Full Text Journal Articles by
Author Rebeccah Slater

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Preterm health: time to bridge the evidence gap.

Rebeccah Slater, Fiona Moultrie, Ralph Bax, John van den Anker, Aomesh Bhatt,

Lancet (Lancet (London, England))
[2020, 396(10255):872-873]

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Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study.

Eugene P Duff, Fiona Moultrie, Marianne van der Vaart, Sezgi Goksan, Alexandra Abos, Sean P Fitzgibbon, Luke Baxter, Tor D Wager, Rebeccah Slater,

Background:In the absence of verbal communication, it is challenging to infer an individual's sensory and emotional experience. In communicative adults, functional MRI (fMRI) has been used to develop multivariate brain activity signatures, which reliably capture elements of human pain experience. We aimed to translate whole-brain fMRI signatures that encode pain ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(9):e458-e467]

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Inferring the infant pain experience: a translational fMRI-based signature study

Eugene Duff, Fiona Moultrie, Marianne van der Vaart, Sezgi Goksan, Alexandra Abos, Sean Fitzgibbon, Luke Baxter, Tor Wager, Rebeccah Slater,

Abstract Background In the absence of verbal communication it is challenging to infer an individual’s sensory and emotional experience. In adults, fMRI has been used to develop multivariate brain activity signatures, which reliably capture elements of human pain experience. We translate whole-brain fMRI signatures that encode pain perception in adults ... Read more >>

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Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity

Luke Baxter, Fiona Moultrie, Sean Fitzgibbon, Marianne Aspbury, Roshni Mansfield, Matteo Bastiani, Richard Rogers, Saad Jbabdi, Eugene Duff, Rebeccah Slater,

Abstract Understanding the neurophysiology underlying pain perception in infants is central to improving early life pain management. In this multimodal MRI study, we use resting-state functional and white matter diffusion MRI to investigate individual variability in infants’ noxious-evoked brain activity. In an 18-infant nociception-paradigm dataset, we show it is possible ... Read more >>

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Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity

Luke Baxter, Fiona Moultrie, Sean Fitzgibbon, Marianne Aspbury, Roshni Mansfield, Matteo Bastiani, Richard Rogers, Saad Jbabdi, Eugene Duff, Rebeccah Slater,

Abstract Understanding the neurophysiology underlying pain perception in infants is central to improving early life pain management. In this multimodal MRI study, we use resting-state functional and white matter diffusion MRI to investigate individual variability in infants’ noxious-evoked brain activity. In an 18-infant nociception-paradigm dataset, we show it is possible ... Read more >>

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Author Correction: A tool for functional brain imaging with lifespan compliance.

Ryan M Hill, Elena Boto, Niall Holmes, Caroline Hartley, Zelekha A Seedat, James Leggett, Gillian Roberts, Vishal Shah, Tim M Tierney, Mark W Woolrich, Charlotte J Stagg, Gareth R Barnes, Richard Bowtell, Rebeccah Slater, Matthew J Brookes,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5628]

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A tool for functional brain imaging with lifespan compliance.

Ryan M Hill, Elena Boto, Niall Holmes, Caroline Hartley, Zelekha A Seedat, James Leggett, Gillian Roberts, Vishal Shah, Tim M Tierney, Mark W Woolrich, Charlotte J Stagg, Gareth R Barnes, Richard Bowtell, Rebeccah Slater, Matthew J Brookes,

The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelopment are limited due to growth in head-size with age and substantial head movement in young participants. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):4785]

Cited: 2 times

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Oral morphine analgesia for preventing pain during invasive procedures in non-ventilated premature infants in hospital: the Poppi RCT

Vaneesha Monk, Fiona Moultrie, Caroline Hartley, Amy Hoskin, Gabrielle Green, Jennifer L Bell, Caz Stokes, Ed Juszczak, Jane Norman, Richard Rogers, Chetan Patel, Eleri Adams, Rebeccah Slater,

BACKGROUND:Identifying better pain management strategies for painful procedures performed in neonatal care is a clinical priority. Retinopathy of prematurity screening and heel-lance blood tests are essential clinical procedures, but adequate pain relief is not currently provided because of a lack of evidence-based analgesia. Morphine provides effective analgesia in older children ... Read more >>

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Nociception and the neonatal brain.

