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Current concepts in the diagnosis of blood stream infections. Are novel molecular methods useful in clinical practice?

Reetta Huttunen, Jaana Syrjänen, Risto Vuento, Janne Aittoniemi,

The decision on the right empirical treatment in bacteremia places particular demands on the clinician. As long as no microbiological diagnosis can be immediately drawn, the clinical diagnosis together with knowledge of local antimicrobial resistance must determine the antimicrobial choice. The use of several amplification, hybridization, and mass spectrometry methods ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2013, 17(11):e934-8]

Cited: 7 times

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Case fatality associated with a hypervirulent strain in patients with culture-positive Clostridium difficile infection: a retrospective population-based study.

Reetta Huttunen, Risto Vuento, Jaana Syrjänen, Päivi Tissari, Janne Aittoniemi,

<h4>Background</h4>Clostridium difficile is a major infectious cause of healthcare-associated diarrhea. The epidemiology of C. difficile infection (CDI) is changing, with evidence of increased incidence and severity. The first patient with a hypervirulent strain type in Pirkanmaa Hospital District, Finland was reported in September 2008.<h4>Methods</h4>We reviewed all culture-positive C. difficile episodes ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2012, 16(7):e532-5]

Cited: 6 times

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Pentraxin 3 (PTX3) is associated with severe sepsis and fatal disease in emergency room patients with suspected infection: a prospective cohort study.

Raija Uusitalo-Seppälä, Reetta Huttunen, Janne Aittoniemi, Pertti Koskinen, Aila Leino, Tero Vahlberg, Esa M Rintala,

<h4>Background</h4>Early diagnostic and prognostic stratification of patients with suspected infection is a difficult clinical challenge. We studied plasma pentraxin 3 (PTX3) upon admission to the emergency department in patients with suspected infection.<h4>Methods</h4>The study comprised 537 emergency room patients with suspected infection: 59 with no systemic inflammatory response syndrome (SIRS) and ... Read more >>

PLoS One (PloS one)
[2013, 8(1):e53661]

Cited: 32 times

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