Deniz Gursul, Caroline Hartley, Rebeccah Slater,

Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological ... Read more >>

Semin Fetal Neonatal Med (Seminars in fetal & neonatal medicine)
[2019, 24(4):101016]

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The challenge of distinguishing pain from distress in young children.

Rebeccah Slater,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2019, 3(6):367-368]

Cited: 1 time

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Preemptive Morphine During Therapeutic Hypothermia After Neonatal Encephalopathy: A Secondary Analysis.

Natasha Liow, Paolo Montaldo, Peter J Lally, Justinas Teiserskas, Paul Bassett, Vânia Oliveira, Josephine Mendoza, Rebeccah Slater, Seetha Shankaran, Sudhin Thayyil,

Although therapeutic hypothermia (TH) improves outcomes after neonatal encephalopathy (NE), the safety and efficacy of preemptive opioid sedation during cooling therapy is unclear. We performed a secondary analysis of the data from a large multicountry prospective observational study (Magnetic Resonance Biomarkers in Neonatal Encephalopathy [MARBLE]) to examine the association of ... Read more >>

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2020, 10(1):45-52]

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Birth experience in newborn infants is associated with changes in nociceptive sensitivity.

Severin Kasser, Caroline Hartley, Hanna Rickenbacher, Noemi Klarer, Antoinette Depoorter, Alexandre N Datta, Maria M Cobo, Sezgi Goksan, Amy Hoskin, Walter Magerl, Evelyn A Huhn, Gabrielle Green, Rebeccah Slater, Sven Wellmann,

Vaginal birth prepares the fetus for postnatal life. It confers respiratory, cardiovascular and homeostatic advantages to the newborn infant compared with elective cesarean section, and is reported to provide neonatal analgesia. We hypothesize that infants born by vaginal delivery will show lower noxious-evoked brain activity a few hours after birth ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):4117]

Cited: 1 time

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Behavioural discrimination of noxious stimuli in infants is dependent on brain maturation.

Gabrielle Green, Caroline Hartley, Amy Hoskin, Eugene Duff, Adam Shriver, Dominic Wilkinson, Eleri Adams, Richard Rogers, Fiona Moultrie, Rebeccah Slater,

Changes in facial expression are an essential form of social communication and in nonverbal infants are often used to alert care providers to pain-related distress. However, studies of early human brain development suggest that premature infants aged less than 34 weeks' gestation do not display discriminative brain activity patterns to ... Read more >>

Pain (Pain)
[2019, 160(2):493-500]

Cited: 3 times

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Stroking modulates noxious-evoked brain activity in human infants.

Deniz Gursul, Sezgi Goksan, Caroline Hartley, Gabriela Schmidt Mellado, Fiona Moultrie, Amy Hoskin, Eleri Adams, Gareth Hathway, Susannah Walker, Francis McGlone, Rebeccah Slater,

A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1] and respond optimally to stroking at ∼1-10 cm/s, serving a protective function by promoting affiliative behaviours. In adult humans, stimulation of these C-tactile (CT) afferents is pleasant, and can reduce pain perception [2]. ... Read more >>

Curr. Biol. (Current biology : CB)
[2018, 28(24):R1380-R1381]

Cited: 5 times

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A universal right to pain relief: balancing the risks in a vulnerable patient population.

Fiona Moultrie, Adam Shriver, Caroline Hartley, Dominic Wilkinson, Andrew K Ewer, Richard Rogers, Eleri Adams, Rebeccah Slater,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2019, 3(2):62-64]

Cited: 0 times

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Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.

Caroline Hartley, Fiona Moultrie, Amy Hoskin, Gabrielle Green, Vaneesha Monk, Jennifer L Bell, Andrew R King, Miranda Buckle, Marianne van der Vaart, Deniz Gursul, Sezgi Goksan, Edmund Juszczak, Jane E Norman, Richard Rogers, Chetan Patel, Eleri Adams, Rebeccah Slater,

BACKGROUND:Infant pain has immediate and long-term effects but is undertreated because of a paucity of evidence-based analgesics. Although morphine is often used to sedate ventilated infants, its analgesic efficacy is unclear. We aimed to establish whether oral morphine could provide effective and safe analgesia in non-ventilated premature infants for acute ... Read more >>

Lancet (Lancet (London, England))
[2018, 392(10164):2595-2605]

Cited: 5 times

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Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants.

Luke Baxter, Sean Fitzgibbon, Fiona Moultrie, Sezgi Goksan, Mark Jenkinson, Stephen Smith, Jesper Andersson, Eugene Duff, Rebeccah Slater,

The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of current MRI analysis tools were designed for use in adults, a primary objective of the Developing Human Connectome Project (dHCP) is to develop optimised methodological pipelines for the analysis ... Read more >>

Neuroimage (NeuroImage)
[2019, 186:286-300]

Cited: 1 time

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The influence of the descending pain modulatory system on infant pain-related brain activity.

Sezgi Goksan, Luke Baxter, Fiona Moultrie, Eugene Duff, Gareth Hathway, Caroline Hartley, Irene Tracey, Rebeccah Slater,

The descending pain modulatory system (DPMS) constitutes a network of widely distributed brain regions whose integrated function is essential for effective modulation of sensory input to the central nervous system and behavioural responses to pain. Animal studies demonstrate that young rodents have an immature DPMS, but comparable studies have not ... Read more >>

Elife (eLife)
[2018, 7:]

Cited: 2 times

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Nociceptive brain activity as a measure of analgesic efficacy in infants.

Caroline Hartley, Eugene P Duff, Gabrielle Green, Gabriela Schmidt Mellado, Alan Worley, Richard Rogers, Richard Rogers, Rebeccah Slater,

Pain in infants is undertreated and poorly understood, representing a major clinical problem. In part, this is due to our inability to objectively measure pain in nonverbal populations. We present and validate an electroencephalography-based measure of infant nociceptive brain activity that is evoked by acute noxious stimulation and is sensitive ... Read more >>

Sci Transl Med (Science translational medicine)
[2017, 9(388):]

Cited: 14 times

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Improving the treatment of infant pain.

Fiona Moultrie, Rebeccah Slater, Caroline Hartley,

PURPOSE OF REVIEW:Pain management presents a major challenge in neonatal care. Newborn infants who require medical treatment can undergo frequent invasive procedures during a critical period of neurodevelopment. However, adequate analgesic provision is infrequently and inconsistently provided for acute noxious procedures because of limited and conflicting evidence regarding analgesic efficacy ... Read more >>

Curr Opin Support Palliat Care (Current opinion in supportive and palliative care)
[2017, 11(2):112-117]

Cited: 6 times

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A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol

Rebeccah Slater, Caroline Hartley, Fiona Moultrie, Eleri Adams, Ed Juszczak, Richard Rogers, Jane Norman, Chetan Patel, Kayleigh Stanbury, Amy Hoskin, Gabrielle Green, ,

Infant pain has both immediate and long-term negative consequences, yet in clinical practice it is often undertreated. To date, few pain-relieving drugs have been tested in infants. Morphine is a potent analgesic that provides effective pain relief in adults, but there is inconclusive evidence for its effectiveness in infants. The ... Read more >>

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A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol.

Rebeccah Slater, Caroline Hartley, Fiona Moultrie, Eleri Adams, Ed Juszczak, Richard Rogers, Jane E Norman, Chetan Patel, Kayleigh Stanbury, Amy Hoskin, Gabrielle Green, ,

Infant pain has both immediate and long-term negative consequences, yet in clinical practice it is often undertreated. To date, few pain-relieving drugs have been tested in infants. Morphine is a potent analgesic that provides effective pain relief in adults, but there is inconclusive evidence for its effectiveness in infants. The ... Read more >>

Wellcome Open Res (Wellcome open research)
[2016, 1:7]

Cited: 4 times

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Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.

Sezgi Goksan, Caroline Hartley, Samuel A Hurley, Anderson M Winkler, Eugene P Duff, Mark Jenkinson, Richard Rogers, Stuart Clare, Rebeccah Slater,

Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin-spin relaxation time constant ( T2*) that describes the decay of transverse magnetization. Use of the optimal TE during fMRI experiments allows maximal sensitivity to BOLD to be ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2017, 78(2):625-631]

Cited: 2 times

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Using only behaviours to assess infant pain: a painful compromise?

Rebecca Pillai Riddell, Maria Fitzgerald, Rebeccah Slater, Bonnie Stevens, Celeste Johnston, Marsha Campbell-Yeo,

Pain (Pain)
[2016, 157(8):1579-1580]

Cited: 8 times

